63768

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Toxicological effect of MPA-CdSe QDs exposure on zebrafish embryo and larvae.

Wei Zhang et al.

Chemosphere, 89(1), 52-59 (2012-05-19)

Cadmium selenium (CdSe) quantum dots (QDs) are semiconductor nanocrystals that hold wide range of applications and substantial production volumes. Due to unique composition and nanoscale properties, their potential toxicity to aquatic organisms has increasingly gained a great amount of interest.

Assembly of streptolysin O pores assessed by quartz crystal microbalance and atomic force microscopy provides evidence for the formation of anchored but incomplete oligomers.

Sarah E Stewart et al.

Biochimica et biophysica acta, 1848(1 Pt A), 115-126 (2014-10-15)

Streptolysin O (SLO) is a bacterial pore forming protein that is part of the cholesterol dependent cytolysin (CDC) family. We have used quartz crystal microbalance with dissipation monitoring (QCM-D) to examine SLO membrane binding and pore formation. In this system

T. Bartok et al.

Journal of Liquid Chromatography, 17, 4391-4391 (1994)

Highly luminescent and biocompatible near-infrared core-shell CdSeTe/CdS/C quantum dots for probe labeling tumor cells.

Li He et al.

Talanta, 146, 209-215 (2015-12-24)

In this study, double shelled NIR CdSeTe/CdS/C quantum dots (QDs) were synthesized by a liquid phase method. The as-prepared QDs showed low cytotoxicity and good biocompatibility due to the formation of carbon shell. The imaging of targeted Human cervical carcinoma

Quantum dot-layer-encapsulated and phenyl-functionalized silica spheres for highly luminous, colour rendering, and stable white light-emitting diodes.

Hyein Yoo et al.

Nanoscale, 7(30), 12860-12867 (2015-07-15)

Although the quantum efficiencies of quantum dots (QDs) are approaching unity through advances in the synthesis of QD materials, their luminescence efficiencies after mixing with resin and thermal curing for white light-emitting diodes (LEDs) are seriously lowered because of aggregation

Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe.

Ricardo Q Aucélio et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 100, 155-160 (2012-05-18)

3MPA-CdTe QDs in aqueous dispersion was used as a fluorescent probe for the determination of lapachol, a natural naphthoquinone found in plants of the Bignoniaceae family genus Tabebuia. Working QDs dispersions (4.5×10(-8) mol L(-1) of QDs) was prepared in aqueous

Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.

Lucia García-Lara et al.

Journal of neuroscience research, 93(9), 1423-1433 (2015-05-28)

L-kynurenine (Kyn) is a key element of tryptophan metabolism; it is enzymatically converted by kynurenine aminotransferase II (KAT II) to kynurenic acid (KYNA), which acts as an antagonist to the NMDA receptor-glycine site. Kyn is also an endogenous ligand of

Photoreductive synthesis of water-soluble fluorescent metal nanoclusters.

Hui Zhang et al.

Chemical communications (Cambridge, England), 48(4), 567-569 (2012-01-19)

Water-soluble fluorescent copper, silver and gold nanoclusters with quantum yields of 2.2, 6.8 and 5.3%, respectively, are prepared by a robust photoreduction of their inorganic precursors in the presence of poly (methacrylic acid) functionalized with pentaerythritol tetrakis 3-mercaptopropionate.

Novel free-paclitaxel-loaded redox-responsive nanoparticles based on a disulfide-linked poly(ethylene glycol)-drug conjugate for intracellular drug delivery: synthesis, characterization, and antitumor activity in vitro and in vivo.

Xingxing Chuan et al.

Molecular pharmaceutics, 11(10), 3656-3670 (2014-09-11)

To address the obstacles facing cancer chemotherapeutics, including toxicity, side effects, water insolubility, and lack of tumor selectivity, a novel stimuli-responsive drug-delivery system was developed based on paclitaxel-loaded poly(ethylene glycol)-disulfide-paclitaxel conjugate nanoparticles (PEG-SS-PTX/PTX NPs). The formulation emphasizes several benefits, including

Synthesis of a carbon-dot-based photoluminescent probe for selective and ultrasensitive detection of Hg(2+) in water and living cells.

Sasmita Mohapatra et al.

The Analyst, 140(4), 1221-1228 (2014-12-30)

A nitrogen and sulphur co-doped carbon dot (NSCD) based highly selective photoluminescent probe for mercury detection has been designed. The NSCDs with a PL quantum yield of 69% are easily prepared from a single polymeric molecular precursor. The turn on-off

Label-free and direct detection of C-reactive protein using reduced graphene oxide-nanoparticle hybrid impedimetric sensor.

Ajay Kumar Yagati et al.

