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Xiaole Qi et al.
The Journal of pharmacy and pharmacology, 67(4), 493-500 (2014-12-17)
The aim of this study was to prepare a disintegrating gastric floating tablet composed of floating pellets coated with acrylic resin to prolong the gastric residence time and increase the oral bioavailability of famotidine. The gastric floating pellets containing famotidine
Judyta Cielecka-Piontek et al.
Pharmaceutical development and technology, 20(2), 146-152 (2013-11-14)
The kinetic and thermodynamic parameters of degradation of clavulanate potassium in the solid state were studied by using a reversed phase high performance liquid chromatography (RP-HPLC) method. The degradation of clavulanate potassium was a first-order reaction depending on the substrate
A Mühlstein et al.
Die Pharmazie, 69(7), 518-524 (2014-07-31)
Arylsulfatase A (ASA) deficiency is the cause of metachromatic leucodystrophy (MLD), a lysosomal storage disease associated with severe neurological disorders. Poly(butyl cyanoacrylate) (PBCA) nanoparticles overcoated with polysorbate 80 enabled the delivery of several drugs across the blood-brain barrier to the
Sharad Mangal et al.
International journal of pharmaceutics, 479(2), 338-348 (2015-01-13)
In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive excipient. The physico-chemical and bulk properties such as particle size, surface composition, surface energy and bulk cohesion of PVP-Leu was measured and compared
Stephen W Stein et al.
Molecular pharmaceutics, 12(9), 3455-3467 (2015-08-11)
A simulation model has been established to predict the residual aerodynamic particle size distribution (APSD) of dual-component pressurized metered dose inhalers (pMDIs). More specifically, this model estimates the APSD of pMDI formulations containing dissolved and suspended compounds for various formulations
Mina Ibrahim Tadros et al.
International journal of pharmaceutics, 472(1-2), 27-39 (2014-06-15)
The current work aimed to develop novel composite sponges of chitosan (CH)-chondroitin sulfate (CS) as a low-density gastroretentive delivery system for lornoxicam (LOR). This triple anti-inflammatory therapy-loaded matrices are expected to expand and float upon contact with gastric fluids for
Tamás Firkala et al.
Journal of pharmaceutical and biomedical analysis, 107, 318-324 (2015-02-01)
This paper reports the application of surface enhanced Raman chemical imaging (SER-CI) as a potentially non-destructive quantitative analytical method for the investigation of model pharmaceutical formulations containing the active pharmaceutical ingredient (API) in low concentrations (0.5-2%). The application of chemometric
Ali Kadivar et al.
PloS one, 10(6), e0126874-e0126874 (2015-06-04)
Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent administration to keep the plasma
Cecilia Arahí Prato et al.
STAR protocols, 1(3), 100204-100204 (2020-12-31)
Galectins are soluble lectins that participate in many physiological and pathological functions. Since they can act extracellularly, the use of the recombinant protein is a recurrent strategy for studying their biological functions. Here, we provide a general protocol for the
Trond Møretrø et al.
Canadian journal of microbiology, 61(7), 503-512 (2015-06-24)
In this study, coaggregation interactions between Rhodococcus and Acinetobacter strains isolated from food-processing surfaces were characterized. Rhodococcus sp. strain MF3727 formed intrageneric coaggregates with Rhodococcus sp. strain MF3803 and intergeneric coaggregates with 2 strains of Acinetobacter calcoaceticus (MF3293, MF3627). Stronger
Daniel Cavanagh et al.
Applied and environmental microbiology, 81(12), 3961-3972 (2015-04-05)
Lactococcus lactis is predominantly associated with dairy fermentations, but evidence suggests that the domesticated organism originated from a plant niche. L. lactis possesses an unusual taxonomic structure whereby strain phenotypes and genotypes often do not correlate, which in turn has
Amberlyn M Wands et al.
ACS infectious diseases, 4(5), 758-770 (2018-02-08)
Cholera toxin (CT) enters host intestinal epithelia cells, and its retrograde transport to the cytosol results in the massive loss of fluids and electrolytes associated with severe dehydration. To initiate this intoxication process, the B subunit of CT (CTB) first
Naser Tavakoli et al.
Journal of microencapsulation, 31(6), 529-534 (2014-04-05)
Repaglinide, an oral antidiabetic agent, has a rapid onset of action and short half-life of approximately 1 h. Designing a controlled release dosage form of the drug is required to maintain its therapeutic blood level and to eliminate its adverse effects
Fan Zhou et al.
Scientific reports, 1, 78-78 (2012-02-23)
The invisibility cloak has been a long-standing dream for many researchers over the decades. Using transformation optics, a three-dimensional (3D) object is perceived as having a reduced number of dimensions, making it "undetectable" judging from the scattered field12345. Despite successful
Jagdeep Shur et al.
