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Wei Liu et al.
PloS one, 10(4), e0122366-e0122366 (2015-04-08)
Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease. This study systematically investigated the in vitro and in vivo metabolism of VAS in rat using
Inês Carneiro et al.
British journal of pharmacology, 171(14), 3404-3419 (2014-04-05)
Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood. We compared the effects of UDP and of the selective P2Y6 receptor agonist
Xin Su et al.
Neurourology and urodynamics, 34(1), 92-97 (2013-10-24)
To determine time course of the bladder inhibitory response to unilateral or bilateral stimulation of the tibial nerve (TN) and spinal nerve (SN) as well as the interaction of stimulation at these two sites. In anesthetized female rats, a wire
M Hadi Saiepour et al.
Current biology : CB, 25(6), 713-721 (2015-03-11)
To ensure that neuronal networks function in a stable fashion, neurons receive balanced inhibitory and excitatory inputs. In various brain regions, this balance has been found to change temporarily during plasticity. Whether changes in inhibition have an instructive or permissive
C A Maggi et al.
Experientia, 42(2), 109-114 (1986-02-15)
The suitability of urethane anesthesia for physiopharmacological investigations is reviewed. Total dose administered and route of administration are recognized as factors having a great influence on both resting parameters and biological responses to drugs. A peculiar characteristic of urethane is
Christianne E Strang et al.
Journal of neurophysiology, 113(1), 203-217 (2014-10-10)
The purpose of this study was to evaluate the expression patterns of nicotinic and muscarinic ACh receptors (nAChRs and mAChRs, respectively) in relation to one another and to understand their effects on rabbit retinal ganglion cell response properties. Double-label immunohistochemistry
Kodai Ingawa et al.
PloS one, 9(4), e94853-e94853 (2014-04-18)
Several systematic reviews have reported that flow mediated dilatation (FMD) was significantly increased in subjects after ingestion of chocolate that contains flavan-3-ols; however, the mechanisms responsible for this effect are not clear. In this study, we evaluated the effects of
J Schlatter et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 28(3), 205-211 (1990-03-01)
Ethyl carbamate is found in fermented foods: bread contains 3-15 ng/g, stone-fruit brandies 200-20,000 ng/g, and about one-third of table-wine samples analysed contained more than 10 ng/g. In animals, ethyl carbamate is degraded to CO2, H2O and NH3, with intermediate
Kun-Ze Lee et al.
Experimental neurology, 263, 314-324 (2014-12-03)
Repeated exposure to hypoxia can induce spinal neuroplasticity as well as respiratory and somatic motor recovery after spinal cord injury (SCI). The purpose of the present study was twofold: to define the capacity for a single bout of hypoxia to
Yutaka Maeda et al.
The Journal of clinical investigation, 122(12), 4388-4400 (2012-11-13)
Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and is associated with decreased or absent expression of the transcription factor NK2 homeobox 1 (NKX2-1; also known as TTF-1). Here, we show that haploinsufficiency of Nkx2-1
Katie M Vance et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 776-785 (2015-01-16)
Severe autonomic dysfunction, including the loss of control of the cardiovascular, respiratory, and gastrointestinal systems, is a common comorbidity of stroke and other bleeding head injuries. Previous studies suggest that this collapse of autonomic control may be caused by thrombin
Cezary Jan Treda et al.
Carcinogenesis, 35(4), 896-904 (2013-11-28)
Secretory leukocyte protease inhibitor (SLPI), 11.7 kDa serine protease inhibitor, is produced primarily in the respiratory tract, but it is often elevated in lung, head/neck and ovarian cancers. SLPI expression in relation to cancer progression, metastasis and invasion has been
On the versatility of urethane/urea bonds: reversibility, blocked isocyanate, and non-isocyanate polyurethane.
Etienne Delebecq et al.
Chemical reviews, 113(1), 80-118 (2012-10-23)
H H Lee et al.
Human & experimental toxicology, 33(11), 1121-1133 (2014-02-08)
When lidocaine is locally delivered into the inner ear, it rapidly paralyzes the peripheral vestibular afferent neurons and induces unilateral vestibular loss. The goals of this study were to explore the possibility of developing intratympanic injection (IT) of lidocaine as
Ajay Padsalgikar et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(1), 159-168 (2014-05-09)
Polyurethane biostability has been the subject of intense research since the failure of polyether polyurethane pacemaker leads in the 1980s. Accelerated in vitro testing has been used to isolate degradation mechanisms and predict clinical performance of biomaterials. However, validation that
Chiao-Jung Kao et al.
