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C Hori et al.
Nephron, 88(4), 313-319 (2001-07-28)
There is little information on the significance of angiotensin-converting enzyme (ACE) genotypes and medical treatments in children with primary focal segmental glomerulosclerosis (FSGS). A multicenter retrospective study was performed on the role of ACE genotypes and medical treatments in 43
M E Peattie et al.
The Science of the total environment, 34(1-2), 73-86 (1984-03-01)
Chlorinated benzenes are produced in large quantities on a world-wide basis. They are important industrial chemicals, chemical intermediates and components of the waste products of chemical synthesis. Their widespread occurrence and persistence, particularly in the case of the more highly
S Kacew et al.
Teratology, 29(1), 21-27 (1984-02-01)
Three tetrachlorobenzene (TCB) congeners (1,2,3,4- 1,2,3,5-, and 1,2,4,5-) were administered daily by gavage to pregnant Sprague-Dawley rats at levels of 50, 100, or 200 mg/kg from day 6 through day 15 of gestation. Mothers were sacrificed on day 21 of
A A Toropov et al.
European journal of medicinal chemistry, 43(4), 714-740 (2007-07-17)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and organic compounds of different classes by optimal descriptors. Statistical characteristics of the best model (vitamins) are the
Hongmei Hu et al.
Journal of chromatographic science, 52(5), 375-382 (2013-05-07)
A simple, rapid, sensitive and high throughput method is described, based on solid-phase disk extraction (SPDE) and gas chromatography-electron capture detection, for the determination of chlorobenzens (CBs) in water samples. The proposed SPDE sample pretreatment method was initially optimized and
I Chu et al.
Journal of toxicology and environmental health, 11(4-6), 663-677 (1983-04-01)
Groups of 10 male and 10 female rats were dosed orally with 1,2,3,4-, 1,2,4,5-, or 1,2,3,5-tetrachlorobenzene (TCB) at levels that ranged from 200 to 4000 mg/kg, and were observed clinically for 14 d. LD50 values for 1,2,3,4-, 1,2,4,5-, and 1,2,3,5-TCB
K T Kitchin et al.
Toxicology, 26(3-4), 243-256 (1983-03-01)
To assess possible maternal hepatic and reproductive effects of this uncharged, low molecular weight, lipophilic chlorinated benzene 0, 100, 300 and 1000 mg/kg/day of 1,2,3,4-tetrachlorobenzene (TCB) was orally administered to pregnant rats on days 9-13 of gestation and the animals
Kenichiro Inoue et al.
Chemosphere, 70(3), 349-357 (2007-09-18)
Adsorption characteristics of carbonaceous adsorbents were examined using 1,2,3,4-tetrachlorobenzene, naphthalene and 2,4,6-tribromophenol as adsorbates. The breakthrough and equilibrium adsorption characteristics were evaluated using laboratory-scale adsorption test equipment. A micropore volume of diameter less than 2 nm is the most important
H Schwartz et al.
Journal of toxicology and environmental health, 15(5), 603-607 (1985-01-01)
[14C(U)]-Labeled 1,2,3,4-tetrachlorobenzene was administered orally to squirrel monkeys. Urine was collected from these animals, pooled and analyzed for metabolites by thin-layer chromatography, high-performance liquid chromatography, and gas chromatography-mass spectroscopy. N-Acetyl-s-(2,3,4,5-tetrachlorophenyl) cysteine was shown to be the major metabolite and accounted
Heather A Leslie et al.
Environmental toxicology and chemistry, 23(8), 2022-2028 (2004-09-09)
The use of internal concentrations as a dose parameter for baseline toxicity requires an understanding of the relationship between accumulation level and toxic effects, not only for acute but also for chronic exposure. In this study of chronic toxicity of
C Siklósi et al.
Dermatosen in Beruf und Umwelt. Occupation and environment, 29(2), 40-42 (1981-01-01)
In answering the question as to what role possible metabolites of hexachlorobenzene play in the procreation of toxic hexachlorobenzene porphyria in rats, both pure hexachlorobenzene and different mixtures were fed to them. In each case 20% of the hexachlorobenzene was
Christopher M Hurdzan et al.
Bulletin of environmental contamination and toxicology, 87(3), 209-214 (2011-06-21)
The acute, lethal potency of the 1,2,3,4-, 1,2,4,5- and 1,2,3,5-tetrachlorobenzene isomers was compared in the terrestrial and aquatic oligochaetes Eisenia andrei and Tubifex tubifex. 1,2,4,5-TeCB was neither lethal, nor produced any perceptible adverse effects, at lipid normalized concentrations predicted to
I Chu et al.
Drug and chemical toxicology, 7(2), 113-127 (1984-01-01)
Tetrachlorobenzenes (TCB) are industrial chemicals which have been used as intermediates for chemical synthesis and for electrical insulation. Recently TCB residues have been found in Great Lakes fish. The present study was designed to determine the subchronic toxicity of these
Kenichiro Inoue et al.
Environmental science & technology, 39(15), 5844-5850 (2005-08-30)
Carbonaceous adsorbents such as activated carbon have been used to reduce the emission of organic pollutants from incineration plants. However, with this method, the amount and type of adsorbent to be used are based only on empirical results, which may
L D Bowers et al.
Clinical chemistry, 43(6 Pt 1), 1033-1039 (1997-06-01)
Limits of detection are important issues for GC/MS screening for anabolic agents and for confirmation of various drugs of abuse. We compared a quadrupole ion trap (QIT) operated in two different selected-ion storage modes and a quadrupole mass filter (QMF)
T K S Janssens et al.
Environment international, 37(5), 929-939 (2011-04-13)
In order to clarify the mechanisms of reproductive toxicity in a QSAR approach, the transcriptional signatures upon the 2 day exposure to the 28 days EC₅₀ of a series of increasingly chlorinated aniline compounds and 1,2,3,4-tetrachlorobenzene were measured in Folsomia
I Chu et al.
Journal of toxicology and environmental health, 13(4-6), 777-786 (1984-01-01)
Adult male rats were given orally single doses of 14C-labeled 1,2,3,4-, 1,2,3,5-, or 1,2,4,5-tetrachlorobenzene (TCB) at 10 mg/kg body weight, and were housed in individual metabolism cages to collect urine and feces for radioassay. For 1,2,3,4- and 1,2,3,5-TCB, approximately 46-51%
Ken G Drouillard et al.
Bulletin of environmental contamination and toxicology, 93(5), 561-566 (2014-06-18)
A vial equilibration technique was used to estimate the fugacity capacities of food and feces samples for 1,2,3,4-tetrachlorobenzene (TCB). The method was calibrated using different volumes of n-octanol and by comparing the measured and predicted fugacity capacity (Zoct) of n-octanol
B A Kimball et al.
Journal of wildlife diseases, 32(3), 505-511 (1996-07-01)
Pentachlorobenzene (PeCB) and 1,2,3,4-tetrachlorobenzene (TeCB) were evaluated as oral chemical biomarkers when administered to coyotes (Canis latrans) during the period of 31 January to 10 August 1994. Three coyotes each received 100 mg of PeCB and three received 100 mg
T Potrawfke et al.
Journal of bacteriology, 183(3), 997-1011 (2001-02-24)
The nucleotide sequence of a 10,528-bp region comprising the chlorocatechol pathway gene cluster tetRtetCDEF of the 1,2,3,4-tetrachlorobenzene via the tetrachlorocatechol-mineralizing bacterium Pseudomonas chlororaphis RW71 (T. Potrawfke, K. N. Timmis, and R.-M. Wittich, Appl. Environ. Microbiol. 64:3798-3806, 1998) was analyzed. The
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