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关键词:'41639'
显示 1-30 共 7647 条结果 关于 "41639" 范围 论文
Chantal Zevenbergen et al.
The Journal of clinical endocrinology and metabolism, 99(11), E2429-E2436 (2014-08-21)
Thyroid hormones (TH) are important for normal brain development and abnormal TH regulation in the brain results in neurocognitive impairments. The type 2 deiodinase (D2) is important for local TH control in the brain by generating the active hormone T3
Minjia Sheng et al.
Journal of peptide science : an official publication of the European Peptide Society, 20(10), 803-810 (2014-06-27)
LfcinB9 is a peptide derived from lactoferricin B. In the present study, the effect and relative mechanism of LfcinB9 on human ovarian cancer cell line (SK-OV-3) in vitro and in vivo was investigated. The data obtained indicated that LfcinB9 exhibited
Mimi C Yung et al.
Journal of bacteriology, 197(19), 3160-3172 (2015-07-22)
The ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. To gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn)
Shiuan Chen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 446-457 (2015-07-05)
Multiple mechanisms exist for endocrine disruption; one nonreceptor-mediated mechanism is via effects on aromatase, an enzyme critical for maintaining the normal in vivo balance of androgens and estrogens. We adapted the AroER tri-screen 96-well assay to 1536-well format to identify potential
Hiroki Yamazaki et al.
Veterinary journal (London, England : 1997), 205(3), 375-380 (2015-06-07)
Histiocytic sarcoma (HS) in dogs exhibits aggressive biological behaviors and currently few effective treatments are available. Survivin could serve as a potential therapeutic target in several cancers. Sepantronium bromide (YM155) is a potential novel survivin-targeting agent and in this study
Min-Cheol Kang et al.
Carbohydrate polymers, 127, 38-46 (2015-05-13)
In this study, the antioxidative effects of a purified polysaccharide isolated from the stems of Acanthopanax koreanum Nakai (ASP) on hydrogen peroxide-induced oxidative stress was investigated both in vitro and in vivo using a zebrafish model. A. koreanum Nakai stem
Saifullah Afridi et al.
Biochemical and biophysical research communications, 456(3), 774-779 (2014-12-20)
Major histocompatibility complex (MHC)-loading enhancers (MLE) have recently attracted attention because of their ability to enhance the efficacy of peptide immunotherapeutics. As small molecular weight compounds, they influence the loading of peptides in MHC molecules by converting them from a
Yunpeng Fan et al.
Carbohydrate polymers, 135, 110-120 (2015-10-11)
The antioxidative and immunoregulatory activities of ophiopogon polysaccharide liposome (OPL) were investigated. The results demonstrated that the radical-scavenging activity increased along with the increasing of OPL concentrations, and the scavenging capability of OPL was slightly stronger than ophiopogon polysaccharide (OP)
Ahmadreza Sardarian et al.
Toxicology mechanisms and methods, 25(2), 98-104 (2014-11-25)
Cyclosporine A (CsA) is an immunosuppressive agent administered to transplant patients. A well-known reported oral side effect of CsA consumption is gingival overgrowth (GO). Changes in the expression of integrins occurring in the gingiva following CsA treatment have been reported
Benito Campos et al.
Glia, 63(10), 1850-1859 (2015-05-07)
Measuring concentrations of the differentiation-promoting hormone retinoic acid (RA) in glioblastoma tissues would help to understand the reason why RA treatment has been inefficient in clinical trials involving brain tumor patients. Here, we apply a recently established extraction and measurement
Lai Wei et al.
International journal of molecular medicine, 34(5), 1257-1267 (2014-09-02)
Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase than normal healthy rats, and the activation of this signaling pathway leads to portal hypertension. Sodium ferulate (SF) has been shown to decrease the production of geranylgeranyl pyrophosphate (GGPP)
Sabine Tricot et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 87(4), 357-368 (2015-02-24)
The recent introduction of mass cytometry, a technique coupling a cell introduction system generating a stream of single cells with mass spectrometry, has greatly increased the number of parameters that can be measured per single cell. As with all new
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)
Ignacio M Larrayoz et al.
Journal of hypertension, 27(12), 2365-2376 (2009-09-05)
Inhibition of angiotensin II receptor type 1 (AT1) reduces chronic inflammation associated with hypertension. We asked whether AT1 receptor inhibition would reduce the innate inflammatory response induced by bacterial lipopolysaccharide (LPS). We used unstimulated human circulating monocytes obtained from healthy
Xiaolian Song et al.
