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Vishwas D Joshi et al.
Journal of immunology (Baltimore, Md. : 1950), 169(5), 2536-2544 (2002-08-24)
LPS enhanced antibacterial host defenses (ABHD) when given at low (75 micro g) doses (16 of 19 mice survived 3x LD(50) Escherichia coli vs 3 of 19 LPS-naive mice; p = 0.0001), but induced lethal inflammation at high (500 micro
Edwin J W Geven et al.
Contrast media & molecular imaging, 10(3), 203-210 (2014-09-11)
Inhibition of the V600E mutated BRAF kinase gene (BRAF(V600E) ) is an important and effective approach to treating melanomas. A new specific small molecule inhibitor of BRAF(V600E) , PLX3603, showed potent melanoma growth-inhibiting characteristics in preclinical studies and is currently
Vishwas D Joshi et al.
Infection and immunity, 70(12), 6896-6903 (2002-11-20)
Sepsis is thought to result from an exaggerated innate immune response to microbial components such as lipopolysaccharide (LPS), but the involvement of a specific mechanism(s) has not been identified. We studied the role of caspase 1 (Cas-1) in the murine
Jan Lotte et al.
Neuropediatrics, 43(1), 17-21 (2012-03-21)
We report a retrospective analysis of bromide therapy in 32 patients suffering from Dravet syndrome with SCN1A-mutations who received bromide. After 3 months of bromide treatment, 26 patients (81%) showed a relevant improvement with a reduction of seizure frequency by
Mona Mostafa Korany et al.
Archives of dermatological research, 311(2), 93-97 (2018-12-06)
Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Perilesional skin
P E Newton et al.
Inhalation toxicology, 13(12), 1093-1116 (2001-11-07)
To evaluate the oncogenic potential of methylethylketoxime (MEKO), CD-1 mice (50/sex/group) and F-344 rats (50/sex/group) were coexposed 6 h/day, 5 days/wk for 18 mo (mice) or 26 mo (rats) via whole-body inhalation exposures to target vapor concentrations of 0, 15
Hiroshi Miyamoto et al.
The American journal of surgical pathology, 34(3), 418-422 (2010-02-16)
Studies predominantly performed on cystectomy specimens have shown that antibodies against smoothelin can distinguish between muscularis mucosae (MM) (negative or weak stain) and muscularis propria (MP) (strong stain). However, studies on diagnostically difficult (transurethral resection) specimens have not been performed.
Oxaliplatin-based chemotherapy in patients aged 75 years or older with metastatic colorectal cancer.
Minoru Fukuchi et al.
Anticancer research, 33(10), 4627-4630 (2013-10-15)
To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as
Noriyasu Chika et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 41(7), 857-862 (2014-08-19)
The safety and efficacy of FOLFIRI as second-line chemotherapy for metastatic colorectal cancer patients ≥ 75 years was retrospectively evaluated. We analyzed 106 patients, who received FOLFIRI or a combination of FOLFIRI and bevacizumab following oxaliplatin-based first-line chemotherapy. The clinical
M Inzinger et al.
The British journal of dermatology, 165(3), 640-645 (2011-05-14)
Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis. To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions. Data from a
F Domergue et al.
Lipids, 35(5), 487-494 (2000-07-25)
Oleoyl-CoA elongase catalyzes four successive reactions: condensation of malonyl-CoA to oleoyl-CoA, reduction, dehydration, and another reduction. Evidence supporting this mechanism and the multienzymatic nature of the elongation complex are reported. A particulate membrane fraction from rapeseed is able to elongate
Bao-hua Yu et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 38(1), 35-41 (2009-06-06)
(1) To investigate the activation of AKT/mTOR signaling transduction pathway in DLBCL and its association with the expression of bcl-6 and some other clinical pathologic factors. (2) To estimation of the signaling pathway function in diverse subtypes of DLBCL and
Chang-Su Park et al.
Applied microbiology and biotechnology, 92(6), 1187-1196 (2011-06-22)
A putative N-acyl-D-glucosamine 2-epimerase from Caldicellulosiruptor saccharolyticus was cloned and expressed in Escherichia coli. The recombinant enzyme was identified as a cellobiose 2-epimerase by the analysis of the activity for substrates, acid-hydrolyzed products, and amino acid sequence. The cellobiose 2-epimerase
Heba Al-Khattabi et al.
Anticancer research, 30(10), 4081-4088 (2010-11-03)
Amplification of the HER-2/neu oncogene and concomitant over-expression of its protein are detected in approximately 18% of invasive ductal carcinoma of the breast and is associated with poor prognosis. This study tested the use of fluorescence in situ hybridization (FISH)
P Sjögren et al.
Diabetologia, 51(2), 328-335 (2007-11-22)
Fatty acid desaturases introduce double bonds into growing fatty acid chains. The key desaturases in humans are Delta5-desaturase (D5D), Delta6-desaturase (D6D) and stearoyl-CoA desaturase (SCD). Animal and human data implicate hepatic desaturase activities in insulin resistance, obesity and dyslipidaemia. However
Nikolaos G Tsiropoulos et al.
