319953

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In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.

Cristina Galiana-Roselló et al.

Journal of medicinal chemistry, 56(22), 8984-8998 (2013-10-25)

We report in vivo and in vitro antileishmanial and trypanocidal activities of a new series of N-substituted benzene and naphthalenesulfonamides 1-15. Compounds 1-15 were screened in vitro against Leishmania infantum , Leishmania braziliensis , Leishmania guyanensis , Leishmania amazonensis

The use of nucleic acid based stable isotope probing to identify the microorganisms responsible for anaerobic benzene and toluene biodegradation.

Alison M Cupples

Journal of microbiological methods, 85(2), 83-91 (2011-03-02)

The remediation of sites contaminated with gasoline has been limited by a lack of information on the microorganisms able to transform these chemicals under anaerobic conditions. To address this, researchers have recently adopted a molecular method, called stable isotope probing

Low-dose metabolism of benzene in humans: science and obfuscation.

Stephen M Rappaport et al.

Carcinogenesis, 34(1), 2-9 (2012-12-12)

Benzene is a ubiquitous air pollutant that causes human leukemia and hematotoxic effects. Although the mechanism by which benzene causes toxicity is unclear, metabolism is required. A series of articles by Kim et al. used air and biomonitoring data from

Versatile ene-thiol photoclick reaction for preparation of multimodal monolithic silica capillary columns.

A Marechal et al.

Journal of chromatography. A, 1365, 140-147 (2014-09-25)

This paper presents a photografting process of monolithic silica capillary columns based on the ene-thiol click chemistry. This study is performed on a "generic" vinyl-functionalized silica monolith (Hmin 6±1μm). The photoclick reaction is investigated using different thiol monomers (octadecanethiol, cysteine

Catalytic oxidation of benzene using mesoporous alpha-Mn2O3.

Hyung Bum An et al.

Journal of nanoscience and nanotechnology, 13(11), 7472-7476 (2013-11-20)

The catalytic oxidation of benzene was carried out over mesoporous alpha-Mn2O3, MnOx/KIT-6, and bulk commercial Mn oxides (Mn2O3, MnO2, and MnO). The catalysts were characterized using X-ray diffraction, X-ray photoelectron spectroscopy, Brunauer-Emmett-Teller analysis, and temperature-programmed reduction analysis. MnOx/KIT-6, prepared by

Modeling the drugs' passive transfer in the body based on their chromatographic behavior.

Maria G Kouskoura et al.

Journal of pharmaceutical and biomedical analysis, 100, 94-102 (2014-08-26)

One of the most challenging aims in modern analytical chemistry and pharmaceutical analysis is to create models for drugs' behavior based on simulation experiments. Since drugs' effects are closely related to their molecular properties, numerous characteristics of drugs are used

Authors' response to comments on Petty et al. (2011), "a quantitative method for estimating dermal benzene absorption from benzene containing hydrocarbon liquids," IJOEH, 17:287-300 by Pamela R.D. Williams, Jennifer Sahmel, Annette L.Bunge, Jeffrey Knutsen, and John Spencer.

Stephen E Petty et al.

International journal of occupational and environmental health, 19(2), 147-154 (2013-07-20)

Emission of volatile organic compounds from religious and ritual activities in India.

Shippi Dewangan et al.

Environmental monitoring and assessment, 185(11), 9279-9286 (2013-05-28)

Worshipping activity is a customary practice related with many religions and cultures in various Asian countries, including India. Smoke from incense burning in religious and ritual places produces a large number of health-damaging and carcinogenic air pollutants include volatile organic

Adsorptive removal of bisphenol-A from water with a metal-organic framework, a porous chromium-benzenedicarboxylate.

Eun Young Park et al.

