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J F Gregory et al.
The Journal of nutrition, 130(12), 2949-2952 (2000-12-09)
Folate turnover involves urinary excretion, fecal excretion, and catabolism that involves cleavage of the C9-N10 bond to yield pterins and para-aminobenzoylglutamate (pABG). Little is known about the relationship between the function of folate pools and their rates of catabolism. We
Liu Yang et al.
Biotechnology letters, 25(14), 1195-1198 (2003-09-12)
In the enzymatic synthesis of cefaclor, 3-chloro-7-d-(2-phenylglycinamide)-3-cephem-4-carboxylic acid, from phenylglycine methyl ester and 7-aminodesacetoxymethyl-3-chlorocephalosporanic acid, the in situ product could influence both the overall conversion and hydrolysis of the ester. Optimization of the parameters, such as pH 6.2, 5 degrees
E K Tan et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 120B(1), 58-62 (2003-06-20)
Cigarette smoking is associated with reduced monoamine oxidase B (MAO B) activity. Polymorphisms of the MAO B gene may modify the relationship between smoking and Parkinson's Disease (PD). We examined the association of MAO B intron 13 G/A polymorphism and
Luana Paula Haubold Neis Veiga et al.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 21(2), 133-136 (2012-07-27)
With the objective of evaluating Rhipicephalus (Boophilus) microplus resistance to cipermetrina and amitraz, were collected engorged tick females from cattle on 20 farms on the Santa Catarina Plateau, in southern Brazil, between January of 2004 and May of 2006. Were
Farhad Ravandi et al.
Blood, 121(23), 4655-4662 (2013-04-25)
Patients received 5-azacytidine (AZA) 75 mg/m(2) intravenously daily for 7 days and sorafenib 400 mg orally twice daily continuously; cycles were repeated at ~1-month intervals. Forty-three acute myeloid leukemia (AML) patients with a median age of 64 years (range, 24-87
Rigobert Lapu-Bula et al.
Journal of the National Medical Association, 97(2), 197-205 (2005-02-17)
The 894T allele in exon 7 of the endothelial nitric oxide synthase (eNOS) gene has been inconsistently associated with hypertension in different racial groups. Because high-normal blood pressure (BP) confers an increased risk for the development of hypertension and other
Todd W Kelley et al.
American journal of clinical pathology, 128(6), 958-965 (2007-11-21)
We studied the prognostic importance of tumor-infiltrating regulatory T lymphocytes (Tregs) and cytotoxic T/NK lymphocytes (CTLs) in 98 diagnostic biopsy specimens from patients with classical Hodgkin lymphoma (cHL). Immunohistochemical analysis was performed for FOXP3 to identify Tregs and for granzyme
Y Miyagoe et al.
The Journal of biological chemistry, 269(11), 8268-8279 (1994-03-18)
We have explored the template and factor requirements for transcription of the gene encoding the murine complement component C4, expressed predominantly but not exclusively in liver and mononuclear phagocytes. Competition experiments in transcription assays with liver nuclear extracts show that
Ambar Kulshreshtha et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 24(2), 447-454 (2014-12-17)
We investigated the association between family history of stroke (FHS) and Life's Simple 7 (LS7), a public health metric defined by the American Heart Association. Reasons for Geographic and Racial Differences in Stroke is a national population-based cohort of 30,239
Anthony M Sammel et al.
Arthritis & rheumatology (Hoboken, N.J.), 71(8), 1319-1328 (2019-03-09)
Positron emission tomography/computed tomography (PET/CT) has not been well studied as a first-line test for giant cell arteritis (GCA), due, in part, to historical limitations in visualizing the cranial arteries. The Giant Cell Arteritis and PET Scan (GAPS) study was
Maryline Bonnet et al.
The Lancet. Infectious diseases, 13(4), 303-312 (2013-02-26)
In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at
Ardeshir Hakam et al.
Digestive diseases and sciences, 48(10), 1972-1978 (2003-11-25)
Aberrant c-Src protein kinase activation has been identified as one of the molecular alterations involved in human pancreatic carcinogenesis. It has been postulated that c-Src may induce transformation by causing the overexpression of the insulinlike growth factor-1 receptor (IGF-1R) in
Koichiro Hayashi et al.
American journal of hypertension, 20(6), 650-656 (2007-05-29)
Increased arterial stiffness is an independent risk factor for cardiovascular disease. The estrogen system (estrogen and estrogen receptor-alpha [ER-alpha]) has potent vasodilator and antiatherosclerotic activity in vascular tissue and therefore was implicated in the regulation of arterial stiffness. We hypothesized
Vittorio Montefusco et al.
British journal of haematology, 188(6), 907-917 (2020-01-04)
Bortezomib- and lenalidomide-containing regimens are well-established therapies in multiple myeloma (MM). However, despite their extensive use, head-to-head comparisons have never been performed. Therefore, we compared bortezomib and lenalidomide in fixed-duration therapies. In this open-label, phase III study, we randomized MM
Suzanne K Jadico et al.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 10(6), 521-527 (2006-12-26)
Apert syndrome, a disorder of craniosynostosis, syndactyly, and other craniofacial malformations, is caused by point mutations (Ser252Trp or Pro253Arg) in the fibroblast growth factor receptor 2 gene. This study's goal was to determine ophthalmic phenotype/genotype correlations in patients with either
Subhadeep Chakrabarti et al.
