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Alexander J Moorhouse et al.
iScience, 25(8), 104796-104796 (2022-08-20)
The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Here we determine the role of BASP1 lipidation in histone modification and the modulation of chromatin accessibility. We find that the removal of
Nutan Chaudhari et al.
Nature communications, 13(1), 5555-5555 (2022-09-23)
Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a family of enzymes that play a critical role in scar formation
John J Krais et al.
Nature communications, 12(1), 5016-5016 (2021-08-20)
DNA damage prompts a diverse range of alterations to the chromatin landscape. The RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K)13/15 (mUb-H2A), forming a binding module for DNA repair proteins. BRCA1 promotes homologous recombination (HR)
Ni Pan et al.
Marine drugs, 20(1) (2022-01-21)
Isaridin E, a cyclodepsipeptide isolated from the marine-derived fungus Amphichorda felina (syn. Beauveria felina) SYSU-MS7908, has been demonstrated to possess anti-inflammatory and insecticidal activities. Here, we first found that isaridin E concentration-dependently inhibited ADP-induced platelet aggregation, activation, and secretion in
Xiangfei Sun et al.
Cell death & disease, 14(12), 839-839 (2023-12-19)
Imatinib (IM) has significantly improved the prognosis of gastrointestinal stromal tumor (GIST) patients, but some patients still have primary resistance to IM, and approximately half of patients develop acquired drug resistance within 2 years of treatment, necessitating exploration of new
Hongda Li et al.
Theranostics, 11(4), 1609-1625 (2021-01-08)
Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor
Lan Li et al.
Annals of translational medicine, 8(16), 1006-1006 (2020-09-22)
To study the effects of forced swimming stress on blood glucose and insulin levels and the expression and phosphorylation of pancreatic PI3K/Akt signal pathway in type 2 diabetic rats. Thirty adult SD rats (8-week-old, male) were randomly divided into three
Chunwan Lu et al.
Oncogene, 41(18), 2651-2662 (2022-03-31)
The role of glucose-6-phosphate dehydrogenase (G6PD) in human cancer is incompletely understood. In a metabolite screening, we observed that inhibition of H3K9 methylation suppressed aerobic glycolysis and enhances the PPP in human mesothelioma cells. Genome-wide screening identified G6PD as an
Qi Li et al.
Experimental and therapeutic medicine, 23(4), 282-282 (2022-03-24)
Cancer cells frequently exhibit an acidic extracellular microenvironment, where inversion of the transmembrane pH gradient is associated with tumor proliferation and metastasis. To elucidate a new therapeutic target against cancer, the current study aimed to determine the mechanism by which
Tim Wartewig et al.
Nature cancer, 4(10), 1508-1525 (2023-09-19)
The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest frequencies of PDCD1 deletions are detected in advanced disease, predicting inferior prognosis. However, the
Yuanyi Mang et al.
Annals of translational medicine, 10(19), 1066-1066 (2022-11-05)
To establish an animal model of pre-sensitization following liver transplantation either with or without immunosuppressors. To study whether accelerated liver rejection or acute antibody-mediated rejection (AMR) occurred and study the characteristics and potential mechanism in the animal model. Lewis (LEW)
Juliane Mooz et al.
Science advances, 8(11), eabk1538-eabk1538 (2022-03-19)
RAF kinases are highly conserved serine/threonine kinases, and among the three RAF isoforms (ARAF, BRAF, and CRAF), the pathophysiological relevance of ARAF is not well defined. Here, we show that patients with lung cancer exhibit low expression of ARAF, which
H Benson Peng et al.
Current protocols, 1(10), e253-e253 (2021-10-19)
The amyloid-β (Aβ) peptides of 40 and 42 amino acids that are implicated in Alzheimer's disease may potentially aggregate into toxic oligomers and form neuritic plaques. The enzyme-linked immunosorbent assay (ELISA) is a facile method used for the determination of
Yun-Kyoung Lee et al.
Nature protocols, 14(11), 3059-3081 (2019-10-06)
The study of cerebral microvessels is becoming increasingly important in a wide variety of conditions, such as stroke, sepsis, traumatic brain injury and neurodegenerative diseases. However, the molecular mechanisms underlying cerebral microvascular dysfunction in these conditions are largely unknown. The
Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome
Ela B, et al.
Glia, 72, 1117-1135 (2024)
L S Lundell et al.
