320-50-3

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关键词:'320-50-3'

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CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes.

Hong-Yan Ling et al.

Clinical and experimental pharmacology & physiology, 36(9), e32-e39 (2009-05-29)

1. MicroRNAs (miRNAs) play essential roles in many biological processes. It is known that aberrant miRNA expression contributes to some pathological conditions. However, it is not known whether miRNAs play any role in the development of insulin resistance in adipocytes

Comparative efficacy of indacaterol 150 μg and 300 μg versus fixed-dose combinations of formoterol + budesonide or salmeterol + fluticasone for the treatment of chronic obstructive pulmonary disease--a network meta-analysis.

Shannon Cope et al.

International journal of chronic obstructive pulmonary disease, 6, 329-344 (2011-06-24)

To compare efficacy of indacaterol to that of fixed-dose combination (FDC) formoterol and budesonide (FOR/BUD) and FDC salmeterol and fluticasone (SAL/FP) for the treatment of chronic obstructive pulmonary disease (COPD) based on the available randomized clinical trials (RCTs). Fifteen placebo-controlled

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Richard I Feldman et al.

The Journal of biological chemistry, 280(20), 19867-19874 (2005-03-18)

The phosphoinositide 3-kinase/3-phosphoinositide-dependent kinase 1 (PDK1)/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor angiogenesis and represents a promising target for anticancer drugs. Here, we describe three potent PDK1 inhibitors, BX-795, BX-912, and BX-320 (IC(50)

Low contrast and radiation dose coronary CT angiography using a 320-row system and a refined contrast injection and timing method.

Seitaro Oda et al.

Journal of cardiovascular computed tomography, 9(1), 19-27 (2015-02-14)

Among CT scanners, 320-row instruments feature decreased photon energy and yield strong contrast enhancement. Consequently, the contrast medium (CM) dose can be reduced. The results of low-tube-voltage coronary CT angiography (CCTA) performed on 320-row scanners have not been adequately assessed.

Transcription suppression of peroxisome proliferator-activated receptor gamma2 gene expression by tumor necrosis factor alpha via an inhibition of CCAAT/ enhancer-binding protein delta during the early stage of adipocyte differentiation.

Masataka Kudo et al.

Endocrinology, 145(11), 4948-4956 (2004-07-31)

TNFalpha is known to inhibit adipocyte differentiation and induce insulin resistance. Moreover, TNFalpha is known to down-regulate peroxisome proliferator-activated receptor (PPAR)gamma2, an adipocyte-specific nuclear receptor of insulin-sensitizer thiazolidinediones. To clarify molecular mechanisms of TNFalpha- mediated PPARgamma2 down-regulation, we here examined

Increasing the instrumental throughput of gas chromatography method using multiple injections in a single experimental run: application in determination of friedelan-3-ol and friedelin in Maytenus ilicifolia.

Jacqueline Pereira Vistuba et al.

Journal of chromatography. A, 1274, 159-164 (2013-01-02)

The aim of this study was to develop a separation method using multiple injections in a single experimental run (MISER) employing gas chromatography with flame ionization detection (GC-FID) for the first time, without instrument modification, to increase the instrumental throughput.

Once-daily treatment with beclomethasone dipropionate nasal aerosol does not affect hypothalamic-pituitary-adrenal axis function.

Paul H Ratner et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 109(5), 336-341 (2012-10-16)

Intranasal corticosteroids are effective in controlling allergic rhinitis (AR) symptoms; however, chronic administration of corticosteroids may suppress hypothalamic-pituitary-adrenal (HPA)-axis function. To evaluate the effects of 6 weeks of treatment with beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol on HPA-axis function in

Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer.

Lecia V Sequist et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(18), 3076-3083 (2010-05-19)

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have had a significant impact on non-small-cell lung cancer (NSCLC) outcomes, particularly for patients with EGFR mutations. Resistance emerges after 9 to 12 months, primarily mediated by the T790M resistance mutation.

DNASE1L3 mutations in hypocomplementemic urticarial vasculitis syndrome.

Z Birsin Ozçakar et al.

Arthritis and rheumatism, 65(8), 2183-2189 (2013-05-15)

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is characterized by recurrent urticaria along with dermal vasculitis, arthritis, and glomerulonephritis. Systemic lupus erythematosus (SLE) develops in >50% of patients with HUVS, although the pathogenesis is unknown. The aim of this study was to

A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

M Jonathan Fray et al.

