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Yuichi Nakamura et al.
Organic letters, 15(2), 322-325 (2012-12-28)
Siladenoserinols A-L were isolated from a tunicate as inhibitors of p53-Hdm2 interaction, a promising target for cancer chemotherapy. Their structures including the absolute configurations were elucidated to be new sulfonated serinol derivatives, each of which contains a 6,8-dioxabicyclo[3.2.1]octane unit and
B N Trawick et al.
Bioconjugate chemistry, 12(6), 900-905 (2001-11-22)
The syntheses and RNA cleavage efficiencies of a new series of oligonucleotide conjugates of Cu(II)-serinol-terpyridine and 1,3-propanediol are reported. These reagents, termed ribozyme mimics, were designed such that they would yield multiple unpaired RNA residues directly opposite the site of
F Pinkerton et al.
Proceedings of the National Academy of Sciences of the United States of America, 73(11), 4007-4011 (1976-11-01)
Successive transfer in synthetic medium of spores and mycelial fragments from original toxin-producing cultures of Helminthosporium sacchari results in attenuated cultures which do not produce the host-specific toxin helminthosporoside. When attenuated cultures are grown on material obtained from the water
Hiroyuki Asanuma et al.
Chemical record (New York, N.Y.), 14(6), 1055-1069 (2014-08-30)
In this account, we demonstrate a new methodology for the de novo design of functional oligonucleotides with the acyclic scaffolds threoninol and serinol. Four functional motifs-wedge, interstrand-wedge, dimer, and cluster-have been prepared from natural DNA or RNA and functional base
Xiaojin Zhang et al.
Macromolecular rapid communications, 33(8), 693-697 (2012-02-23)
A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted
Margherita Bodini et al.
mSphere, 5(5) (2020-09-18)
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is a significant cause of morbidity and mortality worldwide. In Finland, the incidence rate of IMD is low, with meningococcal serogroup B (MenB) accounting for around one-third of IMD cases annually. The
Reiko Ueoka et al.
Bioscience, biotechnology, and biochemistry, 72(11), 3055-3058 (2008-11-11)
A new N-acylated serinol, inconspicamide (1), was isolated from the marine sponge, Stelletta inconspicua, together with a glyceryl ether (2). Their structures were determined on the basis of spectroscopic data and the modified Mosher analysis. They exhibited moderate cytotoxic activity
William C Putnam et al.
Nucleosides, nucleotides & nucleic acids, 24(9), 1309-1323 (2005-10-29)
Six novel artificial ribonucleases were synthesized employing a stereochemically pure abasic serinol backbone residue for attachment of the RNA transesterification agent copper(II) terpyridine. These stereochemically pure abasic residues were synthesized as phosphoramidite building blocks from the parent L-serine and D-serine
Control of the chirality and helicity of oligomers of serinol nucleic acid (SNA) by sequence design.
Hiromu Kashida et al.
Angewandte Chemie (International ed. in English), 50(6), 1285-1288 (2011-02-04)
Gea Prioglio et al.
Polymers, 12(4) (2020-04-25)
The ultimate properties and resistance to fracture of nanocomposites based on poly(1,4-cis-isoprene) from Hevea Brasiliensis (natural rubber, NR) and a high surface area nanosized graphite (HSAG) were improved by using HSAG functionalized with 2-(2,5-dimethyl-1H-pyrrol-1-yl)propane-1,3-diol (serinol pyrrole) (HSAG-SP). The functionalization reaction
D Sivaramakrishna et al.
Biochimica et biophysica acta. Biomembranes, 1861(2), 504-513 (2018-12-12)
N‑Acylserinols (NASOHs) exhibit anti-cancer activity by elevating ceramide levels, and/or by activating proapoptotic effectors. In the present work we investigated the thermotropic phase behavior and supramolecular organization of a homologous series of NASOHs (number of C-atoms in the acyl chain
E Bieberich et al.
The Journal of biological chemistry, 275(1), 177-181 (2000-01-05)
A novel structural analog of ceramide was synthesized by N-acylation of serinol (2-amino-1,3-propanediol) and studied for its effects on glycolipid biosynthesis and cell differentiation of neuroblastoma cells. Incubation with N-palmitoylated serinol (C16-serinol) increased the concentration of endogenous ceramide by 50-80%
Trey A Ronnebaum et al.
Current opinion in structural biology, 53, 1-11 (2018-02-20)
Microbes synthesize small, iron-chelating molecules known as siderophores to acquire iron from the environment. One way siderophores are generated is by nonribosomal peptide synthetases (NRPSs). The bioactive peptides generated by NRPS enzymes have unique chemical features, which are incorporated by
Hiroko Ikushiro et al.
Biochemistry, 43(4), 1082-1092 (2004-01-28)
Serine palmitoyltransferase (SPT) is a key enzyme in sphingolipid biosynthesis and catalyzes the decarboxylative condensation of L-serine and palmitoyl coenzyme A to 3-ketodihydrosphingosine. We have succeeded in the overproduction of a water-soluble homodimeric SPT from Sphingomonas paucimobilis EY2395(T) in Escherichia
Martin Dippe et al.