Journal of vascular research, 50(1), 21-34 (2012-10-26)
The sex hormone estradiol (E(2)) appears to mediate both anti-atherogenic and pro-inflammatory effects in premenopausal women, suggesting a complex immunomodulatory role. Tumor necrosis factor (TNF) is a key pro-inflammatory cytokine involved in the pathogenesis of atherosclerosis and other inflammatory diseases.
Subhadeep Chakrabarti et al.
Journal of vascular research, 50(1), 21-34 (2012-10-26)
The sex hormone estradiol (E(2)) appears to mediate both anti-atherogenic and pro-inflammatory effects in premenopausal women, suggesting a complex immunomodulatory role. Tumor necrosis factor (TNF) is a key pro-inflammatory cytokine involved in the pathogenesis of atherosclerosis and other inflammatory diseases.
H Ludovico-Martins et al.
Transplantation proceedings, 41(3), 862-865 (2009-04-21)
Capillary C4d deposition has been recognized as a marker of antibody-mediated rejection (AMR). Although the detection of capillary C4d by means of immunofluorescence (IF) in cryostat sections is well established, frozen tissue is not always available, thus limiting the diagnosis
Tilakavati Karupaiah et al.
Scientific reports, 9(1), 13666-13666 (2019-09-22)
We conducted this cross-sectional population study with a healthy multi-ethnic urban population (n = 577) in Malaysia, combining nutritional assessments with cardiometabolic biomarkers defined by lipid, atherogenic lipoproteins, inflammation and insulin resistance. We found diametrically opposing associations of carbohydrate (246·6 ± 57·7 g, 54·3 ± 6·5%-TEI) and
Barbara Piccini et al.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 104(5), 248-254 (2012-06-06)
celiac disease (CD) is an immune-mediated chronic inflammatory disease associated with HLA-DQ2 and DQ8 molecules. We evaluated the role of HLA in the CD diagnostic algorithm in order to contribute to the development of practical indications for the use of
Małgorzata Chalimoniuk et al.
Cellular and molecular neurobiology, 26(7-8), 1153-1166 (2006-06-17)
1. Phosphatidylinositol transfer proteins (PI-TP) are responsible for the transport of phosphatidylinositol (PI) and other phospholipids from endoplasmic reticulum to the other membranes and indirectly for lipid mediated signaling. Till now little is known about PI-TPs in brain aging and
Kenneth S Bode et al.
Journal of spinal disorders & techniques, 28(10), E590-E594 (2013-11-20)
Randomized trial. This study described practical magnetic resonance imaging (MRI) characteristics to assist in the identification of these tumors including the corresponding statistics. Identification of vascular spinal tumors using MRI allows the opportunity for angiography and preoperative embolization (PE) to
Hendrik Milting et al.
Cardiovascular research, 71(3), 496-505 (2006-06-14)
Mutations in the cardiac ryanodine receptor (RYR2) gene have been reported to cause arrhythmogenic right ventricular cardiomyopathy (ARVC). The molecular mechanisms by which genetic modifications lead to ARVC are still not well understood. ARVC patients were screened for mutations in
J L Blackshear et al.
Journal of thrombosis and haemostasis : JTH, 12(12), 1966-1974 (2014-09-25)
Mitral valve regurgitation is associated with an acquired hemostatic defect. We sought to assess the prevalence and severity of acquired von Willebrand syndrome in patients with native valve mitral regurgitation (MR). Fifty-three patients were prospectively observed with bleeding questionnaires and
Suman Dwivedi et al.
Journal of translational medicine, 8, 128-128 (2010-12-08)
Platelet activation requires rapid remodeling of the actin cytoskeleton which is regulated by small GTP-binding proteins. By using the Rac1-specific inhibitor NSC23766, we have recently found that Rac1 is a central component of a signaling pathway that regulates dephosphorylation and
Claudia Langebrake et al.
Haematologica, 91(11), 1473-1480 (2006-10-18)
Myeloid leukemia of Down's syndrome (ML-DS) has characteristic biological features (e.g. expression of the truncated GATA1s), which are different from those of non-DS childhood acute myeloid leukemias (AML). The objective of this study was to investigate factors predisposing to the
William B Mathews et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(9), 1529-1536 (2008-08-16)
The endothelin subtype-A (ETA) receptor is a member of a family of G-protein-coupled receptors that plays a central role in vasoconstriction, cell proliferation, and hormone production. The aim of this study was to synthesize and evaluate in vivo (11)C- and
Yuriko Uehara et al.
PloS one, 10(6), e0128066-e0128066 (2015-06-05)
Ovarian clear cell carcinoma (CCC) is generally associated with chemoresistance and poor clinical outcome, even with early diagnosis; whereas high-grade serous carcinomas (SCs) and endometrioid carcinomas (ECs) are commonly chemosensitive at advanced stages. Although an integrated genomic analysis of SC
J Horton
Parasitology, 121 Suppl, S113-S132 (2001-06-02)
This comprehensive review briefly describes the history and pharmacology of albendazole as an anthelminthic drug and presents detailed summaries of the efficacy and safety of albendazole's use as an anthelminthic in humans. Cure rates and 0% egg reduction rates are
Improved transplant survival and long-term disease outcome in children with MHC class II deficiency.
Su Han Lum et al.
Blood, 135(12), 954-973 (2020-01-15)
MHC class II deficiency is a rare, but life-threatening, primary combined immunodeficiency. Hematopoietic cell transplantation (HCT) remains the only curative treatment for this condition, but transplant survival in the previously published result was poor. We analyzed the outcome of 25
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