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Georg Singer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(2), 155-164 (2012-10-19)
Hepatic microvascular dysfunction is a critical event in the development of liver failure during sepsis. Activated blood cells and reactive oxygen and nitrogen species (RONS) have been implicated in the pathogenesis of sepsis. Intravital-videomicroscopy was used to determine whether RONS
Yan Xiao et al.
Magnetic resonance imaging, 33(6), 822-828 (2015-04-04)
A new biodegradable and biocompatible gadolinium (III) -copolymer (ACL-A2-DOTA-Gd) has been developed as a potential liver magnetic resonance imaging (MRI) contrast agent. ACL-A2-DOTA-Gd consisted of a poly (aspartic acid-co-leucine) unit bound with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (Gd-DOTA) via the linkage of ethylenediamine.
Yun Luo et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(10), 2136-2144 (2014-05-14)
Rare-earth-element (Y, Gd) modified Pt nanoparticles (NPs) supported on a carbon substrate (Vulcan XC-72) are synthesized via a water-in-oil chemical route. In both cases, X-ray diffraction (XRD) measurements show the non-formation of an alloyed material. Photoemission spectroscopy (XPS) results reveal
Mohamad Kurdi et al.
PloS one, 7(9), e45111-e45111 (2012-10-11)
Factor X (FX), a plasma glycoprotein playing a central role in coagulation has a long circulatory half-life compared to closely related coagulation factors. The activation peptide of FX has been shown to influence its clearance with two N-glycans as key
Biao Wang et al.
PloS one, 8(1), e52743-e52743 (2013-01-24)
Activation of Kupffer cell (KC) is acknowledged as a key event in the initiation and perpetuation of bile duct warm ischemia/reperfusion injury. The inhibitory effect of gadolinium chloride (GdCl(3)) on KC activation shows potential as a protective intervention in liver
Kengo Hattori et al.
Medical physics, 40(3), 032303-032303 (2013-03-08)
A 3.0-T MRI phantom (called the CAGN-3.0T phantom) having human-equivalent relaxation times and human-equivalent conductivity was developed. The ingredients of the phantom are carrageenan (as a gelatinizer), agarose (as a T2-relaxation modifier), GdCl3 (as a T1-relaxation modifier), NaCl (as a
Yi-Wei Huang et al.
Journal of cellular physiology, 230(9), 2086-2097 (2015-02-03)
Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role of store-operated Ca(2+) entry, which is the major form of extracellular Ca(2+)
Stefanie Gödecke et al.
American journal of physiology. Cell physiology, 302(6), C915-C923 (2011-12-14)
ATP and its degradation products play an important role as signaling molecules in the vascular system, and endothelial cells are considered to be an important source of nucleotide release. To investigate the mechanism and physiological significance of endothelial ATP release
Netanya Y Spencer et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(1), G84-G94 (2013-05-04)
Cell line studies have previously demonstrated that hypoxia-reoxygenation (H/R) leads to the production of NADPH oxidase 1 and 2 (NOX1 and NOX2)-dependent reactive oxygen species (ROS) required for the activation of c-Src and NF-κB. We now extend these studies into
Runtao Gan et al.
Molecular and cellular biochemistry, 361(1-2), 123-134 (2011-10-11)
Our previous studies demonstrated that caclium-sensing receptor (CaR) stimulation elicited phospholipase C (PLC)-mediated inositol triphosphate (IP(3)) formation, leading to an elevation in [Ca(2+)](i) released from the endo(sarco)plasmic reticulum (ER) to induce ER stress and perturbations of ER function, which cause
Hideko Ohama et al.
The American journal of pathology, 185(2), 420-431 (2014-12-09)
Alcohol abuse was found to predispose persons to opportunistic infections. In this study, we tried to improve the host antibacterial resistance of chronic alcohol-consuming (CAC) mice to opportunistic infections. Bactericidal macrophages with functions to produce IL-12 and to express mRNAs
Minako Hara et al.
American journal of physiology. Cell physiology, 302(12), C1741-C1750 (2012-03-31)
When skeletal muscle is stretched or injured, satellite cells, resident myogenic stem cells positioned beneath the basal lamina of mature muscle fibers, are activated to enter the cell cycle. This signaling pathway is a cascade of events including calcium-calmodulin formation
Shohei Takai et al.
Journal of applied toxicology : JAT, 36(1), 35-47 (2015-04-23)
Drug-induced liver injury (DILI) is the most frequent cause of post-marketing warnings and withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans, and its metabolites, formed by cytochrome P450 3A4, are likely more toxic to hepatocytes
Mirandeli Bautista et al.
Molecules (Basel, Switzerland), 16(10), 8319-8331 (2011-10-01)
It is well known that gadolinium chloride (GD) attenuates drug-induced hepatotoxicity by selectively inactivating Kupffer cells. In the present study the effect of GD in reference to cell cycle and postnecrotic liver regeneration induced by thioacetamide (TA) in rats was
Ying-Ying Yang et al.
Clinical science (London, England : 1979), 123(12), 669-680 (2012-06-28)
Cirrhotic portal hypertension is characterized by increased hepatic oxidative stress, AA (arachidonic acid)-derived TXA(2) (thromboxane A(2)) release and exaggerated hepatic response to the α-adrenergic agonist MTX (methoxamine). Besides promoting hepatic fibrosis, the role of hyperleptinaemia in the modulation of vascular
Sonja M Mueller-Tribbensee et al.
