33699

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Etanercept reduces thermal and mechanical orofacial hyperalgesia following inflammation and neuropathic injury.

S C Coelho et al.

European journal of pain (London, England), 18(7), 957-967 (2014-01-09)

This study evaluated the involvement of tumour necrosis factor α (TNF-α) in orofacial thermal and mechanical hyperalgesia induced by an inflammatory stimulus or by chronic constriction of the infraorbital nerve (CION) using etanercept (Eta), a TNF-receptor fusion protein that inhibits

Development of a novel genetically modified bioluminescent-bacteria-based assay for detection of fluoroquinolones in animal-derived foods.

Guyue Cheng et al.

Analytical and bioanalytical chemistry, 406(30), 7899-7910 (2014-10-31)

Fluoroquinolones (FQNs) are broad-spectrum antibacterial agents widely used in animal husbandry and aquaculture. The residues and antimicrobial resistance of such antibiotics are a major public health concern. To realize multianalyte detection of FQN residues, a genetically modified bacterium, Escherichia coli

Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.

Diego G Rocha et al.

Journal of chromatography. A, 1379, 83-91 (2015-01-13)

This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and kidney: ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, flumequine, marbofloxacin, nalidixic acid, norfloxacin, ofloxacin, oxolinic acid

Residues investigation of fluoroquinolones and sulphonamides and their metabolites in bovine milk by quantification and confirmation using ultra-performance liquid chromatography-tandem mass spectrometry.

Zhe Meng et al.

Food chemistry, 174, 597-605 (2014-12-23)

A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 μg kg(-1)

Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice.

Darryl R Overby et al.

Investigative ophthalmology & visual science, 55(8), 4922-4933 (2014-07-17)

To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. Osmotic mini-pumps were implanted subcutaneously

Experimental study of the impact of antimicrobial treatments on Campylobacter, Enterococcus and PCR-capillary electrophoresis single-strand conformation polymorphism profiles of the gut microbiota of chickens.

Gwenaëlle Mourand et al.

Journal of medical microbiology, 63(Pt 11), 1552-1560 (2014-08-22)

An experiment was conducted to compare the impact of antimicrobial treatments on the susceptibility of Campylobacter, Enterococcus faecium and Enterococcus faecalis, and on the diversity of broiler microbiota. Specific-pathogen-free chickens were first orally inoculated with strains of Campylobacter and Enterococcus

Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.

David J Durgan et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(3), 402-411 (2014-11-27)

Obstructive sleep apnea (OSA) is associated with cerebrovascular diseases. However, little is known regarding the effects of OSA on the cerebrovascular wall. We tested the hypothesis that OSA augments endothelin-1 (ET-1) constrictions of cerebral arteries. Repeated apneas (30 or 60

In vitro selection of RNA aptamers that selectively bind danofloxacin.

Seung Ryul Han et al.

Biochemical and biophysical research communications, 448(4), 397-402 (2014-05-06)

Danofloxacin is a synthetic fluoroquinolone with broad spectrum antibacterial activity that is used for the treatment of respiratory diseases in animal husbandry. However, danofloxacin has many adverse reactions and is toxic to humans. Especially, it detrimentally affects muscle, central nerve

ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli.

Vincent Cattoir et al.

Antimicrobial agents and chemotherapy, 52(8), 2929-2932 (2008-06-04)

A novel QnrB-like plasmid-mediated resistance determinant, QnrB19, was identified from an Escherichia coli clinical isolate from Colombia. Its gene was associated with an ISEcp1-like insertion element that did not act as a promoter for its expression. Using an in vitro

The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole--Orbitrap mass spectrometry.

Guntis Cepurnieks et al.

Journal of pharmaceutical and biomedical analysis, 102, 184-192 (2014-10-06)

A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole

Activities of antimicrobial peptides and synergy with enrofloxacin against Mycoplasma pulmonis.

Lina Fassi Fehri et al.

