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Kotaro Nochioka et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(8), 2023-2030 (2012-05-30)
Ezetimibe is an inhibitor of cholesterol absorption in the intestine. We examined whether ezetimibe improves endothelial function, and if so, what mechanisms are involved. Nineteen healthy subjects (male/female 14/5; mean age, 31±3 [SD] years-old) were randomized to receive ezetimibe (10mg/day)
B Pilo de la Fuente et al.
Neurologia (Barcelona, Spain), 26(7), 397-404 (2011-02-25)
cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by a deficiency of mitochondrial enzyme sterol 27-hydrolylase. Such a deficiency results in a reduced production of chenodeoxycholic acid and in an increased formation of cholestanol. It is clinically characterized by
Michel R Hoenig et al.
Atherosclerosis, 184(2), 247-254 (2005-10-12)
Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol:cholesterol ratio can
M Derrien et al.
Water research, 46(13), 4009-4016 (2012-06-08)
Improving the microbiological quality of coastal and river waters relies on the development of reliable markers that are capable of determining sources of fecal pollution. Recently, a principal component analysis (PCA) method based on six stanol compounds (i.e. 5β-cholestan-3β-ol (coprostanol)
Jill K Winkler-Moser et al.
Food chemistry, 169, 92-101 (2014-09-23)
Steryl ferulates synthesised from commercial sterols as well as commercial oryzanol were used to better understand how structural features affect antioxidant activity in vitro by the ABTS(+) radical decolorization assay, by oxidative stability index (OSI) of soybean oil, and by
G Lupattelli et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 21(9), 620-627 (2011-08-23)
Investigating cholesterol metabolism, which derives from balancing cholesterol synthesis and absorption, opens new perspectives in the pathogenesis of dyslipidemias and the metabolic syndrome (MS). Cholesterol metabolism is studied by measuring plasma levels of campesterol, sitosterol and cholestanol, that is, plant
Apinya Jusakul et al.
Mutation research, 731(1-2), 48-57 (2011-11-03)
Oxysterols are cholesterol oxidation products that are generated by enzymatic reactions through cytochrome P450 family enzymes or by non-enzymatic reactions involving reactive oxygen and nitrogen species. Oxysterols have been identified in bile in the setting of chronic inflammation, suggesting that
Eric J Niesor et al.
Atherosclerosis, 219(2), 761-767 (2011-10-11)
Subjects with high HDL-C show elevated plasma markers of cholesterol absorption and reduced markers of cholesterol synthesis. We evaluated the effect of dalcetrapib, a cholesteryl ester transfer protein modulator, on markers of cholesterol homeostasis in healthy subjects. Dalcetrapib was administered
Matthew G K Benesch et al.
Chemistry and physics of lipids, 164(1), 62-69 (2010-11-09)
It is commonly believed that all membrane sterols are rigid all-trans ring systems with a fully extended alkyl side-chain and that they similarly influence phospholipid bilayer physical properties. Here, we report the sterol concentration-dependent, thermotropic phase behaviour of binary dipalmitoylphosphatidylcholine
Bruce K Hope et al.
The Science of the total environment, 417-418, 263-272 (2012-01-17)
Oregon's Senate Bill 737, enacted in 2007, required the state's 52 largest municipal wastewater treatment plants (WWTP) and water pollution control facilities (WPCF) to collect effluent samples in 2010 and analyze them for persistent organic pollutants. These facilities are located
Kyrill S Rogacev et al.
Clinical journal of the American Society of Nephrology : CJASN, 7(6), 943-948 (2012-03-31)
Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which are differentially influenced by various classes of cholesterol-lowering
Estelle Wolff et al.
The Journal of nutrition, 141(10), 1791-1798 (2011-08-26)
LDL-cholesterol (LDL-C) reduction may be achieved by various types of prudent diets, but their effects on surrogate markers of cholesterol absorption and synthesis have not been well studied in humans. We aimed to assess whether the extent of cholesterol absorption
Gerd Liebezeit et al.
Bulletin of environmental contamination and toxicology, 85(6), 585-588 (2010-11-17)
To follow faecal pollution steroid compounds have been analysed in 106 sediment samples from the Siak River, E Sumatra, Indonesia. Coprostanol was detected in 40 of these. Contents ranged from 50 to 10,530 ng/g d.w. with a mean of 878
Monika Ostrowska et al.
Neurologia i neurochirurgia polska, 45(6), 600-603 (2012-01-04)
A 34-year-old patient demonstrating pyramidal and cerebellar signs, accompanied by epilepsy, peripheral neuropathy, mental retardation and bilateral cataract was diagnosed with cerebrotendinous xanthomatosis based on the clinical picture, magnetic resonance imaging of the brain and serum sterol analysis. Tendon xanthomas
Branko S Jursic et al.
Bioorganic & medicinal chemistry letters, 20(24), 7372-7375 (2010-11-03)
Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In addition, 2,3-functionalized steroids are also
César C Martins et al.
