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关键词:'396265'
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Formulating for fast efficacy.
Johann W Wiechers et al.
Journal of cosmetic science, 57(2), 191-192 (2006-06-09)
T Katakura et al.
Clinical and experimental immunology, 142(3), 419-425 (2005-11-22)
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a major cause of sepsis in patients who are immunosuppressed by their burns. In this study, an immunological regulation of MRSA infection was attempted in a mouse model of thermal injury. SCIDbg
Petra Mulder et al.
PloS one, 12(1), e0169740-e0169740 (2017-01-12)
Obese patients with chronic inflammation in white adipose tissue (WAT) have an increased risk of developing non-alcoholic steatohepatitis (NASH). The C-C chemokine receptor-2 (CCR2) has a crucial role in the recruitment of immune cells to WAT and liver, thereby promoting
Yukinori Tamura et al.
Arteriosclerosis, thrombosis, and vascular biology, 28(12), 2195-2201 (2008-09-27)
Recently, adipose tissue inflammation induced by macrophage infiltration through MCP-1/C-C chemokine receptor-2 (CCR2) pathway is considered to play a role in the development of visceral obesity and insulin resistance. In the present study, to further examine the role of CCR2
Kiyoki Kitagawa et al.
The American journal of pathology, 165(1), 237-246 (2004-06-25)
Fibrosis is a hallmark of progressive organ diseases. Monocyte chemoattractant protein (MCP)-1, also termed as macrophage chemotactic and activating factor (MCAF/CCL2) and its receptor, CCR2 are presumed to contribute to progressive fibrosis. However, the therapeutic efficacy of MCP-1/CCR2 blockade in
Y Liu et al.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 36(4), 263-266 (2002-02-21)
To detect the antiproliferation of carboxyethyl germanium sesquioxide (Ge-132) on fibroblasts of pterygium in vitro and try to find a potentially effective agent for treatment of primary pterygium and prevention of its postoperative recurrence. Primary culture and subculture of pterygium
Yun Huan Yuan et al.
Nanoscale, 7(40), 16841-16847 (2015-09-26)
Carbon dots doped with germanium (GeCDs) were firstly prepared by a new simple 15 min carbonation synthesis route, exhibiting excitation-independent photoluminescence (PL), which could avoid autofluorescence in bioimaging applications. The as-prepared GeCDs have low cell toxicity, good biocompatibility, high intracellular
Hiroshi Kanamori et al.
Biochemical and biophysical research communications, 360(4), 772-777 (2007-07-17)
Monocyte chemoattractant protein (MCP-1) is an important mediator for macrophage recruitment in atherosclerosis and various glomerulonephritis. However, the role of MCP-1 and its receptor CCR2 in the progression of diabetic nephropathy remains unknown. Using a type 1 diabetic nephropathy model
Yasuhiro Eto et al.
Journal of cardiovascular pharmacology, 41(2), 171-177 (2003-01-28)
Macrophages play an important role in the pathogenesis of atherosclerosis, for which monocyte chemoattractant protein (MCP)-1 and CCR2 chemokine receptors may be involved. The authors have recently demonstrated that propagermanium exerts inhibitory effect on the CCR2 receptors. In the current
Yukinori Tamura et al.
Journal of atherosclerosis and thrombosis, 17(3), 219-228 (2010-02-25)
Adipose tissue inflammation induced by macrophage infiltration through the MCP-1/CCR2 pathway is considered to play a pivotal role in the development of visceral obesity and insulin resistance. In the present study, therefore, we examined whether pharmacological inhibition of CCR2 is
Takashi Nakamura et al.
Bioscience, biotechnology, and biochemistry, 76(2), 375-377 (2012-02-09)
The organic germanium compound, Ge-132, has immune-modulating effects. We evaluated the symbiotic effects of Ge-132 with lactobacilli and oligosaccharide (LB/OS) on the immune responses of mice. The highest fecal IgA levels were observed in the mice receiving a low concentration
Bonnie J Kaplan et al.
Journal of alternative and complementary medicine (New York, N.Y.), 10(2), 337-344 (2004-05-29)
This paper reviews the history, chemistry, safety, toxicity, and anticancer effects of the organogermanium compound bis (2-carboxyethylgermanium) sesquioxide (CEGS). A companion review follows, discussing the inaccuracies in the scientific record that have prematurely terminated research on clinical uses of CEGS.
Boryana Konstantinova Popivanova et al.
Cancer research, 69(19), 7884-7892 (2009-09-24)
Accumulating evidence indicates the crucial contribution of chronic inflammation to various types of carcinogenesis, including colon carcinoma associated with ulcerative colitis and asbestosis-induced malignant mesothelioma. Ulcerative colitis-associated colon carcinogenesis can be recapitulated in mice by azoxymethane administration followed by repetitive
Kengo Furuichi et al.
Journal of the American Society of Nephrology : JASN, 14(10), 2503-2515 (2003-09-30)
Examined were CCR2-deficient mice to clarify the contribution of macrophages via monocyte chemoattractant protein 1 (MCP-1 or CCL2)/CCR2 signaling to the pathogenesis of renal ischemia-reperfusion injury. Also evaluated was the therapeutic effects via the inhibition of MCP-1/CCR2 signaling with propagermanium
Tomoya Takeda et al.
Scientific reports, 9(1), 13637-13637 (2019-09-22)
Reactive oxygen species (ROS) are very harmful to dermal cells, and it is thus important to develop cosmetics that protect the skin from ROS and other stimuli. Repagermanium is a synthetic water-soluble organogermanium polymer, and in this study, we attempted
Guoqiang Shangguan et al.
