425-75-2

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Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: intermediates formed by a tyrosine 257 variant.

Michael M Mbughuni et al.

Biochemistry, 51(44), 8743-8754 (2012-10-17)

Homoprotocatechuate (HPCA; 3,4-dihydroxyphenylacetate or 4-carboxymethyl catechol) and O(2) bind in adjacent ligand sites of the active site Fe(II) of homoprotocatechuate 2,3-dioxygenase (FeHPCD). We have proposed that electron transfer from the chelated aromatic substrate through the Fe(II) to O(2) gives both

Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.

Lisa F Potts et al.

BMC medical genetics, 13, 16-16 (2012-03-20)

There are no known causes for progressive supranuclear palsy (PSP). The microtubule associated protein tau (MAPT) H1 haplotype is the major genetic factor associated with risk of PSP, with both oxidative stress and mitochondrial dysfunction also implicated. We investigated whether

Linear growth and bone maturation are unaffected by 1 year of therapy with inhaled flunisolide hydrofluoroalkane in prepubescent children with mild persistent asthma: a randomized, double-blind, placebo-controlled trial.

George W Bensch et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 107(4), 323-329 (2011-10-04)

Inhaled corticosteroids (ICS) are the preferred long-term therapy for subjects with persistent asthma. However, concerns remain about potential effects of long-term ICS use on growth in children. To determine the effect of 1 year of inhalation therapy with flunisolide hydrofluoroalkane

Expression of calsequestrin in atrial and ventricular muscle of thermally acclimated rainbow trout.

Hanna Korajoki et al.

The Journal of experimental biology, 212(Pt 21), 3403-3414 (2009-10-20)

Calsequestrin (CASQ) is the main Ca(2+) binding protein within the sarcoplasmic reticulum (SR) of the vertebrate heart. The contribution of SR Ca(2+) stores to contractile activation is larger in atrial than ventricular muscle, and in ectothermic fish hearts acclimation to

Oral tegafur/uracil.

K Wellington et al.

Drugs & aging, 18(12), 935-948 (2002-03-13)

Tegafur is a prodrug of the antineoplastic agent fluorouracil, and is administered in a 1:4 molar ratio with the fluorouracil modulator uracil. Oral tegafur/uracil 300 mg/m(2)/day plus calcium folinate 75 or 90 mg/day for 28 days every 35 days was

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects.

Dieuwertje E G Kok et al.

Clinical epigenetics, 7, 121-121 (2015-11-17)

Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation

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