58-14-0

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Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy.

J M Li et al.

The American journal of physiology, 273(3 Pt 2), H1358-H1367 (1997-10-10)

We postulated that the cyclin-dependent kinase inhibitors p21 and p27 could regulate the alterations in growth potential of cardiomyocytes during left ventricular hypertrophy (LVH). LVH was induced in adult rat hearts by aortic constriction (AC) and was monitored at days

Effective analgesia with low-dose ketamine and reduced dose hydromorphone in ED patients with severe pain.

Terence L Ahern et al.

The American journal of emergency medicine, 31(5), 847-851 (2013-04-23)

We assessed the analgesic effect and feasibility of low-dose ketamine combined with a reduced dose of hydromorphone for emergency department (ED) patients with severe pain. This was a prospective observational study of adult patients with severe pain at an urban

Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age.

C Flohr et al.

The British journal of dermatology, 163(6), 1333-1336 (2010-12-09)

Filaggrin loss-of-function (FLG) mutations are associated with eczema and skin barrier impairment, but it is unclear whether skin barrier impairment precedes phenotypic eczema in FLG mutation carriers. To study the association between FLG mutations, skin barrier impairment and clinical eczema

LC-MS/MS method for the quantification of aldose reductase inhibitor-epalrestat and application to pharmacokinetic study.

Ramakrishna Nirogi et al.

Journal of pharmaceutical and biomedical analysis, 74, 227-234 (2012-12-19)

A simple and rapid LC-MS/MS method was developed and validated for the quantification of epalrestat, an aldose reductase inhibitor for the treatment of diabetic neuropathy. Following protein precipitation epalrestat and IS were eluted with 10mM ammonium acetate and acetonitrile using

Endoscopic submucosal dissection as minimally invasive treatment for superficial pharyngeal cancer: a phase II study (with video).

Noboru Hanaoka et al.

Gastrointestinal endoscopy, 82(6), 1002-1008 (2015-08-04)

Although endoscopic submucosal dissection (ESD) has been applied for superficial pharyngeal cancer, no prospective trials have been reported. To investigate the efficacy and safety of ESD for superficial pharyngeal cancer, we conducted a prospective phase II trial. Fifty-four patients with

Prevalence of JAK29V617F) mutation in intra-abdominal venous thrombosis.

Amarapurkar Deepak et al.

Tropical gastroenterology : official journal of the Digestive Diseases Foundation, 32(4), 279-284 (2012-06-16)

Myeloproliferative disorders (MPD) (like polycythemia vera, essential thrombocythemia and primary myelofibrosis) are responsible for 50% cases of Budd-Chiari syndrome (BCS) and 35% cases of portal venous thrombosis (PVT) in western series. A point mutation at Val617Phe of Janus kinase 2

BAP1 immunohistochemistry and p16 FISH to separate benign from malignant mesothelial proliferations.

Brandon S Sheffield et al.

The American journal of surgical pathology, 39(7), 977-982 (2015-01-31)

A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or malignant mesothelial proliferations. Loss of the p16 tumor suppressor (CDKN2A), through homozygous deletions of 9p21, is a good marker of mesotheliomas but lacks sensitivity. Recent reports

Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy.

Annamaria Ruzzo et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24(12), 1883-1891 (2006-04-20)

To investigate whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with advanced gastric cancer (AGC). Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.

N Bhala et al.

Lancet (London, England), 382(9894), 769-779 (2013-06-04)

The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. We aimed to provide such information

Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.

Bernard Nordlinger et al.

The Lancet. Oncology, 14(12), 1208-1215 (2013-10-15)

Previous results of the EORTC intergroup trial 40983 showed that perioperative chemotherapy with FOLFOX4 (folinic acid, fluorouracil, and oxaliplatin) increases progression-free survival (PFS) compared with surgery alone for patients with initially resectable liver metastases from colorectal cancer. Here we present

Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: a randomised, open-label, phase 2 study.

Akira Kawai et al.

The Lancet. Oncology, 16(4), 406-416 (2015-03-22)

Trabectedin binds to the minor groove of DNA and blocks DNA repair machinery. Preclinical data have shown that trabectedin also modulates the transcription of the oncogenic fusion proteins of translocation-related sarcomas. We aimed to assess the efficacy and safety of

Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.

Charlie Gourley et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(15), 2505-2511 (2010-04-22)

To compare the frequency of visceral relapse of BRCA1/2-deficient ovarian cancer to that of nonhereditary controls. All patients diagnosed in Scotland with epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC) and a germline BRCA1/2 mutation were identified. Those with

Effects of adrenocorticotropic hormone and flunixin meglumine on pregnancy retention in beef cows.

T W Geary

Journal of animal science, 90(1), 207-211 (2011-08-23)

Pregnancy loss in beef cattle after d 28 of gestation is variable, but it has been reported to be as great as 14% and has been related to transportation or handling stress. The primary objective of this study was to

Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.

Luanne L Peters et al.

Mammalian genome : official journal of the International Mammalian Genome Society, 16(10), 749-763 (2005-11-02)

A substantial genetic contribution to baseline peripheral blood counts has been established. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline white blood cell (WBC) count, platelet (Plt) count, and mean platelet

The effect of chlorinated paraffins on hepatic enzymes and thyroid hormones.

I Wyatt et al.

Toxicology, 77(1-2), 81-90 (1993-01-29)

Male rats and mice were administered chlorinated paraffins (CPs) by daily gavage in corn oil for 14 days. Chlorowax 500C (short chain CP with 58% chlorination), Cereclor 56L (short chain CP with 56% chlorination) and Chlorparaffin 40G (medium chain CP

The effect of desloratadine on patch test reactions in Chinese patients.