Antimicrobial agents and chemotherapy, 51(2), 468-474 (2006-11-15)

We showed in a previous study that associations of antimicrobial peptides (AMPs), which are key components of the innate immune systems of all living species, with the fluoroquinolone enrofloxacin can successfully cure HeLa cell cultures of Mycoplasma fermentans and M.

Abscesses associated with a Brucella inopinata-like bacterium in a big-eyed tree frog (Leptopelis vermiculatus).

Dominik Fischer et al.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 43(3), 625-628 (2012-10-23)

A 4-yr-old big-eyed tree frog (Leptopelis vermiculatus) was submitted with two pea-sized (4-mm diameter), firm, and painful masses on the right side of its back. The two abscess-like masses were surgically opened, and a whitish-yellow pasty content was removed. A

First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives.

Alketa Tarushi et al.

Journal of inorganic biochemistry, 121, 53-65 (2013-01-29)

Interaction of equimolar quantities of ZnCl2 with the quinolone antibacterial drugs flumequine (Hflmq), oxolinic acid (Hoxo) or enrofloxacin (Herx) and the N,N'-donor heterocyclic ligands 1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy) results in the formation of 1:1 drug to metal complexes with

Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia.

Yu Bin Ho et al.

The Science of the total environment, 488-489, 261-267 (2014-05-20)

Repeated applications of animal manure as fertilizer are normal agricultural practices that may release veterinary antibiotics and hormones into the environment from treated animals. Broiler manure samples and their respective manure-amended agricultural soil samples were collected in selected locations in

Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype.

Marianne Gunell et al.

Antimicrobial agents and chemotherapy, 53(9), 3832-3836 (2009-07-15)

Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC

FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus.

Rebecca J Henry et al.

Journal of neuroimmunology, 276(1-2), 126-134 (2014-09-24)

The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. Systemic and central (i.c.v.) administration of the FAAH inhibitor URB597 increased hippocampal levels of the N-acylethanolamines palmitoylethanolamide and

Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia.

Jochen Springer et al.

Stroke, 45(12), 3675-3683 (2014-10-30)

Muscle wasting is a common complication accompanying stroke. Although it is known to impair poststroke recovery, the mechanisms of subacute catabolism after stroke have not been investigated in detail. The aim of this study is to investigate mechanisms of local

Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines.

Kyoung won Seo et al.

PloS one, 7(8), e42960-e42960 (2012-08-29)

Despite significant advancements in osteosarcoma research, the overall survival of canine and human osteosarcoma patients has remained essentially static over the past 2 decades. Post-operative limb-spare infection has been associated with improved survival in both species, yet a mechanism for

Production and characterization of a monoclonal antibody against enrofloxacin.

Manaspong Chusri et al.

Journal of microbiology and biotechnology, 23(1), 69-75 (2013-01-15)

Enrofloxacin is a fluoroquinolone antibiotic approved for the treatment of infections in animals. Because of the side effects to consumers of animal products, the maximum residue limits (MRLs) of enrofloxacin in animal tissues for consumption are regulated. In this study

Consumption of ground beef obtained from cattle that had received steroidal growth promotants does not trigger early onset of estrus in prepubertal pigs.

James D Magolski et al.

The Journal of nutrition, 144(11), 1718-1724 (2014-10-22)

The earlier onset of puberty seen in young American girls has led researchers to question if a causal relation exists between dietary sources of estrogenic compounds and precocious puberty. Using the prepubertal gilt (young female pig) as an animal model

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.

Debbie Le Blon et al.

Immunology and cell biology, 92(8), 650-658 (2014-07-02)

Although implantation of cellular material in the central nervous system (CNS) is a key direction in CNS regenerative medicine, this approach is currently limited by the occurrence of strong endogenous immune cell responses. In a model of mesenchymal stem cell

A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS.

Paul D Rainville et al.

