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关键词:'449164'
显示 1-30 共 3884 条结果 关于 "449164" 范围 论文
Christoph Wiedemann et al.
Nucleic acids research, 43(5), 2958-2967 (2015-02-26)
The minichromosome maintenance complex (MCM) represents the replicative DNA helicase both in eukaryotes and archaea. Here, we describe the solution structure of the C-terminal domains of the archaeal MCMs of Sulfolobus solfataricus (Sso) and Methanothermobacter thermautotrophicus (Mth). Those domains consist
Stefano Sanselicio et al.
mBio, 6(5), e01415-e01415 (2015-10-23)
Despite the myriad of different sensory domains encoded in bacterial genomes, only a few are known to control the cell cycle. Here, suppressor genetics was used to unveil the regulatory interplay between the PAS (Per-Arnt-Sim) domain protein MopJ and the
Daniel S Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(43), E4551-E4559 (2014-10-15)
Chemical fluorophores offer tremendous size and photophysical advantages over fluorescent proteins but are much more challenging to target to specific cellular proteins. Here, we used Rosetta-based computation to design a fluorophore ligase that accepts the red dye resorufin, starting from
Vaida Simanaviciene et al.
Journal of medical virology, 87(3), 461-471 (2014-09-10)
Human papillomavirus (HPV) is the main cause of cervical cancer. Therefore, the detection of oncogenic HPV types is important in predicting the risk of cervical cancer. The aim of the current study was to estimate the prevalence of 16 carcinogenic
Y M Wang et al.
Clinical and experimental dermatology, 39(7), 829-834 (2014-09-10)
Basal cell carcinoma (BCC) is a prevalent form of nonmelanoma skin cancer. Although numerous studies in white populations suggest that mutations in the TP53 gene play an important role in the development of BCC, it is not clear whether this
R A Leme et al.
Transboundary and emerging diseases, 62(6), 603-611 (2015-09-24)
Vesicular diseases are clinically and economically important infections that affect farm animals. North American studies have suggested that Senecavirus A infection might be associated with a vesicular disease in pigs known as porcine idiopathic vesicular disease (PIVD). In the beginning
Hua Meng et al.
The Journal of pharmacy and pharmacology, 66(10), 1463-1468 (2014-05-02)
Gastric cancer is one of the most frequently causing cancer-related deaths worldwide. The X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene for influencing gastric cancer risk. This study aimed to evaluate the associations between XRCC1 genetic
Yanmei Sang et al.
Journal of pediatric endocrinology & metabolism : JPEM, 27(5-6), 519-523 (2014-04-05)
The term type 1B diabetes mellitus (T1BDM) refers tonon-autoimmune-mediated type 1 diabetes. Recent studies revealed that monogenic mutations contribute to the genetic onset mechanism of this group. In this study, nine patients with T1BDM were selected as research subjects, and
Bogna M Ignatowska-Jankowska et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(13), 2948-2959 (2015-06-09)
The CB1 receptor represents a promising target for the treatment of several disorders including pain-related disease states. However, therapeutic applications of Δ(9)-tetrahydrocannabinol and other CB1 orthosteric receptor agonists remain limited because of psychoactive side effects. Positive allosteric modulators (PAMs) offer
Marvin M van Luijn et al.
Brain : a journal of neurology, 138(Pt 6), 1531-1547 (2015-04-01)
C-type lectins are key players in immune regulation by driving distinct functions of antigen-presenting cells. The C-type lectin CLEC16A gene is located at 16p13, a susceptibility locus for several autoimmune diseases, including multiple sclerosis. However, the function of this gene
Katherine A Black et al.
Journal of bacteriology, 197(11), 1952-1962 (2015-04-01)
The 2-thiouridine (s(2)U) modification of the wobble position in glutamate, glutamine, and lysine tRNA molecules serves to stabilize the anticodon structure, improving ribosomal binding and overall efficiency of the translational process. Biosynthesis of s(2)U in Escherichia coli requires a cysteine
Thomas Kander et al.
Anesthesia and analgesia, 119(4), 882-890 (2014-05-24)
Patients with bone marrow failure and severe thrombocytopenia are frequently given prophylactic platelet transfusion before interventions. The clinical effects of such transfusions, however, are poorly defined. We performed a prospective observational study on patients with bone marrow failure scheduled for
Zhan Shu et al.
The European journal of neuroscience, 40(2), 2320-2328 (2014-04-29)
The dopamine (DA) terminal fields in the rat dorsal striatum (DS) and nucleus accumbens core (NAcc) are organized as patchworks of domains that exhibit distinct kinetics of DA release and clearance. The present study used fast-scan cyclic voltammetry recordings of
Ali Tevfik Uncu et al.
Journal of agricultural and food chemistry, 63(8), 2284-2295 (2015-02-13)
The aim of this study was to establish a DNA-based identification key to ascertain the cultivar origin of Turkish monovarietal olive oils. To reach this aim, we sequenced short fragments from five olive genes for SNP (single nucleotide polymorphism) identification
John M Farrow et al.
