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J B Kerrison et al.
American journal of ophthalmology, 125(1), 64-70 (1998-01-23)
To describe the clinical features of a large pedigree with autosomal dominant congenital nystagmus linked to chromosome 6p12. In a prospective evaluation of 54 living family members in a single pedigree, 21 persons were affected with autosomal dominant congenital nystagmus
Vasiliki Lagou et al.
Cell reports, 25(3), 798-810 (2018-10-18)
The immune system is highly diverse, but characterization of its genetic architecture has lagged behind the vast progress made by genome-wide association studies (GWASs) of emergent diseases. Our GWAS for 54 functionally relevant phenotypes of the adaptive immune system in
G N Stradling et al.
Human & experimental toxicology, 14(2), 165-169 (1995-02-01)
1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed
Kaori Yamazaki et al.
Clinical physiology and functional imaging, 33(2), 109-116 (2013-02-07)
Time-resolved spectroscopy (TRS-20) measures tissue oxygen saturation (%) by evaluating the absolute concentrations of oxygenated, deoxygenated and total haemoglobin based on measurement of the transit time of individual photons through a tissue of interest. We measured tissue oxygen saturation in
Paulo Castro-Chaves et al.
European journal of pharmacology, 544(1-3), 91-96 (2006-07-18)
We analyzed the influence of endothelin-1 and endocardial endothelium on the myocardial effects of angiotensin-II. Angiotensin-II (10(-9)-10(-5) M) was tested in rabbit right papillary muscles in absence (Protocol-A) or presence of PD-145065 (10(-7) M; Protocol-B), BQ-123 (10(-7) M; Protocol-C) or
Qiu-gui Zhang et al.
Zhonghua er bi yan hou ke za zhi, 39(10), 617-620 (2005-02-09)
To investigate the relation between levels of intercellular adhesion molecule-1, interleukin-6 and airway hyperresponsiveness in patients with allergic rhinitis. Fifty-four patients with allergic rhinitis (AR) and 20 controls were included in the study. The levels of intercellular adhesion molecule-1 (ICAM-1)
Bharat Rekhi et al.
Pathology, 44(1), 11-17 (2011-12-17)
Alveolar soft part sarcoma accounts for 0.5-1.0% of soft tissue sarcomas in the United States. At our Hospital, it constitutes 1.8% of the newly diagnosed soft tissue sarcomas. Lately, TFE3 has been found to be a useful immunohistochemical marker for
Y Aksoy et al.
Protein expression and purification, 21(2), 286-292 (2001-03-10)
Glucose-6-phosphate dehydrogenase was purified from human placenta using DEAE-Sepharose fast flow, 2',5'-ADP Sepharose 4B column chromatography, and chromatofocusing on PBE 94 with PB 74. The enzyme was purified with 62% yield and had a specific activity of 87 units per
Peter F Schnatz et al.
Journal of women's health (2002), 21(8), 858-864 (2012-06-14)
This study analyzed associations between plasma vitamin D(3) (25OHD(3)) and bone mineral density (BMD) and whether the effects of conjugated equine estrogens (CEE) on BMD are modulated by 25OHD(3). Fifty cynomolgus monkeys were fed a diet containing 25OHD(3) (providing a
Y Zhou et al.
Receptor, 4(4), 223-227 (1994-01-01)
A C57 black/6 mouse genomic library was screened for mGHR/BP using a mGHR cDNA hybridization probe. Two clones (mGHR-GA and mGHR-GB) were isolated. mGHR-GA contained an insert of 16 kb and hybridized only to exon 4 whereas mGHR-GB possessed an
Imran Khan et al.
Methods in molecular biology (Clifton, N.J.), 2262, 281-302 (2021-05-13)
RAS is frequently mutated in human cancers with nearly 20% of all cancers harboring mutations in one of three RAS isoforms (KRAS, HRAS, or NRAS). Furthermore, RAS proteins are critical oncogenic drivers of tumorigenesis. As such, RAS has been a
Jonathan F Kalisvaart et al.
Journal of pediatric urology, 8(4), 359-365 (2011-08-09)
Follow-up of patients undergoing dextranomer/hyaluronic acid injection for vesico-ureteral reflux (VUR) is controversial. The purpose of our study was to test the hypothesis that patients undergoing the double hydrodistention-implantation technique (Double HIT) have a higher clinical and radiographic success rate.
Takashi Yamanaka et al.
Journal of vascular and interventional radiology : JVIR, 26(8), 1147-1153 (2015-07-01)
To retrospectively evaluate factors affecting local tumor control in cryoablation of renal cell carcinomas (RCCs). This study examined 61 patients (43 men, 18 women) with a mean age of 69.1 years ± 10.8 (range 38-87 y) who underwent computed tomography
Nurhan Güler et al.
TheScientificWorldJournal, 2012, 946060-946060 (2012-07-11)
The aim of this study was to investigate whether there is any association between inflammation and the expression of markers of cell cycle entry (Ki-67 and MCM-2) in dental follicle (DF) of asymptomatic impacted teeth and odontogenic cysts. The study
Timothy D Jones et al.
The American journal of surgical pathology, 28(7), 935-940 (2004-06-30)
OCT4 (POU5F1) is a transcription factor expressed in embryonic stem and germ cells and is involved in the regulation and maintenance of pluripotency. It has been detected in primary testicular germ cell tumors with pluripotent potential, seminoma, and embryonal carcinoma.
