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Timothy R DeGrado et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1348-1354 (2014-07-23)
Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive imaging method for monitoring zinc in the body would be useful to understand zinc dynamics in health and disease. To provide a PET imaging agent for zinc, we
Kohji Abe et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(12), 1907-1913 (2014-09-18)
To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential of the hydroethidine derivative as a radiotracer to measure in vivo brain ROS
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of
Edyta Bajak et al.
Toxicology letters, 233(2), 187-199 (2014-12-20)
Higher efficacy and safety of nano gold therapeutics require examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells exposed to AuNP (5 and 30nm). Cellular
Rita Salánki et al.
PloS one, 9(10), e111450-e111450 (2014-10-25)
Cell adhesion is a fundamental phenomenon vital for all multicellular organisms. Recognition of and adhesion to specific macromolecules is a crucial task of leukocytes to initiate the immune response. To gain statistically reliable information of cell adhesion, large numbers of
Christof Kaltenmeier et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3768-3777 (2015-03-18)
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4(+) T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine protease
Reymond Barreto
Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 34(4), 417-421 (2007-09-26)
The incidence of contrast-induced nephropathy (CIN) is increasing due to the growing number of patients undergoing radiocontrast studies. CIN is associated with a mortality rate as high as 34%. The purpose of this article is to review the strategies for
Sabine Buhner et al.
Experimental physiology, 99(10), 1299-1311 (2014-06-22)
Based on the discomfort/pain threshold during rectal distension, irritable bowel syndrome (IBS) patients may be subtyped as normo- or hypersensitive. We previously showed that mucosal biopsy supernatants from IBS patients activated enteric and visceral afferent neurons. We tested the hypothesis
Yukie Yoshii et al.
Biomaterials, 51, 278-289 (2015-03-17)
Anti-cancer drug development typically utilizes high-throughput screening with two-dimensional (2D) cell culture. However, 2D culture induces cellular characteristics different from tumors in vivo, resulting in inefficient drug development. Here, we report an innovative high-throughput screening system using nanoimprinting 3D culture
Fu-Chen Kung et al.
Materials science & engineering. C, Materials for biological applications, 45, 578-588 (2014-12-11)
Electrospun fiber sheets with various orientations (random, partially aligned, and aligned) and smooth and roughened casted membranes were prepared. Hydroxyapatite (HA) crystals were in situ formed on these material surfaces via immersion in 10× simulated body fluid solution. The size
Lene H Petersen et al.
Environmental toxicology and chemistry, 34(2), 379-390 (2014-12-04)
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen
G Christodoulopoulos et al.
The Veterinary record, 172(4), 100-100 (2012-12-27)
'Salivary abomasum disease' is a common syndrome in Greece affecting lambs and kids from three to 17 days of age. In this case series, we present clinical and laboratory findings from 37 affected lambs presented alive and subsequently euthanased for
Vishal Khairnar et al.
Nature communications, 6, 6217-6217 (2015-02-19)
B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence
Marion Najac et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4319-4331 (2015-03-13)
The activity of mitral and tufted cells, the principal neurons of the olfactory bulb, is modulated by several classes of interneurons. Among them, diverse periglomerular (PG) cell types interact with the apical dendrites of mitral and tufted cells inside glomeruli
Martin E Lynge et al.
Macromolecular bioscience, 14(12), 1677-1687 (2014-09-13)
Implantable devices equipped with coatings which have the ability to carry and deliver active compounds are of great interest. We report the assembly of liposome-containing poly(dopamine) films, and their interaction with adhering cells. The liposome composition is varied by adding
Jianfeng Shi et al.
Journal of labelled compounds & radiopharmaceuticals, 57(14), 730-736 (2014-12-06)
16α-[(18)F]fluoroestradiol ([(18)F]FES) is known as a clinically important tracer in nuclear medicine as an estrogen receptor ligand for investigating primary and metastatic breast cancers. Synthesizing [(18)F]FES is a two-step process associated with [(18)F]fluoride incorporation to the precursor (3-methoxymethyl 16β,17β-epiestriol-O-cyclic sulfone)
Marie Francene Arnobit Cutiongco et al.
Acta biomaterialia, 10(10), 4410-4418 (2014-07-02)
Hydrogels are highly preferred in soft tissue engineering because they recapitulate the hydrated extracellular matrix. Naturally derived polysaccharides, like pullulan and dextran, are attractive materials with which to form hydrophilic polymeric networks due to their non-immunogenic and non-antigenic properties. However
Patrick M Flanigan et al.