Xiao Jian Chen et al.

Asian Pacific journal of allergy and immunology, 30(3), 209-213 (2012-11-20)

Few data on the effect of antihistamines on patch test results in Chinese patients are currently available. To evaluate the effect of desloratadine on patch test reactions. Patients known to have at least one strongly positive (+ +) test with

A phase II study of 5-fluorouracil/L-leucovorin/oxaliplatin (mFOLFOX6) in Japanese patients with metastatic or unresectable small bowel adenocarcinoma.

Takahiro Horimatsu et al.

International journal of clinical oncology, 22(5), 905-912 (2017-05-26)

Several studies have suggested that chemotherapy prolonged survival in patients with metastatic or recurrent small bowel adenocarcinoma (SBA); however, there is still no standard chemotherapy regimen. Here, we evaluated the efficacy and safety of a 5-fluorouracil (5-FU)/L-leucovorin (l-LV)/oxaliplatin (mFOLFOX6) protocol

Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration.

Matthew Hoffmann et al.

Xenobiotica; the fate of foreign compounds in biological systems, 41(12), 1063-1075 (2011-08-24)

Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthritis. The pharmacokinetics and disposition of [(14)C]apremilast

Clostridium (Clostridioides) difficile shedding by polar bears (Ursus maritimus) in the Canadian Arctic.

J Scott Weese et al.

Anaerobe, 57, 35-38 (2019-03-19)

Clostridium (Clostridioides) difficile has been identified in humans and a wide range of animal species, but there has been little study of remote animal populations with limited human contact. The objective of this study was to determine the prevalence and

Lactase persistence/non-persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption.

Sunil Kumar et al.

Journal of gastroenterology and hepatology, 27(12), 1825-1830 (2012-09-20)

Lactase non-persistence is common in India. We evaluated: (i) frequency of lactase gene (C/T-13910 and G/A-22018) polymorphisms in irritable bowel syndrome (IBS) and healthy controls (HC), (ii) association between these polymorphisms and IBS-subtypes and symptoms. A total of 150 IBS

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

Benjamin Speich et al.

The Lancet. Infectious diseases, 15(3), 277-284 (2015-01-16)

Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy

Long-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial.

Raban V Jeger et al.

Lancet (London, England), 396(10261), 1504-1510 (2020-10-23)

In the treatment of de-novo coronary small vessel disease, drug-coated balloons (DCBs) are non-inferior to drug-eluting stents (DESs) regarding clinical outcome up to 12 months, but data beyond 1 year is sparse. We aimed to test the long-term efficacy and

Prevalence and quantification of contamination of knitted cotton outer gloves during hip and knee arthroplasty surgery.

Thorsten Wichmann et al.

Archives of orthopaedic and trauma surgery, 139(4), 451-459 (2018-11-09)

Knitted cotton outer gloves offer protection against surgical glove perforation and provide improved grip on instruments. These gloves absorb blood and other fluids during surgery, and may therefore also accumulate contaminating bacteria. To date, there is no published data on

Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists.

Trivendra Tripathi et al.

Pharmacological reports : PR, 62(5), 917-925 (2010-11-26)

The present study was designed to delineate the immunomodulatory role of histamine receptors (H1R and H2R) and their antibody generation in a rabbit model. Six groups containing 18 rabbits each received either vehicle (sterile distilled water, 1 ml/kg x b.i.d)

Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes.

Shareen Forbes et al.

Diabetologia, 58(6), 1300-1308 (2015-03-27)

Type 1 diabetes complicated by hypoglycaemia is prevalent in socioeconomically deprived populations. Islet transplantation is of proven efficacy in type 1 diabetes complicated by hypoglycaemia, but it is not known if nationally funded programmes reach the socioeconomically deprived. Our aim

Expression of multidrug resistance 1 and glutathione-S-transferase-Pi protein in nasopharyngeal carcinoma.

C L Chen et al.

Human pathology, 32(11), 1240-1244 (2001-12-01)

Radiotherapy is the modality of choice for the treatment of nasopharyngeal carcinoma (NPC). However, systemic chemotherapy has recently been found to play an increasing role in the treatment of advanced or metastatic disease. The status of drug resistance gene expression

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial.

Nikhil V Joshi et al.

Lancet (London, England), 383(9918), 705-713 (2013-11-15)

The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and high-risk atherosclerotic plaques

Prothrombotic inherited abnormalities other than factor V Leiden mutation do not play a role in venous thrombosis in inflammatory bowel disease.

C Guédon et al.

The American journal of gastroenterology, 96(5), 1448-1454 (2001-05-26)

Because the incidence of thromboembolism is increased in patients with inflammatory bowel disease, we attempted to assess the role of prothrombotic inherited coagulation abnormalities in the development of thrombosis. Four populations were compared: 15 patients with inflammatory bowel disease and

Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.

Andrew O M Wilkie et al.

Pediatrics, 126(2), e391-e400 (2010-07-21)

We describe the first cohort-based analysis of the impact of genetic disorders in craniosynostosis. We aimed to refine the understanding of prognoses and pathogenesis and to provide rational criteria for clinical genetic testing. We undertook targeted molecular genetic and cytogenetic

Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.

Loïc Guillevin et al.

The New England journal of medicine, 371(19), 1771-1780 (2014-11-06)

The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitides. However, even when patients receive maintenance treatment with azathioprine or methotrexate, the relapse rate remains high. Rituximab may help to maintain remission.

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