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Gregory W Charville et al.
The American journal of surgical pathology, 40(10), 1305-1315 (2016-08-16)
Rhabdomyosarcoma, the most common soft tissue malignancy of childhood, is a morphologically variable tumor defined by its phenotype of skeletal muscle differentiation. The diagnosis of rhabdomyosarcoma often relies in part on the identification of myogenic gene expression using immunohistochemical or
Katarina Omholt et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9(17), 6483-6488 (2003-12-26)
Recently, it was reported that BRAF mutations are frequent in melanoma. Previously, we analyzed a large series of paired primary and metastatic melanomas for NRAS codon 61 mutations and showed that they arise early and are preserved during tumor progression.
C J Simpson et al.
Biochemical and biophysical research communications, 180(1), 197-203 (1991-10-15)
A cDNA encoding human platelet 6-phosphofructokinase (PFK; EC 2.7.1.11) has been isolated from a human lymphocyte Raji cell line cDNA library using a cDNA for human muscle PFK as a probe. The platelet cDNA contains 900bp of carboxy terminal coding
G L Hammond et al.
Acta endocrinologica, 112(4), 603-608 (1986-08-01)
Sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) were detected by specific immunoassays in mixed-saliva taken from normal men and women. The immunochemical identity of both proteins was demonstrated by parallelism between dose response curves generated by serial
Yuta Aoyama et al.
Zebrafish, 12(4), 288-295 (2015-05-06)
The zebrafish (Danio rerio) has become a powerful model organism for studying developmental processes and genetic diseases. However, there remain several problems in previous rearing methods. In this study, we demonstrate a novel method for rearing zebrafish larvae by using
Won Joon Seong et al.
Archives of gynecology and obstetrics, 281(5), 907-912 (2009-10-22)
To evaluate cord blood amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels according to the mode of delivery. Between 1 March and 31 May 2007, 106 blood samples were drawn from the umbilical vein at the time of delivery. Eighty-four NT-proBNP levels
Deirdre R Pachman et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(30), 3416-3422 (2015-08-19)
Given that the clinical course of oxaliplatin-induced neuropathy is not well defined, the current study was performed to better understand clinical parameters associated with its presentation. Acute and chronic neuropathy was evaluated in patients receiving adjuvant FOLFOX (fluorouracil, leucovorin, and
Tomás Zelinka et al.
Endocrine-related cancer, 15(1), 311-323 (2008-03-04)
We performed a retrospective analysis of 71 subjects with metastatic pheochromocytoma and paraganglioma (30 subjects with mutation of succinate dehydrogenase enzyme subunit B (SDHB) gene and 41 subjects without SDHB mutation). Sixty-nine percent presented with bone metastases (SDHB +/-: 77%
R Naidu et al.
British journal of cancer, 78(10), 1385-1390 (1998-11-21)
Expression of c-erbB3 protein was investigated in 104 primary breast carcinomas comprising nine comedo ductal carcinoma in situ (DCIS), 91 invasive ductal carcinomas and four invasive lobular carcinomas using two monoclonal antibodies, RTJ1 and RTJ2. Of the 91 invasive ductal
Eloisa Colin-Ramirez et al.
American heart journal, 169(2), 274-281 (2015-02-03)
To determine the feasibility of conducting a randomized controlled trial comparing a low-sodium to a moderate-sodium diet in heart failure (HF) patients. Patients with HF (New York Heart Association classes II-III) were randomized to low (1500 mg/d) or moderate-sodium (2300
Stephan W Jahn et al.
The American journal of pathology, 186(1), 15-23 (2016-01-01)
Usual ductal hyperplasia (UDH) of the breast is generally regarded as a nonneoplastic proliferation, albeit loss of heterozygosity has long been reported in a part of these lesions. To gain deeper insights into the molecular drivers of these lesions, an
A J Davies et al.
Leukemia, 19(8), 1459-1465 (2005-05-20)
The role of TP53 mutation in transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL) was examined in a panel of 91 lymph node biopsies derived from 29 patients pre- and post-transformation. The entire TP53 coding sequence was
D J Edwards et al.
Biochemical pharmacology, 34(8), 1255-1263 (1985-04-15)
The effects in rats of intraventricular injections of 6-hydroxydopamine (6-OHDA) on the urinary excretion 1-3 weeks later of 3-methoxy-4-hydroxyphenethylene glycol (MHPG), 3,4-dihydroxyphenethanol (DHPE), 3-methoxy-4-hydroxyphenethanol (MHPE), p-hydroxyphenylglycol (pHPG), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were examined. The excretion of MHPG
Ana R Costenla et al.
The European journal of neuroscience, 34(1), 12-21 (2011-05-28)
Adenosine neuromodulation depends on a balanced activation of inhibitory A₁ (A₁R) and facilitatory A(₂A) receptors (A(₂A) R). Both A₁ R and A(₂A) R modulate hippocampal glutamate release and NMDA-dependent long-term potentiation (LTP) but ageing affects the density of both A₁
Jérôme Avouac et al.
Arthritis and rheumatism, 63(3), 800-809 (2011-03-02)
The transcription factor STAT-4 has recently been identified as a genetic susceptibility factor in systemic sclerosis (SSc) and other autoimmune diseases. The aim of this study was to investigate the contribution of STAT-4 in the development of a fibrotic phenotype
Nicole Berwald et al.