Bioelectrochemistry (Amsterdam, Netherlands), 107, 37-44 (2015-11-03)

For label-free and direct detection of C-reactive protein (CRP), an impedimetric sensor based on an indium tin oxide (ITO) electrode array functionalized with reduced graphene oxide-nanoparticle (rGO-NP) hybrid was fabricated and evaluated. Analytical measurements were performed to examine the properties

Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species.

Wei Wang et al.

Journal of neuroscience research, 90(6), 1218-1229 (2012-02-23)

Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. Our previous data showed that an apparent SR dimer resistant to sodium dodecyl sulfate

Self-illuminating quantum dots for highly sensitive in vivo real-time luminescent mapping of sentinel lymph nodes.

Qiang Wu et al.

International journal of nanomedicine, 7, 3433-3443 (2012-08-01)

Quantum dots (QDs) show promise as novel nanomaterials for sentinel lymph node (SLN) mapping through their use in noninvasive in vivo fluorescence imaging, and they have provided remarkable results. However, in vivo fluorescence imaging has limitations mainly reflected in the

Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).

Graham W Kay et al.

Neurochemistry international, 55(8), 783-788 (2009-08-12)

Anomalies in neuropeptides and neuroactive amino acids have been postulated to play a role in neurodegeneration in a variety of diseases including the inherited neuronal ceroid lipofuscinoses (NCLs, Batten disease). These are often indicated by concentration changes in cerebrospinal fluid

Cation-size-dependent DNA adsorption kinetics and packing density on gold nanoparticles: an opposite trend.

Biwu Liu et al.

Langmuir : the ACS journal of surfaces and colloids, 30(44), 13228-13234 (2014-10-21)

The property of DNA is strongly influenced by counterions. Packing a dense layer of DNA onto a gold nanoparticle (AuNP) generates an interesting colloidal system with many novel physical properties such as a sharp melting transition, protection of DNA against

Cerebellar fastigial nuclear GABAergic projections to the hypothalamus modulate immune function.

Bei-Bei Cao et al.

Brain, behavior, and immunity, 27(1), 80-90 (2012-10-11)

Our previous work has shown that the cerebellar fastigial nucleus (FN) is involved in modulation of lymphocyte function. Herein, we investigated effect of FN γ-aminobutyric acid (GABA)-ergic projections to the hypothalamus on lymphocytes to understand pathways and mechanisms underlying cerebellar

Direct evidence of active-site reduction and photodriven catalysis in sensitized hydrogenase assemblies.

Brandon L Greene et al.

Journal of the American Chemical Society, 134(27), 11108-11111 (2012-06-22)

We report photocatalytic H(2) production by hydrogenase (H(2)ase)-quantum dot (QD) hybrid assemblies. Quenching of the CdTe exciton emission was observed, consistent with electron transfer from the quantum dot to H(2)ase. GC analysis showed light-driven H(2) production in the presence of

Employing a recombinant strain of Advenella mimigardefordensis for biotechnical production of Homopolythioesters from 3,3'-dithiodipropionic acid.

Yongzhen Xia et al.

Applied and environmental microbiology, 78(9), 3286-3297 (2012-02-22)

Advenella mimigardefordensis strain DPN7(T) was genetically modified to produce poly(3-mercaptopropionic acid) (PMP) homopolymer by exploiting the recently unraveled process of 3,3'-dithiodipropionic acid (DTDP) catabolism. Production was achieved by systematically engineering the metabolism of this strain as follows: (i) deletion of

Electrochemical Determination of Uric Acid at CdTe Quantum Dot Modified Glassy Carbon Electrodes.

Deng Pan et al.

Journal of AOAC International, 98(5), 1260-1266 (2015-11-04)

Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical behavior of uric acid (UA) at a CdTe quantum dot (QD) modified the glassy carbon electrode (GCE). CdTe QDs, as new semiconductor nanocrystals, can greatly improve the peak

Evaluation of cytotoxicity of 3-mercaptopropionic acid-modified quantum dots on Medicago sativa cells and tissues.

Ana Raquel Santos et al.

Methods in molecular biology (Clifton, N.J.), 906, 435-449 (2012-07-14)

Like most of the new technologies designed to interact with biological systems, the applications of -nanomaterials needs a proper assessment for their potential impacts. It is only through addressing the issues raised by toxicological studies that nanotechnology will be able

An amplified electrochemical strategy using DNA-QDs dendrimer superstructure for the detection of thymine DNA glycosylase activity.

Hongying Liu et al.

