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Waseem Hassan et al.
Molecules (Basel, Switzerland), 17(10), 12287-12296 (2012-10-23)
Diphenyl diselenide has shown interesting biological activities in various free-radical-induced damage models and can be considered as a potential candidate drug against oxidative stress. Apart from its anti-oxidant activity, this compound can oxidize various thiols. However there are no detailed
H.J. Reich et al.
Org. React., 44, 1-1 (1993)
The reaction of diphenyl diselenide with peroxydisulphate ions in methanol a convenient procedure to effect the methoxyselenenylation of alkenes.
Tiecco M, et al.
Tetrahedron Letters, 30(11), 1417-1420 (1989)
Samarium (II) di-iodide induced synthesis of allylic phenyl selenides from allylic acetates and diphenyl diselenide in the presence of palladium catalyst.
Fukuzawa S, et al.
Chemistry Letters (Jpn), 6 , 927-930 (1990)
Claire M Weekley et al.
Biochemistry, 51(3), 736-738 (2012-01-17)
The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical form of selenium in human neuroblastoma cells. Cells treated with MeSeCys contain a significant diselenide component
Marina Prigol et al.
Biological trace element research, 150(1-3), 272-277 (2012-06-14)
The purpose of this study was to provide data about in vivo tissue distribution and excretion of diphenyl diselenide ((PhSe)₂) in rats and mice through determination of selenium levels in different biological samples. (PhSe)₂ (500 mg/kg, dissolved in canola oil)
Abhijit Sau et al.
Carbohydrate research, 361, 41-48 (2012-09-18)
Reaction of glycal derivatives with alcohols or glycosyl acceptors in the presence of N-bromosuccinimide (NBS) and diphenyldiselenide resulted in the formation of alkyl 2-deoxy-2-phenylselenyl glycosides or disaccharide derivatives in excellent yield. The reactions are reasonably fast and considerable stereo-selectivity was
Cristiane L Dalla Corte et al.
Brain research, 1430, 101-111 (2011-12-03)
This study was designed to investigate the protective effects of the combination of guanosine and 2 organoselenium compounds (ebselen and diphenyl diselenide) against glutamate-induced oxidative stress in different regions of rat brains. Glutamate caused an increase in reactive oxygen species
Charlene Cavalheiro de Menezes et al.
Ecotoxicology and environmental safety, 81, 91-97 (2012-05-23)
The occurrence of pollutants in the aquatic environment can produce severe toxic effects on non-target organisms, including fish. These sources of contamination are numerous and include herbicides, which represent a large group of toxic chemicals. Quinclorac, an herbicide widely applied
Erico Silva Loreto et al.
Veterinary microbiology, 156(1-2), 222-226 (2011-11-08)
This study evaluated the in vitro activity of diphenyl diselenide against 19 Pythium insidiosum isolates and the in vivo therapeutic response of rabbits with experimentally induced pythiosis. In vitro: susceptibility tests were performed using the broth macrodilution method in accordance
Cleber F Barbosa et al.
Parasitology, 141(13), 1761-1768 (2014-08-12)
SUMMARY The aim of this study was to assess the effect of sulfamethoxazole/trimethoprim (ST) supplemented with diphenyl diselenide and sodium selenite in experimental toxoplasmosis, on oxidant/antioxidant biomarkers and cytokine levels. Eighty-four BALB/c mice were divided in seven groups: group A
Highly Selective Sequential Addition and Cyclization Reactions Involving Diphenyl Diselenide, an Alkyne, and Alkenes under Visible-Light Irradiation.
Tsuchii K, et al.
Angewandte Chemie (International Edition in English), 42(30), 3490-3493 (2003)
Mayara L de Freitas et al.
Environmental toxicology and pharmacology, 34(3), 985-994 (2012-09-18)
The effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)(2) on the toxicity induced by mercuric chloride (HgCl(2)) were investigated and compared with diphenyl diselenide (PhSe)(2). Mice received HgCl(2) for three days and, on the third day, received (PhSe)(2) or (ClPhSe)(2). The results verified
Juliana T da Rocha et al.
Behavioural pharmacology, 23(1), 98-104 (2011-12-06)
Ovarian hormone loss contributes to cognitive decline in postmenopausal women. Studies have demonstrated a positive role of the level of the element selenium in cognitive performance. The present study investigated the effects of the synthetic organoselenium compound diphenyl diselenide (PhSe)₂
Charlene Menezes et al.
Environmental toxicology and pharmacology, 36(2), 706-714 (2013-07-31)
The study investigated the capacity of diphenyl diselenide [(PhSe)2] (3.0mg/kg), on reduce the oxidative damage in liver, gills and muscle of carp and silver catfish exposed to clomazone (192h). Silver catfish exposed to clomazone showed increased thiobarbituric acid-reactive substance (TBARS)
Eco-Friendly Olefin Dihydroxylation Catalyzed by Diphenyl Diselenide.
