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Lara M Kleinfelter et al.
mBio, 6(4), e00801-e00801 (2015-07-02)
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in the Old World and a highly fatal hantavirus cardiopulmonary syndrome (HCPS) in the New World. No vaccines or antiviral therapies are currently available to prevent or treat hantavirus disease, and gaps
Yuan Lu et al.
Applied biochemistry and biotechnology, 177(5), 1164-1175 (2015-08-19)
Interferon (IFN)-λ, also known as IL-28A, IL-28B, or IL-29, is a new type III IFN, which shares many functional characteristics with type I IFN (α/β). Currently, IFN-α is used in the treatment of certain forms of cancer with severe adverse
Xiaohong Du et al.
PloS one, 9(7), e103016-e103016 (2014-07-23)
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand
Ryan L O'Hare Doig et al.
Experimental neurology, 261, 136-146 (2014-06-17)
Secondary degeneration contributes substantially to structural and functional deficits following traumatic injury to the CNS. While it has been proposed that oxidative stress is a feature of secondary degeneration, contributing reactive species and resultant oxidized products have not been clearly
Lauren M Tetz et al.
Reproductive biology and endocrinology : RB&E, 13, 56-56 (2015-06-04)
Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in polyvinyl chloride products. DEHP exposure, which is widespread in the US, increases preterm birth risk; however, the mechanisms driving this relationship are unclear. Because cyclooxygenase-2 (COX-2) dependent prostaglandin synthesis is
Tilman Läppchen et al.
European journal of medicinal chemistry, 89, 279-295 (2014-12-03)
Calixarene 0118 is a potent anti-angiogenic agent that effectively inhibited tumor growth in preclinical studies, and is currently being evaluated in a phase I clinical trial. We have designed two close mimetics of calixarene 0118 containing a terminal alkynyl-functional group
Akiva N Rappaport et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15568-15581 (2015-11-27)
Learning of novel information, including novel taste, requires activation of neuromodulatory transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant brain structures. In addition, drugs enhancing the function of mAChRs are used to treat memory impairment and
Auemphon Mordmuang et al.
Nutrients, 7(10), 8503-8517 (2015-10-27)
Bovine mastitis is one of the most important infectious diseases in dairy herds, and staphylococci are the most important etiologic agents of this disease. Antibiotics and chemical agents used in livestock for prevention and cure of the disease can accumulate
Abel T Demissie et al.
Journal of the American Chemical Society, 137(27), 8819-8828 (2015-06-23)
We report the systematic characterization of anisotropic, π-conjugated oligophenyleneimine (OPI) films synthesized using stepwise imine condensation, or "click" chemistry. Film synthesis began with a self-assembled monolayer (SAM) of 4-formylthiophenol or 4-aminothiophenol on Au, followed by repetitive, alternate addition of terephthalaldehyde
Ana Casadó et al.
Journal of pharmaceutical sciences, 103(10), 3127-3138 (2014-08-06)
The effect of the lipid composition on the physicochemical properties of a liposomal carrier containing irinotecan (CPT-11) and its in vitro antitumoral activity on a colon cancer cell line has been investigated. The paper describes the procurement of a novel
Amedeo Pau et al.
ChemMedChem, 10(6), 1054-1070 (2015-05-01)
By following a multitarget ligand design approach, a library of 47 compounds was prepared, and they were tested as binders of selected G protein-coupled receptors (GPCRs) and inhibitors of acetyl and/or butyryl cholinesterase. The newly designed ligands feature pyridazinone-based tricyclic
Wu-Chao Wang et al.
Life sciences, 122, 100-107 (2014-12-24)
Phagocytosis plays essential roles during inflammation and immune response. This study aims to explore the underlying mechanism of corticotropin-releasing hormone (CRH) and urocortin (UCN)-promoted phagocytosis of rat macrophages. To induce phagocytosis, rat macrophages were incubated with carboxylated fluorescent microspheres. The
Jakob Schöttle et al.
Oncotarget, 6(36), 38458-38468 (2015-11-06)
Treatment with EGFR kinase inhibitors improves progression-free survival of patients with EGFR-mutant lung cancer. However, all patients with initial response will eventually acquire resistance and die from tumor recurrence. We found that intermittent high-dose treatment with erlotinib induced apoptosis more
Fen Hu et al.
PloS one, 9(9), e107217-e107217 (2014-09-26)
The local concentration of extracellular Ca(2+) ([Ca(2+)]o) in bone microenvironment is accumulated during bone remodeling. In the present study we investigated whether elevating [Ca(2+)]o induced store-operated calcium entry (SOCE) in primary rat calvarial osteoblasts and further examined the contribution of
Andreia F Verissimo et al.
The Journal of biological chemistry, 290(27), 16989-17003 (2015-05-17)
The c-type cytochromes are electron transfer proteins involved in energy transduction. They have heme-binding (CXXCH) sites that covalently ligate heme b via thioether bonds and are classified into different classes based on their protein folds and the locations and properties
Zixin Mai et al.
