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P L Cheah et al.
The Malaysian journal of pathology, 41(2), 91-100 (2019-08-21)
Since 2014, the National Comprehensive Cancer Network (NCCN) has recommended that colorectal carcinoma (CRC) be universally tested for high microsatellite instability (MSI-H) which is present in 15% of such cancers. Fidelity of resultant microsatellites during DNA replication is contingent upon
P Henttu et al.
Biochemical and biophysical research communications, 160(2), 903-910 (1989-04-28)
We have isolated four cDNAs encoding the entire preproprotein of prostate specific antigen from human prostatic cDNA libraries. Comparison of the coding regions of prostate specific antigen with human pancreatic kallikrein (1-3) and human glandular kallikrein (4) showed 73%-84% nucleotide
K R Mitchell et al.
Molecular carcinogenesis, 32(2), 55-60 (2001-12-18)
Carcinogenic N-heterocyclic aromatic hydrocarbons are formed during the incomplete combustion of fossil fuels as well as cigarette smoke. N-Methyldibenzo[c,g]carbazole (NMeDBC) and 7H-dibenzo[c,g]carbazole (DBC) are members of this group. DBC induces mouse skin and liver tumors, whereas NMeDBC induces only mouse
P C Ho et al.
The pharmacogenomics journal, 3(6), 335-342 (2003-11-05)
The present study investigated the effect of cytochrome P450 2C9 (CYP2C9) genetic polymorphism on the biotransformation of valproic acid (VPA) to its hepatotoxic metabolite, 4-ene-VPA, and compared that to the formation of the inactive 4-OH-VPA and 5-OH-VPA. cDNA-expressed CYP2C9(*)2 and
Chu-Chung Chou et al.
Medical oncology (Northwood, London, England), 26(3), 322-326 (2008-11-18)
This study was aimed to test whether PIK3CA, BRAF and RAS are mutated in nasopharyngeal carcinomas (NPCs) and, if so, to further determine whether such mutations affect patients' survival. For this purpose, a total of 73 NPCs were subjected to
M Y M Ng et al.
Journal of medical genetics, 42(3), 235-239 (2005-03-04)
The FOXC2 gene on 16q24 is mutated in lymphoedema distichiasis (LD), in which varicose veins (VV) are a common feature. We hypothesised that this gene might be implicated in the development of VV in the normal population, therefore, after performing
Maoqing Dong et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(12), 5092-5105 (2012-09-12)
While it is evident that the carboxyl-terminal region of natural peptide ligands bind to the amino-terminal domain of class B GPCRs, how their biologically critical amino-terminal regions dock to the receptor is unclear. We utilize cysteine trapping to systematically explore
Shishir K Maithel et al.
Annals of surgical oncology, 18(9), 2699-2705 (2011-03-02)
Increased tumor expression of excision repair cross-complementing gene-1 (ERCC1) is associated with decreased survival in patients with various cancers. Its effect in pancreatic adenocarcinoma (PAC) is not defined. Ninety-five patients were selected from a prospective database of all patients (nxa0=xa0220)
Hisayuki Shigematsu et al.
International journal of cancer, 113(4), 600-604 (2004-10-09)
HIN-1 (high in normal-1) is a putative cytokine with growth inhibitory activities and is downregulated by aberrant methylation in breast cancers. We studied HIN-1 methylation status in many types of adult and pediatric malignancies and cell lines. We examined the
R A Atkinson et al.
Journal of molecular biology, 212(3), 541-552 (1990-04-05)
Kringle 4 is an autonomous structural and folding domain within the proenzyme plasminogen. Homologous domains are found throughout the blood clotting and fibrinolytic proteins. In this paper, we present the almost complete assignment of the 1H nuclear magnetic resonance (n.m.r.)
Guohui Wang et al.
Environmental pollution (Barking, Essex : 1987), 175, 110-116 (2013-02-02)
Isosteric heats (ΔH) of sorption/desorption of phenanthrene were determined for carbonaceous materials (Pahokee peat, lignite, and high-volatile bituminous coal) and two soils based on reported equilibrium sorption/desorption isotherms at four different temperatures (4, 20, 46 and 77 °C). In addition, ΔH
Dmitry A Turbin et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(1), 69-74 (2005-11-01)
The protein encoded by the MDM2 oncogene inhibits the function of p53, leading to increased cell growth, avoidance of apoptosis, tolerance of genetic instability, and resistance to chemotherapy. The present study was performed to evaluate the relationship between MDM2 protein
Fabian Rohner et al.
The Journal of nutrition, 137(3), 614-619 (2007-02-22)
Particle size is a determinant of iron (Fe) absorption from poorly soluble Fe compounds. Decreasing the particle size of metallic Fe and ferric pyrophosphate added to foods increases Fe absorption. The aim of this study was to develop and characterize
Charles J Weschler et al.
Environmental science & technology, 41(17), 6177-6184 (2007-10-17)
We have used multiple analytical methods to characterize the gas-phase products formed when ozone was added to cabin air during simulated 4-hour flights that were conducted in a reconstructed section of a B-767 aircraft containing human occupants. Two separate groups
Emilie Lalonde et al.