Santoro S, et al.
Advanced Synthesis & Catalysis, 350(18), 2881-2884 (2008)
Marina Prigol et al.
Applied biochemistry and biotechnology, 169(3), 885-893 (2013-01-08)
The objective of the present study was to evaluate the physicochemical and biochemical profiling of diphenyl diselenide (PhSe)₂, a selenoorganic compound with biological activity. Experimental protocols were established for chemical stability in isotonic phosphate buffer (PBS) pH 7.4 and in
Cristiane Luchese et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(10), 1117-1124 (2012-06-16)
We reported the anti-inflammatory action of diphenyl diselenide [(PhSe)(2)] in an acute inflammation model induced by carrageenan. Male adult Swiss mice. Mice were treated with (PhSe)(2) (50 mg/kg) or vehicle (10 ml/kg) per oral route. After 30 min, animals received saline (0.1 ml) or
Juliana Trevisan da Rocha et al.
Psychopharmacology, 222(4), 709-719 (2012-03-28)
The transition to menopause is associated with an increased risk of depressed mood. This study was conducted to investigate whether diphenyl diselenide [(PhSe)₂] treatment could reduce the effects of postmenopausal depression-like behavior in ovariectomized female mice submitted to subchronic stress
César A Brüning et al.
Neurochemical research, 37(10), 2249-2258 (2012-08-01)
Cerebrovascular diseases, including ischemic stroke, are associated with high mortality worldwide. Oxidative stress and inflammation are important pathophysiological mechanisms involved in post-ischemic cerebral injury. The present study was designed to investigate the potential protective effect of diphenyl diselenide (PhSe)(2), an
Glaecir Roseni Mundstock Dias et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 30(2), 83-89 (2012-01-17)
Cognitive deficits have been observed in different animal models of adult-onset hypothyroidism. Thus, this study was delineated to evaluate whether diphenyl diselenide, an organoselenium compound with neuroprotective and antioxidant properties, could afford protection against the detrimental effects of hypothyroidism on
César Augusto Brüning et al.
Progress in neuro-psychopharmacology & biological psychiatry, 38(2), 168-174 (2012-03-31)
Bipolar disorder (BD) is a common and severe mood disorder associated with higher rates of suicide and disability. Ouabain, a Na(+)/K(+)-ATPase inhibitor, induces behavioral changes in rats and has been used as a model of mania. The aim of this
Photo-initiated addition of diphenyl diselenide to allenes.
Ogawa A, et al.
Tetrahedron Letters, 31(41), 5931-5934 (1990)
Viviane Glaser et al.
Chemico-biological interactions, 206(1), 18-26 (2013-08-21)
Interest in organoselenide chemistry and biochemistry has increased in the past three decades, mainly due to their chemical and biological activities. Here, we investigated the protective effect of the organic selenium compound diphenyl diselenide (PhSe)2 (5 μmol/kg), in a mouse
Reactions of some main group metals with diphenyl disulphide and diphenyl diselenide.
Kumar R, et al.
J. Chem. Soc., Dalton Trans., 4, 1045-1047 (1988)
Fernando Dobrachinski et al.
Neurotoxicity research, 26(4), 317-330 (2014-03-13)
Acute stroke is a major risk for morbidity and mortality in aging population. Mitochondrion has been the focus of a wide stroke-related research. This study investigated if treatment or pre-treatment with diphenyl diselenide (PhSe)2 can prevent mitochondrial damage in cerebral
Marina Prigol et al.
Chemico-biological interactions, 200(2-3), 65-72 (2012-10-02)
In spite of an extensive literature reporting pharmacological properties of diphenyl diselenide, (PhSe)(2), little is known about its metabolism. The aim of this study was to identify possible metabolic pathways of (PhSe)(2) in vitro to get insights into the mechanism
Carmine Inês Acker et al.
Environmental science and pollution research international, 19(8), 3481-3490 (2012-04-06)
In this study, we investigated the effect of diphenyl diselenide [(PhSe)(2)] on chlorpyrifos (CPF)-induced hepatic and hematologic toxicity in rats. Rats were pre-treated with (PhSe)(2) (5 mg/kg) via the oral route (oral gavage) once a day for 7 days. On
R M Rosa et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 40(10), 1287-1304 (2008-06-24)
The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms.
Lucía L Rupil et al.
Innate immunity, 18(4), 627-637 (2012-01-05)
Diphenyl diselenide (PhSe)(2), a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. As macrophages respond to microenvironmental stimuli and can display activities engaged in the initiation and the resolution of inflammation, in the present report we
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