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Yizhi Song et al.
Environmental pollution (Barking, Essex : 1987), 195, 178-184 (2014-09-23)
A whole-cell bacterial bioreporter Acinetobacter baylyi strain ADP1_recA_lux that responds to genotoxins was employed to directly assess the adverse effects of the bioavailable fraction of mitomycin C (MMC), benzo[a]pyrene (BaP), chromium (VI) and lead (II) in amended soils and soil
F Mermillod-Blondin et al.
The Science of the total environment, 450-451, 230-241 (2013-03-19)
The interactions between invertebrates and micro-organisms living in streambed sediments often play key roles in the regulation of nutrient and organic matter fluxes in aquatic ecosystems. However, benthic sediments also constitute a privileged compartment for the accumulation of persistent organic
Liyun Gao et al.
Toxicology letters, 223(2), 205-210 (2013-10-03)
It has recently been found that the new class of transcripts, long non-coding RNAs (lncRNAs), are pervasively transcribed in the genome. LncRNAs are a large family of non-coding RNAs and regulate many protein-coding genes. Growing evidence indicates that lncRNAs may
Lenka Smerdová et al.
Toxicology, 314(1), 30-38 (2013-09-13)
Long-term deregulated inflammation represents one of the key factors contributing to lung cancer etiology. Previously, we have observed that tumor necrosis factor-α (TNF-α), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat
Tianshun Zhang et al.
Mutation research, 752(1-2), 34-41 (2013-02-02)
Black soybean seed coat is a rich source of polyphenols that have been reported to have various physiological functions. The present study investigated the potential protective effects of polyphenolic extracts from black soybean seed coat on DNA damage in human
Heloísa H P Oliveira et al.
Ecotoxicology and environmental safety, 96, 67-74 (2013-07-23)
In an attempt to explore complex metabolic interactions between toxicants present in polluted freshwater, hepatic metabolism of benzo(a)pyrene (BaP) and tributyltin (TBT) in fish was investigated when these compounds were administrated alone, mixed together and along with dichlorodiphenyltrichloroethane (DDT). Ten
M Auslander et al.
Marine biotechnology (New York, N.Y.), 10(3), 250-261 (2008-01-24)
Individuals of the fish Lithognathus mormyrus were exposed to a series of pollutants including: benzo[a]pyrene, pp-DDE, Aroclor 1254, perfluorooctanoic acid, tributyl-tin chloride, lindane, estradiol, 4-nonylphenol, methyl mercury chloride, and cadmium chloride. Five mixtures of the pollutants were injected. Each mixture
Yu Bon Man et al.
Mutation research, 752(1-2), 47-56 (2013-02-09)
The aim of this study was to evaluate mutagenicity and genotoxicity of soils from 12 different land use types such as electronic waste dismantling workshop, open burning site and car dismantling workshop (CDW), based on soil concentrations of polycyclic aromatic
[Information on a new occupational disease: "Lung cancer caused by polycyclic aromatic hydrocarbons with evidence of the effect of a cumulative dose of at least 100 benzo(a)pyrene years ([microgram/m3] * years)].
G Praml et al.
Pneumologie (Stuttgart, Germany), 52(12), 684-686 (1999-02-24)
Katsuyoshi Horibata et al.
Environmental and molecular mutagenesis, 54(9), 747-754 (2013-10-10)
The recently developed Pig-a mutation assay is based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient red blood cells caused by a forward mutation in the Pig-a gene. Because the assay can be conducted in nontransgenic animals and the mutations
Gunnar Boysen et al.
Mutation research, 543(1), 17-30 (2003-01-03)
We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence detection and gas chromatography-mass spectrometry. Although
H Fromme et al.
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 55(4), 195-205 (1993-04-01)
Polycyclic aromatic hydrocarbons (PAH) have become an ubiquitous upper soil component in consequence of industrialisation involving a multitude of combustion processes. Meaningful contaminations can be found on child playgrounds, for example. These may enter into the organism of small children
Ying Pang et al.
Toxicology letters, 218(2), 105-117 (2013-01-22)
Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development
H A Hattemer-Frey et al.
Toxicology and industrial health, 7(3), 141-157 (1991-05-01)
A multimedia transport model was used to evaluate the environmental partitioning of benzo-a-pyrene (BaP). Measured and predicted environmental concentrations were used to estimate the accumulation of BaP in the food chain and the subsequent extent of human exposure from inhalation
Juan Du et al.
