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Elisabeth Corcelle-Termeau et al.
Autophagy, 12(5), 833-849 (2016-04-14)
Sphingomyelin is an essential cellular lipid that traffics between plasma membrane and intracellular organelles until directed to lysosomes for SMPD1 (sphingomyelin phosphodiesterase 1)-mediated degradation. Inactivating mutations in the SMPD1 gene result in Niemann-Pick diseases type A and B characterized by
Ahmet Tektemur et al.
Journal of cancer research and clinical oncology, 145(5), 1297-1311 (2019-03-20)
Transient receptor potential melastatin 2 (TRPM2), a calcium-permeable ion channel, is shown as a prognostic marker candidate in prostate cancer (PCa) and an important regulator of autophagy. We aimed to determine the changes in TRPM2 and autophagic-apoptotic gene expression levels
Nicole A Morrissey et al.
Journal of neuroendocrinology, 33(9), e13027-e13027 (2021-08-24)
Changes in mitochondrial function in a variety of cells/tissues are critical for orchestrating systemic energy homeostasis and are linked to the development of obesity and many of its comorbidities. The mitochondrial translocator protein of 18 kDa (TSPO) is expressed in organs
Jian M Chen et al.
Bioresource technology, 101(21), 8067-8073 (2010-06-26)
Microbes bound to a wheat bran/red wood powder/diatomaceous earth carrier were used as inoculants for a biotrickling filter (BTF) for treating gases contaminated with a mixture of benzene, toluene, and o-xylene (BTo-X). An overall removal efficiency of more than 87.9%
Archita Mishra et al.
Cell, 184(13), 3394-3409 (2021-06-03)
The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation of memory T cells in fetal tissues. We
Vlasta Svecova et al.
Journal of exposure science & environmental epidemiology, 22(5), 455-460 (2012-06-07)
Personal exposures to volatile organic compounds (VOCs) were measured in the three industrial cities in the Czech Republic, Ostrava, Karvina and Havirov, while the city of Prague served as a control in a large-scale molecular epidemiological study identifying the impacts
Mujeeb Shittu et al.
Methods and protocols, 4(1) (2021-04-04)
RNA in situ hybridization (ISH) is used to visualize spatio-temporal gene expression patterns with broad applications in biology and biomedicine. Here we provide a protocol for mRNA ISH in developing pupal wings and abdomens for model and non-model Drosophila species.
Mohammed L Ibrahim et al.
Cell reports, 25(11), 3036-3046 (2018-12-13)
IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. We report here
Lian He et al.
Journal of environmental sciences (China), 23(1), 160-165 (2011-04-12)
The activities of CeO2 nanocubes calcined at different temperatures were tested for catalytic oxidation of o-xylene. Using CeO2 nanocubes as catalysts, complete catalytic oxidation of o-xylene was achieved below 210 degrees C. The CeO2 nanomaterials were characterized by means of
Assessment of paraffin removal from prostate FFPE sections using transmission mode FTIR-FPA imaging.
Hughes C, et al.
Analytical Methods : Advancing Methods and Applications, 6(4), 1028-1035 (2014)
Rafael A Larocca et al.
Cell host & microbe, 26(5), 591-600 (2019-11-02)
Maternal infection with Zika virus (ZIKV) can lead to microcephaly and other congenital abnormalities of the fetus. Although ZIKV vaccines that prevent or reduce viremia in non-pregnant mice have been described, a maternal vaccine that provides complete fetal protection would
Ayman M Ibrahim et al.
International journal of molecular sciences, 21(19) (2020-10-03)
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart muscle disease, with a prevalence of at least 1 in 500 in the general population. The disease is pleiotropic and is characterized by an increased stiffness of the myocardium, partly due
Alberto Camacho et al.
Lipids in health and disease, 17(1), 128-128 (2018-05-31)
Excessive subcutaneous adiposity in obesity is associated to positive white adipocyte tissue (WAT) differentiation (adipogenesis) and WAT expandability. Here, we hypothesized that supplementation with the insulin inhibitor and mitochondrial uncoupler, Tyrphostin (T-AG17), in vitro and in vivo inhibits adipogenesis and
Benjamin D Sachs et al.
Psychoneuroendocrinology, 53, 69-81 (2015-01-21)
Brain 5-HT deficiency has long been implicated in psychiatric disease, but the effects of 5-HT deficiency on stress susceptibility remain largely unknown. Early life stress (ELS) has been suggested to contribute to adult psychopathology, but efforts to study the long-term
Qiming Wang et al.
Nature communications, 5, 4899-4899 (2014-09-17)
Cephalopods can display dazzling patterns of colours by selectively contracting muscles to reversibly activate chromatophores--pigment-containing cells under their skins. Inspired by this novel colouring strategy found in nature, we design an electro-mechano-chemically responsive elastomer system that can exhibit a wide
Jovita M Saquing et al.
