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Alexander Perniss et al.
Immunity, 52(4), 683-699 (2020-04-16)
Mucociliary clearance through coordinated ciliary beating is a major innate defense removing pathogens from the lower airways, but the pathogen sensing and downstream signaling mechanisms remain unclear. We identified virulence-associated formylated bacterial peptides that potently stimulated ciliary-driven transport in the
Cristina Sánchez-González et al.
STAR protocols, 2(3), 100735-100735 (2021-08-26)
Depending on metabolic requirements, skeletal muscle mitochondria integrate O2 consumption and ATP production with lipid, glucose, or amino acid metabolism. Free fatty acids (FFAs) are the main source of energy during rest and mild-intensity exercise. We present a detailed protocol
Redox hydrogel-based bienzyme microelectrodes for amperometric monitoring of L-glutamate.
Mikeladze E, et al.
Electroanalysis, 14(6), 393-393 (2002)
Marten Szibor et al.
Biochimica et biophysica acta. Bioenergetics, 1861(2), 148137-148137 (2019-12-12)
Electron transfer from all respiratory chain dehydrogenases of the electron transport chain (ETC) converges at the level of the quinone (Q) pool. The Q redox state is thus a function of electron input (reduction) and output (oxidation) and closely reflects
Influence of pH Value and Ionic Liquids on the Solubility of l-Alanine and l-Glutamic Acid in Aqueous Solutions at 30? C
M Voges, et al.
Journal of Chemical and Engineering Data, 62, 52-61 (2017)
Shanti Pal Gangwar et al.
STAR protocols, 2(4), 100855-100855 (2021-10-15)
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that play crucial roles in the central nervous system. iGluR homologs, termed glutamate receptor-like channels (GLRs), have been found in plants. Investigating the structural and functional relationship between iGluRs and GLRs was
Xiang-Rong Li et al.
Cell death discovery, 7(1), 11-11 (2021-01-16)
Besides their original regulating roles in the brain, spinal cord, retina, and peripheral nervous system for mediating fast excitatory synaptic transmission, glutamate receptors consisting of metabotropic glutamate receptors (GluRs) and ionotropic glutamate receptors (iGluRs) have emerged to have a critical
Venkata Ramana Vaka et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(2), R256-R262 (2019-11-14)
Preeclampsia (PE) is characterized by new-onset hypertension that usually occurs in the third trimester of pregnancy and is associated with oxidative stress and angiotensin II type 1 receptor agonistic autoantibodies (AT1-AAs). Inhibition of the AT1-AAs in the reduced uterine perfusion
Xiao Wei et al.
Cell reports, 32(13), 108207-108207 (2020-10-01)
Diabetic nephropathy (DN) is a major complication of diabetes mellitus and a primary cause of end-stage renal failure. Clinical studies indicate that metabolic surgery improves DN; however, the mechanism remains unclear. Here, we report that Roux-en-Y Gastric Bypass (RYGB) surgery
Fan Zeng et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 374(1784), 20190197-20190197 (2019-09-10)
Tunicates populate a great variety of marine underwater substrates worldwide and represent a significant concern in marine shipping and aquaculture. Adhesives are secreted from the anterior papillae of their swimming larvae, which attach and metamorphose into permanently adhering, filter-feeding adults.
Precipitation of ? L-glutamic acid: determination of growth kinetics
J Scholl, et al.
Faraday Discussions, 136, 247-264 (2007)
Julian P Maier et al.
Cell death & disease, 12(8), 723-723 (2021-07-23)
Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor treatment. Novel insights into the
Spontaneous exfoliation of large-sized graphene oxide with low defect concentration by simple wet chemistry
WJ Lee, et al.
Carbon, 182, 214-222 (2021)
Inclusion of the stable form of a polymorph within crystals of its metastable form.
Cashell C, et al.
Crystal Growth & Design, 3(6), 869-872 (2003)
Hong-Bo Zhao et al.
