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I Lysnyansky et al.
Antimicrobial agents and chemotherapy, 53(11), 4911-4914 (2009-09-02)
Comparison of the quinolone resistance-determining regions (QRDRs) in 42 Mycoplasma bovis clinical isolates revealed amino acid substitutions at both GyrA (position 83) and ParC (position 84) in 10/11 enrofloxacin-resistant strains. The mutation present in the parC QRDR was discriminative for
Marina Cerquetti et al.
Antimicrobial agents and chemotherapy, 53(7), 3112-3114 (2009-05-20)
A qnrS1-positive strain of Escherichia coli was detected among 73 poultry isolates showing ciprofloxacin MICs of > or =0.125 microg/ml. The qnrS1 gene was associated with a Tn3-like transposon, as previously described to occur in a Salmonella enterica serovar Infantis
Vincent Cattoir et al.
Antimicrobial agents and chemotherapy, 52(8), 2929-2932 (2008-06-04)
A novel QnrB-like plasmid-mediated resistance determinant, QnrB19, was identified from an Escherichia coli clinical isolate from Colombia. Its gene was associated with an ISEcp1-like insertion element that did not act as a promoter for its expression. Using an in vitro
Rebecca J Henry et al.
Journal of neuroimmunology, 276(1-2), 126-134 (2014-09-24)
The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. Systemic and central (i.c.v.) administration of the FAAH inhibitor URB597 increased hippocampal levels of the N-acylethanolamines palmitoylethanolamide and
Guntis Cepurnieks et al.
Journal of pharmaceutical and biomedical analysis, 102, 184-192 (2014-10-06)
A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole
Dominik Fischer et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 43(3), 625-628 (2012-10-23)
A 4-yr-old big-eyed tree frog (Leptopelis vermiculatus) was submitted with two pea-sized (4-mm diameter), firm, and painful masses on the right side of its back. The two abscess-like masses were surgically opened, and a whitish-yellow pasty content was removed. A
Seung Ryul Han et al.
Biochemical and biophysical research communications, 448(4), 397-402 (2014-05-06)
Danofloxacin is a synthetic fluoroquinolone with broad spectrum antibacterial activity that is used for the treatment of respiratory diseases in animal husbandry. However, danofloxacin has many adverse reactions and is toxic to humans. Especially, it detrimentally affects muscle, central nerve
Gwenaëlle Mourand et al.
Journal of medical microbiology, 63(Pt 11), 1552-1560 (2014-08-22)
An experiment was conducted to compare the impact of antimicrobial treatments on the susceptibility of Campylobacter, Enterococcus faecium and Enterococcus faecalis, and on the diversity of broiler microbiota. Specific-pathogen-free chickens were first orally inoculated with strains of Campylobacter and Enterococcus
Diego G Rocha et al.
Journal of chromatography. A, 1379, 83-91 (2015-01-13)
This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and kidney: ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, flumequine, marbofloxacin, nalidixic acid, norfloxacin, ofloxacin, oxolinic acid
Zhe Meng et al.
Food chemistry, 174, 597-605 (2014-12-23)
A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 μg kg(-1)
M Cengiz et al.
The Veterinary record, 172(18), 474-474 (2013-04-23)
The objective of this work was to investigate the bactericidal activity of enrofloxacin against gyrA mutant and qnr-containing Escherichia coli isolates from animals. The minimum inhibitory concentrations (MICs) of gyrA mutant and qnr-containing E coli isolates ranged from 1 µg/ml
Lina Fassi Fehri et al.
Antimicrobial agents and chemotherapy, 51(2), 468-474 (2006-11-15)
We showed in a previous study that associations of antimicrobial peptides (AMPs), which are key components of the innate immune systems of all living species, with the fluoroquinolone enrofloxacin can successfully cure HeLa cell cultures of Mycoplasma fermentans and M.
Maria Bobu et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(3), 251-262 (2012-12-19)
In this study a comparative assessment using various advanced oxidation processes (UV/H(2)O(2), UV/H(2)O(2)/Fe(II), O(3), O(3)/UV, O(3)/UV/H(2)O(2) and O(3)/UV/H(2)O(2)/Fe(II)) was attempted to degrade efficiently two fluoroquinolone drugs ENR [enrofloxacin (1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylic acid)] and CIP [ciprofloxacin (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-quinoline-3-carboxylic acid)] in aqueous solutions at a
David J Durgan et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(3), 402-411 (2014-11-27)
Obstructive sleep apnea (OSA) is associated with cerebrovascular diseases. However, little is known regarding the effects of OSA on the cerebrovascular wall. We tested the hypothesis that OSA augments endothelin-1 (ET-1) constrictions of cerebral arteries. Repeated apneas (30 or 60
S C Coelho et al.
European journal of pain (London, England), 18(7), 957-967 (2014-01-09)
This study evaluated the involvement of tumour necrosis factor α (TNF-α) in orofacial thermal and mechanical hyperalgesia induced by an inflammatory stimulus or by chronic constriction of the infraorbital nerve (CION) using etanercept (Eta), a TNF-receptor fusion protein that inhibits
Darryl R Overby et al.
