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Alessandro R Zorzi et al.
International journal of molecular sciences, 16(11), 26813-26831 (2015-11-17)
Cell therapy is a promising approach to improve cartilage healing. Adipose tissue is an abundant and readily accessible cell source. Previous studies have demonstrated good cartilage repair results with adipose tissue mesenchymal stem cells in small animal experiments. This study
Marcy J Balunas et al.
Journal of natural products, 69(4), 700-703 (2006-04-29)
Natural product drug discovery efforts frequently utilize noncellular screening assays. Fatty acids are commonly found in natural product extracts, and some have been shown to interfere with noncellular assays. Several pure fatty acids were tested using a noncellular aromatase assay
K Subedi et al.
Breast cancer research and treatment, 149(1), 17-29 (2014-11-25)
The 20 and 22 carbon n-3 long-chain polyunsaturated fatty acids (LCPUFA) inhibit the growth of tumors in vitro and in animal models, but less is known about the 18 carbon n-3, stearidonic acid (SDA). This study aimed to establish and
Mehmet Hakan Ozdener et al.
Gastroenterology, 146(4), 995-1005 (2014-01-15)
It is important to increase our understanding of gustatory detection of dietary fat and its contribution to fat preference. We studied the roles of the fat taste receptors CD36 and GPR120 and their interactions via Ca(2+) signaling in fungiform taste
M A Zulet et al.
Journal of physiology and biochemistry, 61(3), 483-494 (2006-01-31)
Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA's) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA's implications on health, the
J Mark Brown et al.
The Journal of nutrition, 133(10), 3041-3046 (2003-10-02)
Conjugated linoleic acid (CLA) isomers, a group of positional and geometric isomers of linoleic acid [18:2(n-6)], have been studied extensively due to their ability to modulate cancer, atherosclerosis, obesity, immune function and diabetes in a variety of experimental models. The
Fengbin Song et al.
Journal of medicinal chemistry, 50(12), 2807-2817 (2007-05-16)
High-throughput screening of a subset of the J&J compound library containing the carboxylic acid functional group uncovered a bromophenyl derivative as a moderate potent GPR40 agonist. Chemical elaboration of this bromophenyl led to the discovery of a novel series of
David S Wishart et al.
Nucleic acids research, 37(Database issue), D603-D610 (2008-10-28)
The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the
Kevin L Fritsche
Prostaglandins, leukotrienes, and essential fatty acids, 79(3-5), 173-175 (2008-11-08)
Controversy exists over how much linoleic acid (LA) should be consumed in a healthy diet. Some claim that high LA intake promotes inflammation through accumulation of tissue arachidonic acid (AA) and subsequent production of pro-inflammatory lipid mediators. Here the author
Ying Yang et al.
Journal of colloid and interface science, 405, 312-321 (2013-06-19)
Vitamin E is an essential micronutrient for humans and animals due to its antioxidant and non-antioxidant biological activities. In this study, an emulsion titration assay was used to quantify the kinetics and extent of vitamin E and vitamin E acetate
Rui Chen et al.
Biomedical chromatography : BMC, 29(4), 604-611 (2014-09-17)
Ankylosing spondylitis (AS) is a common chronic inflammatory rheumatic disease. Early and accurate detection is essential for effective disease treatment. Recently, research has focused on genomics and proteomics. However, the associated metabolic variations, especially fatty acid profiles, have been poorly
Zheng Zheng et al.
Molecular medicine reports, 11(6), 4149-4157 (2015-02-13)
Omega‑3 and ‑6 polyunsaturated fatty acids (PUFAs) can directly or indirectly regulate immune homeostasis via inflammatory pathways, and components of these pathways are crucial targets of microRNAs (miRNAs). However, no study has examined the changes in the miRNA transcriptome during PUFA‑regulated
Saleh Abdelhamid et al.
American journal of hypertension, 16(7), 522-530 (2003-07-10)
The major aldosterone metabolite 3 alpha,5 beta tetrahydroaldosterone reflects up to 45% of the aldosterone secretion. Its 24-h urinary excretion is likely to provide an accurate index of the daily aldosterone production and to be an indicator for primary aldosteronism
Chelsea A Snyder et al.
Molecular and cellular endocrinology, 413, 228-235 (2015-07-15)
Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci. There is a programmed alteration in NCoR mRNA splicing during adipocyte differentiation from an NCoRω isoform, which contains three nuclear receptor interaction domains, to an NCoRδ
Liang Zou et al.
Journal of Asian natural products research, 17(8), 808-812 (2015-03-24)
The EtOH extract of the roots of Paeonia lactiflora afforded a new phenolic glycoside paenoside A (1) and a new monoterpene glycoside paeonin D (2), and five known monoterpene glycosides. Their structures were elucidated on the basis of spectroscopic means
Varsha S Thakoersing et al.