Journal of medicinal chemistry, 46(16), 3514-3525 (2003-07-25)

The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and growth factors and their receptors. The overexpression of MMP-3 (stromelysin-1) and MMP-13 (collagenase-3) is associated with nonhealing wounds, whereas

Single basic amino acid substitutions at position 302 or 320 in the V3 domain of HIV type 1 are not sufficient to alter the antiviral activity of dextran sulfate and heparin.

T Okada et al.

AIDS research and human retroviruses, 11(5), 571-575 (1995-05-01)

The third variable domain (V3 domain) of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 contains a substantial number of positively charged amino acid residues. We previously demonstrated that mutation of basic amino acid residues at position 303

Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.

Patricia L Podolin et al.

The Journal of pharmacology and experimental therapeutics, 312(1), 373-381 (2004-08-19)

Demonstration that IkappaB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-kappaB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment

High affinity interaction of endothelin-3 with recombinant ETA receptors.

J Desmarets et al.

Biochemical and biophysical research communications, 256(2), 357-360 (1999-03-18)

Pharmacological evidence has suggested that endothelin-3 (ET-3) may act via a novel form of ET receptor that is shared by ETA receptor antagonists but not by ETB receptor selective agonists. This study analyses the properties of interaction of ET-3 with

Xanthine oxidase/tyrosinase inhibiting, antioxidant, and antifungal oxindole alkaloids from Isatis costata.

Ijaz Ahmad et al.

Pharmaceutical biology, 48(6), 716-721 (2010-07-22)

Phytochemical investigations on the ethyl acetate soluble fraction of the whole plant of Isatis costata Linn. (Brassicaseae) led to the isolation of the oxindole alkaloids costinones A (1), B (2), isatinones A (3), B (4), indirubin (5), and trisindoline (6).

GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats.

Josiane C Cruz et al.

Autonomic neuroscience : basic & clinical, 146(1-2), 47-55 (2009-01-10)

GABAergic, nitrergic and glutamatergic mechanisms in the PVN on the baseline mean arterial pressure (MAP), heart rate (HR) and on the cardiovascular responses to chemoreflex activation in awake rat were evaluated. Chemoreflex was activated with KCN before and after microinjections

Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family.

S E Moss et al.

European journal of biochemistry, 177(1), 21-27 (1988-10-15)

A plasmid cDNA library prepared from a T-lymphocyte clone of murine strain B10.A origin was screened by cross-species DNA hybridisation using a partial human p68 cDNA clone, identified as containing coding sequences for previously determined amino-acid sequences. The longest p68

Bioavailability of opipramol from a film-coated tablet, a sugar-coated tablet and an aqueous solution in healthy volunteers.

Frieder Kees et al.

Arzneimittel-Forschung, 53(2), 87-92 (2003-03-20)

Opipramol (4-[3-(5H-dibenz[b,f]-azepine-5-yl)-propyl]-1-piperazine-ethanol dihydrochloride, CAS 315-72-0) is regarded as an anxiolytic compound with antidepressant properties, and it is one of the most frequently prescribed psychotropic drugs in Germany. In two open, randomized cross-over studies in 20 (study 1) and 18 (study

Comparing anti-HIV, antibacterial, antifungal, micellar, and cytotoxic properties of tricarboxylato dendritic amphiphiles.

Richard V Macri et al.

Bioorganic & medicinal chemistry, 17(8), 3162-3168 (2009-03-25)

Three series of homologous dendritic amphiphiles--RCONHC(CH(2)CH(2)COOH)(3), 1(n); ROCONHC(CH(2)CH(2)COOH)(3), 2(n); RNHCONHC(CH(2)CH(2)COOH)(3), 3(n), where R = n-C(n)H(2n+1) and n = 13-22 carbon atoms--were assayed for their potential to serve as antimicrobial components in a topical vaginal formulation. Comparing epithelial cytotoxicities to the

Dihydropyrimidine dehydrogenase: a tumoral target for fluorouracil modulation.

J L Fischel et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1(9), 991-996 (1995-09-01)

Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. Ethynyluracil (776C) is a very potent, mechanism-based irreversible DPD inhibitor that improves the antitumor efficacy and the therapeutic index of FU in laboratory animals. We tested the cytotoxic effects

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.

Alexander E Smith et al.

