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Toshitsugu Fujita et al.
PloS one, 10(1), e0116579-e0116579 (2015-01-22)
Accumulating evidence suggests that Pax5 plays essential roles in B cell lineage commitment. However, molecular mechanisms of B cell-specific expression of Pax5 are not fully understood. Here, we applied insertional chromatin immunoprecipitation (iChIP) combined with stable isotope labeling using amino
Mélanie Bonizec et al.
Nucleic acids research, 42(17), 10975-10986 (2014-09-04)
Cdc48/p97 is an evolutionary conserved ubiquitin-dependent chaperone involved in a broad array of cellular functions due to its ability to associate with multiple cofactors. Aside from its role in removing RNA polymerase II from chromatin after DNA damage, little is
Xiaoli Qi et al.
Addiction biology, 20(2), 324-335 (2014-03-13)
Tobacco addiction is characterized by a lack of control over smoking and relapse after periods of abstinence. Smoking cessation leads to a dysphoric state that contributes to relapse to smoking. After the acute withdrawal phase, exposure to stressors increases the
Harshavardhan V Pawar et al.
Journal of pharmaceutical sciences, 103(6), 1720-1733 (2014-04-05)
Wafers combining weight ratios of Polyox with carrageenan (75/25) or sodium alginate (50/50) containing streptomycin and diclofenac were prepared to improve chronic wound healing. Gels were freeze-dried using a lyophilisation cycle incorporating an annealing step. Wafers were characterised for morphology
Emma C Stea et al.
Journal of environmental quality, 44(5), 1556-1567 (2015-10-06)
Surface waters are commonly used as source water for drinking water and irrigation. Knowledge of sources of fecal pollution in source watersheds benefits the design of effective source water protection plans. This study analyzed the relationships between enteric pathogens (
Michael B Gill et al.
The EMBO journal, 34(4), 448-465 (2014-12-05)
Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associated herpesvirus (KSHV) is an extremely inefficient nucleoside kinase, when compared to TKs from related herpesviruses. We now show that KSHV-TK, in contrast to HSV1-TK, associates with the actin cytoskeleton and induces
Chunyan Zhao et al.
Nanoscale, 7(43), 18239-18249 (2015-10-22)
This study explored the influence of polyethylene glycol-linked multi-walled carbon nanotube (PEG-CNT) films on skeletal myogenic differentiation of human mesenchymal stem cells (hMSCs). PEG-CNT films were prepared with nanoscale surface roughness, orderly arrangement of PEG-CNTs, high hydrophilicity and high mechanical
Maura Poli et al.
Biochemical pharmacology, 92(3), 467-475 (2014-09-23)
Hepcidin is a peptide hormone that controls systemic iron availability and is upregulated by iron and inflammation. Heparins have been shown to be efficient hepcidin inhibitors both in vitro and in vivo, even when their anticoagulant activity has been abolished
Elisabetta Moratti et al.
PloS one, 10(3), e0119110-e0119110 (2015-03-17)
PTPRG is a widely expressed protein tyrosine phosphatase present in various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques. We aim at characterizing the plasmatic PTPRG (sPTPRG) form and to identify its source. The
Marie Larousse et al.
Protist, 165(3), 275-292 (2014-04-18)
The plant pathogen Phytophthora parasitica forms a biofilm on the host surface. The biofilm transcriptome is characterized by the expression of PPMUCL1/2/3 (PHYTOPHTHORA PARASITICA MUCIN-LIKE) genes, which we report here to be members of a new, large mucin-like gene family
Iliya Lefterov et al.
Neurobiology of disease, 82, 132-140 (2015-06-15)
We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ levels in brain, biochemical analysis strongly suggested improved clearance of soluble Aβ
Juha R Savinainen et al.
Molecular pharmacology, 86(5), 522-535 (2014-08-21)
The primary route of inactivation of the endocannabinoid 2-arachidonoylglycerol in the central nervous system is through enzymatic hydrolysis, mainly carried out by monoacylglycerol lipase (MAGL), along with a small contribution by the α/β-hydrolase domain (ABHD) proteins ABHD6 and ABHD12. Recent
Shinichiro Mine et al.
Endocrine journal, 53(6), 761-766 (2006-09-13)
Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations
John F Brooks et al.
Journal of bacteriology, 197(6), 1065-1074 (2015-01-07)
Bacterial strain variation exists in natural populations of bacteria and can be generated experimentally through directed or random mutation. The advent of rapid and cost-efficient whole-genome sequencing has facilitated strain-level genotyping. Even with modern tools, however, it often remains a
Seyed Fakhreddin Hosseini et al.
Food chemistry, 194, 1266-1274 (2015-10-17)
The objective of this work was to develop active bio-based nanocomposite films from fish gelatin (FG) and chitosan nanoparticles (CSNPs) incorporated with Origanum vulgare L. essential oil (OEO). CSNPs were obtained by ionic gelation of chitosan with sodium tripolyphosphate, which
R Raspoet et al.
