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A L Gomes et al.
Journal of clinical pathology, 61(2), 203-208 (2007-09-11)
To assess KIT and PDGFRA mutations frequencies in a Portuguese series of gastrointestinal stromal tumours (GISTs). 78 GISTs were evaluated for CD117 expression and screened for mutations in KIT (exons 9, 11, 13, 14 and 17) and PDGFRA (exons 12
Ana Marote et al.
Stem cell research, 27, 90-94 (2018-01-23)
Mutations in the PARK2 gene, which encodes PARKIN, are the most frequent cause of autosomal recessive Parkinson's disease (PD). We report the generation of an induced pluripotent stem cell (iPSC) line from a 78-year-old patient carrying a compound heterozygous mutation
[Expression and significance of Slug, E-cadherin and N-cadherin in gastrointestinal stromal tumors].
Jie Ding et al.
Zhonghua yi xue za zhi, 92(4), 264-268 (2012-04-12)
To explore the expression and clinical significance of Slug, E-cadherin and N-cadherin in gastrointestinal stromal tumors (GIST). Seventy eight GIST specimens removed surgically from 2004 to 2007 were collected from the Department of Gastrointestinal Surgery at Guizhou Provincial People's Hospital.
Marcel Dautzenberg et al.
The Journal of physiology, 589(Pt 19), 4731-4744 (2011-08-10)
Nitric oxide (NO) blunts the myogenic response (MR) in renal blood flow (RBF) autoregulation. We sought to clarify the roles of NO synthase (NOS) isoforms, i.e. neuronal NOS (nNOS) from macula densa, endothelial NOS (eNOS) from the endothelium, and inducible
L Lund et al.
The Journal of urology, 191(5), 1347-1350 (2013-11-23)
We evaluate whether aspiration and sclerosing of hydrocele testis is an effective treatment. Men with symptomatic hydrocele testis were included in this prospective, double-blind, randomized study with polidocanol and placebo. Patients were randomized to active treatment or placebo at the
P J Willems et al.
American journal of medical genetics, 38(1), 111-131 (1991-01-01)
Fucosidosis is a rare, autosomal recessive, lysosomal storage disorder caused by a severe deficiency of alpha-L-fucosidase in all tissues. We have conducted a review of fucosidosis, compiling data from published reports and an international questionnaire survey. Seventy-seven patients affected with
Massimo Imazio et al.
Circulation, 123(10), 1092-1097 (2011-03-02)
The role of inflammatory markers is not well defined for either diagnosis or treatment of pericarditis. The aim of this study is to prospectively evaluate the frequency of high-sensitivity C-reactive protein (hs-CRP) elevation in patients with acute pericarditis, its time
Sheikh Shreaz et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 24(5), 923-933 (2011-04-09)
Antifungal effectivity and utility of cinnamaldehyde is limited because of its high MIC and skin sensitivity. In this study, α-methyl trans cinnamaldehyde, a less irritating derivative, have been self coupled and complexed with Co(II) and Ni(II) to generate N, N'-Bis
Daniela Matei et al.
Gynecologic oncology, 115(1), 90-96 (2009-07-07)
2-Methoxyestradiol (Panzem, 2ME2) is an endogenous metabolite of estradiol that destabilizes microtubules and exerts anti-angiogenic properties. This study was conducted to determine the activity and safety of 2ME2 administered as a NanoCrystal dispersion (NCD) formulation in patients with recurrent, platinum-resistant
W Dimpfel et al.
European journal of medical research, 3(10), 453-460 (1998-10-01)
Sleep in humans is classically assessed by recording a multichannel electroencephalogram (EEG) in connection with an electrooculogram (EOG) and an electromyogram (EMG). In general, human sleep is manually staged into 6 categories (from awake through REM sleep to stage 4
Shirish M Gadgeel et al.
Cancer chemotherapy and pharmacology, 72(5), 1089-1096 (2013-09-24)
Everolimus, an oral inhibitor of mammalian target of rapamycin, can augment the efficacy of HER inhibitors in preclinical studies. This study was conducted to determine the safety and pharmacokinetics (PK) of the combination of lapatinib, a Her1 and 2 inhibitor
Aida Ormazabal et al.
Molecular genetics and metabolism, 94(2), 173-177 (2008-02-26)
Our aim was to establish reference values for cerebrospinal fluid (CSF) pyridoxal 5'-phosphate (PLP) in a paediatric population for the diagnosis of pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency. For reference values, CSF samples from 113 paediatric controls (age range: 1 day-18
Prachi Ghule et al.
Medical science monitor : international medical journal of experimental and clinical research, 12(12), BR385-BR396 (2006-12-01)
Somatic and constitutional mutation screening of p53 in childhood sarcomas and retinoblastoma was investigated by a multitechnical approach to evaluate its role in the development/progression by somatic mutation events and/or genetic predisposition. The studies were carried out on a cohort
Antonia Valenzuela et al.
Journal of clinical gastroenterology, 49(2), 158-164 (2014-05-09)
We aimed to determine the incidence and predictors of recurrent hepatocellular carcinoma (HCC) after partial hepatectomy. Liver transplantation is the preferred treatment for selected patients with HCC, but access to donor organs is limited. Partial hepatectomy is another accepted treatment
Gottfried E Konecny et al.
