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显示 31-60 共 159 条结果 关于 "50-66-8" 范围 论文
Xian-min Zheng et al.
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 24(5), 574-575 (2004-05-21)
To observe the effects of the protocol combining levofloxacin, pasiniazide, M. Vaccae (V+D+M protocol) in the treatment of multi-drug resistant pulmonary tuberculosis (MDR-TB). Ninety-seven cases of MDR-TB randomized into V+D+M treatment protocol group (n=50) and control group (n=47) were observed
J N Bruun et al.
Scandinavian journal of infectious diseases. Supplementum, 74, 49-53 (1990-01-01)
The suction blister technique was used for pharmacokinetic studies with sulfonamides and trimethoprim. Blisters produced by suction (-0.3 kg/cm2) for 1.5 h contained approximately 0.15 ml fluid with a protein content of 40-50% of that in plasma, the main protein
J Stoehlmacher et al.
Anticancer research, 21(4B), 3075-3079 (2001-11-20)
Recently, it has been demonstrated that the Arg399Gln substitution in the XRCC1 gene is associated with increased levels of markers of DNA damage. Deficiency in DNA repair pathways has been shown to confer to resistance to several drugs, including platinum
Miroslav Merta et al.
Renal failure, 24(5), 585-593 (2002-10-17)
The reason of variability of clinical course and progression to end-stage renal failure (ESRF) of two widespread chronic nephropathies--autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IGAN) is not clear. The endothelial dysfunction is considered in the number of
Arne Hønnås et al.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 130(13), 1334-1336 (2010-07-03)
In 2007, new Norwegian guidelines suggested that serum concentrations of digitoxin should be in the interval 8 - 15 nmol/l, which is about 50 % lower than previous recommendations. We studied trends in dosing and serum concentrations of digitoxin in
G Bailliet et al.
Mutation research, 627(2), 171-177 (2006-12-30)
Interethnic differences in the allele frequencies of CYP2D6, NAT2, GSTM1 and GSTT1 deletions have been documented for Caucasians, Asians, and Africans population. On the other hand, data on Amerindians are scanty and limited to a few populations from southern areas
Shu-Yu Hsieh et al.
Nutrition & metabolism, 18(1), 4-4 (2021-01-08)
Non-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium
Zhi Liu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 16(24), 6009-6018 (2010-10-21)
This study was designed to explore the role of IQGAP1 in the invasiveness of thyroid cancer and its potential as a novel prognostic marker and therapeutic target in this cancer. We examined IQGAP1 copy gain and its relationship with clinicopathologic
Chien-Tsun Kuan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(7 Pt 1), 1970-1982 (2006-04-13)
More brain tumor markers are required for prognosis and targeted therapy. We have identified and validated promising molecular therapeutic glioblastoma multiforme (GBM) targets: human transmembrane glycoprotein nonmetastatic melanoma protein B (GPNMB(wt)) and a splice variant form (GPNMB(sv), a 12-amino-acid in-frame
Leonardo Catalano-Iniesta et al.
Journal of clinical medicine, 9(2) (2020-02-20)
The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs family of proteins, such as ANGPTL3, 4, and, 8; the latter
Ilan Bruchim et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 20(7), 1148-1153 (2011-01-06)
Whether and to what extent germline mutations in the BRCA1 and BRCA2 genes increase the risk for developing uterine serous carcinoma (USC) remain controversial. We assessed the rate of the 3 predominant BRCA1/2 mutations in Jewish patients with USC and
Hong-Yan Zhu et al.
Human pathology, 38(3), 426-434 (2006-12-26)
Alzheimer's disease (AD) is the most prevalent cause of dementia in human beings. Its best-known pathologic feature is the presence of senile plaques and neurofibrillary tangles in the brain. Nogo-66 receptor (NgR) is believed to contribute to the inhibitory activities
José A Murillo Pulgarín et al.
Journal of agricultural and food chemistry, 50(5), 1002-1008 (2002-02-21)
A selective and sensitive method for determining napropamide by room-temperature phosphorescence in SDS micelles is proposed and applied to the determination of this substance in a technical formulation and in spiked soil, pepper, and tomato samples. The use of phosphorescence
Jhudit Pérez-Escuredo et al.
Human pathology, 43(11), 1894-1901 (2012-05-12)
Intestinal-type sinonasal adenocarcinoma represents 8% to 25% of all malignant sinonasal cancer and is etiologically related to occupational exposure to wood dust. Despite its clear etiology, the mechanisms behind the carcinogenic effects of wood dust are unclear. Because it is
V Bakels et al.
The American journal of pathology, 150(6), 1941-1949 (1997-06-01)
Differentiation between cutaneous pseudo-T-cell lymphomas and cutaneous T-cell lymphomas (CTCLs) may be extremely difficult. In this study, it was investigated whether demonstration of an aberrant phenotype and detection of clonal T-cell receptor gamma (TCR gamma) gene rearrangements can be used
Bumsup Lee et al.
European journal of pharmacology, 589(1-3), 306-314 (2008-06-10)
The aim of the present research was to characterize the pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel quinazolinone-based dipeptidyl peptidase-4 (DPP-4) inhibitor. Alogliptin potently inhibited human DPP-4 in vitro (mean IC(50), ~ 6.9 nM) and exhibited > 10,000-fold
R M Stockler et al.
