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Arve Ulvik et al.
The American journal of clinical nutrition, 98(4), 934-940 (2013-09-06)
Tryptophan metabolism through the kynurenine pathway includes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes. We recently showed that plasma 3-hydroxykynurenine (HK) was elevated at low PLP concentrations. We further evaluated and characterized kynurenine-based indexes as possible markers of functional B-vitamin
Gottfried K Schroeder et al.
Biochemistry, 52(24), 4204-4216 (2013-05-23)
cis-3-Chloroacrylic acid dehalogenase (cis-CaaD) from Pseudomonas pavonaceae 170 and a homologue from Corynebacterium glutamicum designated Cg10062 are 34% identical in sequence (54% similar). The former catalyzes a key step in a bacterial catabolic pathway for the nematocide 1,3-dichloropropene, whereas the
Undine Mechold et al.
Nucleic acids research, 41(12), 6175-6189 (2013-04-27)
Both ppGpp and pppGpp are thought to function collectively as second messengers for many complex cellular responses to nutritional stress throughout biology. There are few indications that their regulatory effects might be different; however, this question has been largely unexplored
Kinetic characterization of arginine deiminase and carbamate kinase from Streptococcus pyogenes M49.
Silvio Hering et al.
Protein expression and purification, 91(1), 61-68 (2013-07-23)
Streptococcus pyogenes (group A Streptococcus, GAS) is an important human pathogen causing mild superficial infections of skin and mucous membranes, but also life-threatening systemic diseases. S. pyogenes and other prokaryotic organisms use the arginine deiminase system (ADS) for survival in
James L Smith et al.
Canadian journal of microbiology, 59(3), 141-152 (2013-04-02)
Listeria monocytogenes, a major foodborne pathogen, possesses a number of mechanisms that enable it to combat the challenges posed by acidic environments, such as that of acidic foods and the gastrointestinal tract. One mechanism employed by L. monocytogenes for survival
Ya Gao et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(9), 1001-1008 (2014-01-01)
To determine blue-light induced expression of S-adenosyl-L-homocysteine hydrolase-like (sahhl) gene in fungus Mucor amphibiorum RCS1. In the random process of PCR, a sequence of 555 bp was obtained from M. amphibiorum RCS1. The 555 bp sequence was labeled with digoxin
Antonio C Ruzzini et al.
Biochemistry, 52(42), 7428-7438 (2013-09-27)
The meta-cleavage product (MCP) hydrolases utilize a Ser-His-Asp triad to hydrolyze a carbon-carbon bond. Hydrolysis of the MCP substrate has been proposed to proceed via an enol-to-keto tautomerization followed by a nucleophilic mechanism of catalysis. Ketonization involves an intermediate, ES(red)
Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis.
Bradford CM, Ramos I, Cross AK, et al.
Journal of Neuroimmunology, 273(1-2), 85-95 (2014)
Mahmoud Hajj Chehade et al.
The Journal of biological chemistry, 288(27), 20085-20092 (2013-05-28)
Coenzyme Q (ubiquinone or Q) is a redox-active lipid found in organisms ranging from bacteria to mammals in which it plays a crucial role in energy-generating processes. Q biosynthesis is a complex pathway that involves multiple proteins. In this work
Pluripotency: citrullination unravels stem cells.
Daniel J Slade et al.
Nature chemical biology, 10(5), 327-328 (2014-04-20)
Marjan J Smeulders et al.
Journal of bacteriology, 195(18), 4046-4056 (2013-07-10)
Carbon disulfide (CS(2)) and carbonyl sulfide (COS) are important in the global sulfur cycle, and CS(2) is used as a solvent in the viscose industry. These compounds can be converted by sulfur-oxidizing bacteria, such as Acidithiobacillus thiooxidans species, to carbon
Carlo F Morelli et al.
The FEBS journal, 281(1), 232-245 (2013-11-28)
γ-Glutamyltransferases (γ-GTs) are heterodimeric enzymes that catalyze the transfer of a γ-glutamyl group from a donor species to an acceptor molecule in a transpeptidation reaction through the formation of an intermediate γ-glutamyl enzyme. In our search for a γ-GT from
Ahmed Bettaieb et al.
The Journal of biological chemistry, 288(20), 14189-14199 (2013-04-12)
Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial effects in cardiovascular, inflammatory, and metabolic diseases in murine models. Mice with targeted deletion or pharmacological inhibition of sEH exhibit improved insulin signaling in liver and adipose tissue.
Min Wang et al.
FEBS letters, 587(17), 2851-2859 (2013-07-16)
The function of a Bacteroidetes menaquinone biosynthetic pathway fusion protein comprised of an N-terminal haloacid dehalogenase (HAD) family domain and a C-terminal hotdog-fold family domain is described. Whereas the thioesterase domain efficiently catalyzes 1,4-dihydroxynapthoyl-CoA hydrolysis, an intermediate step in the
Anna Kallio et al.