The Lancet. Oncology, 15(13), 1521-1532 (2014-12-03)
Clinical prognostic groupings for localised prostate cancers are imprecise, with 30-50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic
E M Dennison et al.
The Journal of clinical endocrinology and metabolism, 89(10), 4898-4903 (2004-10-09)
Epidemiological studies point to the importance of gene-environment interactions during early life as determinants of later osteoporosis and fracture. We examined associations between common single nucleotide polymorphisms in the human GH (GH1) gene and weight in infancy, adult bone mass
Elisabeth Richert et al.
Advances in medical sciences, 65(1), 71-77 (2020-01-10)
We examined the influence of retinal degeneration 8 (rd8) mutation of crumbs homolog 1 (CRB1) gene on age-related macular degeneration (AMD) phenotype in nuclear factor E2-related factor 2 knock out (NRF2-/-) mouse model. CRB1rd8 mutation genotype was determined by polymerase
Kasper Degn Gejl et al.
Medicine and science in sports and exercise, 46(3), 496-505 (2013-10-05)
The aim of the present study was to investigate the influence of muscle glycogen content on sarcoplasmic reticulum (SR) function and peak power output (Wpeak) in elite endurance athletes. Fourteen highly trained male triathletes (VO2max = 66.5 ± 1.3 mL
Limei Yang et al.
Thrombosis research, 125(4), e159-e166 (2009-11-28)
Warfarin is the most widely used oral anticoagulant. It has been suggested that anticoagulation effect of warfarin is significantly associated with the polymorphism of certain genes, including Cytochrome P450 complex subunit 2C9 (CYP2C9), Vitamin K Epoxide Reductase Complex Subunit 1
Robert S Ackatia-Armah et al.
The American journal of clinical nutrition, 101(3), 632-645 (2015-03-04)
Moderate acute malnutrition (MAM), defined as weight-for-length z score between -3 and -2 or midupper arm circumference between 11.5 and 12.5 cm, affects ∼33 million children aged <5 y worldwide. The objective was to compare the effects of 4 dietary
Romain Guièze et al.
American journal of hematology, 87(12), 1052-1056 (2012-08-23)
The choice of postremission therapy for acute myeloid leukemia (AML) patients is now based on the blasts' cytogenetic and molecular profile. However, the potential benefit of autologous hematopoietic stem cell transplantation (auto-HSCT) according to the NPM1/FLT3-ITD status has been poorly
Yan Beauverd et al.
Platelets, 26(7), 632-637 (2014-10-03)
Thrombocytopenia is frequent in hospitalized patients, and heparin-induced thrombocytopenia (HIT) is often suspected when a decrease in platelet count is concomitant with heparin treatment. ELISA tests used for anti-PF4/heparin antibodies detection usually have high sensitivity but only fair specificity for
Carolien Doorenbos et al.
Genetics, 179(1), 693-699 (2008-05-22)
We investigated the effect of apolipoprotein E (Apoe) on albuminuria in the males of two independent F2 intercrosses between C57BL/6J and A/J mice, using wild-type inbred strains in the first cross and B6-Apoe(-/-) animals in the second cross. In the
Carmine Morisco et al.
Cardiovascular research, 78(1), 36-44 (2008-01-16)
Cardiac hypertrophy by activation of the beta-adrenergic receptor (beta AR) is mediated more efficiently by the beta1-AR than by the beta2-AR. We investigated the signalling mechanism by which the beta1-AR mediates cardiac hypertrophy. Experiments were performed in cultured neonatal rat
M O McCarron et al.
Archives of neurology, 57(10), 1480-1484 (2000-10-13)
The apolipoprotein E (APOE) epsilon 4 allele is a marker of adverse outcome following head injury and intracerebral hemorrhage. Transgenic animal data in a focal cerebral ischemia model suggest that the epsilon 4 allele increases infarct size and functional impairment.
Peter R W Gowler et al.
Pain, 161(1), 61-73 (2019-09-04)
Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evidence also supports a peripheral role of BDNF in osteoarthritis
P J Ho et al.
Clinical endocrinology, 46(3), 333-342 (1997-03-01)
Insulin-like growth factor-binding protein (IGFBP)-2 is a major prostatic IGFBP and may be involved in regulating prostate growth. Patients with prostate carcinoma (PC) have elevated serum IGFBP-2 levels which correlate with the specific PC marker, prostate-specific antigen (PSA). The aims
J-B Delhorme et al.
The British journal of surgery, 105(6), 668-676 (2018-02-08)
The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic
Salama A Salama et al.
Journal of the Society for Gynecologic Investigation, 13(8), 542-550 (2006-11-08)
The current study sought to investigate the effect of the estrogen metabolite 2-methoxyestradiol (2-MeOHE(2)) on apoptosis, cell proliferation, and collagen synthesis in human and rat leiomyoma cells. [(3)H] thymidine and [(3)H] proline incorporation studies were conducted. The expression of vascular
Xiaokang Zhuo et al.
Genes, 9(10) (2018-10-17)
NAC transcription factors (TFs) participate in multiple biological processes, including biotic and abiotic stress responses, signal transduction and development. Cold stress can adversely impact plant growth and development, thereby limiting agricultural productivity. Prunus mume, an excellent horticultural crop, is widely
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