The Analyst, 140(6), 1921-1931 (2015-02-07)

The emergence of micro sampling techniques holds great potential to improve pharmacokinetic data quality, reduce animal usage, and save costs in safety assessment studies. The analysis of these samples presents new challenges for bioanalytical scientists, both in terms of sample

Central V1b receptor antagonism in lactating rats: impairment of maternal care but not of maternal aggression.

D S Bayerl et al.

Journal of neuroendocrinology, 26(12), 918-926 (2014-10-07)

Maternal behaviour in rodents is mediated by the central oxytocin and vasopressin systems, amongst others. The role of vasopressin, acting via the V1a receptor (V1aR), on maternal care and maternal aggression has recently been described. However, a potential involvement of the

Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.

Toyotaka Sato et al.

The Journal of veterinary medical science, 76(7), 937-945 (2014-03-22)

Understanding the prevalence of antimicrobial-resistance and the relationship between emergence of resistant bacteria and clinical treatment can facilitate design of effective treatment strategies. We here examined antimicrobial susceptibilities of Escherichia coli isolated from dogs admitted to a university hospital (University

Concurrent access to nicotine and sucrose in rats.

Leigh V Panlilio et al.

Psychopharmacology, 232(8), 1451-1460 (2014-11-05)

Animal models that allow concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use. We sought to develop and utilize a concurrent access procedure with nicotine and sucrose in rats. Pressing

Comparison of different advanced oxidation processes for the degradation of two fluoroquinolone antibiotics in aqueous solutions.

Maria Bobu et al.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(3), 251-262 (2012-12-19)

In this study a comparative assessment using various advanced oxidation processes (UV/H(2)O(2), UV/H(2)O(2)/Fe(II), O(3), O(3)/UV, O(3)/UV/H(2)O(2) and O(3)/UV/H(2)O(2)/Fe(II)) was attempted to degrade efficiently two fluoroquinolone drugs ENR [enrofloxacin (1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylic acid)] and CIP [ciprofloxacin (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-quinoline-3-carboxylic acid)] in aqueous solutions at a

Suspected seminal vesiculitis in an Asian elephant (Elephas maximus).

Jennifer J Kilburn et al.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 42(3), 485-489 (2012-09-07)

A 32-year-old male Asian elephant (Elephas maximus) underwent routine transrectal stimulation for semen collection as part of an artificial insemination program. The procedure consisted of a preinsemination semen collection followed by two consecutive days of semen collections for artificial insemination.

Stimulus-timing-dependent modifications of rate-level functions in animals with and without tinnitus.

Roxana A Stefanescu et al.

Journal of neurophysiology, 113(3), 956-970 (2014-11-14)

Tinnitus has been associated with enhanced central gain manifested by increased spontaneous activity and sound-evoked firing rates of principal neurons at various stations of the auditory pathway. Yet, the mechanisms leading to these modifications are not well understood. In a

Cobalt(II) complexes with the antimicrobial drug enrofloxacin: structure, antimicrobial activity, DNA- and albumin-binding.

Catherine Protogeraki et al.

European journal of medicinal chemistry, 86, 189-201 (2014-08-26)

The cobalt(II) complexes with the quinolone antimicrobial agent enrofloxacin (Herx) in the presence of the nitrogen-donor heterocyclic ligands pyridine (py), 2,2'-bipyridylamine (bipyam), 1,10-phenanthroline (phen), 2,2'-bipyridine (bipy) or the oxygen-donor ligand N,N-dimethylformamide (DMF) were synthesized and characterized. The crystal structures of

Accumulation and elimination of enrofloxacin and its metabolite ciprofloxacin in the ridgetail white prawn Exopalaemon carinicauda following medicated feed and bath administration.

J P Liang et al.

Journal of veterinary pharmacology and therapeutics, 37(5), 508-514 (2014-03-13)

Accumulation and elimination of enrofloxacin and its metabolite ciprofloxacin were evaluated in Exopalaemon carinicauda following medicated feed at dose of 10 mg/kg weight body per day for five consecutive days and 10 mg/L bath for five consecutive days at 18 °C. At different

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