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Yali Zhang et al.
Journal of dairy science, 98(12), 8445-8453 (2015-10-28)
Dregea sinensis Hemsl. is used as a milk coagulant to produce goat milk cakes in Yunnan, China. However, the composition of milk-clotting compounds and the related mechanism have not been reported. Crude protease was extracted from the stem, purified, and
D B R K Gupta Udatha et al.
Journal of structural biology, 190(3), 314-327 (2015-04-25)
The catalytic residues in carbohydrate esterase enzyme families constitute a highly conserved triad: serine, histidine and aspartic acid. This catalytic triad is generally located in a very sharp turn of the protein backbone structure, called the nucleophilic elbow and identified
Dorsal and medial raphe nuclei participate differentially in reproductive functions of the male rat.
María E Ayala et al.
Reproductive biology and endocrinology : RB&E, 13(1), 132-132 (2015-12-09)
Innervation of the hypothalamus and median eminence arise from the dorsal and medial raphe nuclei (DRN and MRN, respectively). The hypothalamus regulates the secretion of gonadotropins, which in turn regulate the reproductive function of males and females. However, it is
Carolin Dräger et al.
Archives of virology, 160(3), 739-746 (2015-01-07)
Classical swine fever virus (CSFV) is the causative agent of a severe multi-systemic disease of pigs. While several aspects of virus-host-interaction are known, the early steps of infection remain unclear. For the closely related bovine viral diarrhea virus (BVDV), a
Alicia Amadoz et al.
Evolutionary bioinformatics online, 11, 15-24 (2015-03-18)
The combined therapy of pegylated interferon (IFN) plus ribavirin (RBV) has been for a long time the standard treatment for patients infected with hepatitis C virus (HCV). In the case of genotype 1, only 38%-48% of patients have a positive
Alfredo Sahagun-Ruiz et al.
Veterinary research communications, 39(4), 229-236 (2015-11-02)
Neonatal calf colibacillosis caused by enterotoxigenic Escherichia coli (ETEC) is an economically significant problem in most parts of the world. The most common ETEC found in calves express the F5 (K99) fimbriae, which are necessary for the attachment of the
Toshiaki Yoshida
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(1), 71-76 (2015-01-15)
A fluorine-containing pyrethroid metofluthrin is widely used recently in mosquito repellents. The urinary excretion kinetics of its metabolites was evaluated in rats to establish an optimal biomarker for monitoring metofluthrin exposure of the general population. After metofluthrin had been administered
Patricia Carrascosa et al.
Clinical imaging, 39(6), 1000-1005 (2015-09-10)
We explored whether intracycle motion correction algorithms (MCAs) might be applicable to dual energy computed tomography coronary angiography in patients with intermediate to high likelihood of coronary artery disease. MCA reconstructions were associated with higher interpretability rates (96.7% vs. 87.9%
Laura F Corns et al.
Stem cells (Dayton, Ohio), 33(9), 2864-2876 (2015-06-04)
The region surrounding the central canal (CC) of the spinal cord is a highly plastic area, defined as a postnatal neurogenic niche. Within this region are ependymal cells that can proliferate and differentiate to form new astrocytes and oligodendrocytes following
Eric J Arias et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 24(7), 1597-1608 (2015-05-15)
North American and Asian forms of moyamoya have distinct clinical characteristics. Asian adults with moyamoya are known to respond better to direct versus indirect revascularization. It is unclear whether North American adults with moyamoya have a similar long-term angiographic response
You-Jun Li et al.
Oncotarget, 6(35), 36943-36954 (2015-10-16)
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) encodes a tumor suppressor gene implicated in the growth of various tumor types including breast cancer. We previously demonstrated that recombinant adenovirus-mediated mda-7/IL-24 expression in the mammary glands of carcinogen-treated (methylnitrosourea, MNU) rats suppressed mammary
Yoshiyuki Watanabe et al.
Genome research, 25(3), 328-337 (2015-02-06)
Integration of DNA viruses into the human genome plays an important role in various types of tumors, including hepatitis B virus (HBV)-related hepatocellular carcinoma. However, the molecular details and clinical impact of HBV integration on either human or HBV epigenomes
Lauren L Jantzie et al.
Cerebral cortex (New York, N.Y. : 1991), 25(2), 482-495 (2013-09-21)
The pathophysiology of perinatal brain injury is multifactorial and involves hypoxia-ischemia (HI) and inflammation. N-methyl-d-aspartate receptors (NMDAR) are present on neurons and glia in immature rodents, and NMDAR antagonists are protective in HI models. To enhance clinical translation of rodent
Katarzyna Wilpiszewska et al.
Carbohydrate polymers, 128, 82-89 (2015-05-26)
Preparation of novel carboxymethyl starch (CMS)-based biodegradable films with calcium montmorillonite has been described. The biocomposites were obtained by casting method, glycerol and citric acid were used as plasticizer and crosslinking agent, respectively. The effect of calcium montmorillonite (MMT-Ca) on
Paul D Chantler et al.
