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Celja J Uebel et al.
PLoS genetics, 14(7), e1007542-e1007542 (2018-07-24)
In C. elegans, efficient RNA silencing requires small RNA amplification mediated by RNA-dependent RNA polymerases (RdRPs). RRF-1, an RdRP, and other Mutator complex proteins localize to Mutator foci, which are perinuclear germline foci that associate with nuclear pores and P
Saravanapriah Nadarajan et al.
eLife, 5, e12039-e12039 (2016-02-28)
Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog, ECT-2, functions through the conserved
Proliferating infantile hemangioma promotes α-fetoprotein production by HepG2 cells.
Bede van Schaijik et al.
Pediatric research, 87(1), 3-6 (2019-08-15)
Hyun-Min Kim et al.
Genetics, 209(2), 409-423 (2018-03-29)
The histone demethylase LSD1 was originally discovered by removing methyl groups from di- and monomethylated histone H3 lysine 4 (H3K4me2/1). Several studies suggest that LSD1 plays roles in meiosis as well as in the epigenetic regulation of fertility given that
Kevin I Manage et al.
eLife, 9 (2020-04-28)
piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent
Setsuo Kinoshita et al.
Biological & pharmaceutical bulletin, 42(12), 2069-2075 (2019-12-04)
Proteome profiling based on two-dimensional (2D)-DIGE might be a useful tool for investigating drug-like compounds and the mode of action of drugs. However, obtaining data for profiling requires high labor costs, and it is difficult to control the reproducibility of
Kamlesh K Bhopale et al.
Alcoholism, clinical and experimental research, 41(10), 1675-1685 (2017-08-10)
Chronic alcohol abuse, a major risk factor for such diseases as hepatitis and cirrhosis, impairs hepatic alcohol dehydrogenase (ADH; key ethanol [EtOH]-metabolizing enzyme). Therefore, differentially altered hepatic and plasma proteomes were identified in chronic EtOH feeding model of hepatic ADH-deficient
Konrad Pazdrak et al.
Journal of immunology (Baltimore, Md. : 1950), 186(11), 6485-6496 (2011-04-29)
The priming of eosinophils by cytokines leading to augmented response to chemoattractants and degranulating stimuli is a characteristic feature of eosinophils in the course of allergic inflammation and asthma. Actin reorganization and integrin activation are implicated in eosinophil priming by
Kathrin Leppek et al.
Cell reports, 34(3), 108629-108629 (2021-01-21)
Roles for ribosomal RNA (rRNA) in gene regulation remain largely unexplored. With hundreds of rDNA units positioned across multiple loci, it is not possible to genetically modify rRNA in mammalian cells, hindering understanding of ribosome function. It remains elusive whether
Ceri A Fielding et al.
PLoS pathogens, 10(5), e1004058-e1004058 (2014-05-03)
NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A andB, and UL16-binding
Kirin Tan et al.
Plastic and reconstructive surgery. Global open, 6(2), e1686-e1686 (2018-04-05)
The pathogenesis of Dupuytren's disease (DD) remains unclear. An embryonic stem cell (ESC)-like population in the endothelium of the microvessels around tissues that expresses components of the renin-angiotensin system (RAS) has been reported. This study investigated if this primitive population
Amy Bradshaw et al.
Frontiers in surgery, 3, 48-48 (2016-09-13)
To identify and characterize cancer stem cells (CSC) in glioblastoma multiforme (GBM). Four-micrometer thick formalin-fixed paraffin-embedded GBM samples from six patients underwent 3,3-diaminobenzidine (DAB) and immunofluorescent (IF) immunohistochemical (IHC) staining for the embryonic stem cell (ESC) markers NANOG, OCT4, SALL4
Fei-Yan Deng et al.
Molecular & cellular proteomics : MCP, 10(11), M111-M111 (2011-08-06)
Low bone mineral density (BMD) is a risk factor of osteoporosis and has strong genetic determination. Genes influencing BMD and fundamental mechanisms leading to osteoporosis have yet to be fully determined. Peripheral blood monocytes (PBM) are potential osteoclast precursors, which
Matthew J Munro et al.
