CN
Search Within
431788
应用筛选条件
关键词:'431788'
显示 31-60 共 8953 条结果 关于 "431788" 范围 论文
Lukas F Mager et al.
The Journal of clinical investigation, 125(7), 2579-2591 (2015-05-27)
Myeloproliferative neoplasms (MPNs) are characterized by the clonal expansion of one or more myeloid cell lineage. In most cases, proliferation of the malignant clone is ascribed to defined genetic alterations. MPNs are also associated with aberrant expression and activity of
Thibault G Sana et al.
mBio, 6(3), e00712-e00712 (2015-06-04)
Invasion of nonphagocytic cells through rearrangement of the actin cytoskeleton is a common immune evasion mechanism used by most intracellular bacteria. However, some pathogens modulate host microtubules as well by a still poorly understood mechanism. In this study, we aim
Mai Sato et al.
Oncotarget, 6(5), 3292-3305 (2015-02-12)
MYC deregulation is a driver of many human cancers. Altering the balance of MYC protein levels at the level of transcription, protein stability, or turnover is sufficient to transform cells to a tumorigenic phenotype. While direct targeting of MYC is
Yeonju Lee et al.
Journal of ginseng research, 39(3), 250-256 (2015-07-23)
It has been known that ginseng can be applied as a potential nutraceutical for memory impairment; however, experiments with animals of old age are few. To determine the memory enhancing effect of red ginseng, C57BL/6 mice (21 mo old) were
Dilara Kaman et al.
Bosnian journal of basic medical sciences, 15(1), 9-13 (2015-03-01)
The cholesteryl ester transfer protein (CETP) plays a crucial role in high-density lipoprotein (HDL) metabolism. Genetic variants that alter CETP concentration may cause significant alterations in HDL-cholesterol (HDL-C) concentration. In this case-control study, we analyzed the genotype frequencies of CETP
Mariano Sánchez-Siles et al.
International journal of dermatology, 53(12), 1454-1459 (2014-06-06)
A study is made of DNA damage and apoptosis in a group of patients with oral leukoplakia (OL) with mild dysplasia. The study comprised 30 patients with a clinicopathological diagnosis of OL with mild dysplasia and 30 controls. Both samples
Atsuko Nakayama et al.
PloS one, 10(9), e0137106-e0137106 (2015-09-04)
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many
Kazime Gonca Akbulut et al.
Biogerontology, 16(1), 99-108 (2014-11-29)
The protein family of sirtuins and FoXO1 transcription factor have been shown to play significant roles in the aging process. In this study we aimed to investigate the changes in the levels of SIRT2, NFκB and FoXO1 and oxidative parameters
Soo Min Cho et al.
Scientific reports, 4, 6777-6777 (2014-10-28)
Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of Alzheimer's disease (AD), the link
Seri Jeong et al.
PloS one, 9(5), e98284-e98284 (2014-05-30)
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing
Olivera Magdenoska et al.
Analytical biochemistry, 487, 17-26 (2015-07-05)
For quantification of intracellular metabolites, mass spectrometry combined with liquid chromatography, capillary electrophoresis, or gas chromatography is currently the method of choice, especially when combined with stable isotope-labeled internal standards (SIL-ISs). Due to the difficulties in finding a biological matrix
Yanrui Yang et al.
Cell research, 25(4), 496-516 (2015-03-17)
Dendritic spines are actin-rich membrane protrusions that are the major sites of excitatory synaptic input in the mammalian brain, and their morphological plasticity provides structural basis for learning and memory. Here we report that endophilin A1, with a well-established role
Maria Praggastis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(21), 8091-8106 (2015-05-29)
Niemann-Pick Type C1 (NPC1) disease is a rare neurovisceral, cholesterol-sphingolipid lysosomal storage disorder characterized by ataxia, motor impairment, progressive intellectual decline, and dementia. The most prevalent mutation, NPC1(I1061T), encodes a misfolded protein with a reduced half-life caused by ER-associated degradation.
Anni E Sorkio et al.
Biomaterials, 51, 257-269 (2015-03-17)
The environmental cues received by the cells from synthetic substrates in vitro are very different from those they receive in vivo. In this study, we applied the Langmuir-Schaefer (LS) deposition, a variant of Langmuir-Blodgett technique, to fabricate a biomimetic microenvironment
Denis G Knyazev et al.
The Journal of biological chemistry, 289(35), 24611-24616 (2014-07-13)
While engaged in protein transport, the bacterial translocon SecYEG must maintain the membrane barrier to small ions. The preservation of the proton motif force was attributed to (i) cation exclusion, (ii) engulfment of the nascent chain by the hydrophobic pore
Wynne Q Zhang et al.