The AAPS journal, 17(5), 1105-1116 (2015-05-10)
The focus of this investigation was to understand the design space to achieve comparable in vitro performance of two multi-unit dose dry powder inhalers (DPIs)—Flixotide® Accuhaler® (reference product) and MultiHaler® (test product). Flow field, pressure drop and particle trajectories within
Shuichi Nakamura et al.
Microbiology (Reading, England), 161(Pt 4), 701-707 (2015-01-13)
Many strains of lactic acid bacteria have been used for the production of probiotics. Some metabolites produced by lactic acid bacteria impair the motilities of pathogenic bacteria. Because bacterial motility is strongly associated with virulence, the metabolic activities of lactic
Hungyen Lin et al.
Journal of pharmaceutical sciences, 104(8), 2513-2522 (2015-06-04)
A novel in-line technique utilising pulsed terahertz radiation for direct measurement of the film coating thickness of individual tablets during the coating process was previously developed and demonstrated on a production-scale coater. Here, we use this technique to monitor the
Wesley Nyaigoti Omwoyo et al.
International journal of nanomedicine, 9, 3865-3874 (2014-08-22)
Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointestinal-related side
Miriam Pein et al.
Journal of pharmaceutical and biomedical analysis, 114, 321-329 (2015-06-24)
Electronic tongue technology based on arrays of cross-sensitive chemical sensors and chemometric data processing has attracted a lot of researchers' attention through the last years. Several so far reported applications dealing with pharmaceutical related tasks employed different e-tongue systems to
Sharvil S Patil et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 68, 43-50 (2014-12-03)
The current work was undertaken to assess suitability of liquid crystalline phase for engineering of lactose crystals and their utility as a carrier in dry powder inhalation formulations. Saturated lactose solution was poured in molten glyceryl monooleate which subsequently transformed
Separation behaviour of some isomeric organic compounds on sugars, sugar alcohols and their mixed phases by gas-liquid chromatography.
Ono, A.
Journal of Chromatography A, 197, 251-251 (1980)
Julie M Meek et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(7), 527-532 (2014-06-11)
Gabapentinoids are currently being used anecdotally for postoperative pain following photorefractive keratectomy (PRK) despite the lack of evidence. The purpose of this study is to evaluate the effectiveness of pregabalin in mitigating pain after PRK compared to the standard of
Saeed Shojaee et al.
Drug development and industrial pharmacy, 40(11), 1451-1458 (2013-08-22)
Polyethylene oxides (PEOs) are extensively used to control the release rate of drugs from matrices. Unfortunately, polyox polymers are prone to oxidation under high temperature and relative humidity. The aim of this study was to investigate the effect of sodium
Development of modified-release tablets of zolpidem tartrate by biphasic quick/slow delivery system.
Anjan Kumar Mahapatra et al.
AAPS PharmSciTech, 16(3), 579-588 (2014-11-14)
Zolpidem tartrate is a non-benzodiazepine analogue of imidazopyridine of sedative and hypnotic category. It has a short half-life with usual dosage regimen being 5 mg, two times a day, or 10 mg, once daily. The duration of action is considered
Justyna K Czarnocka et al.
International journal of pharmaceutics, 486(1-2), 167-174 (2015-03-23)
The use of naturally derived excipients to develop enteric coatings offers significant advantages over conventional synthetic polymers. Unlike synthetic polymers, they are biodegradable, relatively abundant, have no daily intake limits or restrictions on use for dietary and nutraceutical products. However
Akhtar Siddiqui et al.
International journal of pharmaceutics, 493(1-2), 1-6 (2015-07-26)
The objective of this study was to develop and validate XRPD analytical method for the estimation of percent crystalline warfarin sodium present in drug products. Warfarin sodium (WS) is a clathrate containing Isopropyl alcohol entrapped in the crystalline structure. Four
Zoltan Kovacs et al.
Talanta, 147, 598-608 (2015-11-26)
Online water quality monitoring technologies have been improving continuously. At the moment, water quality is defined by the respective range of few chosen parameters. However, this strategy requires sampling and it cannot provide evaluation of the entire water molecular system
Yasunori Iwao et al.
Chemical & pharmaceutical bulletin, 63(2), 95-101 (2015-03-10)
The manufacture of highly drug-loaded fine globular granules eventually applied for orally disintegrating tablets has been investigated using a unique multi-functional rotor processor with acetaminophen, which was used as a model drug substance. Experimental design and statistical analysis were used
Vasuki Ramachandran et al.
Molecular pharmaceutics, 12(1), 18-33 (2014-11-08)
The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes. This study aimed to investigate the functional relevance of synthonic modeling to the formulation of inhalation powders
Ira Soppela et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 879-885 (2014-09-02)
This paper introduces and discusses a photometric surface imaging approach for on-line monitoring of fluid bed granulation. Five granule batches consisting of paracetamol and varying amounts of lactose and microcrystalline cellulose were manufactured with an instrumented fluid bed granulator. Photometric
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