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S U Wetzels et al.
Journal of dairy science, 98(8), 5572-5587 (2015-06-09)
Ecological balance in the rumen is highly sensitive to concentrate-rich diets. Yet the effects of these feeding practices on the caprine bacterial epimural microbiome (CBEM), a microbial community with putative important physiological functions in the rumen, are largely unexplored. This
Jonai Pujol-Giménez et al.
American journal of physiology. Cell physiology, 308(12), C1008-C1022 (2015-04-10)
GLUT12 is a member of the facilitative family of glucose transporters. The goal of this study was to characterize the functional properties of GLUT12, expressed in Xenopus laevis oocytes, using radiotracer and electrophysiological methods. Our results showed that GLUT12 is
Melanie McFarlane et al.
Journal of virology, 89(10), 5276-5287 (2015-02-27)
High-risk human papillomaviruses (HR-HPV) cause anogenital cancers, including cervical cancer, and head and neck cancers. Human papillomavirus 16 (HPV16) is the most prevalent HR-HPV. HPV oncogenesis is driven by two viral oncoproteins, E6 and E7, which are expressed through alternative
Saima M Sidik et al.
PloS one, 9(6), e100450-e100450 (2014-06-28)
Toxoplasma gondii is a parasite of humans and animals, and a model for other apicomplexans including Plasmodium spp., the causative agents of malaria. Despite many advances, manipulating the T. gondii genome remains labor intensive, and is often restricted to lab-adapted
Fengjuan Yang et al.
BMC microbiology, 15, 32-32 (2015-04-19)
Tight junctions (TJs) maintain the intestinal mucosal barrier, dysfunction of which plays a vital role in the pathophysiology of a variety of gastrointestinal disorders. Previously, we have shown that L. reuteri I5007 maintained the gut epithelial barrier in newborn piglets.
Tamding Wangdi et al.
PLoS pathogens, 10(8), e1004306-e1004306 (2014-08-08)
Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a disseminated infection, while the closely related pathogen S. enterica serovar Typhimurium (S. Typhimurium) is associated with a localized gastroenteritis in humans. Here we investigated whether both pathogens differ in the
Eun Shil Hong et al.
Cardiovascular diabetology, 14, 50-50 (2015-05-10)
The complement component C1q triggers activation of the classical immune pathway and can bind to adiponectin (APN). Recently, some studies have been reported that serum C1q-APN/total APN ratio correlates with atherosclerosis and coronary artery disease (CAD). We assessed the relationships
Luca Lo Piccolo et al.
International journal of molecular sciences, 16(6), 12360-12367 (2015-06-04)
The identification and study of protein's function in several model organisms is carried out using both nuclear and cytoplasmic extracts. For a long time, Drosophila's embryos have represented the main source for protein extractions, although in the last year, the
Adrian G Fischer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(21), 8181-8190 (2015-05-29)
Serotonin (5-HT) has been hypothesized to be implicated in performance monitoring by promoting behavioral inhibition in the face of aversive events. However, it is unclear whether this is restricted to external (punishment) or includes internal (response errors) events. The aim
Esak Lee et al.
Nature communications, 5, 4715-4715 (2014-09-03)
Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles of organ-residing LVs are underinvestigated. Here we show that lymphatic endothelial cells (LECs), a component of LVs within
Paula Ramos-Silva et al.
PloS one, 9(6), e97454-e97454 (2014-06-04)
The scleractinian coral Acropora millepora is one of the most studied species from the Great Barrier Reef. This species has been used to understand evolutionary, immune and developmental processes in cnidarians. It has also been subject of several ecological studies
J Bartzen-Sprauer et al.
Journal of neuroendocrinology, 26(8), 510-520 (2014-06-18)
In many species, sexual activity varies on a seasonal basis. Kisspeptin (Kp), a hypothalamic neuropeptide acting as a strong activator of gonadotrophin-releasing hormone neurones, plays a critical role in this adaptive process. Recent studies report that two other neuropeptides, namely
Cong Xu et al.
Nature communications, 5, 5758-5758 (2014-12-17)
Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that vein-derived
Kyeong Eop Kang et al.
Carbohydrate polymers, 92(2), 1321-1326 (2013-02-13)
This study investigated the effects of NH(4)Cl and MgCl(2) on pretreatment and xylan hydrolysis of miscanthus straw for biofuels production. It was observed that increasing the pretreatment temperature decreased the remaining solid, increased the enzymatic digestibility, and increased the xylan
Nicolas Aznar et al.
eLife, 4, e07091-e07091 (2015-07-01)
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain
Emilie Le Goff et al.