Journal of nanoscience and nanotechnology, 13(4), 2789-2794 (2013-06-15)

Adsorptive removal of bisphenol-A (BPA) using a MOF, Cr-benzenedicarboxylate (MIL-53), has been studied to understand the applicability of MOFs for the removal of hazardous endocrine disturbing chemicals from water. MIL-53 shows very fast adsorption in an hour and the adsorption

BTEX pollution caused by motorcycles in the megacity of HoChiMinh.

Tran Thi Ngoc Lan et al.

Journal of environmental sciences (China), 25(2), 348-356 (2013-04-20)

Monitoring of benzene, toluene and xylenes (BTEX) was conducted along with traffic counts at 17 roadside sites in urban areas of HoChiMinh. Toluene was the most abundant substance, followed by p,m-xylenes, benzene, o-xylene and ethylbenzene. The maximum observed hour-average benzene

Preparation and evaluation of benzyl methacrylate monoliths for capillary chromatography.

Ahmad Aqel et al.

Journal of chromatographic science, 52(3), 201-210 (2013-02-21)

This paper describes the comprehensive fabrication of monolithic materials for use as stationary phases in capillary liquid chromatography. Several columns were synthesized in the confines of 320 µm i.d. fused-silica capillaries by single-step in situ copolymerization of benzyl methacrylate and

Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

Guangtao Zhang et al.

Journal of medicinal chemistry, 56(22), 9251-9264 (2013-10-23)

BRD4, characterized by two acetyl-lysine binding bromodomains and an extra-terminal (ET) domain, is a key chromatin organizer that directs gene activation in chromatin through transcription factor recruitment, enhancer assembly, and pause release of the RNA polymerase II complex for transcription

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.

Cliona M McHale et al.

Carcinogenesis, 33(2), 240-252 (2011-12-15)

Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated

Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy related-disease.

Richard D Irons et al.

Genes, chromosomes & cancer, 52(10), 887-894 (2013-07-11)

Benzene (Bz) is widely regarded as a prototype environmental leukemogen and individuals chronically exposed are at risk for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It is widely assumed that initiation and pathogenesis of AML following Bz exposure (Bz-AML)

Effect of benzene, toluene, xylene on the semen quality and the function of accessory gonad of exposed workers.

G Xiao et al.

Industrial health, 39(2), 206-210 (2001-05-09)

The effects on semen and the function of accessory gonad of workers after short and long term exposure to benzene, toluene, and xylene were examined. The semen and blood of 24 married workers exposed to benzene, toluene, and xylene were

Take a number.

Michelle Francl

Nature chemistry, 5(9), 725-726 (2013-08-24)

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

Shigeo Hayashi et al.

Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage

Designing ternary cocrystals with hydrogen bonds and halogen bonds.

Srinu Tothadi et al.

Chemical communications (Cambridge, England), 49(71), 7791-7793 (2013-07-25)

A graded selection of hydrogen bonds and halogen bonds allows for the isolation of 2 : 1 : 1 ternary cocrystals of the general form 4-nitrobenzamide : diacid : 1,4-dihalogenated benzene, which are mediated by the amide-acid and I···O2N supramolecular synthons.

Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum.

Richard D Irons et al.

Annals of the New York Academy of Sciences, 1310, 84-88 (2014-03-13)

Hematopoiesis in health and disease results from complex interactions between primitive hematopoietic stem cells (HSCs) and the extrinsic influences of other cells in the bone marrow (BM) niche. Advances in stem cell biology, molecular genetics, and computational biology reveal that

Metabolic polymorphisms and biomarkers of effect in the biomonitoring of occupational exposure to low-levels of benzene: state of the art.

G De Palma et al.

Toxicology letters, 231(2), 194-204 (2014-12-03)

Current levels of occupational exposure to benzene, a genotoxic human carcinogen, in Western countries are reduced by two-three orders of magnitude (from ppm to ppb) as compared to the past. However, as benzene toxicity is strongly dependent on biotransformation and

Measurement of BTEX (benzene, toluene, ethybenzene, and xylene) levels at urban and semirural areas of Algiers City using passive air samplers.