Biosensors & bioelectronics, 71, 249-255 (2015-04-29)

A triple-signal amplification strategy was proposed for highly sensitive and selective detection of thymine DNA glycosylase (TDG) by coupling a dendrimer-like DNA label with the electrochemical method and quantum dots (QDs) tagging. The DNA-QDs dendrimer-like superstructure was designed by DNA

Oligodeoxynucleotide containing s-functionalized 2'-deoxy-6-thioguanosine: facile tools for base-selective and site-specific internal modification of RNA.

Shigeki Sasaki et al.

Current protocols in nucleic acid chemistry, Chapter 4, Unit 4-Unit 4 (2012-03-08)

Chemically modified oligonucleotides play a significant role for genomic research. Modified nucleosides, such as with a fluorescent dye, can be obtained by chemical synthesis. Site-specifically modified long nucleic acids are obtained by ligation of chemically modified short oligonucleotides with enzyme

Antiplatelet and antithrombotic activity of a fibrin(ogen)olytic protease from Bacillus cereus strain FF01.

Sourav Majumdar et al.

International journal of biological macromolecules, 79, 477-489 (2015-05-13)

Fibrin(ogen)olytic enzymes offer great promise for the treatment of thrombosis associated disorders. The present study describes the characterization of an extracellular fibrin(ogen)olytic serine protease (named Bacethrombase) purified from the Bacillus cereus strain FF01. The molecular mass of the Bacethrombase was

Poly(N-isopropylacrylamide-co-methacrylic acid) pH/thermo-responsive porous hydrogels as self-regulated drug delivery system.

Marieta Constantin et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 86-95 (2014-05-23)

A dual drug delivery system based on a "biosensor" (pH-sensitive unit) and a delivery component (thermosensitive hydrogel) was developed. The pH/thermosensitive hydrogel is able to restore the thermosensitive characteristics after electrostatic interaction of the pH-sensitive units with selected biologically active

Hydrothermal synthetic mercaptopropionic acid stabled CdTe quantum dots as fluorescent probes for detection of Ag⁺.

Ting-Ting Gan et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 62-68 (2012-10-09)

Mercaptopropionic acid (MPA) capped CdTe quantum dots (QDs) with particle size 3 nm have been successfully synthesized in aqueous medium by hydrothermal synthesis method. And the effects of different metal ions on MPA capped CdTe QDs fluorescence were studied using

Molecularly imprinted polymer based on MWCNT-QDs as fluorescent biomimetic sensor for specific recognition of target protein.

Zhaoqiang Ding et al.

Materials science & engineering. C, Materials for biological applications, 48, 469-479 (2015-01-13)

A novel molecularly imprinted optosensing material based on multi-walled carbon nanotube-quantum dots (MWCNT-QDs) has been designed and synthesized for its high selectivity, sensitivity and specificity in the recognition of a target protein bovine serum albumin (BSA). Molecularly imprinted polymer coated

A simple and visible colorimetric method through Zr(4+)-phosphate coordination for the assay of protein tyrosine phosphatase 1B and screening of its inhibitors.

Juan Zhang et al.

The Analyst, 140(16), 5716-5723 (2015-07-15)

Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors. The method is

Electrochemical impedance spectroscopy characterization of mercaptopropionic acid capped ZnS nanocrystal based bioelectrode for the detection of the cardiac biomarker--myoglobin.

Sujeet K Mishra et al.

Bioelectrochemistry (Amsterdam, Netherlands), 88, 118-126 (2012-08-28)

3-Mercaptopropionic acid (MPA) capped ZnS nanocrystals (ZnS(MPA)) are covalently attached to a self assembled monolayer (SAM) of 3-aminopropyltriethoxysilane (APTES) on an indium-tin-oxide (ITO) coated glass plate. The protein antibody, anti-myoglobin (Ab-Mb), is covalently linked to free carboxyl groups present on

Integration of CdSe/CdSexTe1-x Type-II Heterojunction Nanorods into Hierarchically Porous TiO2 Electrode for Efficient Solar Energy Conversion.

Sangheon Lee et al.

Scientific reports, 5, 17472-17472 (2015-12-08)

Semiconductor sensitized solar cells, a promising candidate for next-generation photovoltaics, have seen notable progress using 0-D quantum dots as light harvesting materials. Integration of higher-dimensional nanostructures and their multi-composition variants into sensitized solar cells is, however, still not fully investigated

Controls and constrains of the membrane disrupting action of Aurein 1.2.

Mahdi Shahmiri et al.

Scientific reports, 5, 16378-16378 (2015-11-18)

Aurein 1.2 is a 13 residue antimicrobial peptide secreted by the Australian tree frog Litoria Aurea. It is a surface-acting membrane disrupting peptide that permeabilizes bacterial membranes via the carpet mechanism; the molecular details of this process are mostly unknown.

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