590088

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Conservative tryptophan mutants of the protein tyrosine phosphatase YopH exhibit impaired WPD-loop function and crystallize with divanadate esters in their active sites.

Gwendolyn Moise et al.

Biochemistry, 54(42), 6490-6500 (2015-10-08)

Catalysis in protein tyrosine phosphatases (PTPs) involves movement of a protein loop called the WPD loop that brings a conserved aspartic acid into the active site to function as a general acid. Mutation of the tryptophan in the WPD loop

Alterations in brain neurotrophic and glial factors following early age chronic methylphenidate and cocaine administration.

Yaarit Simchon-Tenenbaum et al.

Behavioural brain research, 282, 125-132 (2015-01-13)

Attention deficit hyperactivity disorder (ADHD) overdiagnosis and a pharmacological attempt to increase cognitive performance, are the major causes for the frequent (ab)use of psychostimulants in non-ADHD individuals. Methylphenidate is a non-addictive psychostimulant, although its mode of action resembles that of

BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.

Maja Genheden et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 972-984 (2015-01-23)

Although the MAP kinase-interacting kinases (MNKs) have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure. Here, we explore the involvement of the MNKs in brain-derived neurotrophic factor (BDNF)-stimulated protein synthesis in cortical

Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.

Izabella Solti et al.

PloS one, 10(6), e0129217-e0129217 (2015-06-09)

Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions. Peripheral T-cell function in the cuprizone model has already been explored; therefore, in the present study, we investigated, for the

Neurobehavioral and cytotoxic effects of vanadium during oligodendrocyte maturation: a protective role for erythropoietin.

Oluwaseun Mustapha et al.

Environmental toxicology and pharmacology, 38(1), 98-111 (2014-06-14)

Vanadium exposure has been known to lead to lipid peroxidation, demyelination and oligodendrocytes depletion. We investigated behaviour and glial reactions in juvenile mice after early neonatal exposure to vanadium, and examined the direct effects of vanadium in oligodendrocyte progenitor cultures

Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy.

So Woon Kim et al.

Autophagy, 15(2), 327-340 (2018-09-15)

MCOLN3/TRPML3 is a Ca2+-permeable cation channel that is expressed in multiple subcellular compartments with dynamic localization. Our previous studies suggest that upon macroautophagy/autophagy induction MCOLN3/TRPML3 is recruited and provides Ca2+ for the fusion process in autophagosome biogenesis. However, how intracellular

Synthesis of metal oxide nanorods using carbon nanotubes as templates.

Satishkumar B C, et al.

Journal of Materials Chemistry, 10(9), 2115-2119 (2000)

Active corrosion protection and corrosion sensing in chromate-free organic coatings.

Buchheit R G, et al.

Progress in Organic Coatings, 47(3-4), 47(3-474) (2003)

Microbial reduction and precipitation of vanadium by mesophilic and thermophilic methanogens.

Zhang J, et al.

Chemical Geology , 370, 29-39 (2014)

Lack of cyclophilin D protects against the development of acute lung injury in endotoxemia.

Fruzsina Fonai et al.

Biochimica et biophysica acta, 1852(12), 2563-2573 (2015-09-20)

Sepsis caused by LPS is characterized by an intense systemic inflammatory response affecting the lungs, causing acute lung injury (ALI). Dysfunction of mitochondria and the role of reactive oxygen (ROS) and nitrogen species produced by mitochondria have already been proposed

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