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Christopher A Dieni et al.
PeerJ, 2, e558-e558 (2014-09-12)
The wood frog, Rana sylvatica, survives whole-body freezing and thawing each winter. The extensive adaptations required at the biochemical level are facilitated by alterations to signaling pathways, including the insulin/Akt and AMPK pathways. Past studies investigating changing tissue-specific patterns of
Y Gu et al.
Cell death & disease, 5, e1580-e1580 (2014-12-19)
BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to
Georgetta Cannon et al.
PloS one, 9(8), e105385-e105385 (2014-08-29)
Early molecular responses to Influenza A (FLUA) virus strain A/X-31 H3N2 in macrophages were explored using J774.A1 and RAW 264.7 murine cell lines. NF-kappa B (NFκB) was reported to be central to FLUA host-response in other cell types. Our data
Achchhe L Patel et al.
BMC microbiology, 14, 277-277 (2014-12-05)
Chlamydia trachomatis (C. trachomatis) is a clinically significant human pathogen and one of the leading causative agents of sexually transmitted diseases. As obligate intracellular bacteria, C. trachomatis has evolved strategies to redirect the host's signaling and resources for its own
Wei-Kai Chen et al.
Biochemical and biophysical research communications, 453(3), 576-581 (2014-10-11)
The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence.
Claudia Günther et al.
The Journal of clinical investigation, 125(1), 413-424 (2014-12-17)
Genome integrity is continuously challenged by the DNA damage that arises during normal cell metabolism. Biallelic mutations in the genes encoding the genome surveillance enzyme ribonuclease H2 (RNase H2) cause Aicardi-Goutières syndrome (AGS), a pediatric disorder that shares features with
S Busch et al.
Oncogene, 34(1), 27-38 (2013-12-18)
Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data
Amritlal Mandal et al.
Experimental eye research, 132, 52-58 (2015-01-20)
Exposure to hyposmotic solution causes release of ATP from lens cells via hemichannels. Because hemichannel opening feasibly could swamp the cells with calcium, we carried out studies to measure the magnitude of the increase in cytoplasmic calcium concentration caused by
Jonathan Creeth et al.
International dental journal, 63 Suppl 2, 14-24 (2014-01-10)
While toothpaste F(-) concentration and rinsing regimen have well-characterised impacts on fluoride's effectiveness, other aspects of brushing regimen have much less well-established effects, in particular, dentifrice quantity and brushing duration. An in vivo study (n = 42) of oral fluoride
Shunsaku Nakagawa et al.
American journal of physiology. Renal physiology, 307(12), F1404-F1411 (2014-10-31)
Acute kidney injury (AKI) often correlates with poor prognosis and is followed by various severe unfavorable systemic outcomes. It is important to understand the pathophysiology of AKI for the development of novel therapeutic approaches toward promoting renal regeneration after injury.
Yu-Xin Xu et al.
Journal of lipid research, 56(2), 266-276 (2014-12-22)
Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (DI-DV) with disparate structures and
Sandra L Grimm et al.
Molecular endocrinology (Baltimore, Md.), 28(12), 2025-2037 (2014-10-22)
Progesterone receptors (PRs) are phosphorylated on multiple sites, and a variety of roles for phosphorylation have been suggested by cell-based studies. Previous studies using PR-null mice have shown that PR plays an important role in female fertility, regulation of uterine
Nikhil V Joshi et al.
Lancet (London, England), 383(9918), 705-713 (2013-11-15)
The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and high-risk atherosclerotic plaques
Xiao Li Shen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 202-209 (2014-04-24)
Nephrotoxicity is the most prominent toxicological effects of ochratoxin A (OTA). We have previously shown that autophagy might be involved in OTA-induced early renal cytotoxicity, but the mechanisms of action are unknown. Since OTA is known to induce mitochondrial damage
Alessandro Rimessi et al.
Nature communications, 6, 6201-6201 (2015-02-05)
The common pathological manifestation of cystic fibrosis (CF) is associated with an excessive lung inflammatory response characterized by interleukin-1β accumulation. CF airway epithelial cells show an exacerbated pro-inflammatory response to Pseudomonas aeruginosa; however, it is unclear whether this heightened inflammatory
Robert J Huber et al.
PloS one, 9(10), e110544-e110544 (2014-10-21)
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that regulates endocytic pathway trafficking, though
Congshan Sun et al.
BMC developmental biology, 15, 3-3 (2015-01-23)
Dietary interventions during pregnancy alter offspring fitness. We have shown mouse maternal low protein diet fed exclusively for the preimplantation period (Emb-LPD) before return to normal protein diet (NPD) for the rest of gestation, is sufficient to cause adult offspring
Erika Ortolan et al.