Food chemistry, 164, 518-526 (2014-07-06)
In this study, we determined the effect of cultivar on total and individual anthocyanin concentrations and phenolic acid levels in eight purple basil varieties and examined the relationship between anthocyanin content, phenolic acid composition, and antioxidant properties. Cultivar had a
Murali Muniraju et al.
Vaccine, 33(3), 465-471 (2014-12-03)
Across the developing world peste des petits ruminants virus places a huge disease burden on agriculture, primarily affecting the production of small ruminant. The disease is most effectively controlled by vaccinating sheep and goats with live attenuated vaccines that provide
Andrew B Allison et al.
Virology, 474, 154-162 (2014-12-03)
Western equine encephalitis virus (WEEV), Highlands J virus (HJV), and Fort Morgan virus (FMV) are the sole representatives of the WEE antigenic complex of the genus Alphavirus, family Togaviridae, that are endemic to North America. All three viruses have their
Qing Chen et al.
Journal of separation science, 37(19), 2716-2723 (2014-07-22)
Keggin-type phosphomolybdate ((C19H42N)3PMo12O40) is prepared by a one-step solid-state reaction at room temperature and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and elemental analysis. The as-prepared phosphomolybdate is demonstrated to be an efficient adsorbent
Mitsuko Takahashi et al.
Journal of AOAC International, 97(4), 1195-1201 (2014-08-26)
Components that could be used as indicators for the discrimination of senna (Cassia angustifolia) from other cassia plants contained in health teas were identified, and an analytical method for the components was developed. Our results revealed two components in senna
Masatoki Sato et al.
Antimicrobial agents and chemotherapy, 59(3), 1643-1649 (2014-12-31)
We estimated the efficacy of the current single administration of peramivir on the basis of peramivir pharmacokinetics in the upper respiratory tract (URT) and determined the predictive peramivir concentration-time curve to assess its efficacy against viruses with decreased susceptibility to
Ayaid Khadem Zgair et al.
Journal of medical virology, 87(3), 407-416 (2014-08-29)
Chronic hepatitis B involves different immune cells. The direct role of antibody-secreting B cells in the severity of chronic hepatitis B unclear. In this study, the number of plaque forming cells [PFC-(IgG, IgM, anti-HBc IgG, and anti-HBc IgM)], liver function
Xiao-juan Ma et al.
Journal of the science of food and agriculture, 93(13), 3209-3215 (2013-04-05)
Ovalbumin (OVA) is a major allergen in hen egg. During thermal processing, reducing sugars contained in the hen egg white might easily undergo glycation with OVA, but few studies have been conducted on its corresponding immunoreactivity changes. The aim of
A comprehensive proteomic approach to identifying capacitation related proteins in boar spermatozoa.
Woo-Sung Kwon et al.
BMC genomics, 15, 897-897 (2014-10-16)
Mammalian spermatozoa must undergo capacitation, before becoming competent for fertilization. Despite its importance, the fundamental molecular mechanisms of capacitation are poorly understood. Therefore, in this study, we applied a proteomic approach for identifying capacitation-related proteins in boar spermatozoa in order
Faisal Al-Akayleh et al.
Pharmaceutical development and technology, 18(5), 1204-1212 (2011-10-08)
In the present systematic study, a sustained release of terbutaline sulfate tablet (TBS) was developed and optimized by employing the hydrophilic polymers; chitosan and xanthan gum mixed with sodium bicarbonate as a release modifying agent. This formulation was developed using
Treatment of acidosis in CKD.
Muhammad M Yaqoob
Clinical journal of the American Society of Nephrology : CJASN, 8(3), 342-343 (2013-02-02)
Daisuke Torii et al.
Odontology, 103(1), 27-35 (2014-01-09)
The periodontal ligament (PDL) consists of a group of specialized connective tissue fibers embedded in the alveolar bone and cementum that are believed to contain progenitors for mineralized tissue-forming cell lineages. These progenitors may contribute to regenerative cell therapy or
Sara M Oliveira et al.
Biomaterials, 48, 56-65 (2015-02-24)
Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in order to control cell behavior. Platelet lysate (PL) presents itself as a cost-effective source of multiple GFs and other proteins. The instruction given by a construct-PL
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