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Zibin Gao et al.
International journal of pharmaceutics, 328(1), 57-64 (2006-08-31)
Venous malformations (VM) are common vascular abnormality, and their management remains difficult. Pingyangmycin hydrochloride (PYM) is a useful sclerosant to treat venous malformations. This study was aimed to evaluate the effect of a new drug delivery system, PYM-loaded Zein/Zein-sucrose acetate
Ya-xin Lu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(4), 445-449 (2007-07-18)
To study the rheological properties of sucrose acetate isobutyrate (SAIB) in situ gel and the influencing factors. Measurements of shear stress and viscosity were carried out at different shear rate. The rheological properties of SAIB solution were similar to those
B G Procter et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 101-110 (1998-03-31)
Preliminary short-term toxicity studies of sucrose acetate isobutyrate (SAIB) in the dog demonstrated that addition of this additive to the diet was associated with an increase in liver size and elevated serum alkaline phosphatase activity with no evidence of pathological
R Chanamai et al.
Journal of agricultural and food chemistry, 48(11), 5561-5565 (2000-11-23)
The influence of weighting agents and sucrose on gravitational separation in 1 wt % oil-in-water emulsions was studied by measuring changes in the intensity of backscattered light from the emulsions with height. Emulsions with different droplet densities were prepared by
B C Myhr et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 127-134 (1998-03-31)
Sucrose acetate isobutyrate (SAIB) was tested for potential genotoxic activity in four different in vitro assay systems. Two independent trials of a Salmonella reverse mutation assay (using strains TA98, TA100, TA1535, TA1537 and TA1538) showed no increases in revertant frequencies
M Blair et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 121-126 (1998-03-31)
Sucrose acetate isobutyrate (SAIB) is used as an emulsion stabilizer in citrus-based soft drinks. A 4-week range-finding study and a 1-year chronic toxicity study were conducted to determine the tolerance and effects of this food additive in cynomolgus monkeys. SAIB
K M Mackenzie et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 135-140 (1998-03-31)
A three-generation reproduction study of sucrose acetate isobutyrate (SAIB) in Fischer 344 rats and teratology studies in Fischer 344 rats and New Zealand white rabbits were performed. Dietary SAIB concentrations to provide dose levels of 0, 0.5, 1.0 and 2.0
R C Reynolds
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 95-99 (1998-03-31)
Sucrose acetate isobutyrate (SAIB), a mixture of esters of sucrose with a composition approximating the name sucrose diacetate hexaisobutyrate, has been used for over 30 years in many countries as a 'weighting' or 'density-adjusting' agent in non-alcoholic carbonated and non-carbonated
M Chiang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 141-144 (1998-03-31)
A study of the effects of sucrose acetate isobutyrate (SAIB) ingestion was conducted in 13 male and 14 female healthy human volunteers. SAIB, in a gum arabic/water emulsion diluted with orange juice, was ingested once daily, at a dose of
Eun Seong Lee et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 29(5), 435-441 (2006-09-19)
This study investigated the suitability of microsphere formulations for extended protein delivery and complete protein release. These microspheres were prepared by a multi-emulsion method and prepared using a mixture of poly(lactide-co-glycolide) (PLGA), RG 502H (lactide:glycolide=50:50, M(W) 9300) and sucrose acetate
A Knoll et al.
Microvascular research, 58(1), 1-9 (1999-07-02)
The diuretic amiloride has been reported to inhibit both Na+-H+ antiport and the urokinase-type plasminogen activator. As a consequence of these inhibitions, neovascularization may also be inhibited. We hypothesized that if amiloride could be effectively delivered in a site-specific manner
R C Reynolds et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 81-93 (1998-03-31)
Sucrose acetate isobutyrate (SAIB), a mixture of esters of sucrose with a composition approximating the name sucrose diacetate hexaisobutyrate, has been used for over 30 yr in many countries as a 'weighting' or 'density-adjusting' agent in non-alcoholic carbonated and non-carbonated
Franklin W Okumu et al.
Biomaterials, 23(22), 4353-4358 (2002-09-11)
The purpose of this study was to evaluate the release of recombinant human growth hormone (rhGH) from a novel non-polymeric sustained release system, SABER. The SABER system consists of sucrose acetate isobutryate, a solvent and a polymeric release modifier. Spray
Yaxin Lu et al.
Journal of pharmaceutical sciences, 96(12), 3252-3262 (2007-08-28)
The objective of this study was to develop sustained-release sucrose acetate isobutyrate (SAIB) in situ formulations of risperidone for parenteral delivery. The formulations contained SAIB, solvent (anhydrous ethanol, ethyl lactate, or N-methyl-2-pyrrolidone), and additives such as polylactic acid (PLA). In
James Lee et al.
Toxicology and applied pharmacology, 215(1), 64-70 (2006-04-25)
Sucrose acetate isobutyrate (SAIB) is a water insoluble, biodegradable gel used for controlled-release oral and subcutaneous drug delivery. We investigated SAIB compatibility in the rat central nervous system (CNS) by implanting solutions of SAIB in adult and in neonatal brains.
K M Mackenzie et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36(2), 111-120 (1998-03-31)
Sucrose acetate isobutyrate (SAIB), a food additive used as a flavour emulsion stabilizer in citrus-based soft drinks, was evaluated for chronic toxicity in B6C3F1 mice and Fischer 344 rats. SAIB dissolved in acetone was blended into NIH07 rodent diet at
Dilek Sendil Keskin et al.
Biomaterials, 26(18), 4023-4034 (2005-01-01)
Bone morphogenetic proteins (BMPs) are osteoinductive proteins used intensively in clinical investigations involving various bone-related treatments. Owing to their high potential in new bone formation they require local application at the treatment site. For this purpose various controlled delivery systems
P E Noker et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 24(12), 1287-1293 (1986-12-01)
The disposition of 200 mg/kg of 14C-labelled sucrose octa-isobutyrate (14C-SOIB), a component of sucrose acetate isobutyrate (SAIB), a beverage emulsion stabilizer, was studied in rats, dogs and monkeys. After oral administration of 14C-SOIB to three rats, 3-15% of the dose
Jianbo Guo et al.
AAPS PharmSciTech, 16(4), 973-985 (2015-01-23)
Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma efficiency in xenograft animal models after intratumoral injection, which was due to the undesirable initial burst release and the leakage of the particulate carriers from
J E Nally et al.
Vaccine, 19(4-5), 492-497 (2000-10-12)
Streptococcus equi causes equine strangles, a highly contagious disease of the upper respiratory tract. The antiphagocytic surface protein SeM is strongly immunogenic and evokes mucosal and systemic antibodies during convalescence. The present study investigated the potential of sucrose acetate isobutyrate
Rasmus I Jølck et al.
Advanced healthcare materials, 3(10), 1680-1687 (2014-04-16)
External beam radiation therapy relies on the ability to deliver high radiation doses to tumor cells with minimal exposure to surrounding healthy tissue. Advanced irradiation techniques, including image-guided radiation therapy (IGRT), rely on the ability to locate tumors to optimize
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