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Nicholas E Burjek et al.
Critical care medicine, 42(5), 1204-1212 (2013-12-25)
To test the hypothesis that low bispectral index scores and low sedative requirements during therapeutic hypothermia predict poor neurologic outcome. Observational study of a prospectively collected cohort. Cardiovascular ICU. One hundred sixty consecutive cardiac arrest patients treated with therapeutic hypothermia.
Negar Khanlou et al.
Journal of neurovirology, 15(2), 131-138 (2008-12-31)
The frequency of neurodegenerative markers among long surviving human immunodeficiency virus (HIV)-infected individuals is unknown, therefore, the present study investigated the frequency of alpha-synuclein, beta-amyloid, and HIV-associated brain pathology in the brains of older HIV-infected individuals. We examined the substantia
Fernando S Velayos et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 9(3), 329-335 (2005-03-08)
MLH1 promoter hypermethylation has been described as the primary mechanism for high-frequency microsatellite instability (MSI-H) in sporadic colorectal cancers (CRCs). The underlying molecular mechanism for microsatellite instability (MSI) in synchronous and metachronous CRCs is not well described. A total of
Bjørn G Moe et al.
Anticancer research, 29(4), 1053-1058 (2009-05-06)
High concentrations of progesterone (PG) and mifepristone (MF) reinforce the effect of each other, reducing the endometrial cancer (Ishikawa) cell densities in vitro. Whether this effect is caused by cell cycle retardation, induction of apoptosis, or a combination of both
Marija Radak-Perović et al.
Srpski arhiv za celokupno lekarstvo, 140(11-12), 717-721 (2013-01-29)
There are 12 recommendations for gout treatment, based on evidence and opinion of experts. To assess the quality of therapy in patients with gout analyzing adherence to four selected recommendations. Retrospective cross sectional study of 111 patients with gouty flare
Hasan A Majeed et al.
Seminars in arthritis and rheumatism, 31(6), 371-376 (2002-06-22)
To study the phenotype/genotype correlations in Arab patients with familial Mediterranean fever (FMF). The study was performed in a 3-year period (February 1998-February 2001). Patients were seen in the pediatric FMF clinic of Jordan University Hospital, and the diagnosis of
Emilie Lalonde et al.
The Lancet. Oncology, 15(13), 1521-1532 (2014-12-03)
Clinical prognostic groupings for localised prostate cancers are imprecise, with 30-50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic
C J O'Neill et al.
Histopathology, 50(6), 773-779 (2007-05-12)
A dualistic pathway of ovarian serous carcinogenesis is now well established whereby high-grade serous carcinoma and low-grade serous carcinoma represent two distinct tumour types with a different underlying pathogenesis. The aim of this study was to compare expression of p16
Cameron C Murphy et al.
Lipids, 43(5), 391-400 (2008-03-20)
Because X-linked adrenoleukodystrophy is treated using erucic acid (22:1n-9), we assessed its metabolism in rat liver and heart following infusion of [14-(14)C]22:1n-9 (170 Ci/kg) under steady-state-like conditions. In liver, 2.3-fold more tracer was taken up as compared to heart, accounted
I Hunt von Herbing et al.
Journal of fish biology, 87(1), 138-158 (2015-07-08)
The stress response of Oncorhynchus mykiss in high-altitude farms in central Mexico was investigated over two seasons: the cool (9·1-13·7° C) dry winter season, and the warmer (14·7-15·9° C), wetter summer season. Fish were subjected to an acute stress test
Malene Outzen et al.
Nutrients, 7(1), 608-624 (2015-01-20)
Selenium status of the Danish population is below that assumed optimal for the suggested protective effects against chronic diseases, including certain cancers. Fish and shellfish are important dietary sources of selenium in Denmark. We investigated the effect of increased fish
A Gabriella Wernicke et al.
Archives of pathology & laboratory medicine, 135(11), 1486-1489 (2011-10-29)
Prostate-specific membrane antigen (PSMA) is expressed in endothelium of vessels in malignant solid tumors but not in normal vessels. To examine whether neovasculature of glioblastoma multiforme (GBM) expresses PSMA. Design.-After institutional review board approval at Memorial Sloan-Kettering Cancer Center, formalin-fixed
David Cunningham et al.
Lancet (London, England), 381(9880), 1817-1826 (2013-04-26)
Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell lymphoma compared with CHOP every 3 weeks. We investigated whether this survival benefit
E T Lyons et al.
Parasitology research, 103(2), 287-291 (2008-05-13)
Horse foals on five farms in Central Kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-FBZ, ivermectin-IVM, oxibendazole-OBZ, and pyrantel pamoate-PRT) against internal parasites with emphasis on ascarids (Parascaris equorum). It has
Maryam A Farinola et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 26(4), 375-382 (2007-09-22)
The biologic role that estrogen receptor (ER) and progesterone receptor (PR) play in ovarian sex cord-stromal tumors is poorly understood. Furthermore, immunohistochemical data on these hormone receptors in this group of neoplasms are limited and conflicting, with many reports suggesting
Monica Prasad Hayes et al.