Inflammation, 38(2), 485-492 (2014-06-25)
The reparative and immunoregulatory properties of mesenchymal stromal cells (MSCs) have made them attractive candidates for cellular therapy. However, the underlying mechanism of the effects of transplanted MSCs on allergic asthma remains elusive. Here, we show that administration of MSCs
Haiyan Qi et al.
CNS neuroscience & therapeutics, 20(11), 991-998 (2014-10-21)
The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed
Jiwei Ma et al.
Journal of molecular neuroscience : MN, 57(4), 546-553 (2015-08-10)
Asymmetric dimethylarginine (ADMA) is emerging as a key contributor to endothelial dysfunction. The drug probucol was reported to have an anti-lipid peroxidation effect and improve endothelial dilation function. But little is known about the protective effect of probucol on ADMA-induced
C-H Yang et al.
International journal of cosmetic science, 37(5), 550-554 (2015-03-31)
Volatile essential oils of mint species are used for cosmetics and in skin care products. In this study, we evaluated the main chemical components of the lime mint and the anti-melanogenic properties of its main components. The essential oil was
Anna Luisa Di Stefano et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(14), 3307-3317 (2015-01-23)
Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have been proposed as new therapeutic targets. We analyzed frequency and molecular features of FGFR-TACC fusions
Daniel Kanmert et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10851-10865 (2015-08-01)
Recent evidence suggests that tau aggregation may spread via extracellular release and subsequent uptake by synaptically connected neurons, but little is known about the processes by which tau is released or the molecular forms of extracellular tau. To gain insight
Hieng-Ming Ting et al.
Molecular plant, 8(3), 454-466 (2015-01-20)
Plants produce numerous terpenes and much effort has been dedicated to the identification and characterization of the terpene biosynthetic genes. However, little is known about how terpenes are transported within the cell and from the cell into the apoplast. To
Brandon S Bentzley et al.
The European journal of neuroscience, 41(9), 1149-1156 (2015-03-11)
The orexin/hypocretin system is involved in multiple cocaine addiction processes that involve drug-associated environmental cues, including cue-induced reinstatement of extinguished cocaine seeking and expression of conditioned place preference. However, the orexin system does not play a role in several behaviors
Magesh Muthu et al.
Journal of biomedical nanotechnology, 11(9), 1608-1627 (2015-10-22)
The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and poor prognosis, thus presenting an urgent need to develop new and improved therapeutic modalities. Here we
Zhuo-heng Li et al.
Photochemistry and photobiology, 90(6), 1368-1375 (2014-07-30)
Hypericin (HY) is a promising photosensitizer (PS) for use in photodynamic therapy (PDT). Port-wine stains (PWSs) are congenital superficial dermal capillary malformations. In this study, we evaluated the photocytotoxic effects of HY for PDT in human vascular endothelial cells and
Anke Doller et al.
Experimental cell research, 330(1), 66-80 (2014-09-23)
The impact of the RNA-binding protein HuR for the post-transcriptional deregulation of tumor-relevant genes is well established. Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy.
Roger A J Habets et al.
The Journal of biological chemistry, 290(23), 14705-14716 (2015-04-29)
Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in
James D Lord et al.
PloS one, 10(8), e0136485-e0136485 (2015-08-26)
FOXP3+ regulatory T cells (Tregs) are critical for preventing intestinal inflammation. However, FOXP3+ T cells are paradoxically increased in the intestines of patients with the inflammatory bowel disease (IBD) ulcerative colitis (UC) or Crohn's disease (CD). We determined whether these
[Dimethyl sulfoxide in experimental and clinical medicine. The achievements and prospects].
G M Iakovlev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 55(4), 74-76 (1992-07-01)
Masahiko Imai et al.
Bioorganic & medicinal chemistry, 23(13), 3788-3795 (2015-04-26)
Obesity is a risk factor associated with several lifestyle-related diseases, for example, diabetes, high blood pressure, hyperlipidemia and cancer. Caffeic acid 2-phenylethyl ester (CAPE, 1), a naturally-occurring compound found in various plants and propolis, which exhibits anti-inflammatory, immunomodulatory and cytotoxic
Tian-Yu Fan et al.
International journal of clinical and experimental pathology, 7(10), 6662-6670 (2014-11-18)
Glioblastoma remains among the most devastating cancers with a median survival of less than 15 months and virtually no survival beyond five years. Currently, the treatment of glioma includes surgery, radiation therapy, chemotherapy, and comprehensive treatment. Intrinsic or acquired resistance
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