Clinical proteomics, 19(1), 27-27 (2022-07-17)
Colon cancer is the third most common cancer and second highest cause of cancer deaths worldwide. The aim of the study was to find new biomarkers for diagnosis, prognosis and therapeutic drug targets for this disease. Four low-grade and four
Dominic Docter et al.
Nature protocols, 9(9), 2030-2044 (2014-08-01)
Nanoparticle applications in biotechnology and biomedicine are steadily increasing. In biological fluids, proteins bind to nanoparticles that form the protein corona, crucially affecting the nanoparticles' biological identity. As the corona affects in vitro and/or in vivo nanoparticle applications, we developed
Yong Zeng et al.
Protein & cell, 8(2), 123-133 (2016-11-24)
Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by
Olga Lilia Garibay-Cerdenares et al.
Journal of ovarian research, 7, 27-27 (2014-03-01)
Ovarian cancer is the most lethal gynecologic disease due to delayed diagnosis, and ascites production is a characteristic of patients in advanced stages. The aim of this study was to perform the proteomic analysis of ascitic fluids of Mexican patients
Jason A Wall et al.
American journal of physiology. Heart and circulatory physiology, 291(5), H2462-H2472 (2006-06-13)
Ischemia-reperfusion (I/R) has critical consequences in the heart. Recent studies on the functions of I/R-activated kinases, such as p38 mitogen-activated protein kinase (MAPK), showed that I/R injury is reduced in the hearts of transgenic mice that overexpress the p38 MAPK
Deniz Simsek et al.
Cell, 169(6), 1051-1065 (2017-06-03)
During eukaryotic evolution, ribosomes have considerably increased in size, forming a surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an interface for yet uncharacterized interacting proteins. To investigate such protein interactions, we establish a ribosome affinity purification
Kathrin Leppek et al.
Molecular cell, 80(6), 980-995 (2020-11-18)
Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core ribosome in eukaryotes. ESs are remarkably variable
Yong Zeng et al.
Journal of proteomics, 142, 45-52 (2016-05-08)
Osteoporosis is mainly characterized by low bone mineral density (BMD), and can be attributed to excessive bone resorption by osteoclasts. Migration of circulating monocytes from blood to bone is important for subsequent osteoclast differentiation and bone resorption. Identification of those
Fei-Yan Deng et al.
Bone, 63, 69-75 (2014-03-13)
Low bone mineral density (BMD) is a risk factor for osteoporosis. Osteoporosis is more prevalent in females than in males. So far, the pathophysiological mechanisms underlying osteoporosis are unclear. Peripheral blood monocytes (PBMs) are precursors of bone-resorbing osteoclasts. This study
Kiall F Suazo et al.
Current protocols in chemical biology, 10(3), e46-e46 (2018-07-31)
Protein prenylation involves the attachment of a farnesyl or geranylgeranyl group onto a cysteine residue located near the C-terminus of a protein, recognized via a specific prenylation motif, and results in the formation of a thioether bond. To identify putative
Motohide Hori et al.
Journal of neuroinflammation, 9, 256-256 (2012-11-28)
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is considered to be a potential therapeutic agent for prevention of cerebral ischemia. Ischemia is a most common cause of death after heart attack and cancer causing major negative social and economic consequences.
Amy Ruth Bradshaw et al.
Frontiers in surgery, 3, 51-51 (2016-10-13)
To investigate the expression of the renin-angiotensin system (RAS) in cancer stem cells (CSCs), we have previously characterized in glioblastoma multiforme (GBM). 3,3-Diaminobenzidine (DAB) immunohistochemical (IHC) staining for the stem cell marker, SOX2, and components of the RAS: angiotensin converting
Zhen Shi et al.
Molecular cell, 67(1), 71-83 (2017-06-20)
Emerging studies have linked the ribosome to more selective control of gene regulation. However, an outstanding question is whether ribosome heterogeneity at the level of core ribosomal proteins (RPs) exists and enables ribosomes to preferentially translate specific mRNAs genome-wide. Here
Yanli Liu et al.
Cancer research, 80(24), 5464-5477 (2020-10-30)
Activation of transcription factors is a key driver event in cancer. We and others have recently reported that the Krüppel-like transcription factor KLF5 is activated in multiple epithelial cancer types including squamous cancer and gastrointestinal adenocarcinoma, yet the functional consequences
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