Biology open, 4(9), 1109-1121 (2015-08-16)
The paradigm of developmental regulation by Polycomb group (PcG) proteins posits that they maintain silencing outside the spatial expression domains of their target genes, particularly of Hox genes, starting from mid embryogenesis. The Enhancer of zeste [E(z)] PcG protein is
Ikue Nagakura et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10256-10263 (2014-08-01)
Accumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we show that one of its components, STAT1, negatively regulates the
Grzegorz Sienski et al.
Genes & development, 29(21), 2258-2271 (2015-10-24)
The repression of transposable elements in eukaryotes often involves their transcriptional silencing via targeted chromatin modifications. In animal gonads, nuclear Argonaute proteins of the PIWI clade complexed with small guide RNAs (piRNAs) serve as sequence specificity determinants in this process.
Sheng-Hui Yang et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 185(6), 677-693 (2015-06-03)
There are essentially four different morphological types of pseudobranchs in teleosts, including lamellae-free, lamellae semi-free, covered, and embedded types. In the euryhaline silver moony (Monodactylus argenteus), the pseudobranch belongs to the lamellae semi-free type, which is characterized by one row
Yuebo Zhang et al.
Animal science journal = Nihon chikusan Gakkaiho, 86(6), 573-578 (2014-12-03)
The pulmonary surfactant-associated protein (SFTPA1, SP-A) gene has been studied as a candidate gene for lung disease resistance in humans and livestock. The objective of the present study was to identify polymorphisms of the porcine SFTPA1 gene coding region and
A A Spasov et al.
Urologiia (Moscow, Russia : 1999), (1)(1), 29-34 (2013-05-15)
The study was aimed to evaluation the effect of different magnesium salts and their combinations with pyridoxine on a course of calcium-oxalate nephrolithiasis, which was modeled by adding the sodium oxalate (3% of weight of the diet) and selective cyclooxygenase-2
Sushmita Chakraborty et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3852-3860 (2015-03-20)
Leishmania major is a parasite that resides and replicates in macrophages. We previously showed that the parasite enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK signaling to proleishmanial effects. As Raf and PI3K have a Ras-binding domain but exert opposite effects
Peter J Chung et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6416-E6425 (2015-11-07)
Microtubules (MTs) are hollow cytoskeletal filaments assembled from αβ-tubulin heterodimers. Tau, an unstructured protein found in neuronal axons, binds to MTs and regulates their dynamics. Aberrant Tau behavior is associated with neurodegenerative dementias, including Alzheimer's. Here, we report on a
Yan Huang et al.
The Journal of biological chemistry, 290(30), 18865-18873 (2015-06-14)
Maintenance of telomere is regulated by active telomerase complex, including telomerase holoenzyme and its associated proteins. The activity of telomerase is precisely controlled in cells, and its dysregulation is one of the hallmarks of cancer. The telomerase catalytic subunit human
Dennis Wetzl et al.
Chembiochem : a European journal of chemical biology, 16(12), 1749-1756 (2015-06-06)
Recent investigations on imine reductases (IREDs) have enriched the toolbox of potential catalysts for accessing chiral amines, which are important building blocks for the pharmaceutical industry. Herein, we describe the characterization of 20 new IREDs. A C-terminal domain clustering of
Prithiksha Ramkaran et al.
Gene, 571(1), 28-32 (2015-06-23)
Methylenetetrahydrofolate reductase (MTHFR) reduces 5',10'-methylenetetrahydrofolate to 5'-methyltetrahydrofolate, and is involved in remethylation of homocysteine to methionine, two important reactions involved in folate metabolism and methylation pathways. The common MTHFR C677T single nucleotide polymorphism (SNP) (rs1801133) has been associated with raised
Berenice Fernández-Rojas et al.
Molecular and cellular biochemistry, 406(1-2), 183-197 (2015-05-15)
The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the following parameters in isolated kidney mitochondria: adenosine diphosphate
Gabriel E Bertolesi et al.
Pigment cell & melanoma research, 28(5), 559-571 (2015-06-23)
How skin colour adjusts to circadian light/dark cycles is poorly understood. Melanopsin (Opn4) is expressed in melanophores, where in vitro studies suggest it regulates skin pigmentation through a 'primary colour response' in which light photosensitivity is translated directly into pigment
Nathalie Kersual et al.
mAbs, 6(5), 1314-1326 (2014-12-18)
Ovarian cancer has the highest mortality rate among gynecologic malignancies. The monoclonal antibody 12G4 specifically recognizes the human Müllerian inhibiting substance type II receptor (MISRII) that is strongly expressed in human granulosa cell tumors (GCT) and in the majority of
Shaik Mohammad Naushad et al.
Molecular and cellular biochemistry, 392(1-2), 273-280 (2014-03-29)
Obesity, genetic polymorphisms of xenobiotic metabolic pathway, hypermethylation of tumor suppressor genes, and hypomethylation of proapoptotic genes are known to be independent risk factors for breast cancer. The objective of this study is to evaluate the combined effect of these
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