Oncotarget, 5(15), 6191-6205 (2014-07-16)
Malignant mesothelioma is a deadly tumor whose diagnosis and treatment remain very challenging. There is an urgent need to advance our understanding of mesothelioma biology and to identify new molecular markers for improving management of patients. CD157 is a membrane
Yun Tong et al.
Bioorganic & medicinal chemistry letters, 22(5), 1908-1911 (2012-02-14)
Two new cyclic peptides, dianthins G-H (1 and 2), together with the known dianthin E (3), were isolated from the traditional Chinese medicinal plant Dianthus superbus. The sequences of cyclic peptides 1 and 2 were elucidated as cyclo (-Gly(1)-Pro(2)-Leu(3)-Thr(4)-Leu(5)-Phe(6)-) and
Jose C Paz et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17116-17121 (2014-11-19)
In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions in catecholamine signaling, where it contributes
Shanwei Shen et al.
Life sciences, 121, 22-27 (2014-12-03)
The present study aims to systemically characterize the factors that are associated with urinary bladder organ enlargement in spontaneously hypertensive rats (SHR). We compared the SHR to age-matched normotensive Wistar-Kyoto (WKY) control rats in the levels of bladder pro-inflammatory factors
Elena Chiricozzi et al.
Journal of lipid research, 56(1), 129-141 (2014-11-25)
Lactosylceramide [LacCer; β-Gal-(1-4)-β-Glc-(1-1)-Cer] has been shown to contain very long fatty acids that specifically modulate neutrophil properties. The interactions between LacCer and proteins and their role in cell signaling processes were assessed by synthesizing two molecular species of azide-photoactivable tritium-labeled
Harish Potu et al.
Oncotarget, 5(14), 5559-5569 (2014-07-02)
Usp5 is a deubiquitinase (DUB) previously shown to regulate unanchored poly-ubiquitin (Ub) chains, p53 transcriptional activity and double-strand DNA repair. In BRAF mutant melanoma cells, Usp5 activity was suppressed by BRAF inhibitor (vemurafenib) in sensitive but not in acquired or
Jie Mou et al.
Neural regeneration research, 9(23), 2059-2065 (2015-02-07)
Our previous study showed that when glutamate receptor (GluR)6 C terminus-containing peptide conjugated with the human immunodeficiency virus Tat protein (GluR6)-9c is delivered into hippocampal neurons in a brain ischemic model, the activation of mixed lineage kinase 3 (MLK3) and
Brunella Perfetto et al.
Journal of medical microbiology, 63(Pt 11), 1474-1483 (2014-09-05)
Arbidol (ARB) is an antiviral drug that has broad-spectrum activity against a number of viral infections. To date, there are no specific data regarding its effects against a herpesvirus. Here, the in vitro antiviral effect of ARB and structurally related
Min Gyeong Cheon et al.
Cancer letters, 356(2 Pt B), 637-645 (2014-10-15)
SIRT2, a member of the sirtuin family, is involved in the regulation of a variety of physiological functions. In addition, SIRT2 has been studied in the context of pathological conditions including neurodegenerative diseases, metabolic syndrome, and cancer. The effect of
Chong Chen et al.
International journal of hematology, 101(1), 5-12 (2014-10-16)
G-CSF is the most often used agent in clinical hematopoietic stem and progenitor cell (HSPC) mobilization. However, in about 10 % of patients, G-CSF does not efficiently mobilize HSPC in clinically sufficient amounts. Cdc42 activity is involved in HSPC mobilization. In
Sara M Reed et al.
PloS one, 9(11), e112126-e112126 (2014-11-14)
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor of cell proliferation that helps maintain chromosomal stability. It is a novel activator of the ARF-Mdm2-Tip60-p53 tumor suppressor pathway as well as other undefined pathways
Lykke Sylow et al.
The Journal of physiology, 593(3), 645-656 (2014-11-25)
Rac1 regulates stretch-stimulated (i.e. mechanical stress) glucose transport in muscle. Actin depolymerization decreases stretch-induced glucose transport in skeletal muscle. Rac1 is a required part of the mechanical stress-component of the contraction-stimulus to glucose transport in skeletal muscle. An alternative to
Megan D Lee et al.
Molecular immunology, 63(2), 540-549 (2014-12-03)
Antigen engagement of the T-cell receptor (TCR) induces a rapid and dramatic decondensation of chromatin that is necessary for T-cell activation. This decondensation makes T-cells competent to respond to interleukin-2 providing a mechanism to ensure clonotypic proliferation during an immune
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