PloS one, 9(4), e95945-e95945 (2014-04-30)
Cigarette smoking can harm fertility, but the existing research has targeted primarily on ovarian follicles, embryos or sex hormone. In this study, we tested cigarette smoke extract on ovulation, oocyte morphology and ovarian gene expression associated with inhibition of oxidative
Hong Ma et al.
Oncology reports, 33(3), 1161-1170 (2015-01-13)
The aim of the present study was to explore the efficacy and mechanism of the radiosensitisation of icotinib hydrochloride (IH), a novel oral epidermal growth factor receptor-tyrosine kinase activity inhibitor, by evaluating the changes in tumour cell double-strand breaks (DSBs)
Xiaowen Liu et al.
The Journal of experimental medicine, 212(2), 267-280 (2015-01-21)
Neutrophils respond to invading bacteria by adopting a polarized morphology, migrating in the correct direction, and engulfing the bacteria. How neutrophils establish and precisely orient this polarity toward pathogens remains unclear. Here we report that in resting neutrophils, the ERM
Hwan-Jin Hwang et al.
Metabolism: clinical and experimental, 64(9), 1175-1182 (2015-07-01)
Leukocyte cell-derived chemotaxin 2 (LECT2) is a recently discovered novel hepatokine, leading to skeletal muscle insulin resistance by activating c-Jun N-terminal kinase (JNK). However, its role in atherosclerotic inflammatory reactions has not been examined. Therefore, we investigated the function of
Yan Zheng et al.
Aging, 12(23), 23822-23835 (2020-11-23)
In this study, we investigated the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL). CALR expression was significantly higher in the NKTCL tissues than normal control tissues in the GSE80632 dataset. High CALR expression correlated with
Se-Lim Kim et al.
International journal of molecular medicine, 33(5), 1261-1267 (2014-02-28)
Parthenolide (PT) is responsible for the bioactivities of feverfew (Tanacetum parthenium). Apart from its potent anti-inflammatory effects, this compound has been reported to induce apoptosis in various cancer cells. However, little is known about its role in the process of
Fei Guo et al.
Oncotarget, 6(33), 34606-34616 (2015-09-30)
Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 (STAT3) activity. Farnesoid X Receptor (FXR), highly expressed in liver, has an important role
Gabriella Costabile et al.
Molecular pharmaceutics, 12(8), 2604-2617 (2015-05-15)
Inhaled antivirulence drugs are currently considered a promising therapeutic option to treat Pseudomonas aeruginosa lung infections in cystic fibrosis (CF). We have recently shown that the anthelmintic drug niclosamide (NCL) has strong quorum sensing (QS) inhibiting activity against P. aeruginosa
Kasthuri Bai Magalingam et al.
Journal of molecular neuroscience : MN, 55(3), 609-617 (2014-08-19)
Quercetin glycosides, rutin and isoquercitrin, are potent antioxidants that have been found to possess neuroprotective effect in diseases like Parkinson's and Alzheimer's disease. In the present study, we have examined the gene expression changes with rutin and isoquercitrin pretreatment on
Natalie A Venier et al.
The Prostate, 75(2), 113-125 (2014-10-14)
Radio-sensitizing agents sensitize tumor cells to the lethal effects of radiotherapy (RT) allowing for use of lower doses of radiation to achieve equivalent cancer control, while minimizing adverse effects to normal tissues. Given their limited toxicity and ability to easily
Neelima M Bhat et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5178-5188 (2015-10-28)
B cell binding and cytotoxicity by human VH4-34-encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early response in a phase 1 trial for treatment of B cell acute lymphoblastic leukemia. Although
Mashael Al-toub et al.
Stem cell research & therapy, 6, 135-135 (2015-07-25)
Tumor microenvironment conferred by stromal (mesenchymal) stem cells (MSCs) plays a key role in tumor development, progression, and response to therapy. Defining the role of MSCs in tumorigenesis is crucial for their safe utilization in regenerative medicine. Herein, we conducted
Liannv Qiu et al.
Oncology reports, 34(3), 1239-1248 (2015-07-15)
Previously, it was demonstrated that the novel proteasome inhibitor N,N'-di-(m-methylphenyi)-3,6-dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboamide (ZGDHu‑1) possesses activity against chronic lymphocytic leukemia (CLL). In the present study, we attempted to assess whether this drug has a synergistic effect with fludarabine on the apoptosis of CLL
Lisa M Arendt et al.
Breast cancer research : BCR, 16(5), 453-453 (2014-10-16)
Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and differentiation during pregnancy. However, extensive anatomical differences between mouse and human mammary tissues preclude
Hyun Min Jung et al.
Journal of cellular biochemistry, 116(5), 836-843 (2014-12-19)
Head and neck cancer is one of the deadliest malignant diseases and chemotherapy is a common treatment option. Despite the development of chemotherapies for several decades, how these drugs affect the dynamics of gene regulation is still largely unknown. In
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