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Włodzimierz Opoka et al.
Acta poloniae pharmaceutica, 70(6), 961-965 (2014-01-05)
Zinc is an interesting target for detection as it is one of the elements necessary for the proper functioning of the human body, its excess and deficiency can cause several symptoms. Several techniques including electrochemistry have been developed but require
Xuan-Yu Min et al.
International journal of radiation biology, 90(10), 909-913 (2014-05-16)
To develop a new biological dosimeter based on serum zinc concentration. Male mice (8 weeks old) were exposed to different doses (0, 1.0, 2.0, 4.0, or 8.0 Gy) of gamma rays from a (60)Co source. Blood was then collected from
Use of activation methods for organozinc reagents.
Erdik E
Tetrahedron, 43(10), 2203-2212 (1987)
Peter Stenvinkel et al.
Clinical journal of the American Society of Nephrology : CJASN, 1(2), 281-287 (2007-08-21)
Myeloperoxidase (MPO), which is secreted during activation of neutrophils, may serve as one mechanistic link among persistent inflammation, oxidative stress, and cardiovascular disease. This study related MPO activity to inflammatory and oxidative stress biomarkers, comorbidity, and ongoing medication in prevalent
Brittany L Mortensen et al.
Journal of bacteriology, 196(14), 2616-2626 (2014-05-13)
Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia in intensive care units, and the increasing rates of antibiotic resistance make treating these infections challenging. Consequently, there is an urgent need to develop new antimicrobials to treat A. baumannii infections.
J-M Serot et al.
Journal of neurology, neurosurgery, and psychiatry, 76(11), 1585-1587 (2005-10-18)
Homocysteine may be involved in the pathogenesis of late onset Alzheimer's disease. It is implicated in the metabolism of several important pathways in the brain. Methylmalonic acid (MMA) is related to the metabolism of branched chained amino acids and fatty
T Kikuchi et al.
Clinical chemistry, 27(11), 1899-1902 (1981-11-01)
We describe a method for determination of guanidino compounds in plasma and erythrocytes. The compounds are separated by liquid chromatography, the concentrations in the effluent being estimated fluorometrically (Trans. Am. Soc. Artif. Intern. Organs 24: 61, 1978). Guanidinoacetic acid, guanidinosuccinic
Jian-ping Jia et al.
Chinese medical journal, 117(8), 1161-1164 (2004-09-14)
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD). The purpose of
Kohei Takeshita et al.
Nature structural & molecular biology, 21(4), 352-357 (2014-03-04)
The voltage-gated proton channel Hv1 (or VSOP) has a voltage-sensor domain (VSD) with dual roles of voltage sensing and proton permeation. Its gating is sensitive to pH and Zn(2+). Here we present a crystal structure of mouse Hv1 in the
Najjapak Sooksawat et al.
Journal of environmental sciences (China), 25(3), 596-604 (2013-08-08)
The ability for usage of common freshwater charophytes, Chara aculeolata and Nitella opaca in removal of cadmium (Cd), lead (Pb) and zinc (Zn) from wastewater was examined. C. aculeolata and N. opaca were exposed to various concentrations of Cd (0.25
A viewpoint about the treatment of Wilson's disease.
Abdul Qayyum Rana et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 40(4), 612-614 (2013-06-22)
Priscilla K Walker et al.
Health physics, 106(4), 523-527 (2014-02-25)
Beam shaping in scattered and uniform scanned proton beam therapy (PBT) is made commonly by brass apertures. Due to proton interactions, these devices become radioactive and could pose safety issues and radiation hazards. Nearly 2,000 patient-specific devices per year are
Kazuko Nakashima-Kaneda et al.
International archives of allergy and immunology, 161 Suppl 2, 44-51 (2013-06-05)
Zinc (Zn) affects many aspects of immune function, including thymic development and the activities of immune cells. Zn is also involved in many steps of high-affinity IgE receptor (FcεRI)-induced mast cell (MC) activation, which is required for degranulation and cytokine
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism
Eleni Kouremenou-Dona et al.
The Science of the total environment, 359(1-3), 76-81 (2005-06-16)
Serum copper and zinc concentrations of 506 (414 males and 92 females) apparently healthy Greek blood donors aged 18-60 years old were determined by flame atomic absorption spectrometry. The mean copper and zinc concentrations were 115.46+/-23.56 microg/dl and 77.11+/-17.67 microg/dl
Beatriz Garrido-Rodriguez et al.