Cancer immunology research, 2(6), 581-589 (2014-06-05)
The goals of the present study were to define the effects of simultaneous cisplatin/tecemotide therapy on tumor development in a human mucin 1 (MUC1) transgenic lung cancer mouse model and to examine the effects of radiotherapy (RTX) on splenocytes, serum
Yi Zhang et al.
Biomaterials, 34(16), 4048-4056 (2013-03-08)
The field of tissue engineering and drug delivery calls for new measurement tools, non-invasive real-time assays, and design methods for the next wave of innovations. Based on our recent progress in developing intrinsically biodegradable photoluminescent polymers (BPLPs) without conjugating organic
Fatos Belgin Yildirim et al.
Neurochemistry international, 79, 1-11 (2014-09-30)
This study aimed to elucidate locomotor activity changes in 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) and investigate the possible beneficial effects of melatonin on altered levels of locomotor activity, cyclooxygenase (COX), prostaglandin E2 (PGE2), nuclear factor kappa-B (NF-κB), nitrate/nitrite and
Kefei Liu et al.
The European journal of neuroscience, 39(12), 2060-2070 (2014-06-17)
Both theoretical and experimental studies suggest that response properties in the visual system are shaped by signals in the natural environment. Recent studies showed that, in the primary visual cortex (V1), neurons preferring light decrements (OFF stimuli) outnumber those preferring
Hany M El-Bassossy et al.
Journal of diabetes research, 2015, 178540-178540 (2015-03-19)
The aim of the current study was to evaluate the possible protective effect of allopurinol (Allo) on experimentally induced insulin resistance (IR) and vascular complications. Rats were divided into four groups: control, IR, allopurinol-treated IR (IR-Allo), and allopurinol-treated control (Allo).
Marta Cal et al.
Amino acids, 44(3), 1085-1091 (2012-12-20)
1-[(4-Methylphenyl)oxy]pyrrolidine-2,5-dione and 1-[(4-methylphenyl)oxy]piperidine-2,6-dione react in a Lossen-type reaction with primary alcohols in the presence of triethylamine to furnish corresponding N(α)-urethane-protected β-alanine and γ-aminopropionic acid (GABA), respectively, with excellent yields and purities, in an essentially "one-pot" procedure.
Omar Z Ameer et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H143-H151 (2014-05-20)
This study investigated the effects of hypertension on regional aortic biomechanical and structural properties in three rat models of vascular calcification: the hypertensive Lewis polycystic kidney (LPK; n = 13) model of chronic kidney disease, spontaneously hypertensive rats (SHRs; n
Zhaohui Li et al.
Chinese medical journal, 127(19), 3464-3470 (2014-10-02)
Diabetes-related pathogenic factors can cause retinal ganglion cell (RGC) apoptosis, but the specific mechanism is not very clear. The aim of this study is to investigate the correlation between glycogen synthase kinase-3 (GSK-3) activation and retinal neuron apoptosis. In an
Robert T R Huckstepp et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1052-1067 (2015-01-23)
Contiguous brain regions associated with a given behavior are increasingly being divided into subregions associated with distinct aspects of that behavior. Using recently developed neuronal hyperpolarizing technologies, we functionally dissect the parafacial region in the medulla, which contains key elements
Aspects of the mechanism of urethane carcinogenesis.
K Williams et al.
Xenobiotica; the fate of foreign compounds in biological systems, 1(4), 545-550 (1971-07-01)
Ana Maria de Resende Machado et al.
Food chemistry, 138(2-3), 1233-1238 (2013-02-16)
Ethyl carbamate (EC) is a common substance in fermented foods and drinks, and its quantification is important because of its carcinogenic nature and its usually presence in alcoholic beverages. The present work involved the development and validation of an analytical
Toshiya Ueno et al.
Anticancer research, 32(11), 4773-4780 (2012-11-17)
Lung cancer is the leading cause of cancer-related death worldwide. We previously reported that respiration-gated X-ray micro-computed tomography (micro-CT) is a useful tool for analyzing lung tumor development in animal models. Lung tumors were induced by a single intraperitoneal injection
Jonathan M Ehrich et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(13), 3036-3048 (2014-06-28)
Behavioral stressors increase addiction risk in humans and increase the rewarding valence of drugs of abuse including cocaine, nicotine and ethanol in animal models. Prior studies have established that this potentiation of drug reward was mediated by stress-induced release of
New biomedical poly (urethane urea)? layered silicate nanocomposites
Xu R, et al.
Macromolecules, 34, 337-339 (2001)
Fernando Eduardo Padovan-Neto et al.
Neuropharmacology, 89, 87-99 (2014-09-10)
It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID). Here, we investigated the ability of
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