Yacine Kerchich et al.

Journal of the Air & Waste Management Association (1995), 62(12), 1370-1379 (2013-02-01)

The study presents the levels of air pollution by aromatic organic compounds BTEX (benzene, toluene, ethylbenzene, o-, m-, and p-xylenes) in the city of Algiers. The sampling was carried out using Radiello passive sampler. Three sampling campaigns were carried out

Decoys for docking.

Alan P Graves et al.

Journal of medicinal chemistry, 48(11), 3714-3728 (2005-05-27)

Molecular docking is widely used to predict novel lead compounds for drug discovery. Success depends on the quality of the docking scoring function, among other factors. An imperfect scoring function can mislead by predicting incorrect ligand geometries or by selecting

[Studies on relationship between exposure to low concentration of mixed benzene and lower quality of semen and very early fetal loss].

S Wang et al.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 34(5), 271-273 (2001-05-25)

To study the effects of exposure to low concentration of mixed benzene on their semen quality and very early fetal loss (VEFL) in the occupational population. Environmental monitoring and biological monitoring were conducted in 126 employees exposed to mixed benzene

3D-QSAR studies on the toxicity of substituted benzenes to Tetrahymena pyriformis: CoMFA, CoMSIA and VolSurf approaches.

M Salahinejad et al.

Ecotoxicology and environmental safety, 105, 128-134 (2014-03-19)

Three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis were performed on the toxicity of a large set of substituted benzenes toward ciliate Tetrahymena pyriformis. The 3D-QSAR studies were carried out using comparative molecular ﬁeld analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA)

High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging.

Yunbin Xiao et al.

International journal of nanomedicine, 10, 1155-1172 (2015-02-25)

Magnetic resonance imaging (MRI) contrast agents based on chitosan derivatives have great potential for diagnosing diseases. However, stable tumor-targeted MRI contrast agents using micelles prepared from high molecular weight chitosan derivatives are seldom reported. In this study, we developed a

The effect of nC₆₀ on tissue distribution of ibuprofen in Cyprinus carpio.

Qiqing Chen et al.

The Science of the total environment, 496, 453-460 (2014-08-12)

The potential transfer of fullerene aqueous suspension (nC₆₀) associated contaminants in vivo is one of the most significant and currently not well-understood environmental risks. In this study, the carrier function of nC₆₀ for ibuprofen (IBU) was examined through whole-body and

Silver nanoparticles supported on passivated silica: preparation and catalytic performance in alkyne semi-hydrogenation.

Emma Oakton et al.

Dalton transactions (Cambridge, England : 2003), 43(40), 15138-15142 (2014-09-03)

Herein, we report the preparation of small and narrowly distributed (2.1 ± 0.5 nm) Ag nanoparticles supported on passivated silica, where the surface OH groups are replaced by OSiMe3 functionalities. This synthetic method involves the grafting of silver(I) bis(trimethylsilyl)amide ([AgN(SiMe3)2]4)

Catalytic oxidation of benzene with ozone over Mn/KIT-6.

Jong Hwa Park et al.

Journal of nanoscience and nanotechnology, 13(1), 423-426 (2013-05-08)

Benzene is one of the target compounds to be removed from air owing to its carcinogenicity. In this study, benzene oxidation with ozone over a MnOx/KIT-6 catalyst was carried out for the first time. MnOx/KIT-6 was synthesized using two different

[The influence of bacterial autoregulation molecules (homoserine lactones and alkyloxybenzoles) on oxidative metabolism of the natural immunity cellular effectors].

D G Deriabin et al.

Mikrobiologiia, 82(2), 147-156 (2013-07-03)

Occupational benzene exposure and the risk of lymphoma subtypes: a meta-analysis of cohort studies incorporating three study quality dimensions.

Jelle Vlaanderen et al.

Environmental health perspectives, 119(2), 159-167 (2010-10-01)

The use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power. We performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin

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