PloS one, 10(7), e0128242-e0128242 (2015-07-25)
Various transient receptor potential (TRP) channels in sensory neurons contribute to the transduction of mechanical stimuli in the colon. Recently, even the cold-sensing menthol receptor TRPM(melastatin)8 was suggested to be involved in murine colonic mechano-nociception. To analyze the roles of
Daqin Chen et al.
The journal of physical chemistry letters, 6(14), 2833-2840 (2015-08-13)
A strategy to achieve 808 nm excited single-band red upconversion luminescence of Ho(3+) via the core-shell nanoarchitecture design was provided. Specifically, the synthesized Yb/Ho/Ce: NaGdF4@Yb/Nd: NaYF4 active-core@active-shell nanoparticles were evidenced to enable high-content doping of Nd(3+) (∼10 mol %) in
Comparison study on the influence of the central metal ions in palladium (II)-and gadolinium (III)-porphyrins for phosphorescence-based oxygen sensing
Lixin Zang, et al.
Journal of Materials Chemistry, 4, 9581-9587 (2016)
Bryan T Martin et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 218, 147-152 (2012-03-31)
The use of susceptibility matching to minimize spectral distortion of biphasic samples layered in a standard 5 mm NMR tube is described. The approach uses magic angle spinning (MAS) to first extract chemical shift differences by suppressing bulk magnetization. Then
Hiroaki Kito et al.
Biochemical and biophysical research communications, 459(3), 457-462 (2015-03-10)
Store-operated Ca(2+) entry (SOCE) via Orai1 and STIM1 complex is supposed to have obligatory roles in the regulation of cellular functions of vascular endothelial cells, while little is known about the contribution of Orai2. Quantitative PCR and Western blot analyses
Chikara Abe et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(1), 28-36 (2012-11-10)
Water drinking is known to induce the pressor response. The efferent pathway in this response involves sympathoexcitation, because the pressor response was completely abolished by ganglionic blockade or an α(1)-adrenergic antagonist. However, the afferent pathway in this response has not
T Hasezaki et al.
Die Pharmazie, 66(9), 698-703 (2011-10-27)
Nanomaterials have potential toxicity that is not found in micromaterials, and it is therefore essential to understand their biological activity and potential toxicity. We focused on silica nanoparticles, since it was previously reported that the intravenous administration of silica nanoparticles
Alfredo Mijares et al.
Biochemical and biophysical research communications, 452(4), 1054-1059 (2014-09-23)
Duchenne muscular dystrophy (DMD) is a lethal X-inherited disease caused by dystrophin deficiency. Besides the relatively well characterized skeletal muscle degenerative processes, DMD is also associated with a dilated cardiomyopathy that leads to progressive heart failure at the end of
X H Su et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(3), 417-424 (2014-06-17)
Rubus chingii Hu (Rosaceae) is an important traditional Chinese medicine that has been used to improve function of the kidney and treat excessive polyuria. However, the effects of Rubus chingii on the cardiovascular system and its pharmacological mechanisms of action
Huaineng Zhou et al.
Heart (British Cardiac Society), 99(8), 570-576 (2012-12-22)
C-reactive protein (CRP), an inflammation marker, is a strong independent risk factor for cardiovascular disease. Vessels are able to express CRP; however, the molecular mechanism behind this expression is not clear. Reverse transcription PCR and ELISA were used to detect
Puja Gulati et al.
Naunyn-Schmiedeberg's archives of pharmacology, 386(3), 255-264 (2012-12-12)
The present study was designed to investigate the potential of gadolinium, a stretch-activated calcium channel blocker in ischemic reperfusion (I/R)-induced brain injury in mice. Bilateral carotid artery occlusion of 12 min followed by reperfusion for 24 h was given to induce cerebral
Xianjing Li et al.
Immunologic research, 62(2), 137-145 (2015-04-08)
In this study, we found that pretreatment with low dose of lipopolysaccharide (LPS), also known as lipoglycans and endotoxin, obviously attenuated liver injury caused by diethylnitrosamine (DEN) in mice. This protective effect was described by decreased ALT, TNF-α, and IL-1β
Jingsheng Xia et al.
The Journal of physiology, 592(16), 3443-3461 (2014-05-27)
Store-operated calcium channels (SOCs) are calcium-selective cation channels that mediate calcium entry in many different cell types. Store-operated calcium entry (SOCE) is involved in various cellular functions. Increasing evidence suggests that impairment of SOCE is responsible for numerous disorders. A
Yong-Han He et al.
Molecular and cellular biochemistry, 361(1-2), 321-328 (2011-11-01)
Adipocyte differentiation and adipogenesis are closely related to obesity and obesity-induced metabolic disorders. The calcium-sensing receptor (CaSR) has been reported to play an antilipolytic role in human adipocyte and regulate cell differentiation in many tissues. However, the effects of CaSR
Luis A Videla et al.
TheScientificWorldJournal, 2012, 301494-301494 (2012-06-01)
L-3,3',5-triiodothyronine (T(3)) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection. In this work, we studied the role of Kupffer cell respiratory burst activity, a process related to reactive oxygen species generation
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