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Koji Tsuta et al.
Pathology, research and practice, 208(8), 470-474 (2012-07-10)
The majority of neuroendocrine carcinomas (NECs) express somatostatin (SST) receptors (SSTRs). However, the expression of all 5 SSTR subtypes in pulmonary NECs has not been reported. We performed immunohistochemical analysis of all 5 SSTR subtypes (including the SSTR2A and 2B
S F Witchel et al.
Fertility and sterility, 75(4), 724-730 (2001-04-05)
To identify genetic markers associated with premature pubarche in children and hyperandrogenism in adolescent girls. Association study. Academic research environment. Forty children with premature pubarche (PP), 29 adolescent girls with hyperandrogenism (HA), and 15 healthy control women. None. Genetic variations
Masanori Hatasa et al.
Circulation journal : official journal of the Japanese Circulation Society, 83(4), 783-792 (2019-03-01)
Changes in the plasma adenosine concentration and the effects on left ventricular (LV) function and remodeling in patients with acute myocardial infarction (AMI) remain unclear. Methods and Results: In 58 patients with AMI and 14 subjects without cardiac disease (controls), we measured
T Skaaby et al.
The British journal of dermatology, 171(6), 1407-1414 (2014-03-19)
Loss-of-function mutations in the filaggrin gene (FLG) could have opposing effects on cancer risk, as mutations are associated with both 10% higher serum vitamin D levels, which may protect against cancer, and with impaired skin barrier function, which may lead
Kirsten Hülskötter et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose tamoxifen application on Theiler's murine encephalomyelitis
Bharat Rekhi et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 126(1), 45-55 (2017-12-22)
Clear cell carcinoma (CCC) of the ovary is an uncommon, but an aggressive epithelial ovarian cancer (EOC), which has overlapping histopathologic features with other ovarian tumours. Lately, Napsin A has been identified as its useful diagnostic immunohistochemical (IHC) marker. Fifty-eight
Vicente Bodi et al.
Thrombosis research, 124(6), e56-e61 (2009-08-12)
The role of the angiotensin converting enzyme (ACE) gene on the result of thrombolysis at the microvascular level has not been addressed so far. We analyzed the implications of the insertion/deletion (I/D) polymorphism of the ACE gene on the presence
Zhenwu Lin et al.
Physiological genomics, 11(3), 235-243 (2002-12-05)
Random allele expression has recently been observed for several genes including interleukins and genes of the lymphoid system. We studied the hypothesis that the surfactant protein D (SP-D) gene, an innate host defense molecule, exhibits random allele expression in a
J Kraan et al.
British journal of cancer, 111(1), 149-156 (2014-06-04)
Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. CEC measured in patients with advanced cancer are thought not only to derive from damaged normal vasculature (n-CEC), but also from damaged (t-CEC). Therefore, assays that allow the discrimination
Amy C Degnim et al.
Annals of surgery, 258(2), 240-247 (2013-03-23)
To determine whether bacterial colonization of drains can be reduced by local antiseptic interventions. Drains are a potential source of bacterial entry into surgical wounds and may contribute to surgical site infection after breast surgery. After institutional review board approval
Martha María Juárez-Rodríguez et al.
Frontiers in cellular and infection microbiology, 10, 597517-597517 (2021-02-16)
Blocking virulence is a promising alternative to counteract Pseudomonas aeruginosa infections. In this regard, the phenomenon of cell-cell communication by quorum sensing (QS) is an important anti-virulence target. In this field, fatty acids (FA) have gained notoriety for their role
Jens Christian Laursen et al.
EClinicalMedicine, 37, 100895-100895 (2021-08-14)
Inhibitors of the sodium-glucose cotransporter 2 (SGLT2) slow the progression of diabetic kidney disease, possibly by reducing the proximal tubule transport workload with subsequent improvement of renal oxygenation. We aimed to test this hypothesis in individuals with type 1 diabetes
James C Barton et al.
European journal of haematology, 85(5), 439-447 (2010-08-21)
Human leukocyte antigen (HLA) haplotypes may influence iron phenotypes in patients with HFE hemochromatosis and could affect survival. We tabulated general characteristics of HLA-A and -B types and haplotypes of HFE C282Y/C282Y probands diagnosed in medical care and analyzed these
David Cunningham et al.
Lancet (London, England), 381(9880), 1817-1826 (2013-04-26)
Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell lymphoma compared with CHOP every 3 weeks. We investigated whether this survival benefit
Márcia Seiscento et al.
Respirology (Carlton, Vic.), 12(5), 660-663 (2007-09-19)
To clarify the influence of transforming growth factor beta-1 (TGF-beta(1)) in the development of pleural thickening in tuberculosis (TB), the levels of TGF-beta(1) in pleural fluid and in serum of patients with pleural TB and transudative effusions were determined. TGF-beta(1)
R S Kookana et al.
Chemosphere, 107, 360-365 (2014-01-28)
We examined the impact of triclosan (TCS) and triclocarban (TCC) antimicrobial compounds on the biomineralisation of glucose and cadusafos pesticide in three Australian soils. Mineralisations of radiolabelled ((14)C) compounds were measured over a period of up to 77 d in
Rute A Tomaz et al.