Blood, 116(19), 3923-3932 (2010-08-10)

Mutations in the TET2 gene are frequent in myeloid disease, although their biologic and prognostic significance remains unclear. We analyzed 355 patients with myelodysplastic syndromes using "next-generation" sequencing for TET2 aberrations, 91 of whom were also subjected to single-nucleotide polymorphism

Trefoil factors in human milk.

Else Marie Vestergaard et al.

Early human development, 84(10), 631-635 (2008-05-27)

We measured concentrations of the gastrointestinal protective peptides Trefoil factors in human milk. By the use of in-house ELISA we detected high amounts of TFF3, less TFF1 and virtually no TFF2 in human breast milk obtained from 46 mothers with

[Determination of nicacid and its metabolites in human plasma by HPLC-MS/MS].

Lei Wang et al.

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 41(6), 1051-1054 (2011-01-27)

To develop a sensitive HPLC-MS/MS method for the determination of nicacid and its metabolites in human plasma. The assay was conducted with an API 3000 LC-MS/MS system comprising of a Genimi C18 column (50 x 3.00 mm, 3 microm), and

Contribution of bradykinin B2 receptors to the inhibition by valsartan of systemic and renal effects of exogenous angiotensin II in salt-repleted humans.

Almerina Biggi et al.

The Journal of pharmacology and experimental therapeutics, 334(3), 911-916 (2010-05-28)

To investigate whether bradykinin (BK) participates in the inhibition of renal effects of exogenous angiotensin II (AngII) by AngII type 1 receptor (AT1R) blockade, eight salt-repleted volunteers underwent four p-aminohippurate- and inulin-based renal studies of AngII infusion at increasing rates

Burden of First and Recurrent Cardiovascular Events Among Patients With Hyperlipidemia.

Rajeshwari S Punekar et al.

Clinical cardiology, 38(8), 483-491 (2015-06-24)

Acute cardiovascular (CV) events have been evaluated in patients with specific comorbidities but have not focused on patients with hyperlipidemia or on the their long-term costs. To evaluate incidence of CV events, costs, and resource utilization among patients with hyperlipidemia

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.

Miki Terakata et al.

The Journal of nutrition, 143(7), 1046-1051 (2013-05-24)

In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (tdo(-/-)) mice fed a diet without preformed niacin

UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation.

Zhan-Guo Gao et al.

Biochemical pharmacology, 79(6), 873-879 (2009-11-10)

UDP-glucose (UDPG), a glycosyl donor in the biosynthesis of carbohydrates, is an endogenous agonist of the G protein-coupled P2Y(14) receptor. RBL-2H3 mast cells endogenously express a P2Y(14) receptor at which UDPG mediates degranulation as indicated by beta-hexosaminidase (HEX) release. Both

Determination of low levels of an antioxidant in polyolefins by large-volume injection temperature-programmed packed capillary liquid chromatography.

P Molander et al.

Journal of chromatography. A, 864(1), 103-109 (2000-01-12)

Sub-ambient column temperatures, promoting strong interactions between the analyte and the stationary phase material, were utilized to focus large volumes of the polyolefin antioxidant Irganox 1076 [benzenepropanoic acid, 3.5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecyl ester] on the column inlet, using pure acetonitrile as sample

Effect of age, weight, and CYP2C19 genotype on escitalopram exposure.

Yuyan Jin et al.

Journal of clinical pharmacology, 50(1), 62-72 (2009-10-21)

The purpose of this study was to characterize escitalopram population pharmacokinetics (PK) in patients treated for major depression in a cross-national, US-Italian clinical trial. Data from the 2 sites participating in this trial, conducted at Pittsburgh (United States) and Pisa

Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts.

A Gödecke et al.

The Journal of physiology, 532(Pt 1), 195-204 (2001-05-23)

1. The functional consequences of a lack of endothelial nitric oxide synthase (eNOS) on left ventricular force development and the anti-adrenergic effect of acetylcholine (ACh) were investigated in isolated hearts and cardiomyocytes from wild type (WT) and eNOS knockout (eNOS-/-)

High-performance thin-layer chromatographic determination of digoxin and related compounds, digoxigenin bisdigitoxoside and gitoxin, in digoxin drug substance and tablets.

G W Ponder et al.

Journal of chromatography. A, 659(1), 177-183 (1994-01-21)

A high-performance thin-layer chromatographic (HPTLC) method for the determination of digoxin and its related compounds digoxigenin bisdigitoxoside (DBD) and gitoxin in digoxin drug substance and tablets was developed. Separation of the three compounds was accomplished on a C18 wettable reversed-phase

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