Malcolm A Lyons et al.
Physiological genomics, 17(1), 60-68 (2004-01-01)
To identify genetic determinants of lipoprotein levels, we are performing quantitative trait locus (QTL) analysis on a series of mouse intercrosses in a "daisy chain" experimental design, to increase the power of detecting QTL and to identify common variants that
U Reuning et al.
Thrombosis research, 72(1), 59-70 (1993-10-01)
We isolated a full length cDNA clone for bovine u-PAR from a bovine aorta endothelial cell cDNA library and compared the structural properties of this receptor protein to the published human and murine sequences. The bovine u-PAR cDNA clone spans
O K Tollersrud et al.
The Biochemical journal, 260(1), 101-108 (1989-05-15)
1. Rat liver glycosylasparaginase [N4-(beta-N-acetylglucosaminyl)-L-asparaginase, EC 3.5.1.26] was purified to homogeneity by using salt fractionation, CM-cellulose and DEAE-cellulose chromatography, gel filtration on Ultrogel AcA-54, concanavalin A-Sepharose affinity chromatography, heat treatment at 70 degrees C and preparative SDS/polyacrylamide-gel electrophoresis. The purified
T C Wang et al.
Gastroenterology, 118(1), 36-47 (1999-12-28)
Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined. The effects of hypergastrinemia, and possible synergy with Helicobacter felis infection, were
H Chang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 89(2), 79-83 (1990-02-01)
From April 1981 to December 1988, a total of 23 patients were operated upon for the repair of an aneurysm of the descending thoracic aorta with a tridodecylmethylammonium chloride (TDMAC)-heparin-impregnated shunt. There were 20 men and 3 women. The ages
Armin de Meijere et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 16(46), 13862-13875 (2010-10-15)
Thirty-three different N,N-dialkyl- and N-alkyl-N-phosphorylalkyl-substituted carboxamides 9-17 were treated with unsubstituted as well as with 2-alkyl-, 2,2-dialkyl-, and 3-alkenyl-substituted ethylmagnesium bromides 6 in the presence of stoichiometric amounts of titanium tetraisopropoxide or methyltitanium triisopropoxide to furnish substituted cyclopropylamines 20-25 in
Nasir A S Al-Allawi et al.
Neurology India, 57(5), 631-635 (2009-11-26)
Data are conflicting concerning the association between ischemic stroke and methylenetetrahydrofolate reductase (MTHFR) C677T mutation. Studies addressing this matter in developing countries are limited. This study was undertaken to evaluate MTHFR C677T gene polymorphism as a possible risk factor in
Piotr Kozlowski et al.
Human genetics, 121(3-4), 389-400 (2007-02-09)
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by mutations in either of two genes, TSC1 and TSC2. Point mutations and small indels account for most TSC1 and TSC2 mutations. We examined 261 TSC DNA samples (209 small-mutation-negative and
A Allahveisi et al.
Acta endocrinologica (Bucharest, Romania : 2005), 15(3), 295-300 (2020-02-06)
Polycystic ovarian syndrome (PCOS) occurs in 6-10% of all women in their reproductive age. In women with PCOS, controlled ovarian hyperstimulation (COH) often results in an increased risk of ovarian hyperstimulation syndrome (OHSS). In vitro maturation (IVM) of human oocyte
Morten Hostrup et al.
Scandinavian journal of medicine & science in sports, 29(5), 669-677 (2019-01-25)
This study investigated the in-season effect of intensified training comparing the efficacy of duration-matched intense intermittent exercise training with sprint interval training in increasing intermittent running performance, sprint ability, and muscle content of proteins related to ion handling and metabolism
S Höstman et al.
Acta anaesthesiologica Scandinavica, 57(1), 63-70 (2012-11-22)
Ventilation with low tidal volumes reduces mortality in acute respiratory distress syndrome. A further reduction of tidal volumes might be beneficial, and it is known that apneic oxygenation (no tidal volumes) with arteriovenous CO(2) removal can keep acid-base balance and
Courtney Dunn et al.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 19(5), 504-509 (2012-05-19)
Therapies exist for acute organophosphate (OP) exposure but mortality rates remain high (10% to 20%). Currently, treatment focuses on reversing the resultant cholinergic excess effects through the use of atropine. Intralipid fat emulsion (IFE) has been used to treat lipophilic
Jin-Ting Zhang et al.
World journal of gastroenterology, 11(31), 4918-4922 (2005-08-13)
To study the expression of cyclooxygenase-2 (COX-2) in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients. The expression of COX-2 mRNA
Michael R Peterson et al.
Applied immunohistochemistry & molecular morphology : AIMM, 15(3), 242-247 (2007-08-28)
Approximately 10% to 20% of nonsmall cell lung cancer patients respond to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, such as gefitinib. Responders are mostly nonsmokers and women with tumors displaying bronchioloalveolar features. Mutations of the tyrosine kinase domain
Stephan Nieuwoudt et al.
American journal of physiology. Endocrinology and metabolism, 313(3), E314-E320 (2017-05-18)
Type 2 diabetes (T2D) is characterized by reductions in β-cell function and insulin secretion on the background of elevated insulin resistance. Aerobic exercise has been shown to improve β-cell function, despite a subset of T2D patients displaying "exercise resistance." Further
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