Archives of environmental contamination and toxicology, 66(3), 370-378 (2014-02-21)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in aquatic ecosystems and have been shown to be one of the causes of sediment toxicity to benthic invertebrates. Benzo[a]pyrene (BaP) was selected as a representative for the PAH family of compounds for developing
Ming Kei Chung et al.
Analytical biochemistry, 435(2), 140-149 (2013-01-22)
Exposure to polycyclic aromatic hydrocarbons has often been quantified via DNA or human serum albumin (HSA) adducts of the carcinogenic metabolite benzo[a]pyrene diol epoxide (BPDE). We previously reported a sandwich ELISA, using 8E11 as capture antibody and anti-HSA as detection
Chibuike Chigbo et al.
Environmental science and pollution research international, 20(12), 8955-8963 (2013-06-12)
Polycyclic aromatic hydrocarbons and heavy metals in the environment are a concern, and their removal to acceptable level is required. Phytoremediation, the use of plants to treat contaminated soils, could be an interesting alternative to conventional remediation processes. This work
Marten A Schults et al.
Mutagenesis, 28(2), 181-185 (2013-01-18)
Genetic polymorphisms can partially explain the large inter-individual variation in DNA adduct levels following exposure to polycyclic aromatic hydrocarbons. Effects of genetic polymorphisms on DNA adduct formation are difficult to assess in human studies because exposure misclassification attenuates underlying relationships.
Marlon J A Jetten et al.
Toxicology, 323, 61-69 (2014-06-21)
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for
Diane Benford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 Suppl 1, S42-S48 (2009-10-13)
Benzo[a]pyrene (BaP) and a number of other polycyclic aromatic hydrocarbons (PAH) are mutagenic and are also carcinogenic in rodent bioassays. Oral carcinogenicity data are not available for individual PAH other than BaP, and so BaP has been used as a
Wei Zhao et al.
Toxicology, 309, 73-80 (2013-05-09)
To explore the relationship between DNA polymerase β (pol β) overexpression and benzo[a]pyrene (BaP) carcinogenesis. Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase β (pol β cell) and high level of pol β (pol β oe cell)
Bioaccumulation in Marine Organisms: Effect of Contaminants from Oil Well Produced Water (2002)
Tong Liu et al.
Gene, 555(2), 108-118 (2014-12-03)
HSP70 and HSP90 are the most important heat shock proteins (HSPs), which play the key roles in the cell as molecular chaperones and may involve in metabolic detoxification. The present research has obtained full-length cDNAs of genes HSP70 and HSP90
Rapid determination of benzo(a)pyrene in olive oil samples with solid-phase extraction and low-pressure, wide-bore gas chromatography-mass spectrometry and fast liquid chromatography with fluorescence detection
Bogusz MJ, et al.
Journal of Chromatography A, 1026(1-2), 1-7 (2004)
Rajesh Mandarapu et al.
Journal of immunotoxicology, 12(1), 48-55 (2014-02-07)
In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition
Claudia Luckert et al.
Toxicology letters, 222(2), 180-188 (2013-07-13)
Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P₄₅₀ monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Several PAH are known to induce these CYP via aryl hydrocarbon receptor (AhR) signaling. Recently, it was shown that the PAH
Rapid determination of benzo [a] pyrene in roasted coffee and coffee brew by high-performance liquid chromatography with fluorescence detection
De Kruijf N, et al.
Journal of Agricultural and Food Chemistry, 35(4), 545-549 (1987)
S R Crowell et al.
Toxicology letters, 228(1), 48-55 (2014-04-29)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplacental carcinogenic PAH.
Hui Chang et al.
Carcinogenesis, 35(8), 1847-1854 (2014-05-28)
The mammalian target of rapamycin (mTOR), which is a master regulator of cellular catabolism and anabolism, plays an important role in tumourigenesis and progression. In this study, we report the chemopreventive effect of the dietary compound ampelopsin (AMP) on breast
Ramya Mohandass et al.
Journal of environmental biology, 33(6), 985-989 (2013-06-08)
Polycyclic aromatic hydrocarbons are a group of compounds that pose threat to humans and animal life. Methods to reduce the amount of PAHs in the environment are continuously being sought. The bacterial consortium capable of utilizing benzo(a)pyrene as the sole
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