Chemosphere, 107, 379-385 (2014-01-29)
Batch type and column experiments were used to study competitive adsorption-desorption and transport for Cd, Cu, Ni and Zn in a mine soil, both un-amended and amended with mussel shell. Batch type experiments showed that adsorption was affected by the
Marcella C Galvão et al.
Life sciences, 120, 54-60 (2014-12-03)
Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring.
R Paniagua et al.
Nephron, 69(2), 147-150 (1995-01-01)
Patients with chronic renal failure often have low plasma zinc (Zn) levels. Some factors that may account for abnormal Zn metabolism in these patients are low dietary Zn intake, a specific Zn transport defect, or absence of intestinal Zn ligand.
Richa Marwari et al.
Journal of environmental biology, 33(5), 849-854 (2013-06-06)
In this study Sanganer town, Jaipur was selected as study area. The plants of Lycopersicon esculentum var. K 21(Tomato) treated with 20 and 30% textile wastewater were analyzed for metal accumulation, growth and biochemical parameters at per, peak and post
Melissa Shea-Budgell et al.
Experimental biology and medicine (Maywood, N.J.), 231(5), 553-558 (2006-04-26)
Lipopolysaccharide (LPS) triggers a global activation of inflammatory responses leading to liver injury in humans. Zinc pretreatment has been shown to prevent LPS-induced hepatic necrosis. In North America, suboptimal zinc status is more common than once realized. However, the effect
Shuichi Tsuruoka et al.
British journal of clinical pharmacology, 60(2), 204-207 (2005-07-27)
To compare the degree of taste disturbance by candesartan and valsartan. Candesartan cilexetil (4 mg day(-1)), valsartan (40 mg day(-1)), or vehicle was given to subjects (n = 8) for 13 days in a randomized, placebo-controlled, three-way crossover design with
Manuela Mellone et al.
Journal of neurochemistry, 132(2), 159-168 (2014-10-17)
Zinc (Zn(2+) ) is believed to play a relevant role in the physiology and pathophysiology of the brain. Hence, Zn(2+) homeostasis is critical and involves different classes of molecules, including Zn(2+) transporters. The ubiquitous Zn(2+) transporter-1 (ZNT-1) is a transmembrane
FPIN's clinical inquiries. Treatments for symptoms of the common cold.
Cat Livingston et al.
American family physician, 88(12), Online-Online (2013-12-25)
Pietro Minuz et al.
Hypertension (Dallas, Tex. : 1979), 51(5), 1379-1385 (2008-04-02)
The aim of the present cross-sectional study was to investigate whether activation of the renin-angiotensin system in renovascular disease affects the cytochrome P450 omega/omega-1 hydroxylase (20-hydroxyeicosatetraenoic acid [20-HETE]) and epoxygenase (epoxyeicosatrienoic acids [EETs]) pathways of arachidonic acid metabolism in vivo
Woon Ju Song et al.
Science (New York, N.Y.), 346(6216), 1525-1528 (2014-12-20)
The generation of new enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds because of the challenge in designing functional, three-dimensional protein structures from first principles. Here we report an artificial metallo-β-lactamase, constructed via the self-assembly
E P Pasichna et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 137-148 (2014-02-01)
It is known that inflammatory cytokines, which level is significantly increased in the pathogenesis of multiple sclerosis (MS), as well as interferon-beta, which is used to treat autoimmune diseases, can inhibit cytochrome P450-dependent processes of detoxification and biotransformation. The uncontrolled
Nicola M Lowe et al.
Critical reviews in food science and nutrition, 53(10), 1110-1123 (2013-08-21)
Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide
Yongmei Zhao et al.
Stroke, 45(4), 1139-1147 (2014-03-20)
Zinc has been reported to possess both neurotoxic and neuroprotective capabilities. The effects of elevated intracellular zinc accumulation following transient focal cerebral ischemia remain to be fully elucidated. Here, we investigated whether removing zinc with the membrane-permeable zinc chelator, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Tasleem Akhtar et al.
Pakistan journal of pharmaceutical sciences, 27(1), 173-177 (2014-01-01)
Zinc deficiency is a commonly reported health problem throughout the world. This cross sectional survey was conducted in rural Peshawar with an aim to estimate the prevalence of zinc deficiency in women of child bearing age and find its association
C Syburra et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 71(3), 112-115 (1999-12-28)
It is well known that brain and nervous system cells are prone to oxidative damage because of their relatively low content of antioxidants, especially enzymatic ones, and of the high levels of both membrane polyunsaturated fatty acids (PUFA) and iron
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