Applied and environmental microbiology, 80(24), 7710-7716 (2014-10-05)
Salmonella enterica serovar Enteritidis has developed the potential to contaminate table eggs internally, by colonization of the chicken reproductive tract and internalization in the forming egg. The serotype Enteritidis has developed mechanisms to colonize the chicken oviduct more successfully than
Stephan P Willias et al.
Microbial pathogenesis, 76, 33-43 (2014-09-16)
Yersinia pestis biovar Orientalis isolates have lost the capacity to ferment glycerol. Herein we provide experimental validation that a 93 bp in-frame deletion within the glpD gene encoding the glycerol-3-phosphate dehydrogenase present in all biovar Orientalis strains is sufficient to disrupt
Jie Yuan et al.
Stem cell research & therapy, 6, 217-217 (2015-11-07)
Adult stem cell-derived hepatocytes transplantation holds considerable promise for future clinical individualized therapy of liver failure or dysfunction. However, the low engraftment of the available hepatocytes in the liver disease microenvironment has been a major obstacle. Acellular human amniotic membrane
Qizhong Fu et al.
International journal of molecular medicine, 36(5), 1417-1425 (2015-12-10)
Skeletal metastasis is the major problem in the management of prostate cancer (PCa). Even though the regulatory role of microRNAs (miRNAs) in the control of tumor metastases has been well described in numerous types of cancer, the importance in bone
Abhishek Sohni et al.
Molecular and cellular biology, 35(6), 1026-1042 (2015-01-15)
The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine and further oxidized products. Tet1 and Tet2 are highly expressed in mouse pluripotent cells and downregulated to different extents in somatic cells, but the transcriptional mechanisms are unclear. Here we
Ewelina Basiak et al.
Food chemistry, 195, 56-63 (2015-11-18)
To reduce the hygroscopic character of biodegradable starch-based films, rapeseed oil was incorporated by lamination (starch-oil-starch 3-layers technique). The lipid lamination followed by starch solution casting step induced an emulsion type structure of dried films. Composite films are more opalescent
Boyan K Garvalov et al.
Nature communications, 5, 5577-5577 (2014-11-26)
Tumours exploit their hypoxic microenvironment to induce a more aggressive phenotype, while curtailing the growth-inhibitory effects of hypoxia through mechanisms that are poorly understood. The prolyl hydroxylase PHD3 is regulated by hypoxia and plays an important role in tumour progression.
Yu Si et al.
Scientific reports, 5, 16683-16683 (2015-12-08)
Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs
Hamada AbdElgawad et al.
The New phytologist, 208(2), 354-369 (2015-06-04)
Proline (Pro) is a versatile metabolite playing a role in the protection of plants against environmental stresses. To gain a deeper understanding of the regulation of Pro metabolism under predicted future climate conditions, including drought stress, elevated temperature and CO2
Suzanne M McDermott et al.
Molecular and cellular biology, 35(23), 3945-3961 (2015-09-16)
KREPB5 is an essential component of ∼ 20S editosomes in Trypanosoma brucei which contains a degenerate, noncatalytic RNase III domain. To explore the function of this protein, we used a novel approach to make and screen numerous conditional null T.
Fu Jun Li et al.
PloS one, 10(4), e0122275-e0122275 (2015-04-04)
The effects of Corexit 9500A (CE) on respiratory epithelial surfaces of terrestrial mammals and marine animals are largely unknown. This study investigated the role of CE-induced heme oxygenase-1 (HO-1), a cytoprotective enzyme with anti-apoptotic and antioxidant activity, in human bronchial
R S Abidin et al.
Protein science : a publication of the Protein Society, 24(11), 1820-1828 (2015-09-25)
The Polyomavirus coat protein, VP1 has been developed as an epitope presentation system able to provoke humoral immunity against a variety of pathogens, such as Influenza and Group A Streptococcus. The ability of the system to carry cytotoxic T cell
Sung Hwan Kim et al.
Biochemical and biophysical research communications, 451(2), 246-251 (2014-08-03)
The potent cytotoxicity of reactive oxygen species (ROS) can cause various diseases but may also serve as a powerful weapon capable of destroying cancer cells. Although the balance between generation and elimination of ROS is maintained by the proper function
Chayaphat Wongsombat et al.
Molecular and biochemical parasitology, 198(1), 1-10 (2014-12-03)
The human malaria parasite Plasmodium falciparum employs intricate post-transcriptional regulatory mechanisms in different stages of its life cycle. Despite the importance of post-transcriptional regulation, key elements of these processes, namely RNA binding proteins (RBPs), are poorly characterized. In this study
Klaudia Giehl et al.
PloS one, 10(3), e0121589-e0121589 (2015-03-31)
Morphological alterations of cells can lead to modulation of gene expression. An essential link is the MKL1-dependent activation of serum response factor (SRF), which translates changes in the ratio of G- and F-actin into mRNA transcription. SRF activation is only
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