Environmental pollution (Barking, Essex : 1987), 188, 71-80 (2014-02-22)
Babitonga Bay is a South Atlantic estuary with significant ecological function; it is part of the last remaining areas of mangrove communities in the Southern Hemisphere. The aim of this study was to determine the spatial distribution of the faecal
Cerebrotendinous xanthomatosis: a treatable disease with juvenile cataracts as a presenting sign.
Dinelli M Monson et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 129(8), 1087-1088 (2011-08-10)
Annika Kurvinen et al.
Journal of pediatric gastroenterology and nutrition, 54(6), 803-811 (2011-12-27)
We prospectively evaluated incidence of prolonged (>28 days) parenteral nutrition (PN), associated complications, and significance of parenteral plant sterols (PS) in neonatal intestinal failure-associated liver disease (IFALD) compared with children. We recruited 28 neonates (mean age 50 days, range 28-126)
Christian G Daughton
The Science of the total environment, 414, 6-21 (2011-12-06)
A new approach is conceptualized for measuring small-area human populations by using biomarkers in sewage. The basis for the concept (SCIM: Sewage Chemical-Information Mining) is supported by a comprehensive examination and synthesis of data published across several disciplines, including medicine
Amy Cammarata et al.
Bioorganic & medicinal chemistry letters, 21(24), 7379-7386 (2011-11-04)
Invasive fungal infections pose a significant problem to the immune-compromised. Moreover, increased resistance to common antifungals requires development of novel compounds that can be used to treat invasive fungal infections. Naturally occurring steroidal glycosides have been shown to possess a
Sunghwan Suh et al.
European journal of medical genetics, 55(1), 71-74 (2011-10-01)
Cerebrotendinous Xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease caused by sterol 27-hydroxylase (CYP27) deficiency. We report three CTX siblings that shared a novel mutation of the CYP27A1 gene. These siblings presented with elevated cholestanol levels and typical
F Ginanneschi et al.
Journal of neurology, 260(1), 268-274 (2012-08-11)
Polyneuropathy has been reported in cerebrotendinous xanthomatosis (CTX), although its nature and possible association with certain genotypes and phenotypes are unclear. The effect of chronic administration of chenodeoxycholic acid (CDCA) on peripheral nerve conduction parameters is still debated. We report
Rozita Osman et al.
Environmental monitoring and assessment, 184(2), 1001-1014 (2011-04-16)
Increasing urbanization and changes in land use in Langat river basin lead to adverse impacts on the environment compartment. One of the major challenges is in identifying sources of organic contaminants. This study presented the application of selected chemometric techniques:
Claudia Gutterres Vilela et al.
Marine pollution bulletin, 62(10), 2055-2074 (2011-08-30)
Rodrigo de Freitas Lagoon, located in the Rio de Janeiro City, receives several types of polluted discharges. The knowledge of the sediment microfauna correlated with heavy metal and organic matter concentrations could supply important data about the conditions of the
Annika Mutanen et al.
The American journal of clinical nutrition, 100(4), 1085-1094 (2014-08-08)
Increased serum concentrations of plant sterols, including stigmasterol, during parenteral nutrition (PN) have been linked with serum biochemical signs of intestinal failure-associated liver disease (IFALD), whereas clinical data on their correlation to histologic liver injury have been limited. We studied
T Inoue et al.
Journal of clinical pharmacy and therapeutics, 36(1), 103-110 (2011-01-05)
Telmisartan, an angiotensin II type 1 receptor blocker (ARB), acts as a partial agonist for peroxisome proliferator-activated receptor-γ, and thus improves abnormalities of glucose metabolism and hypertriglyceridaemia in addition to its documented blood pressure-lowering effects. Recently, it has been demonstrated
Yousuke Seyama
Journal of medicinal food, 6(3), 217-224 (2003-10-31)
Cholestanol, not cholesterol, is a minor component in the human body and in foods, but an increase in cholestanol concentration in serum induces a pathological condition named cerebrotendinous xanthomatosis (CTX). In our investigation of this disease for more than 25
Philippe de Medina et al.
Biochimie, 95(3), 482-488 (2012-06-20)
We have recently discovered the existence of 5α-Hydroxy-6β-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3β-ol, called Dendrogenin A (DDA), as the first endogenous steroidal alkaloid ever described in mammals. We found that the DDA content of tumors and cancer cell lines was low or absent compared with
Giuseppe Martini et al.
Calcified tissue international, 92(3), 282-286 (2012-12-06)
Cerebrotendinous xanthomatosis (CTX) is known to be associated with osteoporosis and a higher incidence of bone fractures. However, the underlying pathogenesis is still unknown, and the effects of long-term replacement therapy with chenodeoxycholic acid (CDCA) on bone mineral density (BMD)
Ivone de Andrade Rosa et al.
FEMS microbiology letters, 315(1), 72-78 (2010-12-24)
Trichomonas vaginalis is an important human parasite that causes trichomoniasis, a cosmopolitan sexually transmitted disease. Currently, the treatment of choice for T. vaginalis infections is metronidazole. The increase in metronidazole-resistant parasites and undesirable side effects of this drug make the
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