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关键词:'47774'
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Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor κ activation.
Ozaki I, et al.
Clinical Cancer Research, 13(7), 2236-2245 (2007)
Tomohiro Shimizu et al.
Bone, 64, 95-101 (2014-04-16)
Teriparatide (PTH1-34) promotes skeletal repair and increases bone mass. Vitamin K is involved in bone mineralization as a coenzyme of γ-carboxylase for Gla proteins, and therefore vitamin K insufficiency caused by malnutrition or therapeutic intake of the vitamin K antagonist
Asagi Ito et al.
Lipids in health and disease, 10, 158-158 (2011-09-15)
Vitamin K is essential for the posttranslational modification of various Gla proteins. Although it is widespread in several organs, including the testis, the function of vitamin K in these organs is not well characterized. In this study, we investigated the
Jun Iwamoto et al.
Clinical drug investigation, 29(7), 471-479 (2009-06-09)
Patients with neurological diseases such as Alzheimer's disease, stroke and Parkinson's disease have been reported to have vitamin K deficiency secondary to malnutrition, which increases the risk of non-vertebral and hip fractures. The purpose of the present study was to
Peter F Schnatz et al.
Journal of women's health (2002), 21(8), 858-864 (2012-06-14)
This study analyzed associations between plasma vitamin D(3) (25OHD(3)) and bone mineral density (BMD) and whether the effects of conjugated equine estrogens (CEE) on BMD are modulated by 25OHD(3). Fifty cynomolgus monkeys were fed a diet containing 25OHD(3) (providing a
Yoshitomo Suhara et al.
Journal of medicinal chemistry, 55(4), 1553-1558 (2012-01-19)
We synthesized new vitamin K analogues with demethylation or reduction of the double bonds of the side chain of menaquinone-4 (MK-4) and evaluated their SXR-mediated transcriptional activity as well as the extent of their conversion to MK-4. The results indicated
Natsuko Sogabe et al.
Bone, 48(5), 1036-1042 (2011-02-08)
Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in
Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats.
Hara K, et al.
Bone, 31(5), 575-581 (2002)
Pornpimol Rianthavorn et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(3-4), 307-312 (2012-07-10)
Long-term treatment with glucocorticoids can induce bone loss and increase fracture risks. To compare the efficacy of a 12-month treatment between alfacalcidol and menatetrenone in preventing bone loss in children treated with long-term glucocorticoids. Twenty children on a stable dosage
I H Baek et al.
Journal of clinical pharmacy and therapeutics, 36(3), 390-398 (2011-05-07)
This study aimed to model the atypical absorption of menatetrenone and its epoxide metabolite and to examine the influence of the single nucleotide polymorphism (SNP) of vitamin K2 epoxide reductase complex subunit 1 (VKORC1) on the pharmacokinetics. After the administration
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