Gynecologic oncology, 109(2), 263-269 (2008-03-04)
Tight junction (TJ) proteins claudin-3 and claudin-4 may be differentially expressed in uterine serous papillary carcinoma (USPC), a rare form of endometrial cancer characterized by a particularly poor prognosis. Our aim was to determine the expression pattern and prognostic relevance
Margherita Bodini et al.
mSphere, 5(5) (2020-09-18)
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is a significant cause of morbidity and mortality worldwide. In Finland, the incidence rate of IMD is low, with meningococcal serogroup B (MenB) accounting for around one-third of IMD cases annually. The
Gottfried E Konecny et al.
Gynecologic oncology, 109(2), 263-269 (2008-03-04)
Tight junction (TJ) proteins claudin-3 and claudin-4 may be differentially expressed in uterine serous papillary carcinoma (USPC), a rare form of endometrial cancer characterized by a particularly poor prognosis. Our aim was to determine the expression pattern and prognostic relevance
J P Chism et al.
Drug metabolism and disposition: the biological fate of chemicals, 13(6), 651-657 (1985-11-01)
2-Nitrotoluene (2NT) induces DNA repair in the in vivo-in vitro hepatocyte unscheduled DNA synthesis assay in male, but not female, Fischer-344 rats. 3-Nitrotoluene (3NT) and 4-nitrotoluene (4NT) are inactive in both sexes. The structurally related rat hepatocarcinogen, 2,6-dinitrotoluene, which also
Mathieu Boulin et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 43(11), 905-911 (2011-08-02)
There is no consensus about the most effective method for transarterial chemoembolisation of hepatocellular carcinoma. The aim of this phase II trial was to compare the efficacy and toxicity of lipiodol transarterial chemoembolisation with amiodarone in association with pirarubicin or
Luca Maurillo et al.
American journal of hematology, 90(2), 125-131 (2014-11-08)
We assessed by flow cytometry minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) given standard-dose (SDAC) and high-dose ARA-C (HDAC) regimens. Of 163 patients enrolled, 130 (median age, 45 years; range, 18-59 years) qualified for analysis, all
Yoshiko Matsuda et al.
Cancer science, 98(7), 1014-1019 (2007-04-27)
Like gastric and intestinal mucins, the tight junction proteins called claudins can be used to determine the differentiation of gastric mucosa. We investigated the expression of claudins in gastric cancer and proposed a new claudin-based gastric cancer classification system. The
Jayashree C Jagtap et al.
PloS one, 9(2), e88505-e88505 (2014-02-14)
Gliomas are the most common and aggressive of brain tumors in adults. Cancer stem cells (CSC) contribute to chemoresistance in many solid tumors including gliomas. The function of prostate apoptosis response-4 (Par-4) as a pro-apoptotic protein is well documented in
Xin Mao et al.
Blood, 101(4), 1513-1519 (2002-10-24)
Primary cutaneous lymphomas (PCLs) represent a heterogeneous group of extranodal T- and B-cell malignancies. The underlying molecular pathogenesis of this malignancy remains unclear. This study aimed to characterize oncogene abnormalities in PCLs. Using genomic microarray, we detected oncogene copy number
Jun-Hong Sun et al.
Forensic science international, 272, 104-110 (2017-01-28)
The combined use of multiple markers is considered a promising strategy in estimating the age of wounds. We sought to develop an "up, no change, or down" system and to explore how to combine and use various parameters. In total
Kay L Saving et al.
Journal of pediatric hematology/oncology, 24(2), 120-124 (2002-05-07)
To examine the hypothesis that reticulated platelets and reticulocytes show elevated adhesion receptor expression compared with mature cells in both adult and neonatal cells. Flow cytometry was used to examine laminin, fibronectin (VLA-6), and thrombospondin (glycoprotein IV [GPIV]) expression in
Kun-Che Chang et al.
Chemico-biological interactions, 234, 254-260 (2014-12-03)
Chronic hyperglycemia is an important risk factor involved in the onset and progression of diabetic retinopathy (DR). Among other effectors, aldose reductase (AR) has been linked to the pathogenesis of this degenerative disease. The purpose of this study was to
Tao Tang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(5-6), 507-512 (2009-01-24)
Eighteen samples of commercially available Chinese beer were analyzed in order to determine the content of biogenic amines. The method involves pre-column derivatization of the amines with 4-chloro-3,5-dinitrobenzotrifluoride (CNBF) and subsequent analysis by RP-HPLC (reversed phase-high performance liquid chromatography) with
Thomas Quaschning et al.
Kidney & blood pressure research, 31(2), 127-134 (2008-04-09)
Endothelin-1 (ET-1) is one of the most potent biologic vasoconstrictors. Nevertheless, transgenic mice overexpressing ET-1 exhibit normal blood pressure. We hypothesized that in states of ET-1 overproduction, the lack of counterregulatory mediators such as nitric oxide (NO), produced by the
Christophe Hézode et al.
Lancet (London, England), 385(9986), 2502-2509 (2015-04-04)
Hepatitis C virus (HCV) genotype 4 accounts for about 13% of global HCV infections. Because interferon-containing treatments for genotype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-oral regimens. We examined the efficacy and
Fiona V Cresswell et al.
The Lancet. Infectious diseases, 20(3), 308-317 (2020-01-12)
Tuberculous meningitis accounts for 1-5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis diagnosis. In this prospective validation study, we tested the cerebrospinal fluid
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