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Rachel M Stenger et al.
Clinical and vaccine immunology : CVI, 21(5), 641-650 (2014-03-07)
Knowledge of naturally processed Bordetella pertussis-specific T cell epitopes may help to increase our understanding of the basis of cell-mediated immune mechanisms to control this reemerging pathogen. Here, we elucidate for the first time the dominant major histocompatibility complex (MHC)
Xiaofa Qin et al.
Toxicology letters, 232(2), 356-362 (2014-12-03)
Acute and/or chronic alcohol ingestion has been shown to exacerbate the morbidity and mortality rate associated with acute mechanical and/or thermal trauma. While alcohol ingestion can affect many organs and systems, clinical and preclinical studies indicate that alcohol ingestion can
Katherine Camacho Carr et al.
Journal of midwifery & women's health, 49(4), 329-337 (2004-07-09)
Cervical cancer is one of the leading causes of death for middle-aged women in the developing world, yet it is almost completely preventable, if precancerous lesions are identified and treated in a timely manner. Cervical cancer screening based on cytologic
P Palma et al.
The Science of the total environment, 488-489, 208-219 (2014-05-20)
The purpose of this study was to evaluate the potential impact of the pesticides detected in the Alqueva reservoir (Guadiana Basin, South Iberian Peninsula) on the aquatic organisms belonging to this ecosystem. For this purpose, the occurrence and risk assessment
Xin Tang et al.
PLoS computational biology, 10(6), e1003631-e1003631 (2014-06-06)
Traction forces exerted by adherent cells on their microenvironment can mediate many critical cellular functions. Accurate quantification of these forces is essential for mechanistic understanding of mechanotransduction. However, most existing methods of quantifying cellular forces are limited to single cells
Wan Kyu Eo et al.
World journal of gastroenterology, 21(9), 2668-2676 (2015-03-12)
To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score (AMLPS) in patients with gastric cancer. We retrospectively examined the combination of absolute monocyte count (AMC) and absolute lymphocyte count (ALC) as prognostic variables in a cohort
Emilie Degagné et al.
The Journal of clinical investigation, 124(12), 5368-5384 (2014-10-28)
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in enterocytes but downregulated in
Kh Ghanbari et al.
Analytical biochemistry, 473, 53-62 (2015-01-13)
Novel zinc oxide (ZnO) nanosheets and copper oxide (CuxO, CuO, and Cu2O) decorated polypyrrole (PPy) nanofibers (ZnO-CuxO-PPy) have been successfully fabricated for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The morphology and structure of
Venkata P Mantripragada et al.
Materials science & engineering. C, Materials for biological applications, 42, 506-516 (2014-07-27)
The main objective of this study is to maximize growth factor encapsulation efficiency into microparticles. The novelty of this study is to maximize the encapsulated growth factors into microparticles by minimizing the use of organic solvents and using relatively low
Gary R Burnett et al.
American journal of dentistry, 26 Spec No A, 10A-14A (2013-07-10)
To evaluate in vitro the ability for an experimental anhydrous 0.454% w/w stannous fluoride dentifrice to occlude dentin tubules. Scanning electron microscopy (SEM) was used to assess tubule occlusion and the resistance of the occlusion to dietary acid in a
Xianyu Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 121-130 (2014-09-28)
The aim of this study was to develop an analytical method for the quantification of organochlorine (OC), organophosphate (OP), carbamate, and pyrethroid insecticide residues in cow milk, human milk, and baby formula. A total of 25 compounds were included in
Davor Zeljezic et al.
Chemosphere, 120, 45-51 (2014-06-30)
Agricultural workers are often exposed to high levels of pesticides over prolonged periods of time. We attempted to determine whether exposure to multiple pesticides shortens relative telomere length (RTL) and causes nucleoplasmic bridge (NPB) formation via the mechanism of telomere-end
Peixi Zhu et al.
Journal of pharmaceutical and biomedical analysis, 107, 437-443 (2015-02-11)
A simple and sensitive method was developed for characterization of two impurities from commercial bendazac lysine eye drops, by using liquid chromatography combined with electrospray ionization and QTOF mass analyzer (LC-ESI-QTOF MS/MS). A known impurity was characterized rapidly by comparison
Yan Chen et al.
Current biology : CB, 24(17), 1969-1977 (2014-08-19)
Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and
Hsien-Yu Peng et al.
Anesthesiology, 120(2), 436-446 (2013-08-15)
Patients with inflammatory gynecological/obstetrical problems often complain of irritable bowel syndrome. The authors examined whether acute uterus irritation reflexively provokes colonic motility in rat preparations. A modified colon manometry and striated abdominal muscle electromyogram activity in response to mustard oil
Charalambos Camoutsis et al.