Investigative ophthalmology & visual science, 55(8), 4922-4933 (2014-07-17)
To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. Osmotic mini-pumps were implanted subcutaneously
Debbie Le Blon et al.
Immunology and cell biology, 92(8), 650-658 (2014-07-02)
Although implantation of cellular material in the central nervous system (CNS) is a key direction in CNS regenerative medicine, this approach is currently limited by the occurrence of strong endogenous immune cell responses. In a model of mesenchymal stem cell
Paul D Rainville et al.
The Analyst, 140(6), 1921-1931 (2015-02-07)
The emergence of micro sampling techniques holds great potential to improve pharmacokinetic data quality, reduce animal usage, and save costs in safety assessment studies. The analysis of these samples presents new challenges for bioanalytical scientists, both in terms of sample
Guyue Cheng et al.
Analytical and bioanalytical chemistry, 406(30), 7899-7910 (2014-10-31)
Fluoroquinolones (FQNs) are broad-spectrum antibacterial agents widely used in animal husbandry and aquaculture. The residues and antimicrobial resistance of such antibiotics are a major public health concern. To realize multianalyte detection of FQN residues, a genetically modified bacterium, Escherichia coli
J P Liang et al.
Journal of veterinary pharmacology and therapeutics, 37(5), 508-514 (2014-03-13)
Accumulation and elimination of enrofloxacin and its metabolite ciprofloxacin were evaluated in Exopalaemon carinicauda following medicated feed at dose of 10 mg/kg weight body per day for five consecutive days and 10 mg/L bath for five consecutive days at 18 °C. At different
Leigh V Panlilio et al.
Psychopharmacology, 232(8), 1451-1460 (2014-11-05)
Animal models that allow concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use. We sought to develop and utilize a concurrent access procedure with nicotine and sucrose in rats. Pressing
Catherine Protogeraki et al.
European journal of medicinal chemistry, 86, 189-201 (2014-08-26)
The cobalt(II) complexes with the quinolone antimicrobial agent enrofloxacin (Herx) in the presence of the nitrogen-donor heterocyclic ligands pyridine (py), 2,2'-bipyridylamine (bipyam), 1,10-phenanthroline (phen), 2,2'-bipyridine (bipy) or the oxygen-donor ligand N,N-dimethylformamide (DMF) were synthesized and characterized. The crystal structures of
Eleni K Efthimiadou et al.
Bioorganic & medicinal chemistry letters, 17(5), 1238-1242 (2007-01-02)
The neutral mononuclear vanadyl complex with the quinolone antibacterial drug enrofloxacin has been prepared and characterized with physicochemical and spectroscopic techniques and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial
Sandra Burghoff et al.
BMC cancer, 14, 898-898 (2014-12-04)
Recent studies have suggested that adenosine generated by ecto-5'-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulating angiogenesis via A2A and A2B receptors. However, adenosine has also been
Yisheng Chen et al.
Journal of chromatography. A, 1356, 249-257 (2014-07-13)
The world-wide usage and partly abuse of veterinary antibiotics resulted in a pressing need to control residues in animal-derived foods. Large-scale screening for residues of antibiotics is typically performed by microbial agar diffusion tests. This work employing high-performance thin-layer chromatography
Brian T David et al.
Journal of neurotrauma, 31(21), 1800-1806 (2014-06-18)
Spinal cord injury (SCI) affects motor, sensory, and autonomic functions. As current therapies do not adequately alleviate functional deficits, the development of new and more effective approaches is of critical importance. Our earlier investigations indicated that intrathecal administration of a
Elisabetta Giannessi et al.
Journal of reconstructive microsurgery, 30(9), 617-626 (2014-05-20)
The aim of this study was to investigate the ability of suturable platelet-rich plasma (PRP) membrane to promote peripheral nerve regeneration after neurotmesis and neurorraphy. A total of 36 rats were used: 32 animals underwent surgery and were split in
Kyoung won Seo et al.
PloS one, 7(8), e42960-e42960 (2012-08-29)
Despite significant advancements in osteosarcoma research, the overall survival of canine and human osteosarcoma patients has remained essentially static over the past 2 decades. Post-operative limb-spare infection has been associated with improved survival in both species, yet a mechanism for
Manaspong Chusri et al.
Journal of microbiology and biotechnology, 23(1), 69-75 (2013-01-15)
Enrofloxacin is a fluoroquinolone antibiotic approved for the treatment of infections in animals. Because of the side effects to consumers of animal products, the maximum residue limits (MRLs) of enrofloxacin in animal tissues for consumption are regulated. In this study
Jennifer J Kilburn et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 42(3), 485-489 (2012-09-07)
A 32-year-old male Asian elephant (Elephas maximus) underwent routine transrectal stimulation for semen collection as part of an artificial insemination program. The procedure consisted of a preinsemination semen collection followed by two consecutive days of semen collections for artificial insemination.
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