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Ana Maria de Resende Machado et al.
Food chemistry, 138(2-3), 1233-1238 (2013-02-16)
Ethyl carbamate (EC) is a common substance in fermented foods and drinks, and its quantification is important because of its carcinogenic nature and its usually presence in alcoholic beverages. The present work involved the development and validation of an analytical
Hironori Satoh et al.
Cancer research, 73(13), 4158-4168 (2013-04-24)
Nrf2 (Nfe2l2) governs cellular defenses against oxidative and electrophilic stresses and protects against chemical carcinogenesis. However, many cancers have been found to accumulate NRF2 protein, raising questions of precisely how Nrf2 contributes to carcinogenesis. In this report, we explored such
Till F Jakob et al.
Experimental neurology, 266, 55-67 (2015-02-25)
The immediate-early-gene c-fos with its protein product Fos has been used as a powerful tool to investigate neuronal activity and plasticity following sensory stimulation. Fos combines with Jun, another IEG product, to form the dimeric transcription factor activator protein 1
X Meng et al.
Free radical research, 48(7), 823-838 (2014-04-12)
Notoginsenoside R1 (NGR1) is a novel phytoestrogen that is isolated from Panax notoginseng. We have recently found that NGR1 showed neuroprotection in vitro against oxidative stress through estrogen receptor (ER)-dependent activation of Akt/Nrf2 pathways. However, whether NGR1 has neuroprotective effect
R E Sotomayor et al.
Toxicology and industrial health, 6(1), 71-108 (1990-01-01)
Urethane, a known animal carcinogen, has been the subject of intensive research efforts spanning 40 years. Recent concerns have focused on the presence of urethane in a variety of fermented foods and alcoholic beverages, although no epidemiological studies or human
Koji Takeuchi et al.
Journal of gastroenterology and hepatology, 29 Suppl 4, 37-46 (2014-12-19)
We examined the prophylactic effect of rebamipide on gastric bleeding induced by the perfusion of aspirin (acetylsalicylic acid [ASA]) plus clopidogrel under the stimulation of acid secretion in rats. Under urethane anesthesia, acid secretion was stimulated by the i.v. infusion
Lea Ann Dailey et al.
Nanotoxicology, 9(1), 106-115 (2014-03-14)
Inhaled nanomaterials present a challenge to traditional methods and understanding of respiratory toxicology. In this study, a non-targeted metabolomics approach was used to investigate relationships between nanoparticle hydrophobicity, inflammatory outcomes and the metabolic fingerprint in bronchoalveolar fluid. Measures of acute
Takeshi Shima et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(9), G811-G818 (2014-03-22)
A well-developed myenteric plexus exists in the esophagus composed of striated muscle layers, but its functional role in controlling peristaltic movements remains to be clarified. The purpose of this study was to clarify the role of a local neural reflex
J F Cadranel et al.
Journal of clinical gastroenterology, 17(1), 52-56 (1993-07-01)
We report subacute necrosis, peliosis hepatis, venoocclusive disease and hepatic angiosarcoma after long-term administration of urethane. We take this to be the 12th case of urethane-induced hepatitis and the first associated with vascular liver tumor.
Aspects of the mechanism of urethane carcinogenesis.
K Williams et al.
Xenobiotica; the fate of foreign compounds in biological systems, 1(4), 545-550 (1971-07-01)
Giancarla Aparecida Botelho-Santos et al.
Therapeutic advances in cardiovascular disease, 6(5), 201-211 (2012-10-10)
We have recently shown that the acute infusion of angiotensin-(1-7) [Ang-(1-7)] or chronic increase in plasma Ang-(1-7) produces important changes in regional blood flow in rats. To further assess whether these changes are related to Mas, in this study hemodynamic
Jing Bi et al.
Journal of cellular and molecular medicine, 18(6), 1226-1235 (2014-03-22)
Preservation or restoration of normal alveolar epithelial barrier function is crucial for pulmonary oedema resolution. Keratinocyte growth factor-2 (KGF-2), a potent epithelial cell mitogen, may have a role in preventing ventilator-induced lung injury (VILI), which occurs frequently in mechanically ventilated
C Coskun et al.
Irish journal of medical science, 183(4), 539-548 (2013-12-03)
CDP-choline exerts tissue protective effect in several ischemic conditions. Recently we have reported that the drug prevents cardiac arrhythmias and improves survival rate in short-term myocardial ischemia reperfusion in rats. In the current study, we determined the effect of intravenously
Katie M Vance et al.
Neuroscience letters, 582, 115-119 (2014-09-16)
Artemisia extracts have been used as remedies for a variety of maladies related to metabolic and gastrointestinal control. Because the vagal afferent-nucleus of the solitary tract (NST) synapse regulates the same homeostatic functions affected by Artemisia, it is possible that
Luigi Brunetti et al.