The American journal of emergency medicine, 32(7), 768-771 (2014-05-06)
The benefit of antibiotic prophylaxis for simple hand lacerations (lacerations that do not involve special structures) has not been adequately studied. To assess the feasibility of a randomized controlled trial to determine the role of antibiotic prophylaxis in emergency department
John A van Doorninck et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(12), 1989-1994 (2010-03-24)
PURPOSE Ewing sarcoma family tumors (ESFTs) exhibit chromosomal translocations that lead to the creation of chimeric fusion oncogenes. Combinatorial diversity among chromosomal breakpoints produces varying fusions. The type 1 EWS-FLI1 transcript is created as a result of fusion between exons
Eva-Katrin Bentz et al.
Reproductive sciences (Thousand Oaks, Calif.), 14(7), 705-709 (2007-11-15)
The relation between genetic variation of the androgen metabolism and transsexualism is unknown. In a case-control study of 100 male-to-female (MtF) transsexuals, 47 female-to-male (FtM) transsexuals, and 1670 controls, the authors assess allele and genotype frequencies of the steroid 5-alpha
Brian T Steffen et al.
The British journal of nutrition, 110(9), 1664-1671 (2013-04-05)
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for CVD and has been proposed as a marker of vascular inflammation. Polyunsaturated n-3 fatty acids (FA) and several n-6 FA are known to suppress inflammation and may influence Lp-PLA2 mass
Clinical determinants of reduced physical activity in hemodialysis and peritoneal dialysis patients.
Gabriela Cobo et al.
Journal of nephrology, 28(4), 503-510 (2014-12-17)
The phenotype associated to reduced physical activity (PA) in dialysis patients is poorly documented. We here evaluate weekly PA in two independent cohorts. Cross-sectional study with PA assessed by the number of steps/day measured by pedometer in two cohorts of
A L McDevitt et al.
Gene, 267(1), 23-30 (2001-04-20)
Mouse eosinophil-associated ribonuclease-2 (mEAR-2) is one of a cluster of genes identified in the genome of the mouse Mus musculus that are highly divergent orthologs of the primate ribonucleases, eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP). Northern analysis revealed
Federico Caobelli et al.
European heart journal cardiovascular Imaging, 17(9), 1036-1043 (2015-12-03)
Computed tomography (CT)-based attenuation correction (AC) improves the accuracy of standard myocardial perfusion SPECT. Most dedicated cadmium-zinc-telluride (CZT) SPECT cameras are not equipped with an integrated CT component. We aimed to determine the impact of AC on diagnostic performance of
F Stelma et al.
Journal of viral hepatitis, 24(12), 1107-1113 (2017-06-21)
Combining peginterferon-alfa-2a (pegIFN) with a nucleotide analogue can result in higher rates of HBsAg loss than either therapy given alone. Here, we investigated the durability of the response to combination therapy in chronic hepatitis B (CHB) patients after 5 years of
Ibrahim E Ertas et al.
The journal of obstetrics and gynaecology research, 36(5), 970-977 (2010-08-21)
To assess a maternal serum level of high sensitive C-reactive protein (hs-CRP) as a useful clinical parameter in prediction of pre-eclampsia severity and, to evaluate the correlation between hs-CRP and body mass index (BMI). Using cross-sectional study design, CRP was
Alice T Shaw et al.
The Lancet. Oncology, 12(11), 1004-1012 (2011-09-22)
ALK gene rearrangement defines a new molecular subtype of non-small-cell lung cancer (NSCLC). In a recent phase 1 clinical trial, the ALK tyrosine-kinase inhibitor (TKI) crizotinib showed marked antitumour activity in patients with advanced, ALK-positive NSCLC. To assess whether crizotinib
Sunil Kumar et al.
Journal of gastroenterology and hepatology, 27(12), 1825-1830 (2012-09-20)
Lactase non-persistence is common in India. We evaluated: (i) frequency of lactase gene (C/T-13910 and G/A-22018) polymorphisms in irritable bowel syndrome (IBS) and healthy controls (HC), (ii) association between these polymorphisms and IBS-subtypes and symptoms. A total of 150 IBS
R John Baier et al.
BMC medicine, 4, 10-10 (2006-04-14)
Genetic variation in the innate immune system of the host may play a role in determining the risk of developing infection, as well as outcome from infection. Infectious complications were retrospectively determined in 293 (233 African-American (AA), 57 Caucasian and
Anne M Larson et al.
Hepatology (Baltimore, Md.), 42(6), 1364-1372 (2005-12-01)
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over
Elena Tsourdi et al.
Endocrinology, 158(11), 3765-3777 (2017-10-04)
Hyperthyroidism in mice is associated with low bone mass, high bone turnover, and high concentrations of sclerostin, a potent Wnt inhibitor. Here, we explored the effects of either increasing bone formation with sclerostin antibodies (Scl-Ab) or reducing bone turnover with
René Baudrand et al.
Obesity surgery, 20(1), 77-83 (2009-08-20)
The enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes intracellular glucocorticoid reactivation by conversion of cortisone to cortisol in different tissues and have been implicated in several metabolic disorders associated with obesity. The aim of this study was to evaluate the
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