CN
Search Within
67414
应用筛选条件
关键词:'67414'
显示 31-60 共 590 条结果 关于 "67414" 范围 论文
L N Munsie et al.
Human molecular genetics, 24(6), 1691-1703 (2014-11-25)
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosomal protein sorting and intracellular trafficking. We recently linked a mutation in VPS35 (p.D620N) to familial parkinsonism. Here, we characterize human VPS35 and retromer function
Omesha Perera et al.
Cancer letters, 361(1), 104-111 (2015-03-10)
Trefoil factor 3 (TFF3) is a secreted protein which functions in mucosal repair of the gastrointestinal tract. This is achieved through the combined stimulation of cell migration and prevention of apoptosis and anoikis, thus facilitating repair. Deregulated TFF3 expression at
Nathalie Kersual et al.
mAbs, 6(5), 1314-1326 (2014-12-18)
Ovarian cancer has the highest mortality rate among gynecologic malignancies. The monoclonal antibody 12G4 specifically recognizes the human Müllerian inhibiting substance type II receptor (MISRII) that is strongly expressed in human granulosa cell tumors (GCT) and in the majority of
Irene Gallina et al.
Nature communications, 6, 6533-6533 (2015-03-31)
DNA replication stress is a source of genomic instability. Here we identify changed mutation rate 1 (Cmr1) as a factor involved in the response to DNA replication stress in Saccharomyces cerevisiae and show that Cmr1--together with Mrc1/Claspin, Pph3, the chaperonin
Cuyue Tang et al.
Biochemical pharmacology, 91(4), 543-551 (2014-08-06)
Two investigational compounds (FRM-1, (R)-7-fluoro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and FRM-2, (R)-7-cyano-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide) resided in rat brain longer than in systemic circulation. In Caco-2 directional transport studies, they both showed good intrinsic passive permeability but differed significantly in efflux susceptibility (efflux ratio of <2 and
Petcharat Kraivaphan et al.
The Journal of clinical dentistry, 24(1), 20-24 (2013-04-04)
The purpose of this study was to determine the viability of dental plaque at 12 hours following brushing with Colgate Great Regular Flavor (0.83% MFP), Crest Pro-Health (0.454% SnF), and Colgate Total Clean Mint Toothpaste (0.3% triclosan/ copolymer/0.22% NaF). Thirty-two
K P Sharma et al.
Indian journal of experimental biology, 50(12), 897-903 (2013-08-31)
Protective role of diet supplements (Spirulina, tamarind fruit pulp and their combination) on a freshwater fish G. affinis exposed at sublethal concentration of fluoride (F-) (10 ppm), Al(+3) (3 ppm) and aluminum fluoride (AlF3) (35.4 ppm) in the microcosms (15
Eun Hyeon Song et al.
Journal of cell science, 128(5), 913-922 (2015-01-16)
Net1 isoform A (Net1A) is a RhoA GEF that is required for cell motility and invasion in multiple cancers. Nuclear localization of Net1A negatively regulates its activity, and we have recently shown that Rac1 stimulates Net1A relocalization to the plasma
Salunya Tancharoen et al.
PloS one, 10(2), e0117775-e0117775 (2015-02-18)
Lysine-specific gingipain (Kgp) is a virulence factor secreted from Porphyromonas gingivalis (P. gingivalis), a major etiological bacterium of periodontal disease. Keratin intermediate filaments maintain the structural integrity of gingival epithelial cells, but are targeted by Kgp to produce a novel
Yu-Zhou Xiao et al.
Molecular medicine reports, 11(2), 1146-1152 (2014-11-06)
The use of artificial nerves for the repair of peripheral nerve defects is restricted by the limited sources of Schwann cells (SCs). Human mesenchymal stem cell (MSC)‑derived Schwann‑like cells are considered an alternative and desirable cell source. The aim of
Lydia Herrmann et al.
PloS one, 10(3), e0119423-e0119423 (2015-03-24)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons
Saif Ahmad et al.
Journal of neuroimmunology, 277(1-2), 96-104 (2014-12-03)
Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of
J Einwag et al.
Quintessence international (Berlin, Germany : 1985), 26(10), 707-713 (1995-10-01)
A conference concerning the caries-inhibiting efficacy of dentifrices that contain amine and sodium fluorides compared relevant clinical studies and found that both fluoride compounds contribute to the maintenance of dental health. Because of the differing test conditions, the study results
Caine C Smith et al.
Alcoholism, clinical and experimental research, 39(1), 36-44 (2015-01-28)
Binge-like ethanol (EtOH) exposure during the early rat neonatal period results in acute cell loss in specific brain regions, but such acute cell death has not been well established in the hippocampus. Binge alcohol exposure can also result in protein
Jennifer D Lewis et al.