Pharmacological reports : PR, 66(6), 991-995 (2014-12-03)
Omentin is an adipokine expressed in visceral adipose tissue (VAT). In vitro studies demonstrated that omentin induces vasorelaxation in isolated rat mesenteric arteries, and in vivo studies showed inhibition of agonist-induced increases in blood pressure, possibly mediated by nitric oxide
Ping Zhang et al.
Molecular medicine reports, 10(6), 2793-2804 (2014-09-23)
The present study aimed to examine the changes in mesenteric lymph during the development of sepsis and to identify the distinct proteins involved, as targets for further study. The sepsis animal model was constructed by cecal ligation and puncture (CLP).
C A Maggi et al.
Experientia, 42(5), 531-537 (1986-05-15)
The suitability of urethane anesthesia for physiopharmacological experiments in various systems is briefly reviewed. Urethane anesthesia appears to be suitable for various types of studies on respiratory function and on reflex activation of motility of the urinary bladder and some
Chunming Guo et al.
Human molecular genetics, 24(7), 1991-1999 (2014-12-17)
Urofacial syndrome (UFS) is an autosomal recessive disease with severe dysfunctional urination including urinary incontinence (UI). Biallelic mutations of HPSE2 are discovered from UFS patients, suggesting that HPSE2 is a candidate disease gene. Here, we show that deletion of Hpse2
Tzu-Wei Lin et al.
Neurobiology of learning and memory, 118, 189-197 (2014-12-30)
Alzheimer's disease (AD) is an age-related neurodegenerative disease. Post-mortem examination and brain imaging studies indicate that neurodegeneration is evident in the hippocampus and amygdala of very early stage AD patients. Exercise training is known to enhance hippocampus- and amygdala-associated neuronal
Kentaro Takezawa et al.
American journal of physiology. Renal physiology, 307(2), F234-F241 (2014-05-09)
Various animal models have been used in research into bladder dysfunction, and in vivo cystometry is a common method to analyze bladder function in animals. However, it is rather difficult to perform reliably in small animals. Transabdominal bladder ultrasonography combined
Zeliha Bayram et al.
Journal of cardiovascular pharmacology, 64(3), 277-284 (2014-06-03)
We investigated the functional effects of glucagon-like peptide-1 [GLP-1(7-36)] and GLP-1(9-36) and the mechanism(s) playing a role in the effects of these agents in isolated small resistance arteries from control and diabetic rats. Cumulative concentrations of GLP-1(7-36) and GLP-1(9-36) produced
A A Scopinho et al.
British journal of pharmacology, 155(5), 752-756 (2008-07-22)
Control of food intake is a complex behaviour which involves many interconnected brain structures. The present work assessed if the noradrenergic system in the lateral septum (LS) was involved in the feeding behaviour of rats. In the first protocol, the
Erin M Miller et al.
Psychopharmacology, 231(15), 3019-3029 (2014-04-01)
Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased stimulation of dopamine
Hiroyuki Ura et al.
Brain research, 1492, 63-71 (2012-11-28)
Vagus nerve stimulation (VNS) ameliorates deficits of hippocampal functions, such as contextual learning and memory, probably through direct modulation of neuronal activity. Previous studies showed that VNS enhanced excitatory synaptic transmission in the hippocampal CA3 area via activation of β-adrenergic
I-Ching Wang et al.
PloS one, 4(8), e6609-e6609 (2009-08-13)
The Forkhead Box m1 (Foxm1) protein is induced in a majority of human non-small cell lung cancers and its expression is associated with poor prognosis. However, specific requirements for the Foxm1 in each cell type of the cancer lesion remain
Anan Li et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 51(4), 458-463 (2012-10-10)
Different types of oscillations in the olfactory bulb (OB), including θ (1 to 4 and 5 to 12 Hz), β (13 to 30 Hz), and γ oscillations (31 to 64 and 65 to 90 Hz), are important in olfactory information
James W Brodsky et al.
Foot & ankle international, 33(9), 772-778 (2012-09-22)
The most common method of customizing shoe insoles to the shape and surface of the foot is to heat and then mold the materials. The effect of heating on the mechanical properties of these materials is unknown. The properties of
Christina M Perez et al.
Inhalation toxicology, 27(1), 54-63 (2015-01-21)
Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that
Péter Baracskay et al.
BMC neuroscience, 10, 133-133 (2009-11-17)
The impairment of the pontine reticular formation (PRF) has recently been revealed to be histopathologically connected with focal-cortical seizure induced generalized convulsive status epilepticus. To elucidate whether the impairment of the PRF is a general phenomenon during status epilepticus, the
Michal Ríha et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(9), 823-835 (2014-06-06)
Catecholamines are endogenous amines that participate in the maintenance of cardiovascular system homeostasis. However, excessive release or exogenous administration of catecholamines is cardiotoxic. The synthetic catecholamine, isoprenaline (isoproterenol, ISO), with non-selective β-agonistic activity has been used as a viable model
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