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关键词:'46047'
显示 1-30 共 1082 条结果 关于 "46047" 范围 论文
Yang Guo et al.
The Analyst, 140(13), 4642-4647 (2015-05-16)
In this paper, we described a new DNAzyme-based fluorescent biosensor for the detection of Pb(2+). In the biosensor, the bulged structure is formed between the substrate labeled with fluorescein amidite (FAM) and DNAzyme after being annealed. Ethidium bromide (EB), the
Debanjan Mukhopadhyay et al.
PLoS neglected tropical diseases, 9(10), e0004145-e0004145 (2015-10-27)
The high level of functional diversity and plasticity in monocytes/macrophages has been defined within in vitro systems as M1 (classically activated), M2 (alternatively activated) and deactivated macrophages, of which the latter two subtypes are associated with suppression of cell mediated
M Melusova et al.
Neoplasma, 61(6), 690-699 (2014-10-25)
For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effects. In our study we assessed the cytotoxic
Yuxin Fang et al.
European journal of medicinal chemistry, 83, 36-44 (2014-06-20)
Tryptophan and arginine rich antimicrobial peptides (AMPs) possess high potencies against both gram positive and gram negative bacteria, while lipopeptides represent another family of promising antimicrobial agents to combat invading pathogens. In the present study, we have synthesized a series
Liang Deng et al.
Oncology letters, 10(5), 3323-3331 (2016-01-02)
Various human cancers have been revealed to contain cancer stem-like cells (CSCs) and the spherical colonies that possess stem-like properties and cancer-initiating abilities. Malignant fibrous histiocytoma (MFH) is a common soft-tissue sarcoma, and is considered to be a myxoma due
Sara Verpoest et al.
Veterinary microbiology, 172(1-2), 72-77 (2014-06-09)
Aujeszky's disease is an economically important disease in domestic swine caused by suid herpesvirus 1, also called pseudorabies virus (PRV). In several European countries, including Belgium, the virus has successfully been eradicated from the domestic swine population. The presence of
Zhiwei Zhang et al.
Molecular endocrinology (Baltimore, Md.), 29(1), 76-98 (2014-11-15)
Vertebrate reproduction is controlled by two gonadotropins (FSH and LH) from the pituitary. Despite numerous studies on FSH and LH in fish species, their functions in reproduction still remain poorly defined. This is partly due to the lack of powerful
Rakhshinda Sadiq et al.
Drug and chemical toxicology, 38(2), 152-161 (2014-06-05)
Metallic nanoparticles (NPs) have a variety of applications in different industries including pharmaceutical industry where these NPs are used mainly for image analysis and drug delivery. The increasing interest in nanotechnology is largely associated with undefined risks to the human
Selective PCR detection of viable Enterobacter sakazakii cells utilizing propidium monoazide or ethidium bromide monoazide.
Cawthorn DM and Witthuhn RC.
Journal of Applied Microbiology, 105(4), 1178-1185 (2008)
Yu Zhu et al.
Molecular pharmaceutics, 12(2), 332-341 (2014-08-26)
Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm).
Lu-Yao Wang et al.
Microbiological research, 177, 34-42 (2015-07-28)
Fusarium root-rot and fusarium head blight are plant diseases caused by Fusarium sp. in different growth periods of wheat, bring heavy losses to crop production in China. This research is aiming to screen biocontrol agents conjunctively for controlling these two
Anna Sipos et al.
Tuberculosis (Edinburgh, Scotland), 95 Suppl 1, S200-S206 (2015-03-25)
Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various institutions worldwide, including target-based approaches against several validated mycobacterial enzymes
S Nouripour-Sisakht et al.
Journal de mycologie medicale, 25(2), 101-107 (2015-02-07)
Onychomycosis is a common nail infection caused by dermatophytes, non-dermatophyte molds (NDM), and yeasts. Aspergillus species are emerging as increasing causes of toenail onychomycosis. The purpose of this study was species delineation of Aspergillus spp. isolated from patients with onychomycosis.
Ruixia Huang et al.
Anticancer research, 35(7), 3743-3753 (2015-07-01)
A low quantity of mitochondrial DNA (mtDNA) is a risk factor in a variety of tumor types. However, it is unclear how mtDNA reduction influences tumor behavior. mtDNA-deficient ovarian cancer cells were established by ethidium bromide (EtBr) treatment with additive
Jong-Hang Chen et al.
Cell transplantation, 24(5), 779-796 (2014-01-02)
Previous studies showed that transplantation of cultured neural stem/progenitor cells (NSPCs) could improve functional recovery for various neurological diseases. This study aims to develop a stem cell-based model for predictive toxicology of development in the neurological system after acrylamide exposure.
Hiroyuki Furusawa et al.
Analytical biochemistry, 492, 34-42 (2015-09-27)
Quantitative studies of the binding of various DNA-binding antibiotics with dsDNA are useful for drug design, not only for effective antibiotics, but also for antitumor drugs. We studied the binding kinetics, association and dissociation rate constants, and association constants (kon
Shi-Min Yu et al.
