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H Uenishi et al.
Cytogenetics and cell genetics, 93(1-2), 65-72 (2001-07-28)
Interleukin 7 (IL7) is a cytokine that has many immunological functions, including regulation of hematopoiesis and peripheral lymphocytes. cDNA and a genomic DNA segment containing the porcine IL7 gene were isolated and sequenced, showing that porcine IL7 consists of 176
Chemoselective peptide functionalization of starPEG-GAG hydrogels
MV Tsurkan, et al.
Bioconjugate Chemistry, 25, 1942-1950 (2014)
Eduardo Pérez Del Río et al.
Biomaterials, 259, 120313-120313 (2020-08-24)
Recent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, there are still many limitations. For example, these T cells are
Synthesis and investigation of a radioiodinated F3 peptide analog as a SPECT tumor imaging radioligand
MS Bhojani, et al.
PLoS ONE, 6, e22418-e22418 (2011)
Fangbing Qi et al.
International journal of biological macromolecules, 131, 896-904 (2019-03-28)
Staphylokinase (SAK) is a bacterial protein with profibrinolytic activity. However, SAK suffers from short serum half-life and high immunogenicity. PEGylation with high Mw (20 kDa or 40 kDa) could decrease the immunogenicity and prolong the serum half-life of the proteins. However, the
Libin Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 103, 36-46 (2017-03-03)
The aim of this study was to develop a new class of antibody-drug conjugates (ADCs) with the potential to not only enhance treatment efficacy but also improve tolerability for patients with B-cell lymphomas. Classic ADCs consist of monoclonal antibodies (mAbs)
Tamara G Dacoba et al.
ACS nano, 13(5), 4947-4959 (2019-04-10)
The development of an effective HIV vaccine continues to be a major health challenge since, so far, only the RV144 trial has demonstrated a modest clinical efficacy. Recently, the targeting of the 12 highly conserved protease cleavage sites (PCS1-12) has
Di-heterometalation of thiol-functionalized peptide nucleic acids
T Joshi, et al.
Artificial DNA, PNA & XNA, 4, 11-18 (2013)
Synthesis, characterization, and directional binding of anisotropic biohybrid microparticles for multiplexed biosensing
Jung C W, et al.
Macromolecular Rapid Communications, 35(1), 56-65 (2014)
Carmen Teijeiro-Valiño et al.
Journal of controlled release : official journal of the Controlled Release Society, 294, 154-164 (2018-12-12)
So far, the success of anticancer nanomedicines has been moderate due to their lack of adequate targeting properties and/or to their difficulties for penetrating tumors. Here we report a multifunctional drug nanocarrier consisting of hyaluronic acid nanocapsules conjugated with the
Surasa Nagachinta et al.
Colloids and surfaces. B, Biointerfaces, 188, 110793-110793 (2020-01-27)
Organic nanoparticles made out of biodegradable and biocompatible materials have attracted increased attention in the therapeutic and diagnostic fields. In this study, we attempted to explore a new radiolabelling chelating free strategy for biodegradable sphingomyelin nanometric emulsions with fluorine-18 (18F)
Ying Ren et al.
Materials science & engineering. C, Materials for biological applications, 108, 110276-110276 (2020-01-12)
We have successfully designed and synthesized a biomimetic hydrogel system with maleimide-modified hyaluronic acid (HA) as the backbone and conjugated it to the collagen mimetic peptide (GPO)8-CG-RGDS. The matrix metalloproteinase (MMP)-sensitive peptide GCRDGPQGI↓WGQDRCG was the cross-linker. HA has high biocompatibility
Qing Zhou et al.
Theranostics, 7(7), 1806-1819 (2017-06-24)
Poly(β-L-malic acid) (PMLA), a natural aliphatic polyester, has been proven to be a promising carrier for anti-cancer drugs. In spite of excellent bio-compatibility, the application of PMLA as the drug carrier for cancer therapy is limited by its low cellular
Jeong Yi Kang et al.
Journal of materials chemistry. B, 9(2), 464-470 (2020-12-09)
The endoplasmic reticulum (ER) apparatus is a part of the secretory pathway that transports proteins to the plasma membrane through vesicle trafficking, enabling post-translational modification of the newly synthesized proteins. Several diseases such as inflammation, neurodegenerative disorder, and bipolar disorder
Synthesis and investigation of a radioiodinated F3 peptide analog as a SPECT tumor imaging radioligand
Bhojani M S, et al.
PLoS ONE, 6(7), e22418-e22418 (2011)
Yu-Wen Lo et al.
Acta biomaterialia, 86, 280-290 (2019-01-08)
Recently, novel approaches for the delivery of therapeutic antibodies have attracted much attention, especially sustained release formulations. However, sustained release formulations capable of carrying a high antibody load remain a challenge for practical use. In this study, a novel injectable
High resolution bioprinting of multi-component hydrogels
R Zimmermann, et al.
Biofabrication, 11, 045008-045008 (2019)
Wenxi Zhou et al.
Biomaterials, 268, 120546-120546 (2020-12-01)
Immunotherapy has gained increasing focus in treating pancreatic ductal adenocarcinoma (PDAC), since conventional therapies like chemotherapy could not provide satisfactory improvement in overall survival outcome of PDAC patients. However, it is still not the game changing solution due to the
Hang T Ta et al.
Nanoscale, 10(31), 15103-15115 (2018-07-31)
The early detection and accurate characterization of life-threatening diseases such as cardiovascular disease and cancer are critical to the design of treatment. Knowing whether or not a thrombus in a blood vessel is new (fresh) or old (constituted) is very
Keunpoong Lim et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 140, 294-299 (2018-08-12)
In the process of developing [18F]FBEM coupled target peptide, we have instituted a robust automated synthesis of [18F]FBEM, a sulfhydryl (-SH) site specific agent for radiolabeling of peptides and proteins. The radiosynthesis generated 1.67-3.89 GBq (45.1-105.1 mCi, 7.5-18.8% non-decay corrected yield)
Poly (2-alkyl-2-oxazoline)-Heparin Hydrogels?Expanding the Physicochemical Parameter Space of Biohybrid Materials
D Hahn, et al.
Advanced Healthcare Materials, 10, 2101327-2101327 (2021)
Bowen Ren et al.
Journal of biomaterials science. Polymer edition, 29(11), 1344-1359 (2018-04-04)
For practical adipose regeneration, the challenge is to dynamically deliver the key adipogenic insulin-like growth factors in hydrogels to induce adipogenesis. In order to achieve dynamic release, smart hydrogels to sense the change in the blood glucose concentration is required
Di-heterometalation of thiol-functionalized peptide nucleic acids
Joshi T, et al.
Artificial DNA, PNA & XNA, 4(1), 11-18 (2013)
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