Microcirculation (New York, N.Y. : 1994), 22(6), 435-445 (2015-05-28)
Chronic presentation of the MS is associated with an increased likelihood for stroke and poor stroke outcomes following occlusive cerebrovascular events. However, the physiological mechanisms contributing to compromised outcomes remain unclear, and the degree of cerebral cortical MVD may represent
Ivana Stojković et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 98, 117-124 (2015-02-14)
A procedure for the determination of (222)Rn in environmental water samples using liquid scintillation counting (LSC) was applied and optimized. A minimum detectable activity of 0.029Bql(-1) in a 20ml glass vial (10ml water sample mixed with 10ml of liquid scintillation
Mayur Garg et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(3), 559-569 (2014-02-08)
The relationship between intestinal inflammation and circulating components of the renin-angiotensin system (RAS) is poorly understood. Demographic and clinical data were obtained from healthy controls and patients with inflammatory bowel disease (IBD). Plasma concentrations of the classical RAS components (angiotensin-converting
Claudia Venuleo et al.
Social science & medicine (1982), 139, 9-17 (2015-07-05)
This study compares the impact of levels of impulsivity and subjective cultures through which subjects interpret their experience of the social environment on the probability of hazardous and harmful alcohol use. A sample of 501 participants from Southern Italy completed
Stephan Plattner et al.
The Journal of biological chemistry, 290(29), 18056-18067 (2015-05-28)
Thionins are plant-specific antimicrobial peptides that have been isolated from the endosperm and leaves of cereals, from the leaves of mistletoes, and from several other plant species. They are generally basic peptides with three or four disulfide bridges and a
S O Syrjälä et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(8), 2075-2084 (2015-05-02)
The major cause of death during the first year after heart transplantation is primary graft dysfunction due to preservation and ischemia-reperfusion injury (IRI). Angiopoietin-1 is a Tie2 receptor-binding paracrine growth factor with anti-inflammatory properties and indispensable roles in vascular development
Cindy Grandjenette et al.
Anti-cancer agents in medicinal chemistry, 15(3), 363-373 (2014-12-04)
Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve
Niina K Palin et al.
American journal of nephrology, 41(4-5), 383-391 (2015-06-27)
Ischemia-reperfusion injury (IRI) and innate immune response augment adaptive immunity and may also trigger repair processes that lead to uncontrolled fibrosis and atherosclerosis as seen in chronic allograft injury. Simvastatin has been shown to protect from renal IRI in several
Xiaokun Geng et al.
Stroke, 46(2), 492-499 (2015-01-08)
Ischemic stroke induces metabolic disarray. A central regulatory site, pyruvate dehydrogeanse complex (PDHC) sits at the cross-roads of 2 fundamental metabolic pathways: aerobic and anaerobic. In this study, we combined ethanol (EtOH) and normobaric oxygen (NBO) to develop a novel
A Teubner et al.
Theriogenology, 84(3), 323-332 (2015-05-20)
The aim of this study was to determine the effect of the anabolic steroid testosterone on the testicular vascularization, angiogenesis and expression of angiogenic factors, and their receptors in testes of peripubertal stallions. Seven peripubertal stallions were treated with Durateston
Elena Decaneto et al.
Biophysical journal, 109(11), 2371-2381 (2015-12-05)
Membrane type 1-matrix metalloproteinase (MT1-MMP or MMP-14) is a zinc-transmembrane metalloprotease involved in the degradation of extracellular matrix and tumor invasion. While changes in solvation of MT1-MMP have been recently studied, little is known about the structural and energetic changes
Jens Neumann et al.
Acta neuropathologica, 129(2), 259-277 (2014-11-14)
Neuronal injury from ischemic stroke is aggravated by invading peripheral immune cells. Early infiltrates of neutrophil granulocytes and T-cells influence the outcome of stroke. So far, however, neither the timing nor the cellular dynamics of neutrophil entry, its consequences for
Mohammed Abdelsaid et al.
Life sciences, 118(2), 268-273 (2014-01-23)
We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1
Anthony C Pappas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(39), 13375-13384 (2015-10-02)
Physiologically, neurovascular coupling (NVC) matches focal increases in neuronal activity with local arteriolar dilation. Astrocytes participate in NVC by sensing increased neurotransmission and releasing vasoactive agents (e.g., K(+)) from perivascular endfeet surrounding parenchymal arterioles. Previously, we demonstrated an increase in
Nathalie E Blachère et al.
European journal of immunology, 44(11), 3240-3251 (2014-08-12)
Paraneoplastic neurologic diseases (PND) involving immune responses directed toward intracellular antigens are poorly understood. Here, we examine immunity to the PND antigen Nova2, which is expressed exclusively in central nervous system (CNS) neurons. We hypothesized that ectopic expression of neuronal
Fanny Feuillet et al.
Journal of biopharmaceutical statistics, 25(4), 843-856 (2014-06-07)
The high consumption of psychotropic drugs is a public health problem. Rigorous statistical methods are needed to identify consumption characteristics in post-marketing phase. Agglomerative hierarchical clustering (AHC) and latent class analysis (LCA) can both provide clusters of subjects with similar
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