Experimental dermatology, 24(9), 669-674 (2015-05-06)
Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby
Masahiro Murakami et al.
Scientific reports, 5, 17035-17035 (2015-11-26)
An efficient targeting delivery technology is needed for functional oligonucleotides to exert their potential effect on the target gene without an adverse effect in vivo. Development of enteral delivery systems for nucleic acids is a major challenge because of their
G F Hoffmann et al.
Journal of inherited metabolic disease, 16(4), 648-669 (1993-01-01)
Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarboxylic acids from the brain is a major route for
Leland L Black et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4685-4698 (2015-10-16)
Apolipoprotein (Apo)A-I, the major lipid-binding protein of high-density lipoprotein, can prevent autoimmunity and suppress inflammation in hypercholesterolemic mice by attenuating lymphocyte cholesterol accumulation and removing tissue-oxidized lipids. However, whether ApoA-I mediates immune-suppressive or anti-inflammatory effects under normocholesterolemic conditions and the
Brahma Nand Singh et al.
PloS one, 9(9), e106937-e106937 (2014-09-05)
During the last several years, various chemical methods have been used for synthesis of a variety of metal nanoparticles. Most of these methods pose severe environmental problems and biological risks; therefore the present study reports a biological route for synthesis
Christopher Pekor et al.
Tissue engineering. Part C, Methods, 21(7), 705-715 (2015-01-07)
The development of functional engineered tissue constructs depends on high cell densities and appropriate vascularization. In this study we implemented a four-compartment three-dimensional perfusion bioreactor culture model for studying the effects of medium perfusion on endothelial, hepatic, and hematopoietic cell
Yue Zhang et al.
International journal of food microbiology, 215, 25-30 (2015-09-01)
The quality and microbiological safety of cantaloupes can potentially be improved using antimicrobial coatings that are able to maintain effectiveness throughout storage. The objective of this work was to study the effect of coating mixtures containing sodium alginate and cinnamon
"Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice"
Tsuboyama-Kasaoka N, et al.
Diabetes, 49(09), 1534-1542 (2000)
Guangling Jiao et al.
Marine drugs, 13(6), 3849-3876 (2015-06-23)
Northern shrimp (Pandalus borealis) oil, which is rich in omega-3 fatty acids, was recovered from the cooking water of shrimp processing facilities. The oil contains significant amounts of omega-3 fatty acids in triglyceride form, along with substantial long-chain monounsaturated fatty
Jiradej Manosroi et al.
Pharmaceutical biology, 53(6), 862-869 (2014-11-29)
Cleistocalyx nervosum (DC.) Kosterm. var. paniala (Roxb.) J. Parn. & Chantaran. (Myrtaceae) or Ma Kiang contains high amounts of phenolic compounds. Antioxidant activity of its fruit and seed has been investigated. However, limited available information concerning the biological activities of
Małgorzata Jelińska et al.
Biochimica et biophysica acta, 1842(11), 2230-2236 (2014-09-10)
Conjugated linoleic acid (CLA) is thought to exert anticarcinogenic, antiatherogenic, anti-inflammatory and weight loss effects. The impact on eicosanoid biosynthesis may be one of the mechanisms of its action. The aim of this study was to establish whether CLA mixture
Seon-Yeong Kwak et al.
Amino acids, 46(12), 2777-2785 (2014-09-15)
Caffeic acid (CA) is one of the antioxidants found in plants, which protects vascular cells against vascular injuries from oxidative stress. In our previous study, caffeoyl-prolyl-histidine amide (CA-L-Pro-L-His-NH2; CA-PH; a CA derivative) was synthesized, which exhibited a strong antioxidant activity
Norsuhaila Abdul Wahab et al.
Journal of the science of food and agriculture, 95(13), 2704-2711 (2014-11-21)
Diverse plants species in the forest remain under-utilised and they are mainly consumed only by local people. However, increasing issues in food security prompted the present study, which explores the nutritional and antioxidant aspects of Malaysian under-utilised vegetables. The studied
Michael Mouradian et al.
Molecular carcinogenesis, 54(9), 810-820 (2014-04-15)
Docosahexaenoic acid (DHA; C22:6n-3) depresses mammary carcinoma proliferation and growth in cell culture and in animal models. The current study explored the role of interrupting bioenergetic pathways in BT-474 and MDA-MB-231 breast cancer cell lines representing respiratory and glycolytic phenotypes
Shun Wang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 31(4), 623-632 (2008-07-18)
Abnormal fatty acid metabolism may play an important role in the pathogenesis of essential hypertension (EH). We compared fasting serum free fatty acid (FFA) composition between EH patients and nonhypertensive (NH) subjects, and examined the relationships between fasting serum FFA
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