Farmaco (Societa chimica italiana : 1989), 60(10), 826-829 (2005-09-06)
The p-[N,N-bis(2-chloroethyl)amino]phenylacetic acid esters of hecogenin and aza-homo-hecogenin have been prepared and their antineoplastic activity was evaluated against two basic drug screening systems in rodents, P388 lymphocytic and L1210 lymphoid murine leukemias. Among the compounds tested, the p-[N,N-bis(2-chloroethyl)amino]phenylacetic acid ester
Takashi Taniguchi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(2), 517-526 (2014-11-12)
Fli-1, a potential predisposing factor for systemic sclerosis (SSc), is constitutively down-regulated in the lesional skin of patients with SSc by an epigenetic mechanism. To investigate the impact of Fli-1 deficiency on the induction of an SSc phenotype in various
Liheng Shi et al.
Biochimica et biophysica acta, 1853(5), 1154-1164 (2015-02-24)
We previously identified peptide Lv, a novel bioactive peptide that enhances the activity of L-type voltage-gated calcium channels (L-VGCCs) in cone photoreceptors. In this study, we verified that peptide Lv was able to augment L-VGCC currents in cardiomyocytes, as well
Gabriele Di Sante et al.
Molecular endocrinology (Baltimore, Md.), 29(2), 200-212 (2014-12-30)
Hypogonadatropic hypogonadism (HH) can be acquired through energy restriction or may be inherited as congenital hypogonadotropic hypogonadism and its anosmia-associated form, Kallmann's syndrome. Congenital hypogonadotropic hypogonadism is associated with mutations in a group of genes that impact fibroblast growth factor
Catarina L Silva et al.
Talanta, 89, 360-368 (2012-01-31)
A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the
Yan Li et al.
Biomaterials, 41, 1-14 (2014-12-20)
Although PEGylated liposome-based drug delivery systems hold great promising applications for cancer therapy due to their prolonged blood circulation time, PEGylation significantly reduces their cellular uptake, which markedly impairs the in vivo tumor retention and antitumor efficiency of drug-loaded liposomes.
Masakazu Nagafuku et al.
Glycobiology, 25(3), 303-318 (2014-10-12)
Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes. Macrophage-secreted factors
M Gåfvels et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 87-95 (2015-01-21)
Surrogate markers for reverse cholesterol transport (RCT) efficiency such as HDL cholesterol and immune methods for apolipoprotein A-I (ApoA-I) may not fully reflect the actual efficiency of the RCT pathway. Several genetic variants and different posttranslational proteoforms of ApoA-I may
Gilles Provencher et al.
Journal of chromatography. A, 1348, 97-104 (2014-05-20)
Bisphenol A (BPA) and triclosan (TCS) are ubiquitous environmental phenols exhibiting endocrine disrupting activities that may be involved in various health disorders in humans. There is a need to measure separately free forms and conjugated metabolites because only the former
Ewa Wunsch et al.
Hepatology (Baltimore, Md.), 60(3), 931-940 (2014-02-13)
Ursodeoxycholic acid (UDCA) is no longer recommended for management of adult patients with primary sclerosing cholangitis (PSC). We undertook a prospective evaluation of UDCA withdrawal in a group of consecutive patients with PSC. Twenty six patients, all treated with UDCA
Xiaowu Chen et al.
Analytica chimica acta, 836, 61-71 (2014-07-01)
A novel method based on the strategy of N-phosphorylation labeling is described for quantification of twenty natural amino acids in human serum by reversed-phase liquid chromatography-electrospray tandem mass spectrometry (RP-LC/ESI-MS). The derivatization reaction was easily performed in one-pot reaction under
Nan Zhang et al.
Pharmaceutical research, 31(9), 2326-2334 (2014-03-07)
To evaluate the therapeutic efficacy of dexamethasone (DM) and methotrexate (MTX) entrapped within polysialic acid (PSA)-trimethyl chitosan (TMC) nanoparticles using an in vitro model of rheumatoid arthritis (RA). The loading capacity of the PSA-TMC nanoparticles was determined. An RA in
Toru Ogawa et al.
Drug development and industrial pharmacy, 41(2), 315-321 (2013-11-23)
Inorganic extractables from glass vials may cause particle formation in the drug solution. In this study, the ability of eluting Al ion from borosilicate glass vials, and tendencies of precipitation containing Al were investigated using various pHs of phosphate, citrate
Magdalena Mazagova et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(3), 1043-1055 (2014-12-04)
Translocation of bacteria and their products across the intestinal barrier is common in patients with liver disease, and there is evidence that experimental liver fibrosis depends on bacterial translocation. The purpose of our study was to investigate liver fibrosis in
Rasmita Samal et al.
PloS one, 10(3), e0120360-e0120360 (2015-03-24)
Resident cardiac progenitor cells show homing properties when injected into the injured but not to the healthy myocardium. The molecular background behind this difference in behavior needs to be studied to elucidate how adult progenitor cells can restore cardiac function
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