Environmental science & technology, 44(3), 1123-1129 (2009-12-31)
Desorption rates of toluene, o-xylene and tetrachloroethene from individual municipal solid waste components [high-density polyethylene (HDPE); poly(vinyl chloride) (PVC); office paper; newsprint; and rabbit food, a model food and yard waste] were determined. Effects of sorbent and sorbate properties, solvent
Anna Pakula et al.
Human molecular genetics, 28(2), 320-331 (2018-10-12)
Facioscapulohumeral dystrophy type 1 (FSHD-1) is the most common autosomal dominant form of muscular dystrophy with a prevalence of ∼1 in 8000 individuals. It is considered a late-onset form of muscular dystrophy and leads to asymmetric muscle weakness in the
Michelle L Thompson et al.
Molecular pain, 12 (2016-11-12)
Age-related bone fractures are usually painful and have highly negative effects on a geriatric patient's functional status, quality of life, and survival. Currently, there are few analgesic therapies that fully control bone fracture pain in the elderly without significant unwanted
Fluoro-Jade B Staining for Neuronal Cell Death.
Laflamme N, et al.
Bio-protocol, 6(1) (2016)
Dockyu Kim et al.
Applied microbiology and biotechnology, 86(6), 1841-1847 (2010-01-19)
Escherichia coli cells expressing Rhodococcus DK17 o-xylene dioxygenase genes were used for bioconversion of m-xylene. Gas chromatography-mass spectrometry analysis of the oxidation products detected 3-methylbenzylalcohol and 2,4-dimethylphenol in the ratio 9:1. Molecular modeling suggests that o-xylene dioxygenase can hold xylene
Experimental and modeling study of the oxidation of xylenes.
Battin-Leclerc F, et al.
International Journal of Chemical Kinetics, 38(4), 284-302 (2006)
Woon Ju Song et al.
Biochemistry, 50(23), 5391-5399 (2011-05-21)
Site-directed mutagenesis studies of a strictly conserved T201 residue in the active site of toluene/o-xylene monooxygenase hydroxylase (ToMOH) revealed that a single mutation can facilitate kinetic isolation of two distinctive peroxodiiron(III) species, designated T201(peroxo) and ToMOH(peroxo), during dioxygen activation. Previously
Ali Sarafraz-Yazdi et al.
Journal of chromatography. A, 1218(34), 5757-5764 (2011-07-26)
In this study, poly(ethylene glycol) (PEG) grafted onto multi-walled carbon nanotubes (PEG-g-MWCNTs) were synthesized by the covalent functionalization of MWCNTs with hydroxyl-terminated PEG chains. For the first time, functionalized product of PEG-g-MWCNTs was used as selective stationary phase to prepare
Kristine Ravina et al.
International journal of molecular sciences, 19(12) (2018-11-30)
Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived
Laura Broutier et al.
Nature protocols, 11(9), 1724-1743 (2016-08-26)
Adult somatic tissues have proven difficult to expand in vitro, largely because of the complexity of recreating appropriate environmental signals in culture. We have overcome this problem recently and developed culture conditions for adult stem cells that allow the long-term
Yujie Zhang et al.
Journal of environmental sciences (China), 24(1), 124-130 (2012-07-13)
The atmospheric concentrations of carbonyls and BTEX (benzene, toluene, ethylbenzene, m,p-xylene and o-xylene) were measured simultaneously at a same sampling site in Beijing from September 2008 to August 2010. The average concentrations of the total measured carbonyls during autumn, winter
Geovanny Nic-Can et al.
Plant methods, 9(1), 47-47 (2013-12-18)
Epigenetic mechanisms can be highly dynamic, but the cross-talk among them and with the genome is still poorly understood. Many of these mechanisms work at different places in the cell and at different times of organism development. Covalent histone modifications
Deborah M Hegarty et al.
Journal of chemical neuroanatomy, 61-62, 1-12 (2014-07-06)
We examined the substrates for ocular nociception in adult male Sprague-Dawley rats. Capsaicin application to the ocular surface in awake rats evoked nocifensive responses and suppressed spontaneous grooming responses. Thus, peripheral capsaicin was able to activate the central pathways encoding
Sindy Cole et al.
Scientific reports, 5, 16143-16143 (2015-11-06)
The orexin/hypocretin system is important for reward-seeking behaviors, however less is known about its function in non-homeostatic feeding. Environmental influences, particularly cues for food can stimulate feeding in the absence of hunger and lead to maladaptive overeating behavior. The key
Matthew J Baker et al.
Nature protocols, 9(8), 1771-1791 (2014-07-06)
IR spectroscopy is an excellent method for biological analyses. It enables the nonperturbative, label-free extraction of biochemical information and images toward diagnosis and the assessment of cell functionality. Although not strictly microscopy in the conventional sense, it allows the construction
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