PloS one, 9(12), e116152-e116152 (2014-12-30)
Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses and promote bacterial infection. The YopJ/HopZ acetyltransferases are
Frank Y Ma et al.
American journal of physiology. Renal physiology, 307(11), F1263-F1273 (2014-10-10)
Stress-activated kinases p38 MAPK and JNK promote renal fibrosis; however, how the pathways by which these kinases are activated in kidney disease remain poorly defined. Apoptosis signal-regulating kinase 1 (ASK1/MAPKKK5) is a member of the MAPKKK family that can induce
Chou-Wei Chang et al.
Journal of virology, 89(3), 1703-1718 (2014-11-21)
BGLF4 kinase, the only Ser/Thr protein kinase encoded by the Epstein-Barr virus (EBV) genome, phosphorylates multiple viral and cellular substrates to optimize the cellular environment for viral DNA replication and the nuclear egress of nucleocapsids. Previously, we found that nuclear
Chengcheng Christine Zhang et al.
International journal of oncology, 46(2), 667-676 (2014-12-02)
The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated that HMGB1 induces a distinct, necrosis-like
Min Gyeong Cheon et al.
Cancer letters, 356(2 Pt B), 637-645 (2014-10-15)
SIRT2, a member of the sirtuin family, is involved in the regulation of a variety of physiological functions. In addition, SIRT2 has been studied in the context of pathological conditions including neurodegenerative diseases, metabolic syndrome, and cancer. The effect of
Daruka Mahadevan et al.
Oncotarget, 6(4), 1954-1966 (2015-01-06)
c-Kit/α-PDGFR targeted therapies are effective for gastrointestinal stromal tumors (GIST), but, >50% develop drug resistance. RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imatinib (IM) GIST patient samples (n=16) and 4 GIST cell lines were examined for RTK inhibitor
Hye Yeon Choi et al.
PloS one, 9(6), e99421-e99421 (2014-06-13)
Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials. Here, we focused on the antioxidant properties of placental extract and attempted to isolate and identify the main antioxidant factors. Porcine placental extracts were prepared
Seon Min Woo et al.
Journal of pineal research, 58(3), 310-320 (2015-02-26)
Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In this study, we show that melatonin enhances tunicamycin-induced apoptosis
Ai Lyn Tan et al.
Rheumatology (Oxford, England), 52(5), 898-904 (2013-01-12)
This study used high-resolution PET to explore the pattern of DIP joint bone metabolism to test the hypothesis that the nail was functionally integrated with the bone, based on patterns of distal phalange (DP) bone metabolism in PsA compared with
Jamal Ahmad Ansari et al.
Environmental toxicology and pharmacology, 92, 103858-103858 (2022-03-31)
Arsenic activates microglia and exerts bystander effects on neuron. The present study is focused to test whether minocycline, a second generation antibiotic, can reverse the effect of developmental arsenic exposure on microglial activation and function. Pregnant Balb/c dams were gavaged
Mingming Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 39-44 (2014-07-06)
Currently, there are no FDA approved medications for treatment of cocaine addiction underscoring the dire need to develop such a product. There is an accumulating body of evidence that l-tetrahydropalmatine (l-THP), a non-selective dopamine antagonist, can be used for the
Minji Choi et al.
Cancer letters, 357(2), 591-601 (2014-12-20)
Polo-like kinase 1 (PLK1), a critical kinase that regulates multiple steps in mitosis, is overexpressed in diverse human cancers; thus many PLK1 inhibitors have been developed as potential cancer therapeutic agents. One of these compounds, the PLK1-specific inhibitor BI2536, has
Jérôme Salles et al.
Nutrients, 6(12), 5500-5516 (2014-12-04)
Although the management of malnutrition is a priority in older people, this population shows a resistance to refeeding. Fresh bee pollen contains nutritional substances of interest for malnourished people. The aim was to evaluate the effect of fresh bee pollen
E Bertogna et al.
Journal of photochemistry and photobiology. B, Biology, 118, 74-76 (2012-12-19)
The ultra-weak photon emission (biophoton) patterns of wheat germination tests under chemical stress (mercury and fluoride solutions) are presented in comparison to respective control groups run simultaneously in two similar, automatic photon-count chambers. Solutions of Hg (EC(50) and EC(100)) and
Monique Stoffels et al.
Rheumatology (Oxford, England), 54(2), 363-368 (2014-09-01)
The autoinflammatory hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) is characterized by recurrent episodes of fever and inflammation. As part of the mevalonate kinase deficiency spectrum, it is caused by MVK mutations, resulting in decreased mevalonate kinase activity in the
Shahla Karim Baloch et al.
Chirality, 27(3), 274-280 (2015-02-11)
In this study, a shikonin ester derivative, compound , was selected to evaluate its anticancer activities and we found that compound exhibited better antitubulin activities against the human HepG2 cell line with an IC50 value of 1.097 μM. Furthermore, the inhibition
2/20