Molecular medicine reports, 12(3), 3869-3873 (2015-05-23)
Hepatocellular carcinoma (HCC) is a highly malignant tumor, associated with poor patient prognoses, and high rates of morbidity and mortality. To date, the therapeutic strategies available for the treatment of HCC remain limited. The present study aimed to elucidate the
Julia Walochnik et al.
The Journal of eukaryotic microbiology, 62(1), 3-11 (2014-07-23)
Acanthamoebae are the causative agents of an often seriously progressing keratitis (AK) occurring predominantly in contact lens wearers and can cause several disseminating infections potentially resulting in granulomatous amoebic encephalitis (GAE) in the immunocompromised host. Our institution is the Austrian
Robert P Morse et al.
Journal of molecular biology, 427(23), 3766-3784 (2015-10-10)
Contact-dependent growth inhibition (CDI) is a widespread mechanism of inter-bacterial competition mediated by the CdiB/CdiA family of two-partner secretion proteins. CdiA effectors carry diverse C-terminal toxin domains (CdiA-CT), which are delivered into neighboring target cells to inhibit growth. CDI(+) bacteria
Shoudeng Chen et al.
Genes & development, 29(12), 1326-1340 (2015-06-26)
Cells use specific mechanisms such as histone chaperones to abrogate the inherent barrier that the nucleosome poses to transcribing polymerases. The current model postulates that nucleosomes can be transiently disrupted to accommodate passage of RNA polymerases and that histones H3
Jiubo Liang et al.
Insect biochemistry and molecular biology, 58, 76-88 (2014-12-03)
Bombyx mori, a lepidopteran insect, is one of the earliest models for pattern recognition of Gram-negative bacteria, which may induce the IMD pathway for production of antibacterial peptides. So far, several recognition proteins have been reported in B. mori. However
Tingyu Ke et al.
Human gene therapy, 25(9), 787-797 (2014-05-16)
Netrin-1 is typically known as a neuronal guidance factor. Studies have reported the proangiogenic, antiapoptotic, and antiinflammatory properties of Netrin-1. A critical role for Netrin-1 in ischemic organ damage, myocardial infarction (MI) in particular, has also been demonstrated, making Netrin-1
Fabrizia Brisdelli et al.
Molecular and cellular biochemistry, 397(1-2), 33-43 (2014-08-03)
This study investigated the effects of sinusoidal ELF-MF (1 mT; 50 Hz) on the apoptosis induced by four different compounds, namely vinblastine, etoposide, quercetin, and resveratrol, in human K562 chronic myeloid leukemia cells. The exposure to ELF-MF did not affect growth and
Debarati Banik et al.
Oncotarget, 6(17), 15164-15179 (2015-05-27)
Interferon regulatory factor-8 (IRF8), originally identified as a leukemic tumor suppressor, can also exert anti-neoplastic activities in solid tumors. We previously showed that IRF8-loss enhanced tumor growth, which was accompanied by reduced tumor-cell susceptibility to apoptosis. However, the impact of
J A Redondo et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 90, 38-43 (2014-12-03)
In this work, the cationic monomer N-ethyl pyrrolidine methacrylamide (EPA) was copolymerized with the neutral monomer N-hydroxypropyl methacrylamide (HPMA) at different molar ratios obtaining linear random copolymers that were characterized and evaluated in vitro as non-viral gene carriers using murine
Mi-young Song et al.
Nutrition research (New York, N.Y.), 35(8), 655-663 (2015-06-07)
Schisandra chinensis fruit (SCF) is known to have beneficial effects on metabolic diseases, including obesity, and to affect gut microbiota in in vivo studies. However, in human research, there have been a few studies in terms of its clinical roles
Solène Accarias et al.
European journal of immunology, 45(3), 794-806 (2014-12-05)
The relationship between Staphylococcus aureus and innate immunity is highly complex and requires further investigation to be deciphered. i.p. challenge of C57BL/6 and DBA/2 mice, resistant and susceptible to the infection, respectively, resulted in different patterns of cytokine production and
Basak Togar et al.
Cytotechnology, 67(6), 939-946 (2014-05-08)
The main objective of this study is to investigate the cytotoxic, genotoxic and antioxidant properties of zingiberene (ZBN) in an in vitro rat brain cell culture study. The cytotoxic effect was determined against the rat neuron and N2a neuroblastoma (N2a-NB)
Ploypailin Aneknan et al.
Asian Pacific journal of cancer prevention : APJCP, 15(12), 5071-5076 (2014-07-08)
Cholangiocarcinoma (CCA) is one of the aggressive cancers with a very poor prognosis. Several efforts have been made to identify and develop new agents for prevention and treatment of this deadly disease. In the present study, we examined the anticancer
Dan-Ning Hu et al.
Investigative ophthalmology & visual science, 55(9), 5760-5769 (2014-08-16)
Melanocytes are one of the major cellular components in the uvea. Interleukin-8/CXCL8 and monocyte chemoattractant protein-1 (MCP-1/CCL2) are the two most important proinflammatory chemokines. We studied the constitutive and lipopolysaccharide (LPS)-induced expression of IL-8 and MCP-1 in cultured human uveal
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