Gynecologic oncology, 113(3), 370-373 (2009-03-11)
Uterine serous carcinoma (USC) is an aggressive endometrial cancer associated with poor prognosis despite comprehensive surgical staging and adjuvant chemotherapy and radiation therapy. Biologic targets have yet to be fully explored in this disease and research on such targets could
Umasuthan Srirangalingam et al.
Clinical endocrinology, 69(4), 587-596 (2008-04-19)
Phaeochromocytomas and paragangliomas are familial in up to 25% of cases and can result from succinate dehydrogenase (SDH) gene mutations. The aim of this study was to describe the clinical manifestations of subjects with SDH-B gene mutations. Retrospective case-series. Thirty-two
Jacob Nattermann et al.
Journal of hepatology, 55(6), 1201-1206 (2011-06-28)
The CCR5Δ32 mutation has been suspected to adversely affect outcomes of HCV infection, although reports have remained controversial. Here, we investigated the relative genetic contributions of the CCR5Δ32 deletion and the IL28B rs12979860 polymorphisms to spontaneous clearance of hepatitis C
Scott W Powers et al.
JAMA, 310(24), 2622-2630 (2013-12-26)
Early, safe, effective, and durable evidence-based interventions for children and adolescents with chronic migraine do not exist. To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline. A randomized clinical trial of
M M Streppel et al.
Oncogene, 33(3), 347-357 (2013-01-16)
The incidence of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC) is increasing. Next-generation sequencing (NGS) provides an unprecedented opportunity to uncover genomic alterations during BE pathogenesis and progression to EAC, but treatment-naive surgical specimens are scarce. The objective of this study
Eeva S Leinonen et al.
Diabetes care, 25(10), 1807-1812 (2002-09-28)
The aim of the present study was to assess the role of the insulin-like growth factor (IGF) system and lipids in predicting the carotid intima-media thickness (IMT) in type 2 diabetes. A total of 239 type 2 diabetic participants in
Jamie D Kapplinger et al.
Heart rhythm, 6(9), 1297-1303 (2009-09-01)
Long QT syndrome (LQTS) is a potentially lethal, highly treatable cardiac channelopathy for which genetic testing has matured from discovery to translation and now clinical implementation. Here we examine the spectrum and prevalence of mutations found in the first 2,500
Patrick Schöffski et al.
European journal of cancer (Oxford, England : 1990), 134, 62-74 (2020-05-30)
Gastrointestinal stromal tumour (GIST) is commonly treated with tyrosine kinase inhibitors (TKIs), but most patients ultimately develop secondary resistance. Cabozantinib, a multi-targeted TKI inhibitor, has activity in patient-derived GIST mouse xenograft models and can overcome compensatory MET signalling occurring on
L L Siu et al.
Investigational new drugs, 16(2), 113-119 (1998-12-16)
The anti-proliferative effects of pivaloyloxymethyl butyrate (AN-9), a butyric acid (BA) derivative with potent tumor-differentiating properties both in vitro and in vivo, was evaluated against colorectal, breast, lung, ovarian, renal cell, bladder, and other types of tumor colony-forming units in
Elizabeth Park et al.
The American Journal of dermatopathology, 34(1), 41-46 (2011-11-19)
Given the correlation between KIT mutations and immunohistochemical expression of CKIT in acral melanoma, our aim was to confirm the utility of CKIT detection as a screening tool for KIT genotyping in atypical acral nevi and to ascertain the frequency
Tobias Broger et al.
The Lancet. Infectious diseases, 19(8), 852-861 (2019-06-04)
Most tuberculosis-related deaths in people with HIV could be prevented with earlier diagnosis and treatment. The only commercially available tuberculosis point-of-care test (Alere Determine TB LAM Ag [AlereLAM]) has suboptimal sensitivity, which restricts its use in clinical practice. The novel
K J S Anand et al.
British journal of anaesthesia, 101(5), 680-689 (2008-08-30)
Relationships between plasma morphine concentrations and neonatal responses to endotracheal tube (ETT) suctioning are unknown in preterm neonates. Ventilated preterm neonates (n=898) from 16 centres were randomly assigned to placebo (n=449) or morphine (n=449). After an i.v. loading dose (100
M C Chang et al.
British journal of pharmacology, 135(3), 619-630 (2002-02-09)
Hydroxychavicol (HC; 10 - 50 microM), a betel leaf component, was found to suppress the 2% H(2)O(2)-induced lucigenin chemiluminescence for 53 - 75%. HC (0.02 - 2 microM) was also able to trap superoxide radicals generated by a xanthine/xanthine oxidase
C P A Van de Ligt et al.
Journal of animal science, 80(9), 2412-2419 (2002-09-28)
This study was conducted to evaluate potential interactive effects of supplemental Cr and dietary protein levels in growing pigs. Thirty-six individually penned barrows, 22 to 63 kg, were used in a 2 x 3 factorial arrangement of supplemental Cr (0
E Louis et al.
Scandinavian journal of gastroenterology, 37(7), 818-824 (2002-08-23)
Two-thirds to three-fourths of patients with either refractory luminal or fistulizing Crohn disease respond to infliximab treatment. The ability or inability to respond seems to persist over time. Biological characteristics and/or genetic background can influence the response to treatment. The
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