Acta physiologica (Oxford, England), 223(3), e13051-e13051 (2018-02-10)
Spinal cord injury-induced loss of skeletal muscle mass does not progress linearly. In humans, peak muscle loss occurs during the first 6 weeks postinjury, and gradually continues thereafter. The aim of this study was to delineate the regulatory events underlying
Adithya Gopinath et al.
NPJ Parkinson's disease, 7(1), 62-62 (2021-07-22)
Most, if not all, peripheral immune cells in humans and animals express tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis. Since TH is typically studied in the context of brain catecholamine signaling, little is known about changes in
Kuo-Hao Ho et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(2), 1371-1392 (2021-01-08)
Limited therapeutic efficacy of temozolomide (TMZ) against glioblastomas highlights the importance of exploring new drugs for clinical therapy. Sunitinib, a multitargeted receptor tyrosine kinase inhibitor, is currently being tested as therapy for glioblastomas. Unfortunately, sunitinib still has insufficient activity to
Deivid C Rodrigues et al.
Cell reports, 30(12), 4179-4196 (2020-03-27)
Regulation of translation during human development is poorly understood, and its dysregulation is associated with Rett syndrome (RTT). To discover shifts in mRNA ribosomal engagement (RE) during human neurodevelopment, we use parallel translating ribosome affinity purification sequencing (TRAP-seq) and RNA
Eeva Kaisa Rajakylä et al.
Cell reports, 30(12), 4266-4280 (2020-03-27)
Defects in the maintenance of intercellular junctions are associated with loss of epithelial barrier function and consequent pathological conditions, including invasive cancers. Epithelial integrity is dependent on actomyosin bundles at adherens junctions, but the origin of these junctional bundles is
Joseph Nacson et al.
Molecular cell, 78(5), 951-959 (2020-05-04)
BRCA1 promotes the DNA end resection and RAD51 loading steps of homologous recombination (HR). Whether these functions can be uncoupled, and whether mutant proteins retaining partial activity can complement one another, is unclear and could affect the severity of BRCA1-associated
Shengsong Chen et al.
iScience, 26(10), 107866-107866 (2023-10-11)
Whether rutin relieves ventilator-induced lung injury (VILI) remains unclear. Here, we used network pharmacology, bioinformatics, and molecular docking to predict the therapeutic targets and potential mechanisms of rutin in the treatment of VILI. Subsequently, a mouse model of VILI was
Wim Hendricus Quint et al.
Journal of Alzheimer's disease : JAD, 80(2), 813-829 (2021-02-14)
Alzheimer's disease (AD) and other tauopathies are neurodegenerative disorders characterized by cellular accumulation of aggregated tau protein. Tau pathology within these disorders is accompanied by chronic neuroinflammation, such as activation of the classical complement pathway by complement initiation factor C1q.
Carla Maiara Lopes Cardozo et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-14)
There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. Campomanesia xanthocarpa, found in the Brazilian Cerrado, demonstrated beneficial effects in metabolic disorders associated with
Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis.
Rentsendorj, et al.
Frontiers in Immunology, 14, 1155935-1155935 (2023)
Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation
Chen W, et al.
Molecular Medicine Reports, 21(3), 1390-1398 (2020)
Benitta John-Philip et al.
Methods in molecular medicine, 116, 221-232 (2005-07-08)
Gene transfer is a widely used experimental approach to determine the value of specific genes under a variety of conditions. This chapter focuses on the expression of two human anti-viral genes, interferon (IFN)-alpha2 and IFN-beta, driven by a cytomegalovirus immediate-early
Rahul Kumar et al.
Clinical science (London, England : 1979), 137(8), 617-631 (2023-04-05)
Pulmonary hypertension (PH) can occur as a complication of schistosomiasis. In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite eradication. We hypothesized that persistent disease arises as a consequence of exposure repetition. Following intraperitoneal sensitization, mice were experimentally exposed to
Hongshi Cai et al.
Frontiers in oncology, 9, 1446-1446 (2020-01-11)
Aerobic glycolysis is the main pathway for energy metabolism in cancer cells. It provides energy and biosynthetic substances for tumor progression and metastasis by increasing lactate production. Lactate dehydrogenase A (LDHA) promotes glycolysis process by catalyzing the conversion of pyruvate
Saranya Canchi et al.
Journal of neuroinflammation, 17(1), 112-112 (2020-04-12)
HIV-associated neurocognitive disorders (HAND) persist in the era of combined antiretroviral therapy (ART) despite reductions in viral load (VL) and overall disease severity. The mechanisms underlying HAND in the ART era are not well understood but are likely multifactorial, involving alterations
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