Journal of dairy science, 92(9), 4262-4275 (2009-08-25)
The objective was to determine the effect of milking frequency and dosing interval on pharmacokinetics of cephapirin after intramammary infusion. Six healthy Holstein cows were administered cephapirin (200 mg) into 1 rear mammary gland after each of 2 milkings. Cows
Wei Shang et al.
BMC neuroscience, 9, 67-67 (2008-07-23)
Glutathione S-transferases (GSTs) play an important role in metabolizing anti-epileptic drugs (AEDs) in liver. Expressions of GSTs in brain, which may result in poor efficacy of AEDs, have not been well studied. Using clinical cortex specimen from 32 intractable epileptic
Babasaheb P Bandgar et al.
Bioorganic & medicinal chemistry, 18(5), 2060-2065 (2010-02-09)
A combinatorial library of beta-chlorovinyl chalcones (4) were synthesized by Claisen-Schmidt condensation reaction. Catalytic reaction of substituted 3-chloro-3-phenyl-propenal (2) and 1-(2,4-dimethoxy-phenyl)-ethanone or 1-(4-methoxy-phenyl)-ethanone (3) in alkaline conditions furnished the target compound 5-chloro-1-(2,4-dimethoxy-phenyl)-5-phenyl-penta-2,4-dien-1-one (4). The synthesized compounds were screened for their
Jingmei Zhang et al.
Oncogene, 23(12), 2241-2249 (2003-12-24)
Methylation of CpG islands and associated gene silencing may lead to malignant progression, but the mechanisms of CpG island methylation in cancer are unknown. The tazarotene-induced gene 1 (TIG1), also known as retinoid acid (RA) receptor-responsive 1 gene was first
S Martin-Rodriguez et al.
Lupus, 24(11), 1143-1149 (2015-04-01)
Severe deficiency of ADAMTS13 activity leads to von Willebrand factor (VWF) ultralarge multimers with high affinity for platelets, causing thrombotic thrombocytopenic purpura. Other pathological conditions with moderate ADAMTS13 activity exhibit a thrombotic risk. We examined the ADAMTS13 activity in systemic
Jing Ma et al.
Diagnostic pathology, 13(1), 91-91 (2018-11-23)
Immunohistochemistry (IHC) for programmed cell death ligand 1 (PD-L1) displays staining diversity. We compared IHC staining of PD-L1 in gastric cancer (GC) by using three commercially available antibody clones, and analyzed the correlation with the prognosis. IHC using PD-L1 antibodies
Fernanda T Arantes et al.
Journal of thrombosis and thrombolysis, 50(4), 772-781 (2020-05-29)
The role of inflammation in thrombotic complications of primary antiphospholipid syndrome (PAPS) is controversial. The aim of this study was to evaluate levels of inflammation and coagulation markers in patients with thrombotic PAPS (t-PAPS). Patients with t-PAPS and individuals with
Kristen A Neville et al.
Clinical endocrinology, 82(5), 657-662 (2015-01-20)
It is unclear whether the rate of vitamin D deficiency in paediatric cancer survivors is higher than in the background population, and whether this is of pathological significance. 25OHD was measured in a previously studied group of 208 survivors (n
Almudena Matito et al.
International archives of allergy and immunology, 167(1), 47-56 (2015-07-15)
The role of anesthesia as an elicitor of mast cell (MC) mediator release symptoms in mastocytosis is poorly investigated. To determine the frequency and type of MC mediator release symptoms during anesthetic procedures in mastocytosis patients. Medical records were reviewed
M Méndez et al.
The British journal of dermatology, 157(3), 501-507 (2007-07-14)
Porphyria cutanea tarda (PCT) results from decreased hepatic uroporphyrinogen decarboxylase (UROD) activity. In the majority of patients, the disease is sporadic (S-PCT or type I) and the enzyme deficiency is limited to the liver. Familial PCT (F-PCT or type II)
Fang-Qiu Li et al.
BMC cancer, 10, 429-429 (2010-08-18)
Sperm protein 17 (Sp17) is a highly conserved mammalian protein in the testis and spermatozoa and has been characterized as a tumor-associated antigen in a variety of human malignancies. Many studies have examined the role of Sp17 in tumorigenesis and
Su-Young Kim et al.
Diagnostic microbiology and infectious disease, 88(2), 125-137 (2017-03-16)
Mycobacterium avium complex (MAC) was originally composed of 2 species, M. avium and M. intracellulare. However, several new species closely related to M. intracellulare have recently been identified. In addition, M. avium has been further subdivided into 4 subspecies. The
A M Pisacane et al.
Cellular oncology : the official journal of the International Society for Cellular Oncology, 29(1), 59-66 (2007-04-13)
Vasculogenic mimicry, as previously described in aggressive melanoma, is characterized by the de novo generation of intratumoral patterned vascular channels, composed of PAS-positive basement membrane in the absence of endothelial cells, providing additional microcirculation, in support to the classic tumoral
Alkis Pierides et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(9), 2721-2729 (2009-04-10)
Heterozygous mutations in the COL4A3/ COL4A4 genes are currently thought to be responsible for familial benign microscopic haematuria and maintenance of normal long-term kidney function. We report on 11 large Cypriot pedigrees with three such mutations. A total of 236
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