Bioorganic & medicinal chemistry letters, 15(12), 2962-2965 (2005-05-26)
A series of Ge132 derivatives have shown enhanced antitumor activity. Previous studies suggest that DNA can be their primary target. Here we show direct evidence that two newly synthesized Ge132 derivatives can intercalate into DNA. Unexpected methyl substitution effect of
Michael Gliem et al.
Annals of neurology, 71(6), 743-752 (2012-06-22)
Inflammation is increasingly viewed as a new therapeutic target in subacute stages of brain infarction. However, apart from causing secondary damage, inflammation could equally promote beneficial lesion remodeling and repair. Distinct subpopulations of monocytes/macrophages (MOs/MPs) may critically determine the outcome
Hiroaki Shimokawa et al.
Journal of cardiovascular pharmacology, 41(3), 372-380 (2003-02-27)
Although the importance of monocytes/macrophages in the pathogenesis of arteriosclerosis is widely accepted, effective and safe treatment to inhibit those inflammatory cells remains to be developed. It was recently found that propagermanium, which is clinically used for the treatment of
Takashi Nakamura et al.
European journal of pharmacology, 653(1-3), 75-81 (2010-12-21)
Poly-trans-[(2-carboxyethyl) germasesquioxane], Ge-132 is a water-soluble organic germanium compound. Oral intake of dietary Ge-132 changes fecal color and we attempted to identify the fecal red pigment, which increased by the intake of dietary Ge-132. Sprague Dawley rats were given diets
Bonnie J Kaplan et al.
Journal of alternative and complementary medicine (New York, N.Y.), 10(2), 345-348 (2004-05-29)
The preceding paper reviewed the anticancer properties and safety of bis (2-carboxyethylgermanium) sesquioxide (CEGS). An examination of those data leads one to question why this information has not stimulated clinical trials in patients with cancer. The answer is discussed in
Guizhen Jiang et al.
Journal of oral science, 46(2), 75-85 (2004-08-04)
The effect of therapeutic agents on trabecular bone loss in the mandible was investigated in ovariectomized rats. Eighty-seven Wistar SPF female rats were ovariectomized (OVX) or given a sham operation (Sham), and maintained on a diet containing 0.1% calcium. Four
Q Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 18(1), 77-80 (2005-04-07)
Inorganic germanium and carboxyethyl germanium sesquioxide (germanium-132) in health drinks were respectively determined by hydride generation-atomic fluorescence spectrometry (HG-AFS). The conditions of respective determination of inorganic germanium and germanium-132 in natural foods were preliminarily discussed.
Kana Tsukuda et al.
Biochemical and biophysical research communications, 409(2), 275-279 (2011-05-18)
Angiotensin II type 1 (AT(1)) receptor blockers (ARBs) are known to prevent the onset of stroke and to attenuate neural damage. Additional beneficial effects of ARBs, independent of AT(1) receptor blockade, have been highlighted. Irbesartan is reported to act as
Ming-Hsing Lin et al.
International journal of radiation biology, 85(3), 214-226 (2009-03-20)
The aim of this work is to compare the radiosensitizing effect between organic and inorganic germanium compounds and to investigate whether nanometer-sized germanium particles can act as radiosensitizers. Bis (2-carboxyethylgermanium) sesquioxide (Ge-132), germanium oxide (GeO(2)) and germanium nanoparticles were used
Ziping Qi et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(3), 774-785 (2014-05-21)
Mice deficient in tyrosine catabolic enzyme fumarylacetoacetate hydrolase (fah(-/-) ) was a useful animal model for studying liver failure. Tyrosine metabolic toxicants accumulate in hepatocytes over time in fah(-/-) mice, leading to hepatocyte necrosis which we propose release many type
Kousei Ohshima et al.
Journal of the American Society of Hypertension : JASH, 6(6), 375-384 (2012-10-31)
Additional beneficial effects of angiotensin II type 1 (AT(1)) receptor blockers beyond AT(1) receptor blockade have been highlighted. Irbesartan is reported to act as an antagonist of the monocyte chemoattractant protein-1 (MCP-1) receptor, C-C chemokine receptor 2 (CCR2). We examined
Chisato Hirayama et al.
Journal of gastroenterology, 38(6), 525-532 (2003-06-26)
Although antiviral agents have been adopted for the management of chronic hepatitis B, they have only limited efficacy because of the underlying impaired immune status. Propagermanium, a hydrophilic polymer of 3-oxygermyl propionate, has been reported to have potent immune modulatory
Yutaka Tsutsumi et al.
European journal of haematology, 73(6), 397-401 (2004-11-04)
Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved
Alice Y W Chang et al.
Neurobiology of disease, 71, 292-304 (2014-08-19)
Pressor response after stroke commonly leads to early death or susceptibility to stroke recurrence, and detailed mechanisms are still lacking. We assessed the hypothesis that the renin-angiotensin system contributes to pressor response after stroke by differential modulation of the pro-inflammatory
Kanae Yumimoto et al.
The Journal of clinical investigation, 125(2), 621-635 (2015-01-03)
The gene encoding F-box protein FBXW7 is frequently mutated in many human cancers. Although most previous studies have focused on the tumor-suppressive capacity of FBXW7 in tumor cells themselves, we determined that FBXW7 in the host microenvironment also suppresses cancer
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