620-13-3

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Genotype-phenotype correlations in hereditary medullary thyroid carcinoma: oncological features and biochemical properties.

A Machens et al.

The Journal of clinical endocrinology and metabolism, 86(3), 1104-1109 (2001-03-10)

In hereditary medullary thyroid carcinoma (MTC), few genotype-phenotype correlations have been established. RET genotypes (exons 10, 11, 13, and 14) of 63 patients with hereditary MTC (from November 1994 to October 1999) were correlated with age at diagnosis, sex, the

Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses.

A M Riesewijk et al.

Genomics, 42(2), 236-244 (1997-06-01)

We have isolated the human PEG1/MEST gene and have investigated its imprinting status and parental-specific methylation. FISH mapping assigned the gene to chromosome 7q32, and homologous sequences were identified on the short arm of human chromosomes 3 and 5. Through

Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells.

C M Yang et al.

British journal of pharmacology, 111(1), 21-28 (1994-01-01)

1. Stimulation of bradykinin (BK) receptors coupled to phosphoinositide (PI) hydrolysis was investigated in canine cultured tracheal smooth muscle cells (TSMCs). BK, kallidin, and des-Arg9-BK, stimulated [3H]-inositol phosphates (IPs) accumulation in a dose-dependent manner with half-maximal responses (EC50) at 20

Qualitative and quantitative modifications of von Willebrand factor in patients with essential thrombocythemia and controlled platelet count.

S Lancellotti et al.

Journal of thrombosis and haemostasis : JTH, 13(7), 1226-1237 (2015-04-16)

Essential thrombocythemia (ET) is characterized by increased platelets and prevalent thrombosis. An acquired von Willebrand factor (VWF) disease has been hypothesized and inconsistently associated with extreme thrombocytosis or rare bleeding in ET. Whether VWF is modified in ET patients with controlled

EGFR and KRAS mutations in lung carcinomas in the Dutch population: increased EGFR mutation frequency in malignant pleural effusion of lung adenocarcinoma.

Alexander J J Smits et al.

Cellular oncology (Dordrecht), 35(3), 189-196 (2012-04-25)

Frequencies of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) have predominantly been determined in East Asian and North American populations, showing large differences between these populations. The aim of the present study was to determine the frequency

Triblock copolymers based on ε-caprolactone and trimethylene carbonate for the 3D printing of tissue engineering scaffolds.

Aysun Güney et al.

The International journal of artificial organs, 40(4), 176-184 (2017-02-07)

Biodegradable PCL-b-PTMC-b-PCL triblock copolymers based on trimethylene carbonate (TMC) and ε-caprolactone (CL) were prepared and used in the 3D printing of tissue engineering scaffolds. Triblock copolymers of various molecular weights containing equal amounts of TMC and CL were prepared. These

Impact of cytokine release syndrome on cardiac function following CD19 CAR-T cell therapy in children and young adults with hematological malignancies.

Haneen Shalabi et al.

Journal for immunotherapy of cancer, 8(2) (2020-09-05)

Chimeric antigen receptor (CAR) T-cell-associated cytokine release syndrome (CRS) may present with tachycardia, hemodynamic instability and reduced cardiac function. Pediatric CAR studies examining cardiac toxicity are limited. We report on cardiac toxicity observed in children and young adults with hematologic

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