Chemistry and physics of lipids, 152(2), 71-77 (2008-02-28)
A series of new phospholipids with polar head groups have been synthesized by enzymatic transphosphatidylation of 1,2-dioleoyl-sn-glycerophosphocholine and identified by 1H NMR and MALDI-TOF-MS. The acceptor alcohols were N- or C2-substituted derivatives of ethanolamine (diethanolamine, triethanolamine, serinol, Tris, BisTris). Phospholipases
C Pelassy et al.
Journal of lipid mediators, 3(1), 79-89 (1991-01-01)
Phosphatidylserine has been implicated both in the regulation of protein kinase C activity and in the regulation of T lymphocyte activation. Taking into account the fact that some serine analogues modify the activity of the base exchange enzyme system responsible
S S Mitchell et al.
Organic letters, 2(11), 1605-1607 (2000-06-07)
[structure--see text] Bioassay-guided fractionation of extracts of the Palauan ascidian Didemnum guttatum led to the isolation of cyclodidemniserinol trisulfate (1) as an inhibitor of HIV-1 integrase, which is an attractive target for anti-retroviral chemotherapy. The structure of cyclodidemniserinol trisulfate (1)
Suansuan Wang et al.
Soft matter, 13(45), 8609-8617 (2017-11-08)
A new class of bisurea derivatives bearing tetrahydroxy groups have been proven to be non-gelators in water and various organic solvents even under long-term sonication or efficient heating treatment. We found that it is possible to trigger physical gelation behaviour
Jungeun Bae et al.
The AAPS journal, 17(6), 1357-1368 (2015-07-01)
A novel redox-responsive amphiphilic polymer was synthesized with bioreductive trimethyl-locked quinone propionic acid for a potential triggered drug delivery application. The aim of this study was to synthesize and characterize the redox-responsive amphiphilic block copolymer micelles containing pendant bioreductive quinone
Qing Cao et al.
Analytica chimica acta, 703(2), 250-256 (2011-09-06)
Multi-hydroxyl amines including tris(hydroxymethyl)aminomethane (Tris), serinol and ethanolamine were selected as weak affinity ligands using a rapid screening by quartz crystal microbalance (QCM) biosensor. Based on the specific recognition between the ligands and two proteins, lysozyme (LZM) and cytochrome c
Daniele Locatelli et al.
Nanomaterials (Basel, Switzerland), 10(6) (2020-06-21)
The solubility parameters of multiwalled carbon nanotubes (CNTs) was tuned via their chemical modification with pyrrole compounds (PyCs), by means of a simple and sustainable methodology. PyCs were synthesized with high atom efficiency through the Paal-Knorr reaction of primary amines
Josef R Bencsik et al.
Organic letters, 5(15), 2727-2730 (2003-07-19)
[reaction: see text] The bicyclocondensation of 3-aza-1,5-ketoacids and amino alcohols furnished novel oxazolo[3,2-a]pyrazin-5-one scaffolds possessing angular, ring junction substituents in high yield with excellent levels of substrate-based diastereocontrol. Mild oxidation of serinol-derived scaffolds provided access to a new class of
E Halevas et al.
Journal of inorganic biochemistry, 147, 99-115 (2015-04-30)
Among the various roles of vanadium in the regulation of intracellular signaling, energy metabolism and insulin mimesis, its exogenous activity stands as a contemporary challenge currently under investigation and a goal to pursue as a metallodrug against Diabetes mellitus II.
Björn Andreessen et al.
Applied microbiology and biotechnology, 93(1), 357-365 (2011-06-28)
Microbial conversion is an important technology for the refinement of renewable resources. Here, we describe the biotechnological conversion of glycerol to 2-amino-1,3-propanediol (serinol), a relevant intermediate in several chemical syntheses processes. Either the dihydroxyacetone phosphate aminotransferase/dihydrorhizobitoxine synthase (RtxA) of Bradyrhizobium
Jenny Rickerby et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 21-34 (2004-12-14)
Polyesters derived from glycerol and serinol were prepared. These polyesters were designed to be potential surrogate polymers for poly(glycolic acid) (PGA) to extend the properties that aliphatic biomedical polyesters could encompass. The 1- and 2-substituted glycerol derived monomers were liquids
Mi Sook Hong et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 14(11), 3290-3296 (2008-02-20)
Novel enantioselective desymmetrization of 2-substituted 2-amino-1,3-propanediols has been established to generate asymmetric quaternary carbon centers comprising an amino group. Enantioselective as well as chemical conversion proved to be greatly dependent on the protecting group of the amino group in the
Ewa Katzenellenbogen et al.
Carbohydrate research, 355, 56-62 (2012-05-15)
Lipopolysaccharides of four strains of Edwardsiella tarda were degraded by mild acid hydrolysis, and the released O-polysaccharides were isolated by GPC and studied by sugar and methylation analyses along with (1)H and (13)C NMR spectroscopy, including 2D (1)H, (1)H COSY
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