CN
Search Within
545996
应用筛选条件
关键词:'545996'
显示 1-30 共 35 条结果 关于 "545996" 范围 论文
Carolin S Hoefig et al.
The Journal of nutritional biochemistry, 22(10), 945-955 (2010-12-31)
The essential micronutrient selenium (Se) exerts its biological effects mainly through enzymatically active selenoproteins. Their biosynthesis depends on the 21st proteinogenic amino acid selenocysteine and thus on dietary Se supply. Hepatically derived selenoprotein P (SEPP) is the central selenoprotein in
Eric Olm et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(27), 11400-11405 (2009-06-25)
The selenium salt selenite (SeO(3)(2-)) is cytotoxic in low to moderate concentrations, with a remarkable specificity for cancer cells resistant to conventional chemotherapy. Our data show that selenium uptake and accumulation, rather than intracellular events, are crucial to the specific
Tianfeng Chen et al.
The international journal of biochemistry & cell biology, 41(3), 666-676 (2008-08-23)
The role of selenium as potential cancer chemopreventive and chemotherapeutic agents has been supported by epidemiological, preclinical and clinical studies. Although cell apoptosis has been evidenced as a critical mechanism mediating the anticancer activity of selenium, the underlying molecular mechanisms
Amit Kunwar et al.
Radiation and environmental biophysics, 50(2), 271-280 (2011-01-25)
Selenocystine (CysSeSeCys), a diselenide aminoacid exhibiting glutathione peroxidase-like activity and selective antitumor effects, was examined for in vivo antigenotoxic and antioxidant activity in Swiss albino mice after exposure to a sublethal dose (5 Gy) of γ-radiation. For this, CysSeSeCys was administered
Tianfeng Chen et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 63(2), 105-113 (2008-05-31)
Epidemiological and clinical studies have demonstrated that dietary supplementation of selenium (Se) could reduce the incidence of human cancers. In this study, selenocystine, a nutritionally available selenoamino acid, was identified as a novel agent with broad-spectrum antitumor activity. A panel
Novel selenium-containing non-natural diamino acids
Caputo R, et al.
Tetrahedron Letters, 48(8), 1425-1427 (2007)
Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of ?-elimination reactions in rat renal cytosol
Andreadou I, et al.
Journal of Medicinal Chemistry, 39(10), 2040-2046 (1996)
T Chen et al.
Cellular and molecular life sciences : CMLS, 65(17), 2763-2775 (2008-07-29)
Selenocystine (SeC), a naturally occurring selenoamino acid, has been shown to be a novel compound with broad-spectrum anticancer activity. In this study, we showed that SeC triggered time- and dose-dependent apoptosis in A375 human melanoma cells by activating the mitochondria-mediated
B Mishra et al.
The journal of physical chemistry. B, 112(14), 4441-4446 (2008-03-18)
Reactions of hydroxyl radicals (*OH) with selenocystine (SeCys) and two of its analogues, diselenodipropionic acid (SeP) and selenocystamine (SeA), have been studied in aqueous solutions at pHs of 1, 7, and 10 using the pulse radiolysis technique coupled with absorption
Rui Gusmão et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 17(2), 321-329 (2011-10-22)
Selenium-containing compounds play an important role in antioxidant defense systems, binding to toxic metals, preventing their uptake into cells, and thus protecting cells from metal-induced formation of reactive oxygen species. Here, we present a proposal for a relatively new method
Andrzej Gawor et al.
Animals : an open access journal from MDPI, 10(5) (2020-05-13)
Identification and quantification of the selenium species in biological tissues is imperative, considering the need to properly understand its metabolism and its importance in various field of sciences, especially nutrition science. Although a number of studies deals with the speciation
I Andreadou et al.
Journal of medicinal chemistry, 39(10), 2040-2046 (1996-05-10)
Eighteen Se-substituted selenocysteine derivatives were synthesized as potential kidney selective prodrugs which can be activated by renal cysteine conjugate beta-lyase to selenium-containing chemoprotectants or antitumor agents. Selenocysteine derivatives with aliphatic and benzylic Se-substituents were synthesized by reducing selenocystine to selenocysteine
Jorge Moreda-Piñeiro et al.
Food research international (Ottawa, Ont.), 111, 621-630 (2018-07-17)
Fast, green, automated, highly efficient and accurate methodology for extracting selenium species in foods samples (Brazil nut, golden berries and heart of palm) harvested in seleniferous soils by using pressurized-assisted enzymatic hydrolysis (PAEH) and microwave-assisted enzymatic hydrolysis (MAEH) were optimized.
Erin E Battin et al.
Metallomics : integrated biometal science, 3(5), 503-512 (2011-02-03)
Copper and iron are two widely studied transition metals associated with hydroxyl radical (˙OH) generation, oxidative damage, and disease development. Because antioxidants ameliorate metal-mediated DNA damage, DNA gel electrophoresis assays were used to quantify the ability of ten selenium-containing compounds
F Moreno et al.
The Analyst, 135(10), 2700-2705 (2010-08-21)
The simultaneous speciation of elements is of great concern, especially in the study of the interactions of species in living organisms. Here we report a method based on the coupling of HPLC-ICP-MS that is capable of separating and analyzing different
Kristen R Hladun et al.
Environmental toxicology and chemistry, 32(11), 2584-2592 (2013-10-12)
Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because of the biotransfer of Se from plant products such as
Rui Gusmão et al.