Analytica chimica acta, 573-574, 209-215 (2007-08-29)
A methodology is described for greenhouse air analysis by sampling fenhexamid, pyrimethanil, malathion, metalaxyl-M and myclobutanil in solid sorbents. Pesticides were determined by gas chromatography with NP Detector. The trapping efficiency of XAD-2, XAD-4, Supelpak-2, Florisil and C-18 at different
Robert M Cohen et al.
Synapse (New York, N.Y.), 49(3), 150-156 (2003-05-30)
The apolipoprotein E-epsilon4 allele confers an increased susceptibility to age-related memory problems and Alzheimer's disease. Abnormalities in the cholinergic system are also likely contributors to memory deficits associated with aging and AD. To determine the effect of the APOE-epsilon4 allele
B Hall et al.
Molecular immunology, 26(9), 819-826 (1989-09-01)
We have determined the nucleotide sequence of the murine immunoglobulin gamma 2a membrane 3' untranslated region (1413 nucleotides) and approximately 679 nucleotides of downstream sequence. Two AATAAA hexanucleotide sequences are present in the 2092 nucleotide interval. The first one functions
Tatyana Milman et al.
American journal of ophthalmology, 217, 189-197 (2020-05-04)
Since the original description of "dacryadenoma" by Jakobiec and associates, the data on this unusual epibulbar lacrimal gland lesion remain sparse. The aim of this study was to characterize clinically, morphologically, and immunohistochemically this isolated epibulbar lacrimal gland lesion. Retrospective
R G Oshima et al.
Differentiation; research in biological diversity, 33(1), 61-68 (1986-01-01)
Keratin 18 is a type-I keratin that is found in a variety of simple epithelial tissues. In mice, the corresponding protein, called Endo B, is expressed at the 4- to 8-cell stage of mouse development and may be one of
Chin B Eap et al.
European journal of clinical pharmacology, 60(4), 231-236 (2004-04-29)
We investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between subjects with different CYP3A4 and CYP3A5 genotypes. Plasma concentrations of midazolam, and of total (conjugated + unconjugated) 1'OH-midazolam, and 4'OH-midazolam were measured after the oral
Hanna Barchanska et al.
Food chemistry, 335, 127658-127658 (2020-07-31)
Raphanus sativus var. longipinnatus, was exposed under experimental conditions to herbicides: rimsulfuron (RIM), administrated as (1) pure substance, (2) in commercially available formulation (RIMEL), (3) its degradation product: 4,6-dimethoxypyrimidin-2-amine (2ADP), (4) mesotrione (MES), (5) sulcotrione (SUL). Profiling and fingerprinting strategies
T S Wu et al.
Bioorganic & medicinal chemistry, 9(1), 77-83 (2001-02-24)
Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris.
Daniela Remonatto et al.
Applied biochemistry and biotechnology, 185(3), 705-716 (2018-01-04)
The performance of two new commercial low-cost lipases Eversa® Transform and Eversa® Transform 2.0 immobilized in different supports was investigated. The two lipases were adsorbed on four different hydrophobic supports. Interesting results were obtained for both lipases and for the
P Kairenius et al.
Journal of dairy science, 98(8), 5653-5671 (2015-06-22)
The potential of dietary fish oil (FO) supplements to increase milk 20:5n-3 and 22:6n-3 concentrations and the associated effects on milk fatty acid (FA) composition, intake, and milk production were examined. Four multiparous lactating cows offered a grass silage-based diet
L L Reznikov et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(5), 2174-2179 (2000-02-19)
IL-18 shares with IL-1 the same family of receptors and several identical signal transduction pathways. Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent
Queenie K Y Cheuk et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 21(3), 243-250 (2015-05-23)
To evaluate the efficacy and safety of double balloon catheter for induction of labour in Chinese women with one previous caesarean section and unfavourable cervix at term. Retrospective cohort study. A regional hospital in Hong Kong. Women with previous caesarean
F Sassi et al.
The British journal of dermatology, 159(5), 1186-1191 (2008-08-23)
Vitiligo is a pigmentary disorder which may have disfiguring consequences. Its treatment remains a challenge. We designed a parallel-group randomized controlled trial to compare the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in
Olivier Lortholary et al.
Lancet (London, England), 389(10069), 612-620 (2017-01-11)
Indolent systemic mastocytosis, including the subvariant of smouldering systemic mastocytosis, is a lifelong condition associated with reduced quality of life. Masitinib inhibits KIT and LYN kinases that are involved in indolent systemic mastocytosis pathogenesis. We aimed to assess safety and
Perumal Vivekanandan et al.
Human pathology, 40(3), 293-299 (2008-11-01)
Anterior gradient-2 expression is critical in normal embryonic development. Aberrant expression of anterior gradient-2 in adult tissues has been linked to breast, prostate, esophageal, and pancreatic carcinoma. To define the role of anterior gradient-2 in primary hepatocellular neoplasms, we used
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