Clinical endocrinology, 77(6), 926-933 (2012-08-14)
FOXE1 is a transcription factor required for thyroid differentiation and function. FOXE1 locus polymorphisms (chromosome 9q22.33) were recently associated with increased sporadic thyroid cancer risk. In this study, we aimed to investigate the association of FOXE1 variants with nonmedullary thyroid
Terzah M Horton et al.
British journal of haematology, 186(2), 274-285 (2019-04-09)
While survival in paediatric acute lymphoblastic leukaemia (ALL) is excellent, survival following relapse is poor. Previous studies suggest proteasome inhibition with chemotherapy improves relapse ALL response rates. This phase 2 Children's Oncology Group study tested the hypothesis that adding the
Evita B Henderson-Jackson et al.
Anticancer research, 31(9), 2957-2962 (2011-08-27)
Palladin is a metastasis-associated gene regulating cell motility. The expression of palladin protein in pancreatic neuroendocrine tumors (PET) and carcinomas (PECA) is not known. A tissue microarray (TMA) of well-differentiated (WD) PETs/PECAs (AJCC 2010) and non-neoplastic, histologically normal pancreatic tissue/islets
P Opfermann et al.
Clinical and experimental immunology, 180(1), 131-142 (2014-11-18)
Reparixin, a CXCR 1/2 antagonist, has been shown to mitigate ischaemia-reperfusion injury (IRI) in various organ systems in animals, but data in humans are scarce. The aim of this double-blinded, placebo-controlled pilot study was to evaluate the safety and efficacy
Malcolm A Lyons et al.
Physiological genomics, 17(2), 114-121 (2004-02-12)
To determine the genetic contribution to variation among lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) analyses on an intercross between mouse strains RIIIS/J and 129S1/SvImJ. Male mice of the parental strains and the reciprocal F1 and F2 populations
Feng-Cai Zhu et al.
Lancet (London, England), 381(9882), 2024-2032 (2013-06-04)
A vaccine for enterovirus 71 (EV71) is needed to address the high burden of disease associated with infection. We assessed the efficacy, safety, immunogenicity, antibody persistence, and immunological correlates of an inactivated alum-adjuvant EV71 vaccine. We did a randomised, double-blind
Naoki Ishimori et al.
Journal of lipid research, 45(9), 1624-1632 (2004-06-24)
The plasma lipid concentrations and obesity of C57BL/6J (B6) and 129S1/SvImJ (129) inbred mouse strains fed a high-fat diet containing 15% dairy fat, 1% cholesterol, and 0.5% cholic acid differ markedly. To identify the loci controlling these traits, we conducted
N Appleby et al.
Transfusion medicine (Oxford, England), 27(1), 66-71 (2016-10-08)
Real-world studies of the emergency reversal of warfarin using 4-factor prothrombin complex concentrate (PCC) report unwarranted delays. The delay to receiving PCC was ≥ 8 h in 46·7% of patients with warfarin-associated bleeding (PWAB) treated with a variable PCC dosing
P Lemoine et al.
Pharmacopsychiatry, 24(5), 175-179 (1991-09-01)
The efficacy of antidepressants is well established in major depressions, especially those with melancholic features. However, some anxiolytics also appear to have antidepressant properties at least for outpatients. 118 outpatients (25 males, 93 females, age: 18-60) with major depression according
Cong Yu et al.
International journal of systematic and evolutionary microbiology, 64(Pt 4), 1278-1283 (2014-01-16)
A moderately halophilic bacterial strain, designated XH204(T), was isolated from deep-sea sediment core (45° 58' S 163° 11' W) of the South Pacific Gyre during the Integrated Ocean Drilling Program Expedition 329. The strain was Gram-stain-positive, rod-shaped, motile by peritrichous
Carol Beadling et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(21), 6821-6828 (2008-11-05)
We recently identified a KIT exon 11 mutation in an anorectal melanoma of a patient who had an excellent response to treatment with imatinib. To determine the frequency of KIT mutations across melanoma subtypes, we surveyed a large series of
T Kawarasaki et al.
Journal of animal science, 90(13), 4781-4787 (2012-07-26)
In the present study, we investigated the influence of exogenous estrogen on embryo survival after transfer into prepubertal gilts in which estrus had been induced. In the first experiment, estrus was induced in prepubertal gilts by the administration of 1,000
Thomas S Mir et al.
Pediatrics, 112(4), 896-899 (2003-10-03)
The purpose of the study was to examine the possible age dependency of plasma N-terminal pro atrial natriuretic peptide (N-ANP) and N-terminal pro brain natriuretic peptide (N-BNP) levels in healthy term neonates to establish normal ranges for the neonatal period.
Helena W Rodbard et al.
The lancet. Diabetes & endocrinology, 2(1), 30-37 (2014-03-14)
We compared stepwise addition of bolus insulin with a full basal-bolus regimen in patients with type 2 diabetes inadequately controlled on basal insulin plus oral antidiabetic drugs. The FullSTEP study was a phase 4, 32-week, randomised, open-label, two-arm, parallel-group, multinational
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