Infection and immunity, 82(4), 1683-1691 (2014-02-05)
Pneumococcal adherence to mucosal surfaces is a critical step in nasopharyngeal colonization, but so far few pneumococcal adhesins involved in the interaction with host cells have been identified. PhtA, PhtB, PhtD, and PhtE are conserved pneumococcal surface proteins that have
Stefanie Banik et al.
Infection and immunity, 81(7), 2309-2317 (2013-04-17)
Depletion of arginine is a recognized strategy that pathogens use to evade immune effector mechanisms. Depletion depends on microbial enzymes such as arginases, which are considered virulence factors. The effect is mostly interpreted as being a consequence of successful competition
Hepatic gene therapy using lentiviral vectors: has safety been established?
David Dismuke et al.
Hepatology (Baltimore, Md.), 58(1), 13-14 (2013-05-23)
Halina R Novak et al.
FEBS letters, 588(9), 1616-1622 (2014-03-13)
A putative haloalkane dehalogenase has been identified in a marine Rhodobacteraceae and subsequently cloned and over-expressed in Escherichia coli. The enzyme has highest activity towards the substrates 1,6-dichlorohexane, 1-bromooctane, 1,3-dibromopropane and 1-bromohexane. The crystal structures of the enzyme in the
Jeremy Sokolove et al.
Arthritis and rheumatism, 65(7), 1719-1724 (2013-04-05)
To investigate whether citrullinated proteins within the atherosclerotic plaque can be targeted by anti-citrullinated protein antibodies (ACPAs), forming stimulatory immune complexes that propagate the progression of atherosclerosis. Protein lysates prepared from atherosclerotic segments of human aorta were assessed for the
M Yegani et al.
Poultry science, 92(5), 1208-1220 (2013-04-11)
This study was conducted to investigate the effects of exogenous enzymes on growth performance, ileal digestible energy (IDE) and apparent ileal digestibility of CP and amino acids (AA) in broiler chickens fed corn-soy diets formulated using 3 different sources of
Kimberly Martinod et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(21), 8674-8679 (2013-05-08)
Deep vein thrombosis and pulmonary embolism are major health problems associated with high mortality. Recently, DNA-based neutrophil extracellular traps (NETs) resulting from the release of decondensed chromatin, were found to be part of the thrombus scaffold and to promote coagulation.
Isabelle Kuhn et al.
Biochimica et biophysica acta, 1834(12), 2520-2527 (2013-09-17)
Schistosoma mansoni NAD(+) catabolizing enzyme (SmNACE), a distant homolog of mammalian CD38, shows significant structural and functional analogy to the members of the CD38/ADP-ribosyl cyclase family. The hallmark of SmNACE is the lack of ADP-ribosyl cyclase activity that might be
Zachary T Cusumano et al.
Infection and immunity, 82(1), 233-242 (2013-10-23)
A bacterium's ability to acquire nutrients from its host during infection is an essential component of pathogenesis. For the Gram-positive pathogen Streptococcus pyogenes, catabolism of the amino acid arginine via the arginine deiminase (ADI) pathway supplements energy production and provides
Piero Pingitore et al.
Biochimica et biophysica acta, 1841(4), 574-580 (2013-12-27)
The patatin-like phospholipase domain containing 3 (PNPLA3, also called adiponutrin, ADPN) is a membrane-bound protein highly expressed in the liver. The genetic variant I148M (rs738409) was found to be associated with progression of chronic liver disease. We aimed to establish
Chetanya Pandya et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), E3381-E3387 (2013-08-21)
Although the universe of protein structures is vast, these innumerable structures can be categorized into a finite number of folds. New functions commonly evolve by elaboration of existing scaffolds, for example, via domain insertions. Thus, understanding structural diversity of a
Shu Wang et al.
Biochimica et biophysica acta, 1829(10), 1126-1135 (2013-07-19)
Peptidylarginine deiminases are a family of enzymes that mediate post-translational modifications of protein arginine residues by deimination or demethylimination to produce citrulline. In vitro, the activity of PADs is dependent on calcium and reductive reagents carrying a free sulfhydryl group.
Oksana Degtjarik et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 284-287 (2013-03-23)
Haloalkane dehalogenases are microbial enzymes that convert a broad range of halogenated aliphatic compounds to their corresponding alcohols by the hydrolytic mechanism. These enzymes play an important role in the biodegradation of various environmental pollutants. Haloalkane dehalogenase LinB isolated from
Jianshun Chen et al.
The new microbiologica, 36(2), 187-192 (2013-05-21)
Arginine deiminase and agmatine deiminase systems are involved in acid tolerance, and their encoding genes form the cluster lmo0036-0043 in Listeria monocytogenes. While lmo0042 and lmo0043 were conserved in all L. monocytogenes strains, the lmo0036-0041 region of this cluster was
Tycho E T Mevissen et al.
Cell, 154(1), 169-184 (2013-07-06)
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the underlying mechanisms of linkage specificity
Torsten Wuestefeld et al.
Cell, 153(2), 389-401 (2013-04-16)
The liver harbors a distinct capacity for endogenous regeneration; however, liver regeneration is often impaired in disease and therefore insufficient to compensate for the loss of hepatocytes and organ function. Here we describe a functional genetic approach for the identification
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