Journal of bacteriology, 197(12), 1988-2002 (2015-04-08)
Pseudomonas aeruginosa is a Gram-negative bacterium that is ubiquitous in the environment, and it is an opportunistic pathogen that can infect a variety of hosts, including humans. During the process of infection, P. aeruginosa coordinates the expression of numerous virulence
Gabsik Yang et al.
Journal of medicinal food, 18(9), 1013-1021 (2015-06-24)
Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae
Chun-Chi Wu et al.
PloS one, 10(7), e0132052-e0132052 (2015-07-07)
Koelreuteria henryi Dummer, an endemic plant of Taiwan, has been used as a folk medicine for the treatment of hepatitis, enteritis, cough, pharyngitis, allergy, hypertension, hyperlipidemia, and cancer. Austrobailignan-1, a natural lignan derivative isolated from Koelreuteria henryi Dummer, has anti-oxidative
Andrew Bell et al.
Plant molecular biology, 89(6), 539-558 (2015-09-09)
Among a set of genes in pea (Pisum sativum L.) that were induced under drought-stress growth conditions, one encoded a protein with significant similarity to a regulator of chlorophyll catabolism, SGR. This gene, SGRL, is distinct from SGR in genomic
Yakov Y Woldman et al.
Biochemical and biophysical research communications, 465(2), 232-238 (2015-08-09)
A chemiluminescent method is proposed for quantitation of NO generation in cell cultures. The method is based on activation of soluble guanylyl cyclase by NO. The product of the guanylyl cyclase reaction, pyrophosphate, is converted to ATP by ATP sulfurylase
Nicholas J D Wright et al.
Invertebrate neuroscience : IN, 15(1), 175-175 (2014-11-09)
The generation of the novel messenger molecule nitric oxide (NO) has been demonstrated in many tissues across phyla including nervous systems. It is produced on demand by the enzyme nitric oxide synthase often stimulated by intracellular calcium and typically affecting
Christopher J Mitchell et al.
BMC systems biology, 9, 75-75 (2015-11-07)
Cellular function and diversity are orchestrated by complex interactions of fundamental biomolecules including DNA, RNA and proteins. Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel and unbiased measurements. Such high-throughput technologies have been extensively used to
Carina M Hall et al.
PloS one, 10(11), e0143254-e0143254 (2015-11-26)
The global distribution of the soil-dwelling bacterium Burkholderia pseudomallei, causative agent of melioidosis, is poorly understood. We used established culturing methods developed for B. pseudomallei to isolate Burkholderia species from soil collected at 18 sampling sites in three states in
Yeng F Her et al.
PloS one, 10(5), e0127471-e0127471 (2015-05-20)
Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. For unknown reasons, a higher prevalence of PGL has been reported for humans
Chi-Chien Chen et al.
BMC genomics, 16, 1026-1026 (2015-12-03)
MicroRNAs (miRNAs) play a vital role in growth, development, and stress response at the post-transcriptional level. Broccoli (Brassica oleracea L. var italic) is an important vegetable crop, and the yield and quality of broccoli are decreased by heat stress. The
Kausik Bishayee et al.
Molecules and cells, 38(6), 518-527 (2015-05-08)
Controlled release of medications remains the most convenient way to deliver drugs. In this study, we precipitated gold nanoparticles with quercetin. We loaded gold-quercetin into poly(DL-lactide-co-glycolide) nanoparticles (NQ) and tested the biological activity of NQ on HepG2 hepatocarcinoma cells to
Zichun Wang et al.
Immunogenetics, 67(8), 447-461 (2015-07-02)
Although immune pressure exerted by MHC class I-restricted cytotoxic T lymphocytes (CTL) are an important determinant of outcome in pathogenic HIV and SIV infection, lack of data on MHC class I genes has hampered study of its role in natural
Matthew P Nicholas et al.
Nature communications, 6, 6206-6206 (2015-02-12)
Cytoplasmic dynein is a microtubule motor involved in cargo transport, nuclear migration and cell division. Despite structural conservation of the dynein motor domain from yeast to higher eukaryotes, the extensively studied S. cerevisiae dynein behaves distinctly from mammalian dyneins, which
Hans Krügel et al.
Journal of basic microbiology, 55(8), 982-991 (2015-04-03)
Lactobacilli are important microorganisms in various activities, for example, diary products, meat ripening, bread and pickles, but, moreover, are associated directly with human skin and cavities (e.g., mouth, gut, or vagina). Some of them are used as probiotics. Therefore, the
Reza Mahmoudi et al.
International journal of genomics, 2015, 132720-132720 (2015-07-23)
Recent studies have shown that polymorphisms in leptin and leptin receptor genes are associated with increased risk for breast cancer. This study aimed at investigating -2548 G/A polymorphism in leptin gene and Q223R polymorphism in leptin receptor gene in patients with
Esi Kajno et al.
The Biochemical journal, 468(3), 425-434 (2015-04-10)
Protein kinase B (Akt) kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signalling differentially contribute to sustain lipid and glucose homoeostasis; however Akt isoform-specific effectors remain elusive due to the lack of a
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