The journal of physical chemistry. A, 116(25), 6526-6531 (2012-04-20)
The behavior of selenocystine (SeCyst) alone or in the presence of various metal ions (Bi(3+), Cd(2+), Co(2+), Cu(2+), Cr(3+), Ni(2+), Pb(2+), and Zn(2+)) was studied using differential pulse voltammetry (DPV) over a wide pH range. Voltammetric data matrices were analyzed
Thomas Hofer et al.
Biochemistry, 48(50), 12047-12057 (2009-11-10)
Antibody conjugates have broad utility in basic, preclinical, and clinical applications. Conventional antibody conjugation through the amine group of lysine or the thiol group of cysteine residues yields heterogeneous products of undefined stoichiometry and considerable batch-to-batch variability. To preserve the
Scott E Afton et al.
Journal of experimental botany, 60(4), 1289-1297 (2009-03-11)
Although many studies have investigated the metabolism of selenium and arsenic in hyperaccumulating plants for phytoremediation purposes, few have explored non-hyperaccumulating plants as a model for general contaminant exposure to plants. In addition, the result of simultaneous supplementation with selenium
Yingying Su et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 870(2), 216-221 (2008-07-01)
Active oxygen species from the photocatalytic reaction in aqueous solution react with luminol to emit strong chemiluminescence (CL), and this can be inhibited by the UV decomposed-products of selenocystine (SeCys) or selenomethionine (SeMet). Based on this phenomenon, a novel hyphenated
Tianfeng Chen et al.
Journal of agricultural and food chemistry, 56(22), 10574-10581 (2008-10-31)
Selenocystine (SeC) is a nutritionally available selenoamino acid with selective anticancer effects on a number of human cancer cell lines. The present study shows that SeC inhibited the proliferation of human breast adenocarcinoma MCF-7 cells in a time- and dose-dependent
Qin Liu et al.
Journal of inorganic biochemistry, 104(11), 1178-1184 (2010-08-14)
Platinum-based anticancer drugs such as cisplatin induce increased oxidative stress and oxidative damage of DNA and other cellular components, while selenium plays an important role in the antioxidant defense system. In this study, the interaction between a platinum(II) methionine (Met)
A Castañeda-Ovando et al.
Journal of dairy science, 102(8), 6781-6789 (2019-06-04)
Selenium is included in selenoprotein sequences, which participate in enzymatic processes necessary to preserve optimal health. Some lactic acid bacteria carry out the biotransformation of inorganic selenium in their metabolism. The complete biochemical mechanism of selenium biotransformation is still unknown;
Spela Mechora et al.
Chemosphere, 84(11), 1636-1641 (2011-06-28)
The uptake of Se (VI) by two aquatic plants, Myriophyllum spicatum L. and Ceratophyllum demersum L., and its effects on their physiological characteristics have been studied. Plants were cultivated outdoors under semi-controlled conditions and in two concentrations of Na selenate
Nasir Baig Rashid Baig et al.
The Journal of organic chemistry, 75(9), 2910-2921 (2010-04-16)
A variety of N-alkyl-beta-aminodiselenides have been synthesized in high yield from sulfamidates under mild reaction conditions using potassium selenocyanate and benzyltriethylammonium tetrathiomolybdate ([BnNEt(3)](2)MoS(4)) in a sequential, one-pot, multistep reaction. The tolerance of multifarious protecting groups under the reaction conditions is
B Santhosh Kumar et al.
Radiation and environmental biophysics, 48(4), 379-384 (2009-09-17)
Organoselenium compounds belonging to the class of monoselenides, such as selenomethionine (SeM) and methylselenocysteine (MSeCys) and diselenides including selenocystine (SeCys) and selenopropionic acid (SePA), were examined for their comparative radioprotective effects using in vitro models. Effects of these compounds on
Yan Bai et al.
Colloids and surfaces. B, Biointerfaces, 74(1), 150-153 (2009-08-12)
Electrochemical oxidation of selenocystine (SeCys) and selenomethionine (SeMet), on a gold electrode was studied by cyclic voltammetry (CV), rotating disk electrode technique (RDE) and chronocoulometry (CC). In 0.2 mol/L HAc-NaAc (pH=3.90) supporting electrolyte, anodic peak I potential of SeCys and
Eric D Franz et al.
Environmental toxicology and chemistry, 30(10), 2292-2299 (2011-07-19)
The objective of the present study was to describe the uptake and elimination kinetics of selenium (Se) administered in the forms of selenate, selenite, and selenomethionine (seleno-DL-methionine) in different life stages of the midge Chironomus dilutus, and to determine the
Yoshito Kawasaki et al.
Journal of chromatography. A, 1160(1-2), 246-253 (2007-06-08)
The advanced Marfey's method consists of a chromatography technique for the separation of amino acids into each enantiomer by derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-leucinamide (L-FDLA), and a detection method using liquid chromatography/mass spectrometry (LC/MS) which can determine the non-empirically the absolute configuration
Adam P Lothrop et al.
Biochemistry, 48(26), 6213-6223 (2009-04-16)
Mammalian thioredoxin reductase (TR) contains a rare selenocysteine (Sec) residue in a conserved redox-active tetrapeptide of sequence Gly-Cys(1)-Sec(2)-Gly. The high chemical reactivity of the Sec residue is thought to confer broad substrate specificity to the enzyme. In addition to utilizing
1/2