Neuropharmacology, 90, 1-8 (2014-12-03)
Clinical evidence indicates brain serotonin (5-HT) stores and neurotransmission may be inadequate in subpopulations of individuals with autism, and this may contribute to characteristically impaired social behaviors. Findings that depletion of the 5-HT precursor tryptophan (TRP) worsens autism symptoms support
Bin Lou et al.
PloS one, 9(7), e102641-e102641 (2014-07-18)
Sphingomyelin synthase (SMS) plays an important role in plasma atherogenic lipoprotein metabolism, inflammation, and the development of atherosclerosis. To understand whether the impaired apoB secretion and inflammation response is a direct result from lack of SMS activity, in this study
Marjan Steppe et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 129-137 (2014-07-11)
Inflammatory bowel disease (IBD) is a chronic inflammation of the digestive tract, characterized by dysbiosis of the intestinal microbiota. Probiotics have been suggested as a strategy to reduce active disease or extend remission. We isolated and characterized the butyrate-producing strain
Somruedee Yorsin et al.
Journal of ethnopharmacology, 156, 162-174 (2014-08-30)
In Thai traditional medicine, rhizomes of Kaempferia parviflora (KP) have been used for treating hypertension and for the promotion of longevity with good health and well being. Ageing is one of the most important risk factors for development of cardiovascular
Min Jung Kim et al.
Theriogenology, 84(6), 995-1002 (2015-07-15)
Ectopic liver and gallbladder are rare anomalies usually not accompanied by any symptoms and are found during surgical exploration or autopsy. We aimed to find a cause of this anomaly using somatic cell nuclear transfer (SCNT) technology, which can produce
R Brooks et al.
Stem cells (Dayton, Ohio), 33(3), 848-858 (2014-11-18)
Promoting the expansion of adult stem cell populations offers the potential to ameliorate radiation or chemotherapy-induced bone marrow failure and allows for expedited recovery for patients undergoing these therapies. Previous genetic studies suggested a pivotal role for SH2 domain-containing inositol-5-phosphatase
Emmanuel Breard et al.
Vaccine, 33(4), 512-518 (2014-12-17)
Eradication of bluetongue virus is possible, as has been shown in several European countries. New serotypes have emerged, however, for which there are no specific commercial vaccines. This study addressed whether heterologous vaccines would help protect against 2 serotypes. Thirty-seven
S Weisshaar et al.
Journal of thrombosis and haemostasis : JTH, 12(11), 1850-1860 (2014-09-12)
Patients with acute coronary syndrome and concomitant atrial fibrillation may require antithrombotic triple therapy but clinical evidence of safety and efficacy is poor. We have therefore studied the combination of different antithrombotic medicines for coagulation activation in an in vivo
Helen Kaipe et al.
Stem cells and development, 24(12), 1471-1482 (2015-02-07)
Allogeneic mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but little is known about their immunogenicity. In this study, we monitored the therapeutic and immunogenic effects of decidual stromal cells (DSCs) from term placentas when used as a
Hao-Yang Mi et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(5), 960-970 (2014-09-02)
Soft and hard thermoplastic polyurethane (TPU) and their blends were electrospun to fabricate nanofibrous scaffolds with various properties in order to investigate the substrate property effects on cellular response. The scaffolds were characterized with Fourier transform infrared spectroscopy, thermogravimetric analysis
H G Oliveira Barud et al.
Carbohydrate polymers, 128, 41-51 (2015-05-26)
Bacterial cellulose (BC) and silk fibroin (SF) are natural biopolymers successfully applied in tissue engineering and biomedical fields. In this work nanocomposites based on BC and SF were prepared and characterized by scanning electron microscopy (SEM), infrared spectroscopy (FT-IR), X-ray
Yoshimasa Taniguchi et al.
Bioscience, biotechnology, and biochemistry, 79(10), 1684-1694 (2015-05-23)
The bitter acids in hops (Humulus lupulus L.) and beer, such as α-, β-, and iso-α-acids, are known to affect beer quality and display various physiological effects. However, these compounds readily oxidize, and the effect of the oxides on the
J T Richeson et al.
Journal of animal science, 93(8), 4089-4097 (2015-10-07)
Growth implant efficacy may be affected when administered to nutritionally stressed calves, whereas the procedure may alter health or the humoral immune response to respiratory vaccination. The study objective was to determine the effect of different administration times (d 0
Mohamed Aittaleb et al.
Journal of cell science, 128(20), 3744-3756 (2015-09-04)
Rapsyn, a scaffold protein, is required for the clustering of acetylcholine receptors (AChRs) at contacts between motor neurons and differentiating muscle cells. Rapsyn is also expressed in cells that do not express AChRs. However, its function in these cells remains
Yuichi Ohnishi et al.
International journal of oncology, 47(6), 2165-2172 (2015-10-27)
We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive
2/299