Communications biology, 4(1), 24-24 (2021-01-06)
Inner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy
Lingyong Li et al.
Cell reports, 36(3), 109396-109396 (2021-07-22)
Many neurological disorders show an increased prevalence of GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs), which dramatically alters synaptic function. However, the molecular mechanism underlying this distinct synaptic plasticity remains enigmatic. Here, we show that nerve injury potentiates postsynaptic, but not presynaptic
Marten Szibor et al.
Journal of cellular and molecular medicine, 24(6), 3534-3548 (2020-02-11)
Cardiac ischaemia-reperfusion (I/R) injury has been attributed to stress signals arising from an impaired mitochondrial electron transport chain (ETC), which include redox imbalance, metabolic stalling and excessive production of reactive oxygen species (ROS). The alternative oxidase (AOX) is a respiratory
Michelle Bui et al.
BMC neuroscience, 20(1), 27-27 (2019-06-19)
The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations into mosquito sensory systems and their effects on
Venkata Ramana Vaka et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 316(5), R441-R447 (2019-02-28)
Preeclampsia (PE) is characterized by new-onset hypertension during pregnancy and is associated with immune activation and placental oxidative stress. Mitochondrial dysfunction is a major source of oxidative stress and may play a role in the pathology of PE. We (Vaka
Daniela Talhada et al.
Acta neuropathologica communications, 7(1), 216-216 (2019-12-23)
The development of new therapeutic approaches for stroke patients requires a detailed understanding of the mechanisms that enhance recovery of lost neurological functions. The efficacy to enhance homeostatic mechanisms during the first weeks after stroke will influence functional outcome. Thyroid
Rong-Wei Zhang et al.
Cell reports, 27(10), 2871-2880 (2019-06-06)
Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells and bipolar cells, the behavior and
Xiongjun Wang et al.
Molecular cell, 76(1), 148-162 (2019-08-27)
The rapid proliferation of cancer cells and dysregulated vasculature within the tumor leads to limited nutrient accessibility. Cancer cells often rewire their metabolic pathways for adaption to nutrient stress, and the underlying mechanism remains largely unknown. Glutamate dehydrogenase 1 (GDH1)
Rémi Peyraud et al.
Bio-protocol, 7(10), e2289-e2289 (2017-05-20)
Soluble exopolysaccharide is a major virulence factor produced by the plant pathogen Ralstonia solanacearum. Its massive production during plant infection is associated with the arrest of water flow in xylem vessels leading eventually to plant death. The composition of this
Cláudio Roque et al.
Journal of neurochemistry, 149(1), 27-40 (2018-12-21)
Selective activation of the G protein-coupled estrogen receptor has been proposed to avoid some of the side effects elicited by the activation of classical estrogen receptors α and β. Although its contribution to neuroprotection triggered by estradiol in brain disorders
Wen Yu et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 17(3), 1253-1270 (2020-04-17)
The balance of major excitatory (glutamate, Glu) and inhibitory (γ-aminobutyric acid, GABA), named as E/I neurotransmission, is critical for proper information processing. Anxiety-like responses upon stress are accompanied by abnormal alterations in the formation and function of synapses, resulting in
Hee Chan Yoo et al.
Cell metabolism, 31(2), 267-283 (2019-12-24)
Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, the mitochondrial glutamine transporter has long been unknown. Here, we show that the SLC1A5 variant plays
Antonella Denise Losinno et al.
Autophagy, 17(2), 439-456 (2020-01-28)
Cruzipain, the major cysteine protease of the pathogenic protozoa Trypanosoma cruzi, is an important virulence factor that plays a key role in the parasite nutrition, differentiation and host cell infection. Cruzipain is synthesized as a zymogen, matured, and delivered to
Marten Szibor et al.
The Journal of biological chemistry, 295(14), 4383-4397 (2020-02-26)
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activation